Ugt1a1

Summary

Gene Symbol: Ugt1a1
Description: UDP glucuronosyltransferase family 1 member A1
Alias: UDPGT 1-1, Udpgt, Ugt1, UDP-glucuronosyltransferase 1-1, UDP glucuronosyltransferase 1 family, polypeptide A1, UDP glycosyltransferase 1 family, polypeptide A1, UDP-glucuronosyltransferase 1 family member 1, UDP-glucuronosyltransferase 1A1, UGT1*1, UGT1-01, UGT1.1
Species: rat
Products:     Ugt1a1

Top Publications

  1. Yokota H, Kunimasa Y, Shimoyama Y, Kobayashi T, Matsumoto J, Yuasa A. Effects on extrahepatic UDP-glucuronosyltransferases in hypophysectomized rat. J Biochem. 2002;132:265-70 pubmed
    ..The mRNA of UGT1A1, which is an isoform contributing to the glucuronidation of bilirubin, increased significantly in the liver and ..
  2. Cecchin E, Russo A, Corona G, Campagnutta E, Martella L, Boiocchi M, et al. UGT1A1*28 polymorphism in ovarian cancer patients. Oncol Rep. 2004;12:457-62 pubmed
    Uridino-diphosphate)glucuronosyl-transferase enzyme 1A1 isoform (UGT1A1) is involved in glucuronidation of antineoplastic drugs such as SN38, the active metabolite of irinotecan, as well as estrogens and their metabolites...
  3. Bustamante N, Cantarino M, Arahuetes R, Cubero F, Ortiz A. Evolution of the activity of UGT1A1 throughout the development and adult life in a rat. Life Sci. 2006;78:1688-95 pubmed
    ..The glucuronidation of bilirubin is catalysed by the microsomal UDP-glucuronosyltransferase UGT1A1. Patients with Crigler-Najjar syndrome type 1 and Gunn rats, mutant strain of the Wistar rats, bear an autosomal ..
  4. Alkharfy K, Poloyac S, Congiu M, Desmond P, Frye R. Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats. Drug Metab Lett. 2008;2:248-55 pubmed
    ..Real-Time PCR was used to determine mRNA levels of UGT1A1, 1A6, 2B1, and 2B3 in the harvested organs...
  5. Iyanagi T, Watanabe T, Uchiyama Y. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation. J Biol Chem. 1989;264:21302-7 pubmed
    ..rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin...
  6. Jia Z, DANKO I. Long-term correction of hyperbilirubinemia in the Gunn rat by repeated intravenous delivery of naked plasmid DNA into muscle. Mol Ther. 2005;12:860-6 pubmed
    ..The procedure is safe and simple, with great clinical potential. Further studies are needed to explain the mechanisms of loss and improve the stability of recombinant hUGT1A1 in muscle. ..
  7. Innocenti F, Undevia S, Iyer L, Chen P, Das S, Kocherginsky M, et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol. 2004;22:1382-8 pubmed
    Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38...
  8. Emi Y, Omura S, Ikushiro S, Iyanagi T. Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes. Arch Biochem Biophys. 2002;405:163-9 pubmed
    ..rat strain that is inherently deficient in the activity of UDP-glucuronosyltransferase form 1A1 (UGT1A1)...
  9. Han J, Lim H, Shin E, Yoo Y, Park Y, Lee J, et al. Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. J Clin Oncol. 2006;24:2237-44 pubmed
    ..All statistical tests were two-sided. In genotype-PK association analysis, UGT1A1*6/*6 (n = 6), UGT1A7*3/*3 (n = 6), and UGT1A9-118(dT)9/9 (n = 11) were associated with significantly lower area ..

More Information

Publications62

  1. Gao J, Zhou J, Li Y, Peng Z, Li Y, Wang X, et al. Associations between UGT1A1*6/*28 polymorphisms and irinotecan-induced severe toxicity in Chinese gastric or esophageal cancer patients. Med Oncol. 2013;30:630 pubmed publisher
    ..The genotypes of UGT1A1*6 and UGT1A1*28 were analyzed by PCR amplification and Sanger sequencing in 42 gastric and 91 esophageal cancer ..
  2. Xie H, Sun S, Cheng X, Yan T, Zheng X, Li F, et al. Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes. Drug Metab Pharmacokinet. 2013;28:427-34 pubmed
    ..The mRNA levels and enzymatic activities of UGT1A1, -1A6, and -1A7 in the diabetic intestine and colon were higher than those in nondiabetic rats...
  3. Ishii Y, Iwanaga M, Nishimura Y, Takeda S, Ikushiro S, Nagata K, et al. Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex. Drug Metab Pharmacokinet. 2007;22:367-76 pubmed
    ..Larger amounts of UGT1A1 and UGT1A6, compared with UGT2B1, were washed out from UGTs-CYP2C11/13 co-precipitates, whereas UGT-CYP3A2 and UGT-..
  4. Haberkorn V, Heydel J, Mounie J, Artur Y, Goudonnet H. Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine. Br J Nutr. 2001;85:289-97 pubmed
    ..They are responsible for glucuronidation of many substrates, especially including bilirubin (UGT1A1) and phenolic compounds (UGT1A6)...
  5. Montenegro Miranda P, Pichard V, Aubert D, ten Bloemendaal L, Duijst S, de Waart D, et al. In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV. Gene Ther. 2014;21:168-74 pubmed publisher
    ..or scAAV (self-complimentary AAV) ferrying identical liver-specific expression cassettes of the therapeutic gene, UGT1A1, were injected into the tail vein...
  6. Mori S, Terada K, Ueki Y. Tocilizumab-induced hyperbilirubinemia in Japanese patients with rheumatoid arthritis: its association with UDP glucuronosyltransferase 1A1 gene polymorphisms. Mod Rheumatol. 2012;22:515-23 pubmed publisher
    ..of an association between polymorphisms within the uridine diphosphate glucuronosyltransferase 1A1 gene (UGT1A1) and hyperbilirubinemia arising during tocilizumab therapy...
  7. Boyd M, Srasuebkul P, Ruxrungtham K, Mackenzie P, Uchaipichat V, Stek M, et al. Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Pharmacogenet Genomics. 2006;16:321-9 pubmed
    To investigate the association between the UGT1A1*6 (G71R) and UGT1A1*28 (promoter (TA)7-repeat) genotypes and hyperbilirubinaemia in Thai patients treated with indinavir, and characterize the inhibition of human UGTs by indinavir in ..
  8. Kessler F, Kessler M, Auyeung D, Ritter J. Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases. Drug Metab Dispos. 2002;30:324-30 pubmed
    ..The involvement of other UGTs besides 1A6 is further underscored by the presence of significant residual APAP-glucuronidating activity by Gunn rat hepatocytes, indicating the activity of an unknown UGT2 family member. ..
  9. Grove A, Kessler F, Metz R, Ritter J. Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol. J Biol Chem. 1997;272:1621-7 pubmed
    ..UGT1A7 appears to represent an important cellular chemoprotective enzyme which mediates conjugation and elimination of toxic benzo(a)pyrene metabolites. ..
  10. Coffman B, Green M, King C, Tephly T. Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin. Mol Pharmacol. 1995;47:1101-5 pubmed
    ..Clone pM1 was found to be a full length cDNA coding for a member of the rat UGT1 gene family. Specifically, pM1 represents the full length homologue of the Gunn rat liver pseudo-gene product UGT1...
  11. Strasser S, Mashford M, Desmond P. Regulation of uridine diphosphate glucuronosyltransferase during the acute-phase response. J Gastroenterol Hepatol. 1998;13:88-94 pubmed
    ..01). In contrast, the mRNA level of UGT1*1 (which metabolizes bilirubin, not phenols) was depressed to 16% of control (P<0...
  12. Metz R, Ritter J. Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz. J Biol Chem. 1998;273:5607-14 pubmed
    ..One possibility is that the polycyclic aromatic-mediated regulation of UGT1A7 occurs via the xenobiotic response element flanking the UGT1A6 locus 7 kilobase pairs downstream. ..
  13. King C, Green M, Rios G, Coffman B, Owens I, Bishop W, et al. The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1. Arch Biochem Biophys. 1996;332:92-100 pubmed
    ..1 share > 70% identity in their deduced primary amino acid sequences. We have previously shown that rat UGT1.1, stably expressed in human embryonic kidney 293 cells, catalyzes the glucuronidation of bilirubin and the mixed ..
  14. Vasavda N, Menzel S, Kondaveeti S, Maytham E, Awogbade M, Bannister S, et al. The linear effects of alpha-thalassaemia, the UGT1A1 and HMOX1 polymorphisms on cholelithiasis in sickle cell disease. Br J Haematol. 2007;138:263-70 pubmed
    ..SCD) are influenced by genetic variation in the hepatic uridine diphosphate (UDP)-glucuronosyltransferase (UGT1A1) gene, but the association is not consistent...
  15. Joseph T, Wang S, Liu X, Kulkarni K, Wang J, Xu H, et al. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm. 2007;4:883-94 pubmed
    ..we showed that UGT1A7, UGT1A8, and UGT1A9 were mainly responsible for the formation of metabolite 1, whereas UGT1A1, UGT1A8, and UGT1A10 were mainly responsible for the formation of metabolite 2...
  16. Radominska A, Little J, Lehman P, Samokyszyn V, Rios G, King C, et al. Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT). Drug Metab Dispos. 1997;25:889-92 pubmed
    Rat liver recombinant BR1UGT1.1 was found to have significant activity toward retinoid substrates. UGT1.1 glucuronidation activity was 91 +/- 18 pmol/mg x min for atRA and 113 +/- 19 pmol/mg x min for 5,6-epoxy-atRA...
  17. Ikushiro S, Emi Y, Iyanagi T. Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies. Arch Biochem Biophys. 1995;324:267-72 pubmed
    ..microsomes, UGT1B1 (54 kDa) of bilirubin cluster was found to be a major form and minor forms were identified as UGT1A1 (53 kDa), UGT1B2 (56 kDa), and UGT1B5 (57 kDa)...
  18. Wen H, Yang H, An Y, Kim J, Lee D, Jin X, et al. Enhanced phase II detoxification contributes to beneficial effects of dietary restriction as revealed by multi-platform metabolomics studies. Mol Cell Proteomics. 2013;12:575-86 pubmed publisher
    ..Taken together, our metabolomic and biochemical studies provide a possible metabolic perspective for understanding the complex mechanism underlying the beneficial effects of DR. ..
  19. Embola C, Sohn O, Fiala E, Weisburger J. Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats. Food Chem Toxicol. 2002;40:841-4 pubmed
    ..Therefore, a major mechanism of tea as a chemopreventive agent is induction of the microsomal detoxification enzyme, UDP-glucuronosyltransferase. ..
  20. Magnanti M, Giuliani L, Gandini O, Gazzaniga P, Santiemma V, Ciotti M, et al. Follicle-stimulating hormone, testosterone, and hypoxia differentially regulate UDP-glucuronosyltransferase 1 isoforms expression in rat sertoli and peritubular myoid cells. J Steroid Biochem Mol Biol. 2000;74:149-55 pubmed
    ..However, little information is available concerning UGTs expression in testis. The UGT1A1, UGT1A2, and UGT1B1 mRNAs expression in whole rat testis, in Sertoli and peritubular myoid cells in basal ..
  21. del Giudice E, Perrotta S, Nobili B, Specchia C, d Urzo G, Iolascon A. Coinheritance of Gilbert syndrome increases the risk for developing gallstones in patients with hereditary spherocytosis. Blood. 1999;94:2259-62 pubmed
    ..The 2-bp (TA) insertion within the promoter of the uridine diphosphate-glucuronosyltransferase gene (UGT1A1), associated with Gilbert syndrome, was screened...
  22. Takano M, Kato M, Yoshikawa T, Sasaki N, Hirata J, Furuya K, et al. Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study. Oncology. 2009;76:315-21 pubmed publisher
    To investigate the effects of UDP-glucuronosyltransferase 1A1 (UGT1A1) *28, *6 and *27 in patients with gynecologic cancer who received chemotherapy with irinotecan and cisplatin...
  23. Deming S, Zheng W, Xu W, Cai Q, Ruan Z, Xiang Y, et al. UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:563-70 pubmed publisher
    ..Genetic variation in the estrogen metabolism UGT1A1 gene may modify the effect of estrogenic exposures on endometrial cancer risk...
  24. McGill M, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013;30:2174-87 pubmed publisher
    ..These reactions are catalyzed by UDP-glucuronosyltransferases (UGT1A1 and 1A6) and sulfotransferases (SULT1A1, 1A3/4, and 1E1), respectively...
  25. Ishii Y, Tsuruda K, Tanaka M, Oguri K. Purification of a phenobarbital-inducible morphine UDP-glucuronyltransferase isoform, absent from Gunn rat liver. Arch Biochem Biophys. 1994;315:345-51 pubmed
    ..The N-terminal amino acid sequences of morphine UGTPB were identical to those of UGT1*01P which is deficient to homozygous Gunn rat...
  26. Auyeung D, Kessler F, Ritter J. An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene. Toxicol Appl Pharmacol. 2001;174:60-8 pubmed
    ..These data suggest that transcription from a second promoter contributes to tissue- and inducer-specific expression of rat UGT1A6. ..
  27. Tian H, Ou J, Strom S, Venkataramanan R. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Pharm Res. 2005;22:2007-15 pubmed
    ..The in vitro activity of UGTs was evaluated using different substrates such as estradiol (UGT1A1), acetaminophen (UGT1A6/7), morphine (UGT2B1), testosterone (UGT2B1/3/6), androsterone (UGT2B2), and (-)-borneol (..
  28. Borgna Pignatti C, Rigon F, Merlo L, Chakrok R, Micciolo R, Perseu L, et al. Thalassemia minor, the Gilbert mutation, and the risk of gallstones. Haematologica. 2003;88:1106-9 pubmed
    ..6% OR=2.15). Among the control group, the prevalence of gallstones did not differ significantly in relation to UGT1-A1 genotype, while in women carriers of beta-thalassemia it increased in an allele dose-dependent fashion...
  29. Mackenzie P, Bock K, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, et al. Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics. 2005;15:677-85 pubmed
    ..The mammalian UGT gene superfamily currently has 117 members that can be divided into four families, UGT1, UGT2, UGT3 and UGT8...
  30. D Andrea V, Pérez L, Sanchez Pozzi E. Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide. Life Sci. 2005;77:683-92 pubmed
    ..Three substrates were chosen to cover both UGT1A and UGT2B family isozymes: bilirubin (substrate of UGT1A1), p-nitrophenol (UGT1A6) and ethinylestradiol (UGT2B1 and 2B3 for position C17 and UGT1A1 for position C3)...
  31. van der Wegen P, Louwen R, Imam A, Buijs Offerman R, Sinaasappel M, Grosveld F, et al. Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vector. Mol Ther. 2006;13:374-81 pubmed
    ..a self-inactivating lentiviral vector (LV-ALBUGT) that expresses the human bilirubin UDP-glucuronosyltransferase (UGT1A1) from a liver-specific promoter. UGT1A1 is involved in the clearance of heme metabolites in the liver...
  32. Moriya H, Saito K, Helsby N, Sugino S, Yamakage M, Sawaguchi T, et al. Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers. Oncol Lett. 2014;7:2035-2040 pubmed
    ..is associated with the *6 and *28 alleles of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1)...
  33. Otsuka H, Fujii T, Toh U, Iwakuma N, Takahashi R, Mishima M, et al. Phase II clinical trial of metronomic chemotherapy with combined irinotecan and tegafur-gimeracil-oteracil potassium in metastatic and recurrent breast cancer. Breast Cancer. 2015;22:335-42 pubmed publisher
    ..breast cancer (MRBC), and the association between irinotecan metabolizing enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) gene polymorphisms and adverse events. The study group comprised 40 patients aged 35-79 years...
  34. Emi Y, Ikushiro S, Iyanagi T. Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. J Biochem. 1995;117:392-9 pubmed
    Genomic clones of UDP-glucuronosyltransferase family 1 (UGT1) were isolated from wild-type Wistar rats. The UGT1 locus spans > 120 kb and forms a gene complex...
  35. Gantla S, Bakker C, Deocharan B, Thummala N, Zweiner J, Sinaasappel M, et al. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Am J Hum Genet. 1998;62:585-92 pubmed
    ..In all CN-1 patients studied, structural mutations in one of the five exons of the gene (UGT1A1) encoding the uridinediphosphoglucuronate glucuronosyltransferase (UGT) isoform bilirubin-UGT1 were implicated in ..
  36. Haberkorn V, Oziol L, Goudonnet H. 9-cis-Retinoic acid regulation of four UGT isoforms in hepatocytes from rats with various thyroid states. Pharm Res. 2003;20:1568-73 pubmed
    ..Variations in the expression levels of four different UGT isoforms (UGT1A1, 1A2, 1A5, and 1A6) that are involved in the glucuronication of bilirubin and phenols were determined by ..
  37. Martins R, Morais A, Dias A, Soares I, Rolão C, Ducla Soares J, et al. Early modification of sickle cell disease clinical course by UDP-glucuronosyltransferase 1A1 gene promoter polymorphism. J Hum Genet. 2008;53:524-8 pubmed publisher
    ..We investigated whether the (TA)n promoter polymorphism in the UDP-glucuronosyltransferase 1A1 gene (UGT1A1) may modify bilirubin metabolism, influencing bilirubinaemia, predisposition to cholelithiasis and subsequent ..
  38. Shatalova E, Loginov V, Braga E, Kazubskaia T, Sudomoina M, Blanchard R, et al. [Association of polymorphisms in SULT1A1 and UGT1A1 Genes with breast cancer risk and phenotypes in Russian women]. Mol Biol (Mosk). 2006;40:263-70 pubmed
    ..Sulfotransferase 1A1 (SULT1A1) and UDP-glucuronosyltransferase 1A1 (UGT1A1) conjugate and inactivate both estrogens and their metabolites, thus preventing estrogen-mediated mitosis and ..
  39. Iyanagi T. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat). J Biol Chem. 1991;266:24048-52 pubmed
    ..rat which has unconjugated hyperbilirubinemia as a result of the absence of hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin...
  40. Yu W, Liu W, Jin Y. Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Environ Toxicol Chem. 2009;28:990-6 pubmed publisher
    ..were the messenger RNA (mRNA) levels for two isoforms of uridine diphosphoglucuronosyl transferases (UGT1A6 and UGT1A1) and type 1 deiodinase (DIO1) in liver, sodium iodide symporter (NIS), TSH receptor (TSHR), and DIO1 in thyroid as ..
  41. Li Y, Wang K, Yu T, Zhao B, Li J, Zhang S, et al. [The expression of uridine diphosphate glucuronosyltransferase mRNA regulated by alcohol]. Zhonghua Gan Zang Bing Za Zhi. 2001;9:172-4 pubmed
    ..Following treatment with alcohol in rats, UGT1A1 mRNA and UGT1A5 mRNA were increased to a mean of 177% and 166% of control, respectively...
  42. Bellemare J, Rouleau M, Girard H, Harvey M, Guillemette C. Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab Dispos. 2010;38:1785-9 pubmed publisher
    ..In this study, we explored the potential of multiple active UGT1A_i1 proteins (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10) to interact with all spliced i2s by ..
  43. Roques B, Lacroix M, Puel S, Gayrard V, Picard Hagen N, Jouanin I, et al. CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats. Toxicol Sci. 2012;127:29-41 pubmed publisher
    ..Both treatments induced a 2.5-fold increase in Ugt1a1 and Sult1b1 messenger RNA (mRNA) expressions and a twofold increase in UGT1A activity suggesting that T(4) ..
  44. Braun L, Coffey M, Puskas F, Kardon T, Nagy G, Conley A, et al. Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats. Biochem J. 1998;336 ( Pt 3):587-92 pubmed
    ..In the present study the activity and expression of bilirubin UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats...
  45. Emi Y, Ikushiro S, Iyanagi T. Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 gene complex. J Biol Chem. 1996;271:3952-8 pubmed
    ..and Iyanagi, T. (1995) J. Biochem. (Tokyo) 117, 392-399). The UGT1 locus encodes at least nine UGT1 isoforms. UGT1A1 is a major 3-methylcholanthrene (MC)-inducible form in rat liver...
  46. Richardson T, Sherman M, Kalman D, Morgan E. Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney. Drug Metab Dispos. 2006;34:351-3 pubmed
    ..Hepatic mRNA expression of UGT1A1, 1A9, and 2B5 was similarly down-regulated after LPS exposure and C...
  47. Operaña T, Tukey R. Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation. J Biol Chem. 2007;282:4821-9 pubmed
    ..This technique demonstrated that UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 self-oligomerize (homodimerize)...
  48. Gagez A, Rouguieg Malki K, Sauvage F, Marquet P, Picard N. Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry. Anal Biochem. 2012;427:52-9 pubmed publisher
    ..The method consists of incubations of probe substrates for UGT1A1 (etoposide), UGT1A3 (chenodeoxycholic acid), UGT1A4 (trifluoperazine), UGT1A6 (serotonin), UGT1A9 (mefenamic acid),..
  49. Tankanitlert J, Morales N, Fucharoen P, Fucharoen S, Chantharaksri U. Association between promoter and coding region mutations of UDP-glucuronosyltransferase 1A1 and beta-thalassemia/Hb E with cholelithiasis. Eur J Haematol. 2008;80:351-5 pubmed
    ..Recent studies have shown that a variant TATA-box in the promoter region of the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene is associated with the development of cholelithiasis...
  50. Glimelius B, Garmo H, Berglund A, Fredriksson L, Berglund M, Kohnke H, et al. Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. Pharmacogenomics J. 2011;11:61-71 pubmed publisher
    ..Irinotecan's active metabolite is inactivated by UDP-glucuronosyltransferase 1A1 (UGT1A1), which is deficient in Gilbert's syndrome...
  51. Wang X, Sarkar D, Mani P, Steer C, Chen Y, Guha C, et al. Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon. Hepatology. 2009;50:815-24 pubmed publisher
    ..Intravenous injection of the FPL-entrapped pSB-hUGT1A1 (4-8 microg/day, 1-4 doses) into UGT1A1-deficient hyperbilirubinemic Gunn rats (model of Crigler-Najjar syndrome type 1) resulted in hUGT1A1 expression in ..
  52. Kishi M, Emi Y, Sakaguchi M, Ikushiro S, Iyanagi T. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Biochem Biophys Res Commun. 2008;377:815-9 pubmed publisher
    ..In contrast, expression of UGT1A1 surged immediately after birth. Expression of UGT1A5 was transiently elevated in childhood...
  53. Bellemare J, Rouleau M, Harvey M, Guillemette C. Modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. J Biol Chem. 2010;285:3600-7 pubmed publisher
    ..Initially, using an inducible system that mimics the relative abundance of isoforms 1 and 2 of UGT1A1 in human tissues, the rates of formation of glucuronides were significantly reduced...