Umod

Summary

Gene Symbol: Umod
Description: uromodulin
Alias: THP, uromodulin, Urmodulin (Tamm-Horsfall protein), tamm-Horsfall urinary glycoprotein
Species: rat
Products:     Umod

Top Publications

  1. Stuiver M, Lainez S, Will C, Terryn S, Gunzel D, Debaix H, et al. CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet. 2011;88:333-43 pubmed publisher
    ..The mutations found in CNNM2, its observed sensitivity to extracellular Mg(2+), and its basolateral localization signify a critical role for CNNM2 in epithelial Mg(2+) transport. ..
  2. Bachmann S, Koeppen Hagemann I, Kriz W. Ultrastructural localization of Tamm-Horsfall glycoprotein (THP) in rat kidney as revealed by protein A-gold immunocytochemistry. Histochemistry. 1985;83:531-8 pubmed
    The present study describes the intracellular distribution of Tamm-Horsfall protein (THP) in rat kidney. The localization was determined by immunoelectron microscopy using the protein A-gold technique...
  3. Hu E, Chen Z, Fredrickson T, Spurr N, Gentle S, Sims M, et al. Rapid isolation of tissue-specific genes from rat kidney. Exp Nephrol. 2001;9:156-64 pubmed
    ..Our results suggested that tissue-specific genes can be rapidly isolated and characterized using PCR-select techniques and this methodology may be generally applicable to isolate specific genes from a variety of tissues. ..
  4. Hart T, Gorry M, Hart P, Woodard A, Shihabi Z, Sandhu J, et al. Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet. 2002;39:882-92 pubmed
    ..We identified four novel uromodulin (UMOD) gene mutations that segregate with the disease phenotype in three families with FJHN and in one family ..
  5. Schmitt R, Kahl T, Mutig K, Bachmann S. Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys. Histochem Cell Biol. 2004;121:319-27 pubmed
    ..Synthesis of Tamm-Horsfall protein (THP), the most abundant urinary protein produced in the TAL, has been suggested to interfere with TAL function...
  6. Mo L, Huang H, Zhu X, Shapiro E, Hasty D, Wu X. Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. Kidney Int. 2004;66:1159-66 pubmed
    ..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout ..
  7. Aigner B, Rathkolb B, Herbach N, Kemter E, Schessl C, Klaften M, et al. Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am J Physiol Renal Physiol. 2007;292:F1560-7 pubmed
  8. Huang H, Chen J, Chen C, Ma M. Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors. Kidney Int. 2006;70:699-710 pubmed
    ..S-transferase, proliferating cell nuclear antigen (PCNA), osteopontinin (OPN), and Tamm-Horsfall protein (THP) were also measured, and TUNEL staining was performed to examine the viability of the tubular epithelium...
  9. Rindler M, Naik S, Li N, Hoops T, Peraldi M. Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a phosphatidylinositol-linked membrane protein. J Biol Chem. 1990;265:20784-9 pubmed
    b>Uromodulin, originally identified as an immunosuppressive glycoprotein in the urine of pregnant women, has been previously shown to be identical to human Tamm-Horsfall glycoprotein (THP)...

Scientific Experts

More Information

Publications22

  1. Schmid M, Prajczer S, Gruber L, Bertocchi C, Gandini R, Pfaller W, et al. Uromodulin facilitates neutrophil migration across renal epithelial monolayers. Cell Physiol Biochem. 2010;26:311-8 pubmed publisher
    The glycosylated protein uromodulin is exclusively found in the thick ascending limb cells (TAL) of the kidney, where it is produced on mass and apically targeted, eventually being secreted into the urine...
  2. Shen H, Xu Z, Huang L, Liu D, Lin D, Cao J, et al. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. Mol Cell Biochem. 2009;321:73-83 pubmed publisher
    ..In rat kidney LZP and Tamm-Horsfall protein (THP) were co-localized in TAL...
  3. Trzpis M, Popa E, McLaughlin P, van Goor H, Timmer A, Bosman G, et al. Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys. Nephron Exp Nephrol. 2007;107:e119-31 pubmed
    ..The spatiotemporal expression pattern of EpCAM changes during nephrogenesis. In the adult kidney, the expression varies markedly along the nephron. These data provide a basis for further studies on EpCAM in developing and adult kidneys. ..
  4. Pragasam V, Kalaiselvi P, Sumitra K, Srinivasan S, Varalakshmi P. Oral L-arginine supplementation ameliorates urinary risk factors and kinetic modulation of Tamm-Horsfall glycoprotein in experimental hyperoxaluric rats. Clin Chim Acta. 2005;360:141-50 pubmed
    ..with excretion of urinary marker enzymes and lithogenic salts with special reference to Tamm-Horsfall glycoprotein (THP). Hyperoxaluria was induced by 0.75% ethylene glycol (EG) in drinking water...
  5. Thorup C, Ollerstam A, Persson A, Torffvit O. Increased tubuloglomerular feedback reactivity is associated with increased NO production in the streptozotocin-diabetic rat. J Diabetes Complications. 2000;14:46-52 pubmed
    ..This model is known to induce damage in the distal tubular system and thus Tamm-Horsfall protein (THP) secretion...
  6. Sikri K, Foster C, MacHugh N, Marshall R. Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques. J Anat. 1981;132:597-605 pubmed
    ..obtained by immuno-fluorescence and immuno-electron microscopical techniques show that Tamm-Horsfall glycoprotein (THP) is present in the thick ascending limbs of the loops of Henle and the distal convoluted tubules...
  7. Fukuoka S, Freedman S, Yu H, Sukhatme V, Scheele G. GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney. Proc Natl Acad Sci U S A. 1992;89:1189-93 pubmed
    ..GPI)-linked glycoprotein of pancreatic zymogen granule membranes, and Tamm-Horsfall protein (THP), a GPI-linked glycoprotein associated with apical vesicles in kidney thick ascending limb of Henle (TALH) cells...
  8. Welker P, Geist B, Frühauf J, Salanova M, Groneberg D, Krause E, et al. Role of lipid rafts in membrane delivery of renal epithelial Na+-K+-ATPase, thick ascending limb. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1328-37 pubmed
    ..These results may have functional implications regarding the turnover, trafficking, and regulated surface expression of NKA as the major basolateral ion transporter of TAL. ..
  9. El Achkar T, Plotkin Z, Marcic B, Dagher P. Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent. Am J Physiol Renal Physiol. 2007;293:F1187-96 pubmed
    ..The TLR4-dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein. ..
  10. Yu H, Papa F, Sukhatme V. Bovine and rodent tamm-horsfall protein (THP) genes: cloning, structural analysis, and promoter identification. Gene Expr. 1994;4:63-75 pubmed
    We have isolated bovine and rodent cDNA and genomic clones encoding the kidney-specific Tamm-Horsfall protein (THP). In both species the gene contains 11 exons, the first of which is noncoding...
  11. Zaucke F, Boehnlein J, Steffens S, Polishchuk R, Rampoldi L, Fischer A, et al. Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression. Hum Mol Genet. 2010;19:1985-97 pubmed publisher
    b>Uromodulin (UMOD) mutations are responsible for three autosomal dominant tubulo-interstitial nephropathies including medullary cystic kidney disease type 2 (MCKD2), familial juvenile hyperuricemic nephropathy and glomerulocystic kidney ..
  12. Mary S, Small H, Siwy J, Mullen W, Giri A, Delles C. Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat. Hypertension. 2017;69:910-918 pubmed publisher
    ..fragments of collagen ?-chains, albumin, prothrombin, actin, serpin A3K, proepidermal growth factor, and uromodulin. Uromodulin peptides showed a pregnancy-specific alteration in SHRSP with a 7.8-fold (P<0.01) and 8...
  13. Georgas K, Rumballe B, Wilkinson L, Chiu H, Lesieur E, Gilbert T, et al. Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem Cell Biol. 2008;130:927-42 pubmed publisher
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...