Ucn

Summary

Gene Symbol: Ucn
Description: urocortin
Alias: urocortin, corticotensin
Species: rat

Top Publications

  1. pmc Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
    K Lewis
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:7570-5. 2001
  2. pmc A subset of presympathetic-premotor neurons within the centrally projecting Edinger-Westphal nucleus expresses urocortin-1
    Najmul S Shah
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Chem Neuroanat 52:25-35. 2013
  3. ncbi Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists
    Sam R J Hoare
    Department of Pharmacology, Neurocrine Biosciences Inc, San Diego, California 92121 1102, USA
    Biochemistry 43:3996-4011. 2004
  4. doi Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain
    T Rouwette
    Department of Cellular Animal Physiology, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuroscience 183:15-24. 2011
  5. doi Expression of urocortin and its receptors in the rat epididymis
    Adriana De Luca
    Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Veterinaria 1, I 80137 Naples, Italy Electronic address
    Reprod Biol 14:140-7. 2014
  6. pmc Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR
    Irene Coin
    Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 155:1258-69. 2013
  7. doi Sex difference in urocortin production is contributory to the gender disparity in a rat model of vasculitis induced by sodium laurate
    Rong Wan
    Department of Pharmacology, Nanjing Medical University Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Nanjing, China
    Endocrinology 154:4663-74. 2013
  8. pmc Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
    E M Fekete
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Br J Pharmacol 164:1959-75. 2011
  9. ncbi Intron retention as an alternative splice variant of the rat urocortin 1 gene
    E Blanco
    Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, Alameda 340, 833 1010, Santiago, Chile
    Neuroscience 140:1245-52. 2006
  10. ncbi Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger-Westphal nucleus
    Balazs Gaszner
    Department of Anatomy, Medical Faculty, Pécs University and Neurohumoral Regulations Research Group of Hungarian Academy of Sciences, H 7643 Pecs, Szigeti ut 12, Hungary
    J Comp Neurol 500:708-19. 2007

Scientific Experts

Detail Information

Publications79

  1. pmc Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
    K Lewis
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:7570-5. 2001
    The corticotropin-releasing factor (CRF) family of neuropeptides includes the mammalian peptides CRF, urocortin, and urocortin II, as well as piscine urotensin I and frog sauvagine...
  2. pmc A subset of presympathetic-premotor neurons within the centrally projecting Edinger-Westphal nucleus expresses urocortin-1
    Najmul S Shah
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Chem Neuroanat 52:25-35. 2013
    ..Neurons within EWcp are the major source of urocortin 1 (Ucn-1), an analog of the corticotropin-releasing factor that binds the CRFR1 and CRFR2 receptors and has been ..
  3. ncbi Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists
    Sam R J Hoare
    Department of Pharmacology, Neurocrine Biosciences Inc, San Diego, California 92121 1102, USA
    Biochemistry 43:3996-4011. 2004
    ..2) Agonist-J-domain interaction is allosterically enhanced by receptor-G-protein interaction and inhibited by nonpeptide antagonist...
  4. doi Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain
    T Rouwette
    Department of Cellular Animal Physiology, Faculty of Science, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuroscience 183:15-24. 2011
    It has been hypothesized that corticotropin-releasing factor (CRF) and its related neuropeptide urocortin 1 (Ucn1) play different roles in the initiation and adaptive phases of the stress response, which implies different temporal ..
  5. doi Expression of urocortin and its receptors in the rat epididymis
    Adriana De Luca
    Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via Veterinaria 1, I 80137 Naples, Italy Electronic address
    Reprod Biol 14:140-7. 2014
    b>Urocortin (UCN; 40 aa) is a corticotrophin-releasing hormone (CRH)-related peptide...
  6. pmc Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR
    Irene Coin
    Jack H Skirball Center for Chemical Biology and Proteomics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 155:1258-69. 2013
    ..between the corticotropin releasing factor receptor type 1 (CRF1R) and its native 40-mer peptide ligand Urocortin-I directly in mammalian cells...
  7. doi Sex difference in urocortin production is contributory to the gender disparity in a rat model of vasculitis induced by sodium laurate
    Rong Wan
    Department of Pharmacology, Nanjing Medical University Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Nanjing, China
    Endocrinology 154:4663-74. 2013
    ..Increasing evidence shows that urocortin (Ucn1), an autocrine or paracrine pro-inflammatory factor, can be regulated by sex hormones...
  8. pmc Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
    E M Fekete
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Br J Pharmacol 164:1959-75. 2011
    Infusion of corticotropin-releasing factor (CRF)/urocortin (Ucn) family peptides suppresses feeding in mice. We examined whether rats show peripheral CRF/Ucn-induced anorexia and determined its behavioural and pharmacological bases.
  9. ncbi Intron retention as an alternative splice variant of the rat urocortin 1 gene
    E Blanco
    Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, Alameda 340, 833 1010, Santiago, Chile
    Neuroscience 140:1245-52. 2006
    b>Urocortin 1, highly conserved metazoan gene of the corticotropin-releasing hormone family, is a simple gene structured in two exons and the corresponding intron. The urocortin 1 prepropeptide is entirely coded in the second exon...
  10. ncbi Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger-Westphal nucleus
    Balazs Gaszner
    Department of Anatomy, Medical Faculty, Pécs University and Neurohumoral Regulations Research Group of Hungarian Academy of Sciences, H 7643 Pecs, Szigeti ut 12, Hungary
    J Comp Neurol 500:708-19. 2007
    Central regulatory pathways promoting stress adaptation utilize various neurotransmitters/neuropeptides, such as urocortin 1 (Ucn1) and neuropeptide Y (NPY)...
  11. doi Cardioprotective activity of urocortin by preventing caspase-independent, non-apoptotic death in cultured neonatal rat cardiomyocytes exposed to ischemia
    Tomoka Takatani-Nakase
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien, Nishinomiya, Hyogo 663 8179, Japan
    Biochem Biophys Res Commun 402:216-21. 2010
    ..Moreover, we investigated whether the potent cardioprotective corticotropin-releasing hormone (CRH), urocortin, which had been less focused on non-apoptotic cell death, inhibits the ischemic myocyte death...
  12. ncbi The activation of urocortin immunoreactive neurons in the Einger-Westphal nucleus following stress in rats
    T Kozicz
    Pecs University, Medical Faculty, Pkcs, Szigeti at 12 H 7624, Hungary
    Stress 4:85-90. 2001
    b>Urocortin, a member of the corticotropin releasing factor (CRF) peptide family, has a 45%sequence identity to CRF...
  13. doi Acute ether stress differentially affects corticotropin-releasing factor and urocortin 1 in the Brattleboro rat
    Linda Sterrenburg
    Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, PO Box 9010, 6500 GL Nijmegen, The Netherlands
    Brain Res 1398:21-9. 2011
    Arginine-vasopressin (AVP), corticotropin-releasing factor (CRF) and urocortin 1 (Ucn1) play a role in the stress response...
  14. doi Sex-specific effects of fasting on urocortin 1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 expression in the rat Edinger-Westphal nucleus
    L Xu
    Department of Cellular Animal Physiology, Faculty of Science, EURON, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
    Neuroscience 162:1141-9. 2009
    ..Central regulatory pathways involved in food intake utilize various neuropeptides, such as urocortin 1 (Ucn1), cocaine- and amphetamine-regulated transcript peptide (CART) and nesfatin-1...
  15. pmc Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization
    Paul J Currie
    Department of Psychology, Reed College, 3203 SE Woodstock Blvd, Portland, OR 97202, USA
    Brain Res 1385:127-34. 2011
    The corticotropin releasing hormone-related ligand, urocortin-I (UcnI), suppresses food intake when injected into multiple hypothalamic and extrahypothalamic areas...
  16. pmc Urocortin 1 reduces food intake and ghrelin secretion via CRF(2) receptors
    Koji Yakabi
    Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
    Am J Physiol Endocrinol Metab 301:E72-82. 2011
    Although it is known that urocortin 1 (UCN) acts on both corticotropin-releasing factor receptors (CRF(1) and CRF(2)), the mechanisms underlying UCN-induced anorexia remain unclear...
  17. doi Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes
    Damien Gruson
    Pôle de recherche en Endocrinologie, diabète et nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc and Université Catholique de Louvain, Brussels, Belgium
    Peptides 33:351-3. 2012
    Urotensin II (UII) and urocortin (UCN) are potent contributors to the physiopathology of heart failure. Our study investigated the effects of UII and UCN on the expression of myostatin (Mstn) in primary culture of adult cardiomyocytes...
  18. pmc Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats
    Lixin Wang
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 39:164-70. 2013
    ..We examined plasma levels of ghrelin and blood glucose after intravenous (iv) injection of Ucn 1, the CRF receptor subtype involved and underlying mechanisms in ad libitum fed rats equipped with a chronic iv ..
  19. ncbi Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene
    Paola Haeger
    Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, 833 1010 Santiago, Chile
    J Neurosci 26:4908-16. 2006
    b>Urocortin (Ucn), a highly conserved metazoan gene, is related to stress and feeding, behaviors with significant gender differences...
  20. ncbi High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension
    Pasquale Florio
    Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
    J Hypertens 24:1831-40. 2006
    We evaluated maternal and fetal plasma levels and placental mRNA expression of urocortin, a placental vasoactive neuropeptide, in singleton pregnancies (n = 70) complicated by hypertensive disorders classified as gestational hypertension ..
  21. ncbi Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    Neuroendocrinology 84:49-57. 2006
    The stress neuropeptides, corticotropin-releasing hormone (CRH) and urocortin (UCN), modulate the inflammatory response via the hypothalamus-pituitary-adrenal axis and locally, in a paracrine manner, act on mast and macrophage cells...
  22. ncbi Reduced urocortin 1 immunoreactivity in the non-preganglionic Edinger-Westphal nucleus during late pregnancy in rats
    A Fatima
    Institute of Medical Neurobiology, Otto von Guericke University Magdeburg, Germany
    Regul Pept 143:34-8. 2007
    ..In rats, urocortin 1, a corticotropin-releasing factor-like peptide, is expressed mainly in the non-preganglionic Edinger-Westphal ..
  23. ncbi Urocortin trafficking in cerebral microvessel endothelial cells
    Hong Tu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Mol Neurosci 31:171-81. 2007
    b>Urocortin, a potent peptide inhibitor of feeding behavior, can enter the brain from blood by leptin-facilitated permeation across the blood-brain barrier...
  24. pmc Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress
    Paul A Townsend
    Human Genetics Division, University of Southampton, Southampton, UK
    Am J Physiol Heart Circ Physiol 293:H928-38. 2007
    b>Urocortin (UCN) protects hearts against ischemia and reperfusion injury whether given before ischemia or at reperfusion...
  25. pmc Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease
    Amjad Abuirmeileh
    Department of Pharmacology, The School of Pharmacy, London, UK
    J Neuroinflammation 4:19. 2007
    We have recently observed that the corticotrophin releasing hormone (CRF) related peptide urocortin (UCN) reverses key features of nigrostriatal damage in the hemiparkinsonian 6-hydroxydopamine lesioned rat...
  26. ncbi Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway
    G Gourcerol
    Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Endocrinology 148:6115-23. 2007
    ..We investigated whether cholecystokinin (CCK)-8 and urocortin systems potentiate each other to inhibit FI and gastric emptying (GE) in fasted mice...
  27. doi Microinjection of urocortin into the rat nucleus tractus solitarii decreases arterial blood pressure
    Toshiya Yamazaki
    Department of Physiology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Auton Neurosci 142:51-4. 2008
    Systemic administration of urocortin I (Ucn I), a member of the corticotrophin-releasing factor (CRF) peptide family, modulates cardiovascular system...
  28. pmc Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors
    Takeshi Nakamura
    Department of Neurological Surgery, MSB H 586, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Am J Physiol Heart Circ Physiol 296:H2022-9. 2009
    b>Urocortin 1 (Ucn1) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing factor (CRF) peptide family...
  29. ncbi Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells
    Kazunori Kageyama
    Department of Endocrinology, Metabolism and Infectious Diseases Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 27:1814-9. 2006
    ..In addition to CRF, other additional members of the family, urocortins, have been identified in mammals. Urocortin 1 (UCN 1), a peptide of the CRF family, binds both CRF1 receptor and CRF2 receptor with equal affinities...
  30. doi Urocortin induces positive inotropic effect in rat heart
    Eva Calderón-Sanchez
    Laboratorio de Investigación Cardiovascular, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Sevilla 41013, Spain
    Cardiovasc Res 83:717-25. 2009
    The aim of this study is to evaluate the positive inotropic effect of urocortin (Ucn) and to characterize its signalling pathways.
  31. pmc Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors
    Youhua Xu
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Br J Pharmacol 157:1368-79. 2009
    b>Urocortin is a locally expressed pro-inflammatory peptide. Here we have examined the effects of urocortin on sodium laurate-induced peripheral arterial vasculitis in rats, modelling the mechanisms of thromboangiitis obliterans (TAO).
  32. pmc Urocortin induced expression of COX-2 and ICAM-1 via corticotrophin-releasing factor type 2 receptor in rat aortic endothelial cells
    Rongjian Zhang
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Br J Pharmacol 158:819-29. 2009
    Our previous study showed that urocortin (Ucn1) exacerbates the hypercoagulable state and vasculitis in a rat model of sodium laurate-induced thromboangiitis obliterans...
  33. doi Regulation of somatodendritic dopamine release by corticotropin-releasing factor via the inhibition of voltage-operated Ca2+ channels
    Yonjung Kim
    Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Neurosci Lett 465:31-5. 2009
    ..Since corticotropin-releasing factor (CRF) regulates VOCC, we sought to determine whether urocortin affects somatodendritic DA release in the isolated DA neurons using amperometry method...
  34. doi Plasma urocortin 1 in human heart failure
    Sue P Wright
    Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    Circ Heart Fail 2:465-71. 2009
    ..We have investigated plasma urocortin 1 as a potential diagnostic marker of heart failure and documented its relationships to symptoms, measures of ..
  35. pmc Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation
    Elizabeth L Cureton
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Endocrinology 150:5428-37. 2009
    b>Urocortin 1 (Ucn1) is a neuropeptide that regulates vascular tone and is implicated in both the vascular and immune cell-mediated responses to inflammation...
  36. doi Sex differences in urocortin 1 dynamics in the non-preganglionic Edinger-Westphal nucleus of the rat
    Nicole M Derks
    Department of Cellular Animal Physiology, Faculty of Science, EURON, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
    Neurosci Res 66:117-23. 2010
    ..b>Urocortin 1 (Ucn1) in the npEW plays an important role in stress adaptation...
  37. doi Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase
    Hsin Yi Huang
    Department of Research, Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan, ROC
    Neurobiol Aging 32:1662-77. 2011
    b>Urocortin (UCN) is a member of the corticotropin-releasing hormone (CRH) family of neuropeptides that regulates stress responses...
  38. doi Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting enzyme in spontaneously hypertensive rats
    Cui Yang
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Can J Physiol Pharmacol 88:168-76. 2010
    Our previous acute study on urocortin (Ucn) demonstrated that Ucn altered serum and tissue angiotensin-converting enzyme (ACE) activity in rats...
  39. doi mRNA expression of corticotropin-releasing factor and urocortin 1 after restraint and foot shock together with alprazolam administration
    Isabel C Cespedes
    Department of Biosciences, Federal University of Sao Paulo, Campus Baixada Santista, Sao Paulo, Brazil
    Peptides 31:2200-8. 2010
    ..Urocortins 1-3 are additional ligands to the CRF receptors 1 and 2. Ucn 1 neurons are primarily concentrated in the Edinger-Westphal (EW) nucleus and also have been associated with stress ..
  40. pmc Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2
    Jen Chang
    Dept of Surgery, Univ of California, San Francisco, 94143 0660, USA
    Am J Physiol Gastrointest Liver Physiol 300:G884-94. 2011
    ..Thus we conclude that local CRF(2) and pERK1/2 activation is pivotal for macroscopic spread of colitis and resolution of edema. Elimination of CRF(2), but not CRF(1), results in uncoordinated immune and pERK1/2 signaling responses...
  41. doi Odorranalectin-conjugated nanoparticles: preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration
    Ziyi Wen
    Department of Pharmaceutical Science, School of Pharmacy, Fudan University, Shanghai, China
    J Control Release 151:131-8. 2011
    ..Besides, urocortin peptide (UCN), as a macromolecular model drug, was incorporated into nanoparticles and evaluated for its ..
  42. ncbi Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I
    Ward A Pedersen
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci 22:404-12. 2002
    b>Urocortin and urocortin II are members of the corticotropin-releasing hormone (CRH) family of neuropeptides that function to regulate stress responses...
  43. ncbi Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression
    K M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, UK
    FASEB J 17:2313-5. 2003
    ..gene expression caused by a 24 h exposure of rat primary neonatal cardiac myocytes to the cardioprotective agent urocortin. We observed a 2...
  44. ncbi Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 35:1295-305. 2003
    b>Urocortin (UCN), a member of the Corticotropin-Releasing Factor (CRF) family of peptides is a well described cardioprotective agent...
  45. ncbi Stimulation of rat pancreatic exocrine secretion by urocortin and corticotropin releasing factor
    Eduardo A Guzman
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0331, USA
    Peptides 24:727-34. 2003
    ..The effects of the corticotropin releasing factor (CRF) related neuropeptide urocortin (UCN) on pancreatic exocrine secretion were examined...
  46. ncbi Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells
    Kazunori Kageyama
    The Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Endocrinology 144:2234-41. 2003
    ..This receptor is coupled positively to adenylate cyclase and is bound preferentially by the urocortin (Ucn)-related peptides (Uncs): Ucn, Ucn II, and Ucn III...
  47. ncbi Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger-Westphal nucleus in the rat
    T Kozicz
    University of Pecs, Medical Faculty, Department of Human Anatomy, Pecs, Szigeti ut 12, H 7624, Hungary
    Neuroscience 116:315-20. 2003
    ..releasing factor, central stress regulatory pathways utilize various neurotransmitters/neuropeptides, such as urocortin and cocaine and amphetamine-regulated transcript, which play an important role in modifying the efferent ..
  48. ncbi The localisation of urocortin in the adult rat cerebellum: a light and electron microscopic study
    J D Swinny
    Laboratory for Cell Biology and Electron Microscopy, Graduate School of Behavioural and Cognitive Neuroscience, University of Groningen, Antonius Deusinglaan 1, The Netherlands
    Neuroscience 114:891-903. 2002
    ..and electron microscopic immunocytochemistry was used to identify the cellular and subcellular localisation of urocortin in the adult rat cerebellum...
  49. ncbi Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors
    Eric P Zorrilla
    Neurocrine Biosciences, Inc, La Jolla, CA, USA
    Brain Res 952:200-10. 2002
    ..In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF receptor antagonists, to determine which CRF receptor subtype(s) ..
  50. ncbi Cardiotrophin-1 and urocortin cause protection by the same pathway and hypertrophy via distinct pathways in cardiac myocytes
    Julia E Railson
    Medical Molecular Biology Unit, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    Cytokine 17:243-53. 2002
    ..CT-1 and the corticotrophin releasing hormone-like hormone urocortin protect cardiac myocytes by the same p42/44 mitogen activated protein kinase (p42/44 MAPK) dependent pathway...
  51. ncbi Urocortin
    David S Latchman
    Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH, London, UK
    Int J Biochem Cell Biol 34:907-10. 2002
    b>Urocortin (Ucn) is a 40 amino acid peptide which is closely related to corticotrophin-releasing factor (CRF). It is expressed in specific regions of the brain but is also detectable in other organs notably the heart...
  52. ncbi Cardiac expression of urocortin (Ucn) in diseased heart; preliminary results on possible involvement of Ucn in pathophysiology of cardiac diseases
    Keiichi Ikeda
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Mol Cell Biochem 252:25-32. 2003
    Recently, several studies reported that urocortin (Ucn) had beneficial effects on cardiovascular system and was expressed both in the normal heart and in the heart of dilated cardiomyopathy (DCM), yet the relationship between high ..
  53. ncbi Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient
    P J Currie
    Department of Psychology, Barnard College, Columbia University, New York, NY 10027, USA
    Brain Res 916:222-8. 2001
    ..The recently identified CRH-related peptide, urocortin (UCN), also binds with high affinity to CRH receptor subtypes and decreases food intake in food-deprived and non-..
  54. ncbi Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart
    T Nishikimi
    Research Institute, National Cardiovascular Center, Suita, Osaka 565, Japan
    Am J Physiol Heart Circ Physiol 279:H3031-9. 2000
    ..the present study we investigated the form of expression, action, second messenger, and the cellular location of urocortin, a member of the corticotropin-releasing factor (CRF) family, in the heart...
  55. ncbi Genomic organization and tissue-specific expression of rat urocortin
    J H Park
    Protein Engineering Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, P O Box 115, 305 600, Taejon, South Korea
    Neurosci Lett 292:45-8. 2000
    The genomic organization of rat urocortin was determined using both cDNA and liver genomic DNA as templates for polymerase chain reactions...
  56. ncbi Urocortin in the ventromedial hypothalamic nucleus acts as an inhibitor of feeding behavior in rats
    H Ohata
    Department of Physiology, Nippon Medical School, 1 1 5 Sendagi Bunkyo ku, Tokyo, Japan
    Brain Res 861:1-7. 2000
    b>Urocortin (UCN), a member of the corticotropin-releasing factor (CRF) family, inhibits food intake when it is injected intracerebroventricularly in rats...
  57. ncbi Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors
    J C Bittencourt
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Comp Neurol 415:285-312. 1999
    ..and axonal transport methods were used to clarify the central organization of cells and fibers that express urocortin (UCN), a recently discovered corticotropin-releasing factor (CRF)-related neuropeptide, which has been proposed ..
  58. ncbi Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2
    J Radulovic
    Max Planck Institute for Experimental Medicine, Department for Molecular Neuroendocrinology, 37075 Goettingen, Germany
    J Neurosci 19:5016-25. 1999
    ..The involvement of either receptor subtype was demonstrated by region-specific injections of astressin and antisauvagine-30...
  59. ncbi Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin
    J Gottowik
    Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    Neuropharmacology 36:1439-46. 1997
    The binding of the novel radioligand, [3H]-rat urocortin to homogenates of rat cerebellum and homogenates of cells stably transfected with the human CRF1, rat CRF2alpha and rat CRF2beta receptors was examined...
  60. ncbi Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
    J Vaughan
    Clayton Foundation Laboratories for Peptide Biology, La Jolla, California, USA
    Nature 378:287-92. 1995
    ..The deduced protein encodes a peptide that we name urocortin, which is related to urotensin (63% sequence identity) and CRF (45% sequence identity)...
  61. ncbi The postnatal developmental expression pattern of urocortin in the rat olivocerebellar system
    Jerome D Swinny
    Laboratory for Cell Biology and Electron Microscopy, University of Groningen, 9713AV Groningen, The Netherlands
    J Comp Neurol 472:40-51. 2004
    b>Urocortin belongs to the family of corticotropin-releasing factor (CRF)-like peptides, which play an important role in sensorimotor coordination. CRF induces locomotor activity, and urocortin has an inhibitory effect...
  62. ncbi The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease...
  63. ncbi Enhanced expression of urocortin in lung tissues of rats with allergic asthma
    Yuqing Wu
    Department of Pharmacology, Nanjing Medical University, Nanjing, PR China
    Biochem Biophys Res Commun 341:532-40. 2006
    ..b>Urocortin (UCN) is synthesized and secreted by human mast cells and activated mast cells release more UCN...
  64. ncbi Chronic disruption of body weight but not of stress peptides or receptors in rats exposed to repeated restraint stress
    Ruth B S Harris
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30605, USA
    Horm Behav 49:615-25. 2006
    ..to measure mRNA expression of corticotrophin releasing factor (CRF) and CRF receptors in hypothalamic nuclei, of urocortin (UCN) in the Edinger Westphal nucleus and of UCN III in the rostral perifornical area and medial amygdaloidal ..
  65. ncbi Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrum
    Christophe Porcher
    Groupe d Etude du Stress et des Interactions Neuro Digestives GESIND, EA3744, CHRU Grenoble, BP 217, Grenoble 38043, France
    Peptides 27:1464-75. 2006
    In vivo studies suggest that corticotrophin-releasing factor (CRF) and CRF-like peptides, urocortin 1 (UCN 1) and UCN 2, inhibit gastric emptying and stimulate colonic motility through CRF2 and CRF1 receptors, respectively...
  66. ncbi CRF and urocortin differentially modulate GluRdelta2 expression and distribution in parallel fiber-Purkinje cell synapses
    Natalia V Gounko
    Department of Cell Biology, Laboratory for Electron Microscopy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Mol Cell Neurosci 30:513-22. 2005
    Corticotropin-releasing factor (CRF) and urocortin (UCN) are closely related multifunctional regulators, governing, among other processes, Purkinje cell development...
  67. ncbi Possible role of CRF peptides in burn-induced hypermetabolism
    William T Chance
    Burns Institute, Shriners Hospitals for Children, 3229 Burnet Ave, Cincinnati, OH, USA
    Life Sci 78:694-703. 2006
    ..Although these results suggest a role of CRF receptors in mediating burn-induced hypermetabolism, CRF itself may not be the principle ligand, as suggested by the significant elevation of hypothalamic urocortin 15 days after burn injury.
  68. pmc Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts
    Angel Luis García-Villalón
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma, Arzobispo Morcillo 2, 28029 Madrid, Spain
    Br J Pharmacol 145:490-4. 2005
    1 Urocortin is a vasodilator peptide related to corticotrophin-releasing factor, which may protect endothelial function during coronary ischemia-reperfusion (I-R)...
  69. ncbi Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres
    B A Henry
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Bristol, UK
    J Neuroendocrinol 17:135-44. 2005
    ..CRF-BP) is a 37-kDa protein with high affinity binding sites for both corticotropin-releasing factor (CRF) and urocortin 1. Previous studies have examined the distribution of CRF-BP mRNA and peptide within the central nervous system...
  70. ncbi Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway
    Anastasios Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Biochem Biophys Res Commun 328:442-8. 2005
    The UCN homologues SCP and SRP bind specifically to the CRFR2 receptor, whereas UCN binds to both CRFR1 and CRFR2...
  71. ncbi Role of corticotropin-releasing factor receptor type 2 beta in urocortin-induced vasodilation of rat aortas
    Izumi Miki
    Department of Pharmacology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Pharmacol Sci 96:170-6. 2004
    b>Urocortin has a high affinity for the corticotropin-releasing factor receptor type 2beta (CRF-R2beta). This study was conducted to reveal the role of CRF-R2beta in blood vessels...
  72. ncbi Colocalization of urocortin and neuronal nitric oxide synthase in the hypothalamus and Edinger-Westphal nucleus of the rat
    Mariarosa G Spina
    Institute of Medical Neurobiology, Otto von Guericke University, Magdeburg D 39120, Germany
    J Comp Neurol 479:271-86. 2004
    Different lines of studies suggest that both the corticotropin-releasing hormone-related peptide Urocortin I (Ucn) and the neuromodulator nitric oxide (NO) are involved in the regulation of the complex mechanisms controlling feeding and ..
  73. ncbi Corticotropin-releasing factor and Urocortin I modulate excitatory glutamatergic synaptic transmission
    Jie Liu
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Neurosci 24:4020-9. 2004
    ..by two endogenous CRF-related peptide ligands, corticotropin-releasing factor [CRF rat/human (r/h)] and Urocortin I (Ucn I), within the central nucleus of the amygdala (CeA) and the lateral septum mediolateral nucleus (LSMLN)...
  74. ncbi Corticotropin-releasing factor and urocortin differentially modulate rat Purkinje cell dendritic outgrowth and differentiation in vitro
    J D Swinny
    Laboratory for Cell Biology and Electron Microscopy, Graduate School of Behavioural and Cognitive Neurosciences, University of Groningen, The Netherlands
    Eur J Neurosci 19:1749-58. 2004
    ..modulator of Purkinje cell dendritic development is corticotropin-releasing factor (CRF) and family member, urocortin, both of which are localized in climbing fibers...
  75. ncbi The use of H-2 mutants as models for the study of T cell activation
    I F McKenzie
    Immunol Rev 35:179-230. 1977
  76. ncbi Urocortin modulates inflammatory response and neurotoxicity induced by microglial activation
    Mei Jen Wang
    Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Tzu Chi College of Technology, Hualien, Taiwan, Republic of China
    J Immunol 179:6204-14. 2007
    ..b>Urocortin (UCN) is a member of the corticotropin-releasing hormone (CRH) family of neuropeptides that function to regulate ..
  77. ncbi Natural expression of immature Ucn antisense RNA in the rat brain. Evidence favoring bidirectional transcription of the Ucn gene locus
    Paola Haeger
    Department of Cell and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, Alameda 340, Santiago, Chile
    Brain Res Mol Brain Res 139:115-28. 2005
    Recently, it has been shown the endogenous expression of an antisense urocortin (Ucn) transcript in the rat brain and other tissues...
  78. ncbi Analysis of the mechanism of the vasodepressor effect of urocortin in anesthetized rats
    Aly M Abdelrahman
    Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada
    Pharmacology 73:175-9. 2005
    The aim was to examine if the depressor effect of urocortin involves activation of the nitric oxide (NO)/L-arginine pathway, production of prostanoids or opening of K(+)-channels. I. v. bolus urocortin (0...
  79. ncbi Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons
    F Spiga
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, BS1 3NY Bristol, UK
    Neuroscience 138:1265-76. 2006
    ..that injections of the anxiety-related neuropeptide corticotropin-releasing factor or the related neuropeptide urocortin 1 into the region of the basolateral amygdaloid nucleus induce anxiety-like behavior in several behavioral ..

Research Grants5

  1. Role of Ghrelin in the Induction of Anxiogenic Behavior
    PAUL CURRIE; Fiscal Year: 2004
    ..abstract_text> ..
  2. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..CRF and urocortin were the first and second mammalian members of the CRF peptide family to be identified...
  3. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  5. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....