Gene Symbol: Uba1
Description: ubiquitin-like modifier activating enzyme 1
Alias: Ube1x, ubiquitin-like modifier-activating enzyme 1, ubiquitin-activating enzyme E1, Chr X
Henne W, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, et al
. FCHo proteins are nucleators of clathrin-mediated endocytosis. Science. 2010;328:1281-4 pubmed publisher
..The FCHo F-BAR membrane-bending activity was required, leading to the proposal that FCHo1/2 sculpt the initial bud site and recruit the clathrin machinery for CCV formation. ..
Moudry P, Lukas C, Macurek L, Hanzlikova H, Hodny Z, Lukas J, et al
. Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage. Cell Cycle. 2012;11:1573-82 pubmed publisher
..Here, we identify ubiquitin-activating enzyme UBA1 as the E1 enzyme required for responses to IR and replication stress in human cells...
Schwartz A, Trausch J, Ciechanover A, Slot J, Geuze H. Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells. Proc Natl Acad Sci U S A. 1992;89:5542-6 pubmed
..The lumen of rough endoplasmic reticulum, Golgi complex, endosomes, and lysosomes were negative. The specific localization of E1 to distinct subcellular organelles suggests that E1 may play multiple physiological roles within the cell. ..
Imai N, Kaneda S, Nagai Y, Seno T, Ayusawa D, Hanaoka F, et al
. Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1. Gene. 1992;118:279-82 pubmed
..The 3495-bp cDNA encodes 1058 amino acids (aa), and shares extensive homology with the human E1 enzyme at both the nucleotide and aa sequence levels. ..
Yurchenko V, Xue Z, Sadofsky M. The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev. 2003;17:581-5 pubmed
..This finding suggests a new way in which V(D)J recombination can be regulated and coupled to other aspects of cell physiology. ..
Chou A, Maidment N, Klintenberg R, Casida J, Li S, Fitzmaurice A, et al
. Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome. J Biol Chem. 2008;283:34696-703 pubmed publisher
..Chronic exposure to widely used dithiocarbamate fungicides may contribute to the development of PD, and elucidation of its mechanism would identify a new potential therapeutic target...
Zhang L, Fairall L, Goult B, Calkin A, Hong C, Millard C, et al
. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 2011;25:1262-74 pubmed publisher
..These results identify the IDOL-UBE2D complex as an important determinant of LDLR activity, and provide insight into molecular mechanisms underlying the regulation of cholesterol uptake. ..
Qin Z, Cui B, Jin J, Song M, Zhou B, Guo H, et al
. The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis. Atherosclerosis. 2016;247:142-53 pubmed publisher
The ubiquitin-activating enzyme E1 (UBA1, E1), the apex of the ubiquitin proteasome pathway, plays a critical role in protein degradation and in pathological processes...