Gene Symbol: Tyk2
Description: tyrosine kinase 2
Alias: non-receptor tyrosine-protein kinase TYK2
Species: rat
Products:     Tyk2

Top Publications

  1. Velazquez L, Fellous M, Stark G, Pellegrini S. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell. 1992;70:313-22 pubmed
    ..Complementary DNAs were cloned and found to be virtually identical to tyk2, a human mRNA encoding a non-receptor protein tyrosine kinase of previously unknown function...
  2. Muller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, et al. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature. 1993;366:129-35 pubmed
    ..The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect ..
  3. Pan J, Fukuda K, Kodama H, Makino S, Takahashi T, Sano M, et al. Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in the rat heart. Circ Res. 1997;81:611-7 pubmed
    ..Immunoprecipitation-Western blot analysis revealed that pressure overload activated JAK1, JAK2, and Tyk2 as early as 5 minutes and that STAT1, STAT2, and STAT3 were tyrosine-phosphorylated rapidly after exposure to the ..
  4. Hellgren G, Jansson J, Carlsson L, Carlsson B. The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. Growth Horm IGF Res. 1999;9:212-8 pubmed
    ..growth hormone (GH) stimulates tyrosine phosphorylation of Jak1 and Jak3 in certain cell lines, while the effect on Tyk2 has not been analysed...
  5. Kisseleva T, Bhattacharya S, Braunstein J, Schindler C. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002;285:1-24 pubmed
    ..Similarly, the solution of the crystal structure of two STATs has and will continue to facilitate our understanding of how STATs function. This review will highlight these exciting developments in JAK/STAT signaling. ..
  6. Verma A, Kambhampati S, Parmar S, Platanias L. Jak family of kinases in cancer. Cancer Metastasis Rev. 2003;22:423-34 pubmed
    The family of Jak kinases is composed from at least four different tyrosine kinases (Tyk2, Jak1, Jak2, Jak3) that share significant structural homology with each other...
  7. Murray P. The JAK-STAT signaling pathway: input and output integration. J Immunol. 2007;178:2623-9 pubmed
    ..New data suggests that SOCS proteins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated STATs that alters downstream gene activation. ..
  8. Jones S, Scheller J, Rose John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 2011;121:3375-83 pubmed publisher
    ..Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer. ..
  9. Li H, Spagnol G, Zheng L, Stauch K, Sorgen P. Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2. J Biol Chem. 2016;291:15867-80 pubmed publisher
    ..characterized the biological significance of a novel tyrosine kinase that phosphorylates Cx43, tyrosine kinase 2 (Tyk2)...

More Information


  1. Sabat R, Grutz G, Warszawska K, Kirsch S, Witte E, Wolk K, et al. Biology of interleukin-10. Cytokine Growth Factor Rev. 2010;21:331-44 pubmed publisher
    ..At the same time, IL-10 strengthens the "scavenger"-function and contributes to induced tolerance. This review provides an overview about the cellular sources, molecular mechanisms, effects, and biological role of IL-10. ..