Ttc21b

Summary

Gene Symbol: Ttc21b
Description: tetratricopeptide repeat domain 21B
Alias: RGD1565122, tetratricopeptide repeat protein 21B
Species: rat

Top Publications

  1. Tran P, Haycraft C, Besschetnova T, Turbe Doan A, Stottmann R, Herron B, et al. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet. 2008;40:403-410 pubmed publisher
    ..RNA-interference knockdown of Ttc21b (which we call Thm1 and which encodes THM1) in mouse inner medullary collecting duct cells expressing an IFT88-..
  2. Hong W, Li J, Wang B, Chen L, Niu W, Yao Z, et al. Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation. Biochem Biophys Res Commun. 2011;415:650-5 pubmed publisher
    ..Taken together, our data indicate that ESET is involved in TR?1-mediated transcription repression and provide a molecular basis of thyroid hormone-induced repression of proliferation. ..
  3. Stottmann R, Tran P, Turbe Doan A, Beier D. Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol. 2009;335:166-78 pubmed publisher
    ..Here we characterize the forebrain phenotype caused by loss of Ttc21b, a gene we identified in an ENU mutagenesis screen as a novel ciliary gene required for retrograde intraflagellar ..
  4. Gascue C, Tan P, Cardenas Rodriguez M, Libisch G, Fernández Calero T, Liu Y, et al. Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation. J Cell Sci. 2012;125:362-75 pubmed publisher
    ..Our data indicate a hitherto unappreciated, direct role for the BBS proteins in transcriptional regulation and potentially expand the mechanistic spectrum that underpins the development of ciliary phenotypes in patients. ..