Gene Symbol: Ucp2
Description: uncoupling protein 2
Alias: mitochondrial uncoupling protein 2, UCP 2, Uncoupling protein 2, mitochondrial, solute carrier family 25 member 8, uncoupling protein 2 (mitochondrial, proton carrier)
Species: rat
Products:     Ucp2

Top Publications

  1. Ito E, Ozawa S, Takahashi K, Tanaka T, Katsuta H, Yamaguchi S, et al. PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein. Biochem Biophys Res Commun. 2004;324:810-4 pubmed
    ..And it is possible that its site of action can be located in the energy-consuming exocytotic process of insulin secretory granules, and that the reduction of ATP production through increased UCP-2 reduces insulin exocytosis. ..
  2. Chen S, Lin T, Yang D, Lee S, Shaw F, Liou C, et al. Protective effects of peroxisome proliferator-activated receptors gamma coactivator-1alpha against neuronal cell death in the hippocampal CA1 subfield after transient global ischemia. J Neurosci Res. 2010;88:605-13 pubmed publisher
    ..Expression of uncoupling protein 2 (UCP2) and superoxide dismutases 2 (SOD2) in the hippocampal CA1 neurons was upregulated 4-48 hr after TGI...
  3. Affourtit C, Brand M. Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J. 2008;409:199-204 pubmed
    ..This relatively high leak activity was decreased more than 30% upon knock-down of UCP2 (uncoupling protein-2) by RNAi (RNA interference)...
  4. Oberkofler H, Iglseder B, Klein K, Unger J, Haltmayer M, Krempler F, et al. Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women. Arterioscler Thromb Vasc Biol. 2005;25:604-10 pubmed
    Reactive oxygen species (ROS) contribute to atherogenesis. Uncoupling protein 2 (UCP2) reduces mitochondrial ROS generation and protects against the disease in animal models...
  5. Hurtaud C, Gelly C, Bouillaud F, Levi Meyrueis C. Translation control of UCP2 synthesis by the upstream open reading frame. Cell Mol Life Sci. 2006;63:1780-9 pubmed
    Uncoupling protein 2 (UCP2) belongs to a family of transporters of the mitochondrial inner membrane...
  6. Bodyak N, Rigor D, Chen Y, Han Y, Bisping E, Pu W, et al. Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol. 2007;293:H829-35 pubmed
    Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane proton carrier that uncouples ATP synthesis. The aim of this study was to determine whether UCP2 plays a role in survival of adult rat cardiac myocytes...
  7. Chan S, Wu C, Wu K, Ho Y, Chang A, Chan J. Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. Circ Res. 2009;105:886-96 pubmed publisher
    ..We assessed the hypothesis that UCP2 participates in central cardiovascular regulation by maintaining reactive oxygen species homeostasis in the rostral ..
  8. Friederich M, Fasching A, Hansell P, Nordquist L, Palm F. Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells. Biochim Biophys Acta. 2008;1777:935-40 pubmed publisher
    ..This mechanism may be protective against diabetes-induced oxidative stress, but will increase O(2) usage. The subsequently reduced O(2) availability may contribute to diabetes-induced progressive kidney damage. ..
  9. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning B, Miroux B, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26:435-9 pubmed
    The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a protein homologous to the brown fat uncoupling protein Ucp1 (refs 1-3)...

More Information


  1. Kitahara T, Li H, Balaban C. Localization of the mitochondrial uncoupling protein family in the rat inner ear. Hear Res. 2004;196:39-48 pubmed
    ..Although UCP2, UCP4 and brain mitochondrial carrier protein-1 (BMCP-1, i.e...
  2. De Souza C, Gasparetti A, Pereira Da Silva M, Araujo E, Carvalheira J, Saad M, et al. Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion. Diabetologia. 2003;46:1522-31 pubmed
    ..Increased UCP-2 expression under these conditions could reduce the beta-cell ATP/ADP ratio and negatively regulate insulin secretion. ..
  3. Li L, Yoshikawa H, Egeberg K, Grill V. Interleukin-1beta swiftly down-regulates UCP-2 mRNA in beta-cells by mechanisms not directly coupled to toxicity. Cytokine. 2003;23:101-7 pubmed
    ..In conclusion, down-regulation of UCP-2 mRNA by IL-1beta is an early event of cytokine interaction with beta-cells which is not directly coupled to toxicity. ..
  4. McLeod C, Aziz A, Hoyt R, McCoy J, Sack M. Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia. J Biol Chem. 2005;280:33470-6 pubmed
    ..In the cytoprotective hierarchy, uncoupling protein-2 appears to play a greater role than uncoupling protein-3 in modulating ischemia/anoxia tolerance in heart-derived cells. ..
  5. Tripathi G, Sharma R, Baburaj V, Sankhwar S, Jafar T, Agrawal S. Genetic risk factors for renal failure among north Indian ESRD patients. Clin Biochem. 2008;41:525-31 pubmed publisher
    ..couple receptor (G-Prot), endothelial nitric oxide synthase (ecNOS), Leptin -2548G/A and uncoupling protein (UCP2) are potent regulators of intra renal hemodynamics and may be the causative factors contributing to the ..
  6. Yoshida T, Kato K, Fujimaki T, Yokoi K, Oguri M, Watanabe S, et al. Association of genetic variants with chronic kidney disease in Japanese individuals. Clin J Am Soc Nephrol. 2009;4:883-90 pubmed publisher
    ..for covariates revealed that the -219G-->T polymorphism of APOE, the -519A-->G of MMP1, the -866G-->A of UCP2, the -1607/1G-->2G of MMP1, the A-->G (Lys45Glu) of MMP3, the G-->A (Ala163Thr) of AGTR1, the G-->A (..
  7. Zhang C, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001;105:745-55 pubmed
    ..Uncoupling protein-2 (UCP2) mediates mitochondrial proton leak, decreasing ATP production...
  8. Di Castro S, Scarpino S, Marchitti S, Bianchi F, Stanzione R, Cotugno M, et al. Differential modulation of uncoupling protein 2 in kidneys of stroke-prone spontaneously hypertensive rats under high-salt/low-potassium diet. Hypertension. 2013;61:534-41 pubmed publisher
    ..SHR animals, we determined blood pressure levels, degree of kidney lesions, renal uncoupling protein 2 (UCP2) gene and protein expression levels along with rattus norvegicus (rno)-microRNA (miR) 24 and 34a gene expression, ..
  9. Serviddio G, Bellanti F, Tamborra R, Rollo T, Capitanio N, Romano A, et al. Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut. 2008;57:957-65 pubmed publisher
    ..reduced glutathione/oxidised glutathione, 4-hydroxy-2-nonenal (HNE)-protein adducts, uncoupling protein-2 (UCP2) expression and ATP homeostasis were evaluated before and after ischaemia-reperfusion injury...
  10. Galetti S, Sarre A, Perreten H, Produit Zengaffinen N, Muzzin P, Assimacopoulos Jeannet F. Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1. Pflugers Arch. 2009;457:931-40 pubmed publisher
    b>UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion...
  11. Azzu V, Affourtit C, Breen E, Parker N, Brand M. Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochim Biophys Acta. 2008;1777:1378-83 pubmed publisher
    Uncoupling protein 2 (UCP2) regulates glucose-stimulated insulin secretion in pancreatic beta-cells...
  12. Echtay K, Roussel D, St Pierre J, Jekabsons M, Cadenas S, Stuart J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature. 2002;415:96-9 pubmed
    ..The functions of its homologues, UCP2 and UCP3, in other tissues are debated...
  13. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med. 2003;9:1062-8 pubmed
    ..identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing human UCP-2, brain damage was diminished after experimental stroke and traumatic brain ..
  14. Castro M, Massa M, Del Zotto H, Gagliardino J, Francini F. Rat liver uncoupling protein 2: changes induced by a fructose-rich diet. Life Sci. 2011;89:609-14 pubmed publisher
    To evaluate the role of uncoupling protein 2 (UCP2) and peroxisome proliferator-activated receptors (PPARs) in the response of liver to glycoxidative stress triggered by administration of a fructose-rich diet (FRD)...
  15. Yoshitomi H, Yamazaki K, Tanaka I. Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map. Gene. 1998;215:77-84 pubmed
    ..It has been known that UCP1 and UCP2 function as the main effector of the thermogenesis: the former is expressed exclusively in brown adipose tissue, ..
  16. Rudofsky G, Schroedter A, Schlotterer A, Voron ko O, Schlimme M, Tafel J, et al. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Diabetes Care. 2006;29:89-94 pubmed
    ..subsequent cleavage by restriction endonucleases for the promoter variants A-3826G in the UCP1 gene, G-866A in the UCP2 gene, and C-55T in the UCP3 gene...
  17. Friederich Persson M, Aslam S, Nordquist L, Welch W, Wilcox C, Palm F. Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys. PLoS ONE. 2012;7:e39635 pubmed publisher
    ..However, blockade of the diabetes-induced upregulation of UCP- 2 results in excessive uncoupling and reduced oxidative stress in the kidney via activation of ANT. ..
  18. Hidaka S, Kakuma T, Yoshimatsu H, Yasunaga S, Kurokawa M, Sakata T. Molecular cloning of rat uncoupling protein 2 cDNA and its expression in genetically obese Zucker fatty (fa/fa) rats. Biochim Biophys Acta. 1998;1389:178-86 pubmed
    We isolated rat UCP2 cDNA, which has been proposed to play an important role in mammalian thermogenesis and body weight regulation...
  19. Rubattu S, Stanzione R, Bianchi F, Cotugno M, Forte M, Della Ragione F, et al. Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat. Cell Death Dis. 2017;8:e2891 pubmed publisher
    b>UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP...
  20. Oberkofler H, Klein K, Felder T, Krempler F, Patsch W. Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells. Endocrinology. 2006;147:966-76 pubmed
    A role of uncoupling protein 2 (UCP2) as negative modulator of insulin secretion has been suggested, but the transcriptional pathways regulating beta-cell UCP2 gene expression have been established in rodents only...
  21. Rivera A, Agnati L, Horvath T, Valderrama J, De la Calle A, Fuxe K. Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: relevance for volume transmission. Neuroscience. 2006;137:1447-61 pubmed
    ..Taken together, these findings open up the possibility that uncoupling protein 2/3 could play an important role modulating the dopaminergic and noradrenergic neurotransmission within discrete brain regions. ..
  22. Friederich M, Nordquist L, Olerud J, Johansson M, Hansell P, Palm F. Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney. Adv Exp Med Biol. 2009;645:205-12 pubmed publisher
    ..Furthermore, diabetic rats have increased UCP-2 levels compared to controls, but the mechanisms underlying this increase and its consequences warrants further studies. ..
  23. Amerkhanov Z, Kashapova I, Popov V. The role of UCP2 and ADP/ATP antiporter in superoxide radical-induced uncoupling in kidney mitochondria. Dokl Biochem Biophys. 2008;423:328-30 pubmed
  24. Fernández Millán E, Martín M, Goya L, Lizárraga Mollinedo E, Escrivá F, Ramos S, et al. Glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation. Free Radic Biol Med. 2016;95:16-26 pubmed publisher
    ..but pre-treated with GLP-1, probably through the down-regulation of the mitochondrial uncoupling-protein2 (UCP2)...
  25. Huang J, Chen S, Lyu J, Liu C, Zeng Q. [Correlation between uncoupling protein 2 expression and myocardial mitochondrial injury in rats with sepsis induced by lipopolysaccharide]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:159-64 pubmed
    To investigate the correlation between uncoupling protein 2 (UCP2) expression and myocardial mitochondria injury in rats with sepsis induced by lipopolysaccharide (LPS)...
  26. Echtay K, Esteves T, Pakay J, Jekabsons M, Lambert A, Portero Otin M, et al. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003;22:4103-10 pubmed
    ..and other 2-alkenals) specifically induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT)...
  27. Poulsen M, Larsen J, Hamilton Dutoit S, Clasen B, Jessen N, Paulsen S, et al. Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet. Nutr Res. 2012;32:701-8 pubmed publisher
  28. Arsenijevic D, Gallmann E, Moses W, Lutz T, Erlanson Albertsson C, Langhans W. Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin. Am J Physiol Endocrinol Metab. 2005;289:E40-5 pubmed
    ..Enterostatin infusion resulted in increased uncoupling protein-2 (UCP2) expression in various tissues, including epididymal fat and liver...
  29. Grav H, Tronstad K, Gudbrandsen O, Berge K, Fladmark K, Martinsen T, et al. Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression: evidence for peroxisome proliferator-activated rece. J Biol Chem. 2003;278:30525-33 pubmed
  30. Roshon M, Kline J, Thornton L, Watts J. Cardiac UCP2 expression and myocardial oxidative metabolism during acute septic shock in the rat. Shock. 2003;19:570-6 pubmed
    ..This study tested whether the mitochondrial uncoupling protein UCP2 was responsible for decreased cardiac mechanical efficiency after polymicrobial septic shock...
  31. Montez P, Vázquez Medina J, Rodriguez R, Thorwald M, Viscarra J, Lam L, et al. Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats. Endocrinology. 2012;153:5746-59 pubmed publisher
    ..However, the mechanisms linking renin-angiotensin system, steatosis, and UCP2 to hepatic oxidative damage during insulin resistance are not described...
  32. Chan S, Wu K, Kung P, Chan J. Oral intake of rosiglitazone promotes a central antihypertensive effect via upregulation of peroxisome proliferator-activated receptor-gamma and alleviation of oxidative stress in rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertension. 2010;55:1444-53 pubmed publisher
    ..Activation of PPAR-gamma protects against oxidative stress in RVLM by upregulation of mitochondrial uncoupling protein 2 (UCP2)...
  33. Zou Y, Yang M, Gong D, Guan L, Tian N. [Effects of vagotomy on UCP2 mRNA expression and gastric acid secretion in rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21:290-2 pubmed
    The relationship between gastric acid secretion and ATP level, and regulation of uncoupling protein 2 (UCP2) mRNA expression by vagus nerve were studied in vagotomies rats...
  34. Amaral S, Mota P, Rodrigues A, Martins L, Oliveira P, Ramalho Santos J. Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak. FEBS Lett. 2008;582:4191-6 pubmed publisher
    ..a decrease in mitochondrial function was matched with an increase in proton leak and expression and activity of uncoupling protein 2 (UCP2), suggesting that proton leak may be involved in managing age-dependent mitochondrial dysfunction.
  35. Minamiyama Y, Takemura S, Bito Y, Shinkawa H, Tsukioka T, Nakahira A, et al. Supplementation of alpha-tocopherol improves cardiovascular risk factors via the insulin signalling pathway and reduction of mitochondrial reactive oxygen species in type II diabetic rats. Free Radic Res. 2008;42:261-71 pubmed publisher
    ..Mitochondrial reactive oxygen species production and uncoupling protein 2 (UCP2) expression were significantly increased in the heart and aorta of OLETF rats compared with LETO rats...
  36. López Solache I, Marie V, Camirand A, Silva J. Regulation of uncoupling protein-2 mRNA in L6 myotubules: II: Thyroid hormone amplifies stimulation of uncoupling protein-2 gene by thiazolidinediones and other peroxisome proliferator-activated receptor ligands in L6 myotubules: evidence for a primi. Endocrine. 2002;19:209-17 pubmed
    The stimulation of the uncoupling protein-2 gene (ucp2) by thyroid hormone (triiodothyronine [T3]) in vivo is variable, suggesting complex interactions and even the possibility of indirect effects...
  37. Matsuda J, Hosoda K, Itoh H, Son C, Doi K, Tanaka T, et al. Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. FEBS Lett. 1997;418:200-4 pubmed
    ..6-fold) in the epididymal WAT. Augmented expression of UCPs may provide defense against high-fat induced obesity and impairment of glucose metabolism. ..
  38. Segersvard R, Rippe C, Duplantier M, Herrington M, Isaksson B, Adrian T, et al. mRNA for pancreatic uncoupling protein 2 increases in two models of acute experimental pancreatitis in rats and mice. Cell Tissue Res. 2005;320:251-8 pubmed
    Uncoupling-protein 2 (UCP2) is a mitochondrial protein that appears to be involved in cellular oxidant defense and in the regulation of oncotic cell death, both of which are important features of acute pancreatitis...
  39. Friederich M, Olerud J, Fasching A, Liss P, Hansell P, Palm F. Uncoupling protein-2 in diabetic kidneys: increased protein expression correlates to increased non-transport related oxygen consumption. Adv Exp Med Biol. 2008;614:37-43 pubmed publisher
    ..The elevated UCP-2 levels may represent an effort to reduce the increased production of superoxide radicals which is evident during diabetes. ..
  40. Bhat M, Noolu B, Qadri S, Ismail A. Vitamin D deficiency decreases adiposity in rats and causes altered expression of uncoupling proteins and steroid receptor coactivator3. J Steroid Biochem Mol Biol. 2014;144 Pt B:304-12 pubmed publisher
    ..Furthermore, the expression of uncoupling proteins (Ucp1 and Ucp2) was elevated in the white adipose tissue of the deficient rat indicative of higher energy expenditure, thereby ..
  41. Qiu W, Zhou Y, Jiang L, Fang L, Chen L, Su W, et al. Genipin inhibits mitochondrial uncoupling protein 2 expression and ameliorates podocyte injury in diabetic mice. PLoS ONE. 2012;7:e41391 pubmed publisher
    ..The protective role of genipin on DN is probably through suppressing the up-regulation of mitochondrial uncoupling protein 2 (UCP2) in diabetic kidneys...
  42. Bravo C, Vargas Suárez M, Rodriguez Enriquez S, Loza Tavera H, Moreno Sanchez R. Metabolic changes induced by cold stress in rat liver mitochondria. J Bioenerg Biomembr. 2001;33:289-301 pubmed
    ..The overall data suggest that cold stress promoted decoupling of oxidative phosphorylation, and hence, changes in several matrix metabolites, by increasing free fatty acids and the UCP2 content.
  43. Pheiffer C, Jacobs C, Patel O, Ghoor S, Muller C, Louw J. Expression of UCP2 in Wistar rats varies according to age and the severity of obesity. J Physiol Biochem. 2016;72:25-32 pubmed publisher
    ..Increased expression of uncoupling protein 2 (UCP2) during obesity is an adaptive response to suppress the production of reactive oxygen species...
  44. Lee S, Sang Hoon L, Lee H, Hyun Young L, Kim S, So Yeon K, et al. Enhancing effect of taurine on glucose response in UCP2-overexpressing beta cells. Diabetes Res Clin Pract. 2004;66 Suppl 1:S69-74 pubmed
    Uncoupling protein 2 (UCP2) is up-regulated in pancreatic beta cells when exposed to long-term high glucose or free fatty acids, which results in impaired glucose-induced insulin secretion (GIIS)...
  45. Cirelli C, Tononi G. Uncoupling proteins and sleep deprivation. Arch Ital Biol. 2004;142:541-9 pubmed
    ..We measured UCP2, UCP3, and UCP5 mRNA levels in rats during the spontaneous sleep/waking cycle and after short (8 hours) and long (7 ..
  46. Strobel A, Combettes Souverain M, Doare L, Strosberg A, Issad T. Rat uncoupling protein 2 (UCP2): expression in obese ventromedial hypothalamus (VMH)-lesioned animals. Int J Obes Relat Metab Disord. 1998;22:1121-6 pubmed
    ..The recently discovered uncoupling protein 2 (UCP2) is upregulated in genetically obese rodent models and during long term high fat feeding...
  47. Jones M, Mark P, Lewis J, Mori T, Keelan J, Waddell B. Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2. Biol Reprod. 2010;83:254-60 pubmed publisher
    ..species (ROS) damages DNA, proteins and lipids, an outcome that is limited by antioxidant enzymes; mitochondrial uncoupling protein 2 (UCP2) may also limit oxidative stress by reducing ROS production...
  48. Demori I, Burlando B, Gerdoni E, Lanni A, Fugassa E, Voci A. Uncoupling protein-2 induction in rat hepatocytes after acute carbon tetrachloride liver injury. J Cell Physiol. 2008;216:413-8 pubmed publisher
    ..A role of UCP-2 in moderating CCl(4)-induced oxidative stress during tissue regeneration after injury is suggested. ..
  49. De Simone R, Ajmone Cat M, Pandolfi M, Bernardo A, De Nuccio C, Minghetti L, et al. The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses. J Neurochem. 2015;135:147-56 pubmed publisher
    ..role of mitochondria in the modulation of neuroinflammation, we focused on the mitochondrial uncoupling protein-2 (UCP2), known to control mitochondrial functions and to be implicated in a variety of physiological and pathological ..
  50. Lindqvist A, Mei J, Sundler F, Erlanson Albertsson C. Decreased UCP2 mRNA expression in rat stomach following vagotomy: novel role for UCP2 as free radical scavenger in the stomach?. Nutr Neurosci. 2004;7:217-22 pubmed
    Uncoupling protein 2 (UCP2) is a protein, located in the inner mitochondrial membrane, which dissipates the proton gradient of this membrane and uncouples respiration from oxidative phosphorylation...
  51. Chang K, Chen Y, Wu Y, Lee W, Chen C. Downregulation of genes involved in metabolism and oxidative stress in the peripheral leukocytes of Huntington's disease patients. PLoS ONE. 2012;7:e46492 pubmed publisher
    ..CAP1, demonstrated consistent downregulation in peripheral leukocytes of both PreHD carriers and HD patients, while UCP2 was only down-regulated in HD patients...
  52. Du Z, Yang Y, Hu Y, Sun Y, Zhang S, Peng W, et al. A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. Hear Res. 2012;287:15-24 pubmed publisher
    ..The present study demonstrated that HFD may induce oxidative stress, mitochondrial damage and apoptosis in the inner ear, and it provided evidence regarding the link between HFD and an increased risk of age-related hearing loss. ..
  53. Liu J, Zhao H, Zhu M, Chen J, Zhu J. [Relationship between the expression of uncoupling protein 2 and the damage by oxygen free radicals in acute liver failure rats]. Zhonghua Gan Zang Bing Za Zhi. 2011;19:55-7 pubmed publisher
    To investigate the relationship between uncoupling protein 2 (UCP2) expression and the damage caused by oxygen free radicals in acute liver failure rat models...
  54. Gomez Ambrosi J, Fruhbeck G, Martinez J. Interactions between an alpha2-adrenergic antagonist and a beta3-adrenergic agonist on the expression of UCP2 and UCP3 in rats. J Physiol Biochem. 2002;58:17-23 pubmed
    ..05) by trecadrine, while yohimbine had no effect. White adipose tissue UCP2 and muscle UCP3 were not modified by either trecadrine or yohimbine administration...
  55. Echtay K, Murphy M, Smith R, Talbot D, Brand M. Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem. 2002;277:47129-35 pubmed
    Superoxide activates nucleotide-sensitive mitochondrial proton transport through the uncoupling proteins UCP1, UCP2, and UCP3 (Echtay, K. S., et al. (2002) Nature 415, 1482-1486)...
  56. Bo H, Jiang N, Ma G, Qu J, Zhang G, Cao D, et al. Regulation of mitochondrial uncoupling respiration during exercise in rat heart: role of reactive oxygen species (ROS) and uncoupling protein 2. Free Radic Biol Med. 2008;44:1373-81 pubmed publisher
    The physiological significance of cardiac mitochondrial uncoupling protein 2 (UCP2)-mediated uncoupling respiration in exercise is unknown...
  57. Yang K, Xu X, Nie L, Xiao T, Guan X, He T, et al. Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK/UCP2 signaling pathway. Toxicol Lett. 2015;234:110-9 pubmed publisher
    ..Uncoupling protein 2 (UCP2), a member of the uncoupling protein family, may protect cardiomyocytes from oxidative stress by suppressing ..
  58. Ježek J, Dlasková A, Zelenka J, Jabůrek M, Ježek P. H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells. Antioxid Redox Signal. 2015;23:958-72 pubmed publisher
    ..Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-..
  59. Graw J, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies C. Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int J Med Sci. 2015;12:995-9 pubmed publisher
    ..Therefore, chronic alcohol consumption leads to a tissue specific expression of UCP-2. ..
  60. Yang Q, Hu S, Zhang Y, Xie W, Li N, Ji G, et al. Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats. Chin J Integr Med. 2011;17:205-11 pubmed publisher
    To observe the effect of berberine on uncoupling protein-2 (UCP2) mRNA and protein expressions in the hepatic tissue of non-alcoholic fatty liver disease (NAFLD) in rats, and to explore the molecular mechanism...
  61. Lou D, Li H, Yang W, Xiao J, Du R, Wang B, et al. [Relationship between oxidative stress and beta cell lipoapoptosis in rats]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009;38:620-5 pubmed
    ..insulin secretion in beta cells, the beta cell apoptosis (TUNEL technology) and the uncoupling protein 2 (UCP2) gene expression in islets were measured...
  62. Yamada S, Isojima Y, Yamatodani A, Nagai K. Uncoupling protein 2 influences dopamine secretion in PC12h cells. J Neurochem. 2003;87:461-9 pubmed
    Uncoupling protein 2 (UCP2) belongs to the UCP family, and is distributed in many organs including the brain...
  63. Jiang Y, Zhang H, Dong L, Wang D, An W. Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter region. J Cell Biochem. 2008;105:277-89 pubmed publisher
    Uncoupling protein-2 (UCP2) is a mitochondrial inner-membrane carrier protein that is involved in the control of fatty acid metabolism...
  64. Enochsson L, Isaksson B, Strömmer L, Erlanson Albertsson C, Permert J. Bile duct obstruction is associated with early postoperative upregulation of liver uncoupling protein-2 and reduced circulating glucose concentration in the rat. Nutrition. 2010;26:405-10 pubmed publisher
  65. Hoshovs ka I, Lisovyĭ O, Shymans ka T, Sahach V. [UCP2 and UCP3 gene expression, heart function and oxygen cost of myocardial work changes during aging and ischemia-reperfusion]. Fiziol Zh. 2009;55:26-36 pubmed
    ..Therefore, the levels of mRNA of UCP2 in aging hearts were higher and mRNA levels of UCP3 were tended to increase...
  66. Liu Y, Chen L, Xu X, Vicaut E, Sercombe R. Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol. 2009;9:17 pubmed publisher
    ..One element believed to contribute to reduce ROS production is the uncoupling protein UCP2 (and UCP3 in the heart)...
  67. Safari F, Bayat G, Shekarforoush S, Hekmatimoghaddam S, Anvari Z, Moghadam M, et al. Expressional profile of cardiac uncoupling protein-2 following myocardial ischemia reperfusion in losartan- and ramiprilat-treated rats. J Renin Angiotensin Aldosterone Syst. 2014;15:209-17 pubmed publisher
    The aim of this study was to investigate the early changes of cardiac uncoupling protein-2 (UCP2) expression following myocardial ischemia reperfusion in rats chronically treated with ramiprilat and losartan...
  68. Casas F, Pessemesse L, Grandemange S, Seyer P, Baris O, Gueguen N, et al. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. PLoS ONE. 2009;4:e5631 pubmed publisher
    ..In addition, these data underline the importance of a tight control of p43 expression and suggest that a deregulation of the direct T3 mitochondrial pathway could be one of the parameters involved in the occurrence of sarcopenia. ..
  69. Chen G, Yan J, Wang X, Zheng M, Jiang J, Zhou X, et al. Mechanism of uncoupling protein 2?mediated myocardial injury in hypothermic preserved rat hearts. Mol Med Rep. 2016;14:1857-64 pubmed publisher
    In the present study, the alterations in uncoupling protein 2 (UCP2) expression following hypothermic preservation in rat hearts were investigated...
  70. Affourtit C, Jastroch M, Brand M. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med. 2011;50:609-16 pubmed publisher
    ..Glucose-stimulated insulin secretion (GSIS) by pancreatic ? cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS improvement and impairment, have been reported for different Ucp2-ablated mouse ..
  71. Brondani L, Rech T, Boelter G, Bauer A, Leitao C, Eizirik D, et al. UCP2 Expression Is Increased in Pancreas From Brain-Dead Donors and Involved in Cytokine-Induced ? Cells Apoptosis. Transplantation. 2017;101:e59-e67 pubmed publisher
    ..A recent study from our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with BD as compared with controls...
  72. Zungu M, Alcolea M, García Palmer F, Young M, Essop M. Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function. Am J Physiol Heart Circ Physiol. 2007;293:H2819-25 pubmed
    ..receptor-gamma-coactivator-1alpha, cytochrome oxidase (COX) subunit II, and uncoupling protein-2 (UCP2) were coordinately induced in the hypertrophied right ventricle following hypoxia...
  73. Graw J, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies C. Chronic alcohol consumption increases the expression of uncoupling protein-2 and -4 in the brain. Alcohol Clin Exp Res. 2013;37:1650-6 pubmed publisher
    ..This study reveals a compensatory effect of UCP-2 and -4 in the brain during chronic alcohol consumption. ..
  74. Clapham J, Coulthard V, Moore G. Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. Biochem Biophys Res Commun. 2001;287:1058-62 pubmed
    ..The present data contribute to the argument that UCP-3 and MTE-1 are linked within the same metabolic pathway either in response to, or as regulators of, fatty acid beta-oxidation. ..
  75. Zhang H, Yang S, Cao H. [Effect of Pingtang recipe containing drug-serum on INS-1 pancreatic beta cells lipoapoptosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:978-81 pubmed
    ..286 +/- 0.373 (P < 0.01) and 1.627 +/- 0.348 (P < 0.05) respectively. DS-PTR shows a protective effect on INS-1 beta pancrentic cells against lipoapoptosis, which is possibly play its mechanism through regulating ROS and UCP-2. ..
  76. Jiang L, Qiu W, Zhou Y, Wen P, Fang L, Cao H, et al. A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-?1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. Kidney Int. 2013;84:285-96 pubmed publisher
    ..Here we found that mitochondrial uncoupling protein 2 (UCP2) was induced in kidney tubular epithelial cells after unilateral ureteral obstruction in mice ..
  77. Guo J, Liu Y, Li M, Yang Y, Recker R, Deng H. Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. Biochem Biophys Res Commun. 2005;332:602-8 pubmed
    Leptin (LEP) and the uncoupling proteins 2 and 3 (UCP2/UCP3) are key molecules involved in the regulation of food intake and energy expenditure...
  78. Papkovskaia T, Chau K, Inesta Vaquera F, Papkovsky D, Healy D, Nishio K, et al. G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. Hum Mol Genet. 2012;21:4201-13 pubmed publisher
  79. Li N, Wang J, Gao F, Tian Y, Song R, Zhu S. The role of uncoupling protein 2 in the apoptosis induced by free fatty acid in rat cardiomyocytes. J Cardiovasc Pharmacol. 2010;55:161-7 pubmed publisher
    ..and recent studies have shown that free fatty acids dramatically elevate mRNA levels of uncoupling protein 2 (UCP2) in some cell lines...
  80. Yang N, Wang C, Xu M, Hu X. [UCPs and PPARgamma2 mRNA in diet induced obesity resistant rats]. Wei Sheng Yan Jiu. 2005;34:556-8 pubmed
    ..Reverse transcription-polymerase chain reaction (RT-PCR) was used to measure the expression of UCP2, UCP3, and PPARgamma2 mRNA in white adipose...
  81. Růzicka M, Skobisová E, Dlasková A, Santorová J, Smolkova K, Spacek T, et al. Recruitment of mitochondrial uncoupling protein UCP2 after lipopolysaccharide induction. Int J Biochem Cell Biol. 2005;37:809-21 pubmed
    Rat liver mitochondria contain a negligible amount of mitochondrial uncoupling protein UCP2 as indicated by 3H-GTP binding...
  82. Ji Q, Ikegami H, Fujisawa T, Kawabata Y, Ono M, Nishino M, et al. A common polymorphism of uncoupling protein 2 gene is associated with hypertension. J Hypertens. 2004;22:97-102 pubmed
    ..A functional polymorphism in the uncoupling protein 2 (UCP2) promoter has been reported to be associated with obesity in Caucasians...