Gene Symbol: Uhmk1
Description: U2AF homology motif kinase 1
Alias: KIS, Kist, serine/threonine-protein kinase Kist, P-CIP2, PAM COOH-terminal interactor protein 2, U2AF homology motif (UHM) kinase 1, kinase interacting stathmin, kinase interacting with leukemia-associated gene (stathmin), kinase interacting with stathmin
Maucuer A, Ozon S, Manceau V, Gavet O, Lawler S, Curmi P, et al
. KIS is a protein kinase with an RNA recognition motif. J Biol Chem. 1997;272:23151-6 pubmed
..here the first identification of a serine/threonine kinase that possesses an RNP-type RNA recognition motif: KIS. We originally isolated KIS in a two-hybrid screen through its interaction with stathmin, a small phosphoprotein ..
Boehm M, Yoshimoto T, Crook M, Nallamshetty S, True A, Nabel G, et al
. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 2002;21:3390-401 pubmed
..Here, we identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression...
Alam M, Caldwell B, Johnson R, Darlington D, Mains R, Eipper B. Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme. J Biol Chem. 1996;271:28636-40 pubmed
..P-CIP2 and P-CIP10 may be members of a family of cytosolic proteins involved in the routing of membrane proteins that function in the regulated secretory pathway. ..
Caldwell B, Darlington D, Penzes P, Johnson R, Eipper B, Mains R. The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999;274:34646-56 pubmed
..P-CIP2, through its highly selective phosphorylation of a key site in the cytosolic domain of PAM, appears to play a critical role in the trafficking of this protein. ..
Manceau V, Kielkopf C, Sobel A, Maucuer A. Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors. J Mol Biol. 2008;381:748-62 pubmed publisher
The protein kinase KIS is made by the juxtaposition of a unique kinase domain and a C-terminal domain with a U2AF homology motif (UHM), a sequence motif for protein interaction initially identified in the heterodimeric pre-mRNA splicing ..
Cambray S, Pedraza N, Rafel M, Garí E, Aldea M, Gallego C. Protein kinase KIS localizes to RNA granules and enhances local translation. Mol Cell Biol. 2009;29:726-35 pubmed publisher
..We show that KIS, a serine/threonine kinase functionally related to microtubule dynamics and axon development, interacts with three ..