Ucn

Summary

Gene Symbol: Ucn
Description: urocortin
Alias: urocortin, corticotensin
Species: rat
Products:     Ucn

Top Publications

  1. Lewis K, Li C, Perrin M, Blount A, Kunitake K, Donaldson C, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001;98:7570-5 pubmed
    The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine...
  2. Vaughan J, Donaldson C, Bittencourt J, Perrin M, Lewis K, Sutton S, et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 1995;378:287-92 pubmed
    ..The deduced protein encodes a peptide that we name urocortin, which is related to urotensin (63% sequence identity) and CRF (45% sequence identity)...
  3. Gruson D, Ginion A, Lause P, Ketelslegers J, Thissen J, Bertrand L. Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes. Peptides. 2012;33:351-3 pubmed publisher
    Urotensin II (UII) and urocortin (UCN) are potent contributors to the physiopathology of heart failure. Our study investigated the effects of UII and UCN on the expression of myostatin (Mstn) in primary culture of adult cardiomyocytes...
  4. García Villalón A, Amezquita Y, Monge L, Fernandez N, Climent B, Sanchez A, et al. Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts. Br J Pharmacol. 2005;145:490-4 pubmed
    1 Urocortin is a vasodilator peptide related to corticotrophin-releasing factor, which may protect endothelial function during coronary ischemia-reperfusion (I-R)...
  5. Zhang R, Xu Y, Fu H, Wang J, Jin L, Li S. Urocortin induced expression of COX-2 and ICAM-1 via corticotrophin-releasing factor type 2 receptor in rat aortic endothelial cells. Br J Pharmacol. 2009;158:819-29 pubmed publisher
    Our previous study showed that urocortin (Ucn1) exacerbates the hypercoagulable state and vasculitis in a rat model of sodium laurate-induced thromboangiitis obliterans...
  6. Wen Z, Yan Z, Hu K, Pang Z, Cheng X, Guo L, et al. Odorranalectin-conjugated nanoparticles: preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration. J Control Release. 2011;151:131-8 pubmed publisher
    ..Besides, urocortin peptide (UCN), as a macromolecular model drug, was incorporated into nanoparticles and evaluated for its ..
  7. Chance W, Dayal R, Friend L, Sheriff S. Possible role of CRF peptides in burn-induced hypermetabolism. Life Sci. 2006;78:694-703 pubmed
    ..Although these results suggest a role of CRF receptors in mediating burn-induced hypermetabolism, CRF itself may not be the principle ligand, as suggested by the significant elevation of hypothalamic urocortin 15 days after burn injury.
  8. Abuirmeileh A, Harkavyi A, Lever R, Biggs C, Whitton P. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. J Neuroinflammation. 2007;4:19 pubmed
    We have recently observed that the corticotrophin releasing hormone (CRF) related peptide urocortin (UCN) reverses key features of nigrostriatal damage in the hemiparkinsonian 6-hydroxydopamine lesioned rat...
  9. Liu J, Yu B, Neugebauer V, Grigoriadis D, Rivier J, Vale W, et al. Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission. J Neurosci. 2004;24:4020-9 pubmed
    ..by two endogenous CRF-related peptide ligands, corticotropin-releasing factor [CRF rat/human (r/h)] and Urocortin I (Ucn I), within the central nucleus of the amygdala (CeA) and the lateral septum mediolateral nucleus (LSMLN)...
  10. Kageyama K, Suda T. Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Endocrinology. 2003;144:2234-41 pubmed
    ..This receptor is coupled positively to adenylate cyclase and is bound preferentially by the urocortin (Ucn)-related peptides (Uncs): Ucn, Ucn II, and Ucn III...

Detail Information

Publications79

  1. Lewis K, Li C, Perrin M, Blount A, Kunitake K, Donaldson C, et al. Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A. 2001;98:7570-5 pubmed
    The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine...
  2. Vaughan J, Donaldson C, Bittencourt J, Perrin M, Lewis K, Sutton S, et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 1995;378:287-92 pubmed
    ..The deduced protein encodes a peptide that we name urocortin, which is related to urotensin (63% sequence identity) and CRF (45% sequence identity)...
  3. Gruson D, Ginion A, Lause P, Ketelslegers J, Thissen J, Bertrand L. Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes. Peptides. 2012;33:351-3 pubmed publisher
    Urotensin II (UII) and urocortin (UCN) are potent contributors to the physiopathology of heart failure. Our study investigated the effects of UII and UCN on the expression of myostatin (Mstn) in primary culture of adult cardiomyocytes...
  4. García Villalón A, Amezquita Y, Monge L, Fernandez N, Climent B, Sanchez A, et al. Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts. Br J Pharmacol. 2005;145:490-4 pubmed
    1 Urocortin is a vasodilator peptide related to corticotrophin-releasing factor, which may protect endothelial function during coronary ischemia-reperfusion (I-R)...
  5. Zhang R, Xu Y, Fu H, Wang J, Jin L, Li S. Urocortin induced expression of COX-2 and ICAM-1 via corticotrophin-releasing factor type 2 receptor in rat aortic endothelial cells. Br J Pharmacol. 2009;158:819-29 pubmed publisher
    Our previous study showed that urocortin (Ucn1) exacerbates the hypercoagulable state and vasculitis in a rat model of sodium laurate-induced thromboangiitis obliterans...
  6. Wen Z, Yan Z, Hu K, Pang Z, Cheng X, Guo L, et al. Odorranalectin-conjugated nanoparticles: preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration. J Control Release. 2011;151:131-8 pubmed publisher
    ..Besides, urocortin peptide (UCN), as a macromolecular model drug, was incorporated into nanoparticles and evaluated for its ..
  7. Chance W, Dayal R, Friend L, Sheriff S. Possible role of CRF peptides in burn-induced hypermetabolism. Life Sci. 2006;78:694-703 pubmed
    ..Although these results suggest a role of CRF receptors in mediating burn-induced hypermetabolism, CRF itself may not be the principle ligand, as suggested by the significant elevation of hypothalamic urocortin 15 days after burn injury.
  8. Abuirmeileh A, Harkavyi A, Lever R, Biggs C, Whitton P. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. J Neuroinflammation. 2007;4:19 pubmed
    We have recently observed that the corticotrophin releasing hormone (CRF) related peptide urocortin (UCN) reverses key features of nigrostriatal damage in the hemiparkinsonian 6-hydroxydopamine lesioned rat...
  9. Liu J, Yu B, Neugebauer V, Grigoriadis D, Rivier J, Vale W, et al. Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission. J Neurosci. 2004;24:4020-9 pubmed
    ..by two endogenous CRF-related peptide ligands, corticotropin-releasing factor [CRF rat/human (r/h)] and Urocortin I (Ucn I), within the central nucleus of the amygdala (CeA) and the lateral septum mediolateral nucleus (LSMLN)...
  10. Kageyama K, Suda T. Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Endocrinology. 2003;144:2234-41 pubmed
    ..This receptor is coupled positively to adenylate cyclase and is bound preferentially by the urocortin (Ucn)-related peptides (Uncs): Ucn, Ucn II, and Ucn III...
  11. De Luca A, Liguori G, Squillacioti C, Paino S, Germano G, Ali S, et al. Expression of urocortin and its receptors in the rat epididymis. Reprod Biol. 2014;14:140-7 pubmed publisher
    b>Urocortin (UCN; 40 aa) is a corticotrophin-releasing hormone (CRH)-related peptide...
  12. Wang X, Su H, Copenhagen L, Vaishnav S, Pieri F, Shope C, et al. Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response. Mol Cell Biol. 2002;22:6605-10 pubmed
    ..Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential mediator of ..
  13. Ikeda K, Tojo K, Tokudome G, Ohta M, Sugimoto K, Tamura T, et al. Cardiac expression of urocortin (Ucn) in diseased heart; preliminary results on possible involvement of Ucn in pathophysiology of cardiac diseases. Mol Cell Biochem. 2003;252:25-32 pubmed
    Recently, several studies reported that urocortin (Ucn) had beneficial effects on cardiovascular system and was expressed both in the normal heart and in the heart of dilated cardiomyopathy (DCM), yet the relationship between high ..
  14. Calderón Sanchez E, Delgado C, Ruiz Hurtado G, Dominguez Rodriguez A, Cachofeiro V, Rodriguez Moyano M, et al. Urocortin induces positive inotropic effect in rat heart. Cardiovasc Res. 2009;83:717-25 pubmed publisher
    The aim of this study is to evaluate the positive inotropic effect of urocortin (Ucn) and to characterize its signalling pathways. Contractility was measured in ex vivo Langendorff-perfused hearts isolated from Wistar rats...
  15. Porcher C, Peinnequin A, Pellissier S, Meregnani J, Sinniger V, Canini F, et al. Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrum. Peptides. 2006;27:1464-75 pubmed
    In vivo studies suggest that corticotrophin-releasing factor (CRF) and CRF-like peptides, urocortin 1 (UCN 1) and UCN 2, inhibit gastric emptying and stimulate colonic motility through CRF2 and CRF1 receptors, respectively...
  16. Abdelrahman A, Syyong H, Tjahjadi A, Pang C. Analysis of the mechanism of the vasodepressor effect of urocortin in anesthetized rats. Pharmacology. 2005;73:175-9 pubmed
    The aim was to examine if the depressor effect of urocortin involves activation of the nitric oxide (NO)/L-arginine pathway, production of prostanoids or opening of K(+)-channels. I. v. bolus urocortin (0...
  17. Huang H, Lin S, Chen W, Li K, Kuo J, Wang M. Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3? and histone deacetylase. Neurobiol Aging. 2011;32:1662-77 pubmed publisher
    b>Urocortin (UCN) is a member of the corticotropin-releasing hormone (CRH) family of neuropeptides that regulates stress responses...
  18. Gounko N, Rybakin V, Kalicharan D, Siskova Z, Gramsbergen A, van der Want J. CRF and urocortin differentially modulate GluRdelta2 expression and distribution in parallel fiber-Purkinje cell synapses. Mol Cell Neurosci. 2005;30:513-22 pubmed
    Corticotropin-releasing factor (CRF) and urocortin (UCN) are closely related multifunctional regulators, governing, among other processes, Purkinje cell development...
  19. Sumii K, Miyake H, Enatsu N, Chiba K, Fujisawa M. Characterization of urocortin as an anti-apoptotic protein in experimental ischemia-reperfusion model of the rat testis. Biochem Biophys Res Commun. 2016;479:387-392 pubmed publisher
    The objective of this study was to investigate the role of urocortin in testicular apoptosis using an experimental ischemia-reperfusion rat model...
  20. Townsend P, Davidson S, Clarke S, Khaliulin I, Carroll C, Scarabelli T, et al. Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress. Am J Physiol Heart Circ Physiol. 2007;293:H928-38 pubmed
    b>Urocortin (UCN) protects hearts against ischemia and reperfusion injury whether given before ischemia or at reperfusion...
  21. Wu Y, Zhou H, Xu Y, Li S. Enhanced expression of urocortin in lung tissues of rats with allergic asthma. Biochem Biophys Res Commun. 2006;341:532-40 pubmed
    ..b>Urocortin (UCN) is synthesized and secreted by human mast cells and activated mast cells release more UCN...
  22. Wang M, Lin S, Kuo J, Huang H, Tzeng S, Liao C, et al. Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation. J Immunol. 2007;179:6204-14 pubmed
    ..b>Urocortin (UCN) is a member of the corticotropin-releasing hormone (CRH) family of neuropeptides that function to regulate ..
  23. Kozicz T, Li M, Arimura A. The activation of urocortin immunoreactive neurons in the Einger-Westphal nucleus following stress in rats. Stress. 2001;4:85-90 pubmed
    b>Urocortin, a member of the corticotropin releasing factor (CRF) peptide family, has a 45%sequence identity to CRF...
  24. Cureton E, Ereso A, Victorino G, Curran B, Poole D, Liao M, et al. Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation. Endocrinology. 2009;150:5428-37 pubmed publisher
    b>Urocortin 1 (Ucn1) is a neuropeptide that regulates vascular tone and is implicated in both the vascular and immune cell-mediated responses to inflammation...
  25. Hoare S, Sullivan S, Schwarz D, Ling N, Vale W, Crowe P, et al. Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists. Biochemistry. 2004;43:3996-4011 pubmed
    ..2) Agonist-J-domain interaction is allosterically enhanced by receptor-G-protein interaction and inhibited by nonpeptide antagonist. ..
  26. Chang J, Adams M, Clifton M, Liao M, Brooks J, Hasdemir B, et al. Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2. Am J Physiol Gastrointest Liver Physiol. 2011;300:G884-94 pubmed publisher
    ..Thus we conclude that local CRF(2) and pERK1/2 activation is pivotal for macroscopic spread of colitis and resolution of edema. Elimination of CRF(2), but not CRF(1), results in uncoordinated immune and pERK1/2 signaling responses. ..
  27. Shah N, Pugh P, Nam H, Rosenthal D, van Wijk D, Gaszner B, et al. A subset of presympathetic-premotor neurons within the centrally projecting Edinger-Westphal nucleus expresses urocortin-1. J Chem Neuroanat. 2013;52:25-35 pubmed publisher
    ..Neurons within EWcp are the major source of urocortin 1 (Ucn-1), an analog of the corticotropin-releasing factor that binds the CRFR1 and CRFR2 receptors and has been ..
  28. Gourcerol G, Wang L, Wang Y, Million M, Tache Y. Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway. Endocrinology. 2007;148:6115-23 pubmed
    ..We investigated whether cholecystokinin (CCK)-8 and urocortin systems potentiate each other to inhibit FI and gastric emptying (GE) in fasted mice...
  29. Cespedes I, de Oliveira A, da Silva J, da Silva A, Sita L, Bittencourt J. mRNA expression of corticotropin-releasing factor and urocortin 1 after restraint and foot shock together with alprazolam administration. Peptides. 2010;31:2200-8 pubmed publisher
    ..Urocortins 1-3 are additional ligands to the CRF receptors 1 and 2. Ucn 1 neurons are primarily concentrated in the Edinger-Westphal (EW) nucleus and also have been associated with stress ..
  30. Derks N, Gaszner B, Roubos E, Kozicz L. Sex differences in urocortin 1 dynamics in the non-preganglionic Edinger-Westphal nucleus of the rat. Neurosci Res. 2010;66:117-23 pubmed publisher
    ..b>Urocortin 1 (Ucn1) in the npEW plays an important role in stress adaptation...
  31. Currie P, Coiro C, Duenas R, Guss J, Mirza A, Tal N. Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization. Brain Res. 2011;1385:127-34 pubmed publisher
    The corticotropin releasing hormone-related ligand, urocortin-I (UcnI), suppresses food intake when injected into multiple hypothalamic and extrahypothalamic areas...
  32. Sterrenburg L, Borch A, Peeters B, Pintér O, Zelena D, Roubos E, et al. Acute ether stress differentially affects corticotropin-releasing factor and urocortin 1 in the Brattleboro rat. Brain Res. 2011;1398:21-9 pubmed publisher
    Arginine-vasopressin (AVP), corticotropin-releasing factor (CRF) and urocortin 1 (Ucn1) play a role in the stress response...
  33. Fatima A, Haroon M, Wolf G, Engelmann M, Spina M. Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats. Regul Pept. 2007;143:34-8 pubmed
    ..In rats, urocortin 1, a corticotropin-releasing factor-like peptide, is expressed mainly in the non-preganglionic Edinger-Westphal ..
  34. Haeger P, Andrés M, Forray M, Daza C, Araneda S, Gysling K. Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. J Neurosci. 2006;26:4908-16 pubmed
    b>Urocortin (Ucn), a highly conserved metazoan gene, is related to stress and feeding, behaviors with significant gender differences...
  35. Henry B, Lightman S, Lowry C. Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. J Neuroendocrinol. 2005;17:135-44 pubmed
    ..CRF-BP) is a 37-kDa protein with high affinity binding sites for both corticotropin-releasing factor (CRF) and urocortin 1. Previous studies have examined the distribution of CRF-BP mRNA and peptide within the central nervous system...
  36. Charalampopoulos I, Androulidaki A, Minas V, Chatzaki E, Tsatsanis C, Notas G, et al. Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells. Neuroendocrinology. 2006;84:49-57 pubmed
    The stress neuropeptides, corticotropin-releasing hormone (CRH) and urocortin (UCN), modulate the inflammatory response via the hypothalamus-pituitary-adrenal axis and locally, in a paracrine manner, act on mast and macrophage cells...
  37. Harris R, Palmondon J, Leshin S, Flatt W, Richard D. Chronic disruption of body weight but not of stress peptides or receptors in rats exposed to repeated restraint stress. Horm Behav. 2006;49:615-25 pubmed
    ..to measure mRNA expression of corticotrophin releasing factor (CRF) and CRF receptors in hypothalamic nuclei, of urocortin (UCN) in the Edinger Westphal nucleus and of UCN III in the rostral perifornical area and medial amygdaloidal ..
  38. Lawrence K, Scarabelli T, Turtle L, Chanalaris A, Townsend P, Carroll C, et al. Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression. FASEB J. 2003;17:2313-5 pubmed
    ..gene expression caused by a 24 h exposure of rat primary neonatal cardiac myocytes to the cardioprotective agent urocortin. We observed a 2...
  39. Ciriello J. Sex and estrogen affect the distribution of urocortin-1 immunoreactivity in brainstem autonomic nuclei of the rat. Brain Res Bull. 2015;116:81-92 pubmed publisher
    b>Urocortin-1 (UCN-1), a neuropeptide closely related to the hypothalamic hormone corticotropin-releasing factor, has been associated with stress, feeding behaviors, cardiovascular control, and to exhibit functional gender differences...
  40. McKenzie I, Pang T, Blanden R. The use of H-2 mutants as models for the study of T cell activation. Immunol Rev. 1977;35:179-230 pubmed
  41. Gaszner B, Korosi A, Palkovits M, Roubos E, Kozicz T. Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger-Westphal nucleus. J Comp Neurol. 2007;500:708-19 pubmed
    Central regulatory pathways promoting stress adaptation utilize various neurotransmitters/neuropeptides, such as urocortin 1 (Ucn1) and neuropeptide Y (NPY)...
  42. Xu Y, Zhang R, Chen J, Zhang Q, Wang J, Hu J, et al. Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors. Br J Pharmacol. 2009;157:1368-79 pubmed publisher
    b>Urocortin is a locally expressed pro-inflammatory peptide. Here we have examined the effects of urocortin on sodium laurate-induced peripheral arterial vasculitis in rats, modelling the mechanisms of thromboangiitis obliterans (TAO)...
  43. Yakabi K, Noguchi M, Ohno S, Ro S, Onouchi T, Ochiai M, et al. Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors. Am J Physiol Endocrinol Metab. 2011;301:E72-82 pubmed publisher
    Although it is known that urocortin 1 (UCN) acts on both corticotropin-releasing factor receptors (CRF(1) and CRF(2)), the mechanisms underlying UCN-induced anorexia remain unclear...
  44. Ohata H, Suzuki K, Oki Y, Shibasaki T. Urocortin in the ventromedial hypothalamic nucleus acts as an inhibitor of feeding behavior in rats. Brain Res. 2000;861:1-7 pubmed
    b>Urocortin (UCN), a member of the corticotropin-releasing factor (CRF) family, inhibits food intake when it is injected intracerebroventricularly in rats...
  45. Spina M, Langnaese K, Orlando G, Horn T, Rivier J, Vale W, et al. Colocalization of urocortin and neuronal nitric oxide synthase in the hypothalamus and Edinger-Westphal nucleus of the rat. J Comp Neurol. 2004;479:271-86 pubmed
    Different lines of studies suggest that both the corticotropin-releasing hormone-related peptide Urocortin I (Ucn) and the neuromodulator nitric oxide (NO) are involved in the regulation of the complex mechanisms controlling feeding and ..
  46. Pedersen W, Wan R, Zhang P, Mattson M. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. J Neurosci. 2002;22:404-12 pubmed
    b>Urocortin and urocortin II are members of the corticotropin-releasing hormone (CRH) family of neuropeptides that function to regulate stress responses...
  47. Xu L, Bloem B, Gaszner B, Roubos E, Kozicz T. Sex-specific effects of fasting on urocortin 1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus. Neuroscience. 2009;162:1141-9 pubmed publisher
    ..Central regulatory pathways involved in food intake utilize various neuropeptides, such as urocortin 1 (Ucn1), cocaine- and amphetamine-regulated transcript peptide (CART) and nesfatin-1...
  48. Huang H, Chiu T, Chang H, Hsu H, Pang C, Liew H, et al. Epigenetic regulation contributes to urocortin-enhanced midbrain dopaminergic neuron differentiation. Stem Cells. 2015;33:1601-17 pubmed publisher
    ..b>Urocortin (UCN) is a peptide of the corticotropin-releasing hormone family that mediates various responses to stress...
  49. Fekete E, Zhao Y, Szucs A, Sabino V, Cottone P, Rivier J, et al. Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. Br J Pharmacol. 2011;164:1959-75 pubmed publisher
    Infusion of corticotropin-releasing factor (CRF)/urocortin (Ucn) family peptides suppresses feeding in mice. We examined whether rats show peripheral CRF/Ucn-induced anorexia and determined its behavioural and pharmacological bases...
  50. Park J, Lee Y, Na S, Kim K. Genomic organization and tissue-specific expression of rat urocortin. Neurosci Lett. 2000;292:45-8 pubmed
    The genomic organization of rat urocortin was determined using both cDNA and liver genomic DNA as templates for polymerase chain reactions...
  51. Bittencourt J, Vaughan J, Arias C, Rissman R, Vale W, Sawchenko P. Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol. 1999;415:285-312 pubmed
    ..and axonal transport methods were used to clarify the central organization of cells and fibers that express urocortin (UCN), a recently discovered corticotropin-releasing factor (CRF)-related neuropeptide, which has been proposed ..
  52. Haeger P, Cuevas R, Forray M, Rojas R, Daza C, Rivadeneira J, et al. Natural expression of immature Ucn antisense RNA in the rat brain. Evidence favoring bidirectional transcription of the Ucn gene locus. Brain Res Mol Brain Res. 2005;139:115-28 pubmed
    Recently, it has been shown the endogenous expression of an antisense urocortin (Ucn) transcript in the rat brain and other tissues...
  53. Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc R, et al. Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin. Neuropharmacology. 1997;36:1439-46 pubmed
    The binding of the novel radioligand, [3H]-rat urocortin to homogenates of rat cerebellum and homogenates of cells stably transfected with the human CRF1, rat CRF2alpha and rat CRF2beta receptors was examined...
  54. Chanalaris A, Lawrence K, Townsend P, Davidson S, Jamshidi Y, Jashmidi Y, et al. Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway. Biochem Biophys Res Commun. 2005;328:442-8 pubmed
    The UCN homologues SCP and SRP bind specifically to the CRFR2 receptor, whereas UCN binds to both CRFR1 and CRFR2...
  55. Hillhouse E, Grammatopoulos D. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev. 2006;27:260-86 pubmed
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease. ..
  56. Spiga F, Lightman S, Shekhar A, Lowry C. Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons. Neuroscience. 2006;138:1265-76 pubmed
    ..that injections of the anxiety-related neuropeptide corticotropin-releasing factor or the related neuropeptide urocortin 1 into the region of the basolateral amygdaloid nucleus induce anxiety-like behavior in several behavioral ..
  57. Zorrilla E, Schulteis G, Ormsby A, Klaassen A, Ling N, McCarthy J, et al. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Res. 2002;952:200-10 pubmed
    ..In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF receptor antagonists, to determine which CRF receptor subtype(s) ..
  58. Currie P, Coscina D, Bishop C, Coiro C, Koob G, Rivier J, et al. Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient. Brain Res. 2001;916:222-8 pubmed
    ..The recently identified CRH-related peptide, urocortin (UCN), also binds with high affinity to CRH receptor subtypes and decreases food intake in food-deprived and non-..
  59. van der Doelen R, Robroch B, Arnoldussen I, Schulpen M, Homberg J, Kozicz T. Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal nuclei after early life stress in serotonin transporter knockout rats. Neuroscience. 2017;340:345-358 pubmed publisher
    ..separation paradigm as a model for ELS exposure in homozygous and heterozygous 5-HTT knockout rats and measured urocortin 1 (Ucn1) mRNA and/or protein levels, Ucn1 DNA methylation, as well as 5-HT innervation in the centrally ..
  60. Yang C, Liu X, Li S. Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting enzyme in spontaneously hypertensive rats. Can J Physiol Pharmacol. 2010;88:168-76 pubmed publisher
    Our previous acute study on urocortin (Ucn) demonstrated that Ucn altered serum and tissue angiotensin-converting enzyme (ACE) activity in rats...
  61. Nishikimi T, Miyata A, Horio T, Yoshihara F, Nagaya N, Takishita S, et al. Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Am J Physiol Heart Circ Physiol. 2000;279:H3031-9 pubmed
    ..the present study we investigated the form of expression, action, second messenger, and the cellular location of urocortin, a member of the corticotropin-releasing factor (CRF) family, in the heart...
  62. Nakamura T, Sapru H. Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. Am J Physiol Heart Circ Physiol. 2009;296:H2022-9 pubmed publisher
    b>Urocortin 1 (Ucn1) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing factor (CRF) peptide family...
  63. Railson J, Liao Z, Brar B, Buddle J, Pennica D, Stephanou A, et al. Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes. Cytokine. 2002;17:243-53 pubmed
    ..CT-1 and the corticotrophin releasing hormone-like hormone urocortin protect cardiac myocytes by the same p42/44 mitogen activated protein kinase (p42/44 MAPK) dependent pathway...
  64. Kageyama K, Kimura R, Suga S, Ogawa Y, Suda T, Wakui M. Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Peptides. 2006;27:1814-9 pubmed
    ..In addition to CRF, other additional members of the family, urocortins, have been identified in mammals. Urocortin 1 (UCN 1), a peptide of the CRF family, binds both CRF1 receptor and CRF2 receptor with equal affinities...
  65. Wang L, Stengel A, Goebel Stengel M, Shaikh A, Yuan P, TACHE Y. Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats. Peptides. 2013;39:164-70 pubmed publisher
    ..We examined plasma levels of ghrelin and blood glucose after intravenous (iv) injection of Ucn 1, the CRF receptor subtype involved and underlying mechanisms in ad libitum fed rats equipped with a chronic iv ..
  66. Radulovic J, Rühmann A, Liepold T, Spiess J. Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2. J Neurosci. 1999;19:5016-25 pubmed
    ..The involvement of either receptor subtype was demonstrated by region-specific injections of astressin and antisauvagine-30. ..
  67. Yamazaki T, Waki H, Kohsaka A, Nakamura T, Cui H, Yukawa K, et al. Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure. Auton Neurosci. 2008;142:51-4 pubmed publisher
    Systemic administration of urocortin I (Ucn I), a member of the corticotrophin-releasing factor (CRF) peptide family, modulates cardiovascular system...
  68. Aschrafi A, Verheijen J, Gordebeke P, Olde Loohuis N, Menting K, Jager A, et al. MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression. J Psychiatry Neurosci. 2016;41:342-53 pubmed publisher
    Altered levels of urocortin 1 (Ucn1) in the centrally projecting Edinger-Westphal nucleus (EWcp) of depressed suicide attempters or completers mediate the brain's response to stress, while the mechanism regulating Ucn1 expression is ..
  69. Rouwette T, Klemann K, Gaszner B, Scheffer G, Roubos E, Scheenen W, et al. Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain. Neuroscience. 2011;183:15-24 pubmed publisher
    It has been hypothesized that corticotropin-releasing factor (CRF) and its related neuropeptide urocortin 1 (Ucn1) play different roles in the initiation and adaptive phases of the stress response, which implies different temporal ..
  70. Tu H, Kastin A, Bjorbaek C, Pan W. Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci. 2007;31:171-81 pubmed
    b>Urocortin, a potent peptide inhibitor of feeding behavior, can enter the brain from blood by leptin-facilitated permeation across the blood-brain barrier...
  71. Kozicz T. Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger-Westphal nucleus in the rat. Neuroscience. 2003;116:315-20 pubmed
    ..releasing factor, central stress regulatory pathways utilize various neurotransmitters/neuropeptides, such as urocortin and cocaine and amphetamine-regulated transcript, which play an important role in modifying the efferent ..
  72. Guzman E, Zhang W, Lin T, Mulholland M. Stimulation of rat pancreatic exocrine secretion by urocortin and corticotropin releasing factor. Peptides. 2003;24:727-34 pubmed
    ..The effects of the corticotropin releasing factor (CRF) related neuropeptide urocortin (UCN) on pancreatic exocrine secretion were examined...
  73. Miki I, Seya K, Motomura S, Furukawa K. Role of corticotropin-releasing factor receptor type 2 beta in urocortin-induced vasodilation of rat aortas. J Pharmacol Sci. 2004;96:170-6 pubmed
    b>Urocortin has a high affinity for the corticotropin-releasing factor receptor type 2beta (CRF-R2beta). This study was conducted to reveal the role of CRF-R2beta in blood vessels...
  74. Swinny J, Metzger F, Ijkema Paassen J, Gounko N, Gramsbergen A, van der Want J. Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro. Eur J Neurosci. 2004;19:1749-58 pubmed
    ..modulator of Purkinje cell dendritic development is corticotropin-releasing factor (CRF) and family member, urocortin, both of which are localized in climbing fibers...
  75. Coin I, KATRITCH V, Sun T, Xiang Z, SIU F, Beyermann M, et al. Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell. 2013;155:1258-69 pubmed publisher
    ..between the corticotropin releasing factor receptor type 1 (CRF1R) and its native 40-mer peptide ligand Urocortin-I directly in mammalian cells...
  76. Blanco E, Rojas R, Haeger P, Cuevas R, Perez C, Munita R, et al. Intron retention as an alternative splice variant of the rat urocortin 1 gene. Neuroscience. 2006;140:1245-52 pubmed
    b>Urocortin 1, highly conserved metazoan gene of the corticotropin-releasing hormone family, is a simple gene structured in two exons and the corresponding intron. The urocortin 1 prepropeptide is entirely coded in the second exon...