Tyr

Summary

Gene Symbol: Tyr
Description: tyrosinase
Alias: tyrosinase
Species: rat
Products:     Tyr

Top Publications

  1. Garai J, Tiller A, Clark J. Tyrosinase-like polypeptides in the uterus and in the central nervous system of rats. Steroids. 1992;57:183-8 pubmed
    ..of rat uteri and tissues from the central nervous system contain proteins that are recognized by a polyclonal tyrosinase antibody...
  2. Petris M, Strausak D, Mercer J. The Menkes copper transporter is required for the activation of tyrosinase. Hum Mol Genet. 2000;9:2845-51 pubmed
    ..In this study, we investigated whether the MNK protein is required for the activity of tyrosinase, a copper-dependent enzyme involved in melanogenesis that is synthesized within the secretory pathway...
  3. Hirobe T, Wakamatsu K, Ito S. Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur J Cell Biol. 1998;75:184-91 pubmed
    ..results suggest that the coat-color genes exert their influences on the proliferation and differentiation of mouse epidermal melanocytes by affecting tyrosinase activity, melanosome maturation and transport, and eumelanin synthesis.
  4. Zheng H, Huang Z, Wen R, Li H. [Study of tyrosinase gene mutation in oculocutaneous albinism type 1 patients]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011;27:329-32 pubmed
    To explore the patients' genotypes and the mutation spectrum of Tyrosinase (TYR) gene and the effects on protein structure and function in oculocutaneous albinism type 1 (OCA1)...
  5. Fukai K, Holmes S, Lucchese N, Siu V, Weleber R, Schnur R, et al. Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism. Nat Genet. 1995;9:92-5 pubmed
    ..We analysed 12 unrelated patients with AROA, and found that two had abnormalities of the tyrosinase (TYR) gene...
  6. DeRossi C, Laiosa M, Silverstone A, Holdener B. Mouse fzd4 maps within a region of chromosome 7 important for thymus and cardiac development. Genesis. 2000;27:64-75 pubmed
    ..Through morphological and histological characterization of embryos homozygous for the Del(7)Tyr(c-112K) and Del(7)Tyr(c-3H) albino deletions, we identified abnormalities that are consistent with aberrant ..
  7. Murillo Cuesta S, Contreras J, Zurita E, Cediel R, Cantero M, Varela Nieto I, et al. Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice. Pigment Cell Melanoma Res. 2010;23:72-83 pubmed publisher
    ..We have analyzed the auditory brainstem responses (ABR) of two transgenic mice: YRT2, carrying the entire mouse tyrosinase (Tyr) gene expression-domain and undistinguishable from wild-type pigmented animals; and TyrTH, non-pigmented ..
  8. Coleman D. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys. 1962;96:562-8 pubmed
  9. Chen K, Manga P, Orlow S. Pink-eyed dilution protein controls the processing of tyrosinase. Mol Biol Cell. 2002;13:1953-64 pubmed
    The processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis, was investigated in melan-p1 melanocytes, which are null at the p locus...

More Information

Publications37

  1. Ohbayashi N, Maruta Y, Ishida M, Fukuda M. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012;125:1508-18 pubmed publisher
    ..These findings reveal a new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes through interaction with RILP and is involved in the centripetal movement of melanosomes. ..
  2. Gargiulo A, Bonetti C, Montefusco S, Neglia S, Di Vicino U, Marrocco E, et al. AAV-mediated tyrosinase gene transfer restores melanogenesis and retinal function in a model of oculo-cutaneous albinism type I (OCA1). Mol Ther. 2009;17:1347-54 pubmed publisher
    ..albinism type 1 (OCA1) is characterized by congenital hypopigmentation and is due to mutations in the TYROSINASE gene (TYR)...
  3. Tanaka S, Yamamoto H, Takeuchi S, Takeuchi T. Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Development. 1990;108:223-7 pubmed
    We introduced a mouse tyrosinase minigene, mg-Tyrs-J, in which the authentic genomic 5' non-coding flanking sequence was fused to a mouse tyrosinase cDNA, into fertilized egges of albino mice...
  4. Abdel Malek Z, Swope V, Collins C, Boissy R, Zhao H, Nordlund J. Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes. J Cell Sci. 1993;106 ( Pt 4):1323-31 pubmed
    ..heterogeneity may be attributed to differences in the activity and expression of the three melanogenic proteins: tyrosinase and tyrosinase-related proteins 1 and 2 (gp75 and DOPAchrome tautomerase, respectively), which in turn are ..
  5. Markert C, Silvers W. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics. 1956;41:429-50 pubmed
  6. Baharav E, Merimski O, Shoenfeld Y, Zigelman R, Gilbrud B, Yecheskel G, et al. Tyrosinase as an autoantigen in patients with vitiligo. Clin Exp Immunol. 1996;105:84-8 pubmed
    ..In the present study we point towards a newly defined autoantigen in vitiligo, the enzyme tyrosinase, which participates in the process of melanogenesis...
  7. Marubashi S, Shimada H, Fukuda M, Ohbayashi N. RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016;291:1427-40 pubmed publisher
    ..Rab32 and Rab38 (Rab32/38), have been proposed as regulating the trafficking of melanogenic enzymes, including tyrosinase and tyrosinase-related protein 1 (Tyrp1), to melanosomes in melanocytes...
  8. Jimenez Cervantes C, Martinez Esparza M, Solano F, Lozano J, Garcia Borron J. Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. Biochem Biophys Res Commun. 1998;253:761-7 pubmed
    Melanin synthesis in mammals is catalyzed by three structurally related, membrane-bound proteins, tyrosinase, and the tyrosinase-related proteins 1 and 2 (TRP1 and TRP2)...
  9. Tripathi R, Strunk K, Giebel L, Weleber R, Spritz R. Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions. Am J Med Genet. 1992;43:865-71 pubmed
    Type I (tyrosinase-deficient) oculocutaneous albinism (OCA) results from mutations of the gene encoding tyrosinase, the enzyme that catalyzes the first 2 steps of melanin pigment biosynthesis...
  10. Ozeki H, Ito S, Wakamatsu K, Hirobe T. Chemical characterization of hair melanins in various coat-color mutants of mice. J Invest Dermatol. 1995;105:361-6 pubmed
    ..These results indicate that our methodology, high-performance liquid chromatography and spectrophotometric methods combined, may be useful in chemically characterizing melanin pigments produced in follicular melanocytes. ..
  11. Lin Y, Wei A, Zhou Z, Zhu W, He X, Lian S. A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China. Chin Med J (Engl). 2011;124:3358-61 pubmed
    The mutation of the tyrosinase (TYR) gene results in oculocutaneous albinism type 1 (OCA1), an autosomal recessive genetic disorder. OCA1 is the most common type of OCA in the Chinese population...
  12. Liu J, Choy K, Chan L, Leung T, Tam P, Chiang S, et al. Tyrosinase gene (TYR) mutations in Chinese patients with oculocutaneous albinism type 1. Clin Exp Ophthalmol. 2010;38:37-42 pubmed publisher
    To identify the sequence variants of the tyrosinase (TYR) gene in Chinese families with oculocutaneous albinism.
  13. Pavlovitch J, Rizk M, Balsan S. Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation. Mol Cell Endocrinol. 1982;25:295-302 pubmed
    ..Melanogenesis, assessed by the activity of skin tyrosinase (radiometric assay), was studied in vitamin-D-deficient and vitamin-D-fed rats exposed to UV (0...
  14. Park K, Park S, Lee Y, Youn S, Park B, Kim K, et al. Mutations of the tyrosinase gene in three Korean patients with type I oculocutaneous albinism. Jpn J Hum Genet. 1996;41:299-305 pubmed
    ..Type I (tyrosinase-deficient) OCA results from mutations of the tyrosinase (TYR) gene encoding tyrosinase, the enzyme that ..
  15. Ko J, Yang J, Jeong S, Kim H. Mutation spectrum of the TYR and SLC45A2 genes in patients with oculocutaneous albinism. Mol Med Rep. 2012;5:943-8 pubmed publisher
    ..OCA1, the most common and severe form, is caused by mutations in the tyrosinase (TYR) gene...
  16. Kwon B, Halaban R, Chintamaneni C. Molecular basis of mouse Himalayan mutation. Biochem Biophys Res Commun. 1989;161:252-60 pubmed
    ..One of these interesting mutants is a Himalayan, which produces temperature sensitive tyrosinase, and the basis of this sensitivity remains unknown...
  17. Giménez E, Lavado A, Giraldo P, Cozar P, Jeffery G, Montoliu L. A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism. Pigment Cell Res. 2004;17:363-70 pubmed
    Congenital defects in retinal pigmentation, as in oculocutaneous albinism Type I (OCA1), where tyrosinase is defective, result in visual abnormalities affecting the retina and pathways into the brain...
  18. Schmidt A, Beermann F. Molecular basis of dark-eyed albinism in the mouse. Proc Natl Acad Sci U S A. 1994;91:4756-60 pubmed
    Dark-eyed albino (C44H) is a recessive allele at the mouse albino (c) locus, which encodes tyrosinase (monophenol,L-dopa:oxygen oxidoreductase, EC 1.14.18.1), the key enzyme in melanin synthesis...
  19. Ohlemiller K, Rice M, Lett J, Gagnon P. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Hear Res. 2009;249:1-14 pubmed publisher
    ..The latter mice carry a naturally occurring inactivating mutation of the tyrosinase locus, and produce no strial melanin...
  20. Johnson B, Cole B, Geisert E, Ikeda S, Ikeda A. Tyrosinase is the modifier of retinoschisis in mice. Genetics. 2010;186:1337-44 pubmed publisher
    ..4-Mb region on chromosome 7. In this genetic region, the AKR strain is known to carry a mutation in the tyrosinase (Tyr) gene...
  21. Dorđić M, Matić I, Filipović Lješković I, Dzodic R, Sašić M, Eric Nikolic A, et al. Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo. BMC Complement Altern Med. 2012;12:109 pubmed
    ..this study was to determine the presence and the intensity of humoral immunity to melanoma-associated antigens: tyrosinase and melanin, in patients with melanoma, in persons with vitiligo and in control healthy people...
  22. Blaszczyk W, Arning L, Hoffmann K, Epplen J. A Tyrosinase missense mutation causes albinism in the Wistar rat. Pigment Cell Res. 2005;18:144-5 pubmed
    b>Tyrosinase serves as a key enzyme in the synthesis of melanin. In humans mutations in the TYR gene are associated with type 1 oculocutaneous albinism (OCA1) that leads to reduced or absent pigmentation of skin, hair and eye...
  23. Hu H, Guedj M, Descamps V, Jouary T, Bourillon A, Ezzedine K, et al. Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects. J Dermatol Sci. 2011;64:127-33 pubmed publisher
    b>Tyrosinase (TYR) is a key pigmentation gene that is highly polymorphic and responsible for the most common form of autosomal recessive albinism, OCA1...
  24. Saran A, Spinola M, Pazzaglia S, Peissel B, Tiveron C, Tatangelo L, et al. Loss of tyrosinase activity confers increased skin tumor susceptibility in mice. Oncogene. 2004;23:4130-5 pubmed
    The tyrosinase (Tyr) gene encodes the enzyme tyrosinase that catalyses the conversion of L-tyrosine into DOPA (3,4-dihydroxyphenylalanine)-quinone...
  25. Palmer L, Civan M. Intracellular distribution of free potassium in Chironomus salivary glands. Science. 1975;188:1321-2 pubmed
    ..The data provide the first rigorous evidence that potassium is at electrochemical equilibrium across the nuclear membrane. In addition, no difference in potassium chemical activity was found between nucleus and cytoplasm. ..
  26. Waldmann V, Wacker J, Deichmann M, Jäckel A, Bock M, Naher H. Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time. Recent Results Cancer Res. 2001;158:118-25 pubmed
    Recent publications suggest that tyrosinase mRNA in blood as well as in bone marrow is detectable only in a subgroup of patients with metastatic melanoma. This would imply that tyrosinase mRNA is of limited value as a tumor marker...
  27. Mashimo T, Kaneko T, Sakuma T, Kobayashi J, Kunihiro Y, Voigt B, et al. Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes. Sci Rep. 2013;3:1253 pubmed publisher
    ..to ~30% with Exo1 was also observed in fertilized rat eggs, and in the production of knockout rats for the albino (Tyr) gene...
  28. Kunter U, Buer J, Probst M, Duensing S, Dallmann I, Grosse J, et al. Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma. J Natl Cancer Inst. 1996;88:590-4 pubmed
    ..has recently been suggested that reverse transcription and polymerase chain reaction (RT-PCR)-based detection of tyrosinase messenger RNA (mRNA) in peripheral blood might be useful in the early detection of circulating tumor cells, ..