Gene Symbol: Tut1
Description: terminal uridylyl transferase 1, U6 snRNA-specific
Alias: speckle targeted PIP5K1A-regulated poly(A) polymerase, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase, star-PAP
Species: rat
Products:     Tut1

Top Publications

  1. Trippe R, Guschina E, Hossbach M, Urlaub H, Luhrmann R, Benecke B. Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. RNA. 2006;12:1494-504 pubmed
    ..Finally, RNAi knockdown experiments revealed that U6-TUTase is essential for cell proliferation. Surprisingly, large amounts of the recombinant enzyme were found to accumulate within nucleoli. ..
  2. Mellman D, Gonzales M, Song C, Barlow C, Wang P, Kendziorski C, et al. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature. 2008;451:1013-7 pubmed publisher
    ..The results reveal a mechanism for the integration of nuclear phosphoinositide signals and a method for regulating gene expression. ..
  3. Gonzales M, Mellman D, Anderson R. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem. 2008;283:12665-73 pubmed publisher
    ..The Star-PAP complex therefore represents a location where multiple signaling pathways converge to regulate the expression of specific mRNAs. ..
  4. Laishram R, Anderson R. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. EMBO J. 2010;29:4132-45 pubmed publisher
    ..The data support a model where Star-PAP binds to the RNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. ..