Tspo

Summary

Gene Symbol: Tspo
Description: translocator protein
Alias: Bzrp, MBR, PTBZR02, Ptbzr, RATPTBZR02, translocator protein, Benzodiazepin receptor (peripheral), PBR, PKBS, benzodiazepine receptor, peripheral, mitochondrial benzodiazepine receptor, peripheral-type benzodiazepine receptor
Species: rat
Products:     Tspo

Top Publications

  1. Casalotti S, Pelaia G, Yakovlev A, Csikos T, Grayson D, Krueger K. Structure of the rat gene encoding the mitochondrial benzodiazepine receptor. Gene. 1992;121:377-82 pubmed
    The gene encoding the rat mitochondrial benzodiazepine receptor (MBR) was cloned and characterized...
  2. Sprengel R, Werner P, Seeburg P, Mukhin A, Santi M, Grayson D, et al. Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. J Biol Chem. 1989;264:20415-21 pubmed
    This report describes the cloning of a full length cDNA encoding PKBS, a protein of approximately 17 kDa associated with peripheral-type benzodiazepine binding sites...
  3. Bar Ami S, Amiri Z, Fares F, Gavish M. Modulation of peripheral benzodiazepine receptors in female rat genital organs by various gonadal steroids. Life Sci. 1994;54:1965-75 pubmed
    Peripheral benzodiazepine receptors (PBR) in the ovary, oviduct, uterus, and kidney of immature rats were studied under short- and long-term treatment with testosterone (T), progesterone (P4), and diethylstilbestrol (DES)...
  4. Mazurika C, Veenman L, Weizman R, Bidder M, Leschiner S, Golani I, et al. Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats. Mol Cell Endocrinol. 2009;307:43-9 pubmed publisher
    We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats...
  5. Papadopoulos V, Amri H, Li H, Boujrad N, Vidic B, Garnier M. Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem. 1997;272:32129-35 pubmed
    To evaluate the role of the mitochondrial peripheral-type benzodiazepine receptor (PBR) in steroidogenesis, we developed a molecular approach based on the disruption of the PBR gene, by homologous recombination, in the constitutive ..
  6. Veiga S, Carrero P, Pernia O, Azcoitia I, Garcia Segura L. Translocator protein 18 kDa is involved in the regulation of reactive gliosis. Glia. 2007;55:1426-36 pubmed
    b>Translocator protein (18 kDa) (TSPO), previously known as peripheral-type benzodiazepine receptor, is a critical component of the mitochondrial permeability transition pore...
  7. Panickar K, Jayakumar A, Rama Rao K, Norenberg M. Downregulation of the 18-kDa translocator protein: effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes. Glia. 2007;55:1720-7 pubmed
    ..A notable feature of ammonia neurotoxicity is an upregulation of the 18-kDa translocator protein (TSPO) (formerly referred to as the peripheral benzodiazepine receptor or PBR), which is found on the outer ..
  8. Karchewski L, Bloechlinger S, Woolf C. Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons. Eur J Neurosci. 2004;20:671-83 pubmed
    The peripheral benzodiazepine receptor (PBR), a benzodiazepine but not gamma-aminobutyric acid-binding mitochondrial membrane protein, has roles in steroid production, energy metabolism, cell survival and growth...
  9. Zilz A, Li H, Castello R, Papadopoulos V, Widmaier E. Developmental expression of the peripheral-type benzodiazepine receptor and the advent of steroidogenesis in rat adrenal glands. Endocrinology. 1999;140:859-64 pubmed
    ..membrane is uncertain, a multimeric receptor complex termed the peripheral-type benzodiazepine receptor (PBR) appears essential for this process...

More Information

Publications65

  1. Kruczek C, Gorg B, Keitel V, Pirev E, Kröncke K, Schliess F, et al. Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes. Glia. 2009;57:79-92 pubmed publisher
    ..and expression of the mRNAs encoding metallothionein and the Sp1-regulated peripheral-type benzodiazepine receptor (PBR). These effects were abolished by the Zn2+ chelator TPEN...
  2. Masonis A, McCarthy M. Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse. J Steroid Biochem Mol Biol. 1996;58:551-5 pubmed
    The peripheral benzodiazepine receptor (PBR) is a mitochondrial protein involved in regulating steroid synthesis and transport...
  3. Chung J, Chen H, Midzak A, Burnett A, Papadopoulos V, Zirkin B. Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells. Endocrinology. 2013;154:2156-65 pubmed publisher
    b>Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterol-binding protein that is integrally involved in cholesterol transfer from intracellular stores into mitochondria, the rate-determining step in steroid formation...
  4. Mukhopadhyay S, Guillory B, Mukherjee S, Das S. Antiproliferative effect of peripheral benzodiazepine receptor antagonist PK11195 in rat mammary tumor cells. Mol Cell Biochem. 2010;340:203-13 pubmed publisher
    ..study aims to establish the antiproliferative effects of PK11195, a peripheral benzodiazepine receptor antagonist (PBR) in rat mammary tumor cells...
  5. Levin E, Premkumar A, Veenman L, Kugler W, Leschiner S, Spanier I, et al. The peripheral-type benzodiazepine receptor and tumorigenicity: isoquinoline binding protein (IBP) antisense knockdown in the C6 glioma cell line. Biochemistry. 2005;44:9924-35 pubmed
    Peripheral-type benzodiazepine receptors (PBR) are constituted by three protein components, the isoquinoline binding protein (IBP), the voltage-dependent anion channel (VDAC), and the adenine nucleotide transporter (ANT)...
  6. Hatori A, Yui J, Yamasaki T, Xie L, Kumata K, Fujinaga M, et al. PET imaging of lung inflammation with [18F]FEDAC, a radioligand for translocator protein (18 kDa). PLoS ONE. 2012;7:e45065 pubmed publisher
    The translocator protein (18 kDa) (TSPO) is highly expressed on the bronchial and bronchiole epithelium, submucosal glands in intrapulmonary bronchi, pneumocytes and alveolar macrophages in human lung...
  7. Ishikawa M, Yoshitomi T, Covey D, Zorumski C, Izumi Y. TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model. Neuropharmacology. 2016;111:142-159 pubmed publisher
    ..The aim of this study was to determine whether AlloP synthesis involves activation of translocator protein 18 kD (TSPO) and whether TSPO modulates pressure-induced retinal injury...
  8. Chen C, Kuo J, Wong A, Micevych P. Estradiol modulates translocator protein (TSPO) and steroid acute regulatory protein (StAR) via protein kinase A (PKA) signaling in hypothalamic astrocytes. Endocrinology. 2014;155:2976-85 pubmed publisher
    ..signaling leading to activation of steroid acute regulatory protein (StAR) and transporter protein (TSPO), which mediate the rate-limiting step in steroidogenesis, ie, the transport of cholesterol into the mitochondrion...
  9. Kubova H, Mares P. Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats. Physiol Res. 2012;61:319-23 pubmed
    ..No signs of hypersensitivity were seen at 4-day interval. There is a difference between immature and adult brain in an appearance of withdrawal symptom after administration of the partial agonist of benzodiazepine receptors Ro 19-8022. ..
  10. Rechichi M, Salvetti A, Chelli B, Costa B, Da Pozzo E, Spinetti F, et al. TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells. Biochim Biophys Acta. 2008;1782:118-25 pubmed publisher
    ..The molecular bases regulating the onset of such tumors are still poorly understood. The translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is a mitochondrial permeability ..
  11. Lee J, Eisenberg P, Papadopoulos V, Wang J, Widmaier E. Reversible changes in adrenocorticotropin (ACTH)-induced adrenocortical steroidogenesis and expression of the peripheral-type benzodiazepine receptor during the ACTH-insensitive period in young rats. Endocrinology. 2004;145:2165-73 pubmed
    ..decreased adrenal content of a mitochondrial cholesterol transporter [peripheral-type benzodiazepine receptor (PBR)] during the first postnatal week in rats, when ACTH-inducible steroidogenesis is low...
  12. Raff H, Hong J, Oaks M, Widmaier E. Adrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR. Am J Physiol Regul Integr Comp Physiol. 2003;284:R78-85 pubmed
    ..Peripheral-type benzodiazepine receptor (PBR) protein was also increased at 6 and 7 days of age in pups exposed to hypoxia from birth...
  13. Toyama H, Hatano K, Suzuki H, Ichise M, Momosaki S, Kudo G, et al. In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand: [11C]PK-11195 and animal PET following ethanol injury in rat striatum. Ann Nucl Med. 2008;22:417-24 pubmed publisher
    ..These results suggest that [(11)C]PK-11195 PET imaging would be a useful tool for evaluating microglial activation in a rat brain injury model. ..
  14. Hernstadt H, Wang S, Lim G, Mao J. Spinal translocator protein (TSPO) modulates pain behavior in rats with CFA-induced monoarthritis. Brain Res. 2009;1286:42-52 pubmed publisher
    b>Translocator protein 18 kDa (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), is predominantly located in the mitochondrial outer membrane and plays an important role in steroidogenesis, immunomodulation, cell ..
  15. Wei X, Wei X, Chen F, Zang Y, Xin W, Pang R, et al. The upregulation of translocator protein (18 kDa) promotes recovery from neuropathic pain in rats. J Neurosci. 2013;33:1540-51 pubmed publisher
    ..Recent studies have shown that the ligands of translocator protein (TSPO, 18 kDa), a peripheral receptor for benzodiazepine, modulate inflammatory pain...
  16. Krestinina O, Grachev D, Odinokova I, Reiser G, Evtodienko Y, Azarashvili T. Effect of peripheral benzodiazepine receptor (PBR/TSPO) ligands on opening of Ca2+-induced pore and phosphorylation of 3.5-kDa polypeptide in rat brain mitochondria. Biochemistry (Mosc). 2009;74:421-9 pubmed
    The effect of nanomolar concentrations of PBR/TSPO ligands--Ro 5-4864, PK11195, and PPIX--on Ca2+-induced permeability transition pore (PTP) opening in isolated rat brain mitochondria was investigated...
  17. Herman M, Rivier C. Activation of a neural brain-testicular pathway rapidly lowers Leydig cell levels of the steroidogenic acute regulatory protein and the peripheral-type benzodiazepine receptor while increasing levels of neuronal nitric oxide synthase. Endocrinology. 2006;147:624-33 pubmed
    ..EtOH on levels of the steroidogenic acute regulatory (StAR) protein, the peripheral-type benzodiazepine receptor (PBR), and the cytochrome P450 side-chain cleavage enzyme in semipurified Leydig cells...
  18. Gatliff J, East D, Crosby J, Abeti R, Harvey R, Craigen W, et al. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy. 2014;10:2279-96 pubmed publisher
    The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport...
  19. Kunduzova O, Escourrou G, De La Farge F, Salvayre R, Seguelas M, Leducq N, et al. Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J Am Soc Nephrol. 2004;15:2152-60 pubmed
    The peripheral benzodiazepine receptor (PBR) is a critical component of the mitochondrial permeability transition pore, which is involved in the regulation of cell death...
  20. Jayakumar A, Panickar K, Norenberg M. Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. J Neurochem. 2002;83:1226-34 pubmed
    The effect of peripheral benzodiazepine receptor (PBR) ligands on free radical production was investigated in primary cultures of rat brain astrocytes and neurons as well as in BV-2 microglial cell lines using the fluorescent dye ..
  21. Campioli E, Carnevale G, Avallone R, Guerra D, Baraldi M. Morphological and receptorial changes in the epididymal adipose tissue of rats subjected to a stressful stimulus. Obesity (Silver Spring). 2011;19:703-8 pubmed publisher
    ..We decided to study the expression of the translocator protein (TSPO) 18-kDa, peroxisome proliferator-activated receptor-? (PPAR-?), mitochondrial uncoupling protein-1 (..
  22. Wilms H, Claasen J, Rohl C, Sievers J, Deuschl G, Lucius R. Involvement of benzodiazepine receptors in neuroinflammatory and neurodegenerative diseases: evidence from activated microglial cells in vitro. Neurobiol Dis. 2003;14:417-24 pubmed
    ..that after experimental lesions in animal models and in human neurodegenerative/-inflammatory diseases upregulated PBR expression with increased binding of its ligand PK11195 is confined mainly to activated microglia in vivo/in situ...
  23. Maeda J, Higuchi M, Inaji M, Ji B, Haneda E, Okauchi T, et al. Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor. Brain Res. 2007;1157:100-11 pubmed
    Elevated levels of peripheral benzodiazepine receptor (PBR) in glia have been documented in diverse nervous system injuries, while the identity and spatiotemporal characteristics of the cells showing upregulation of PBR remain elusive...
  24. Hatori A, Yui J, Xie L, Kumata K, Yamasaki T, Fujinaga M, et al. Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis. Sci Rep. 2015;5:17327 pubmed publisher
    ..In this study, we aimed to evaluate the utility of translocator protein (18 kDa) (TSPO) as a molecular imaging biomarker for monitoring the progression of hepatic fibrosis ..
  25. Rao R, Jo Y, Babb Tarbox M, Syapin P, Stocco D. Regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of the cholesterol transfer proteins StAR and PBR. Endocr Res. 2002;28:387-94 pubmed
    ..Given the proposed role of the peripheral-type benzodiazepine receptor (PBR) in conferring a constitutively steroidogenic phenotype to the R2C cells, the current study was conducted to ..
  26. Ostuni M, Marazova K, Peranzi G, Vidic B, Papadopoulos V, Ducroc R, et al. Functional characterization and expression of PBR in rat gastric mucosa: stimulation of chloride secretion by PBR ligands. Am J Physiol Gastrointest Liver Physiol. 2004;286:G1069-80 pubmed
    ..the polypeptide diazepam binding inhibitor, the endogenous ligand of the peripheral-type benzodiazepine receptor (PBR). However, the expression and function of this receptor protein in these tissues have not been investigated...
  27. Sileikyte J, Petronilli V, Zulian A, Dabbeni Sala F, Tognon G, Nikolov P, et al. Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor). J Biol Chem. 2011;286:1046-53 pubmed publisher
    ..differences between mitochondria and mitoplasts emerged in PTP regulation by ligands of the outer membrane translocator protein of 18 kDa, TSPO, formerly known as the peripheral benzodiazepine receptor...
  28. Desjardins P, Todd K, Hazell A, Butterworth R. Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats. Neurochem Int. 1999;35:363-9 pubmed
    ..Positron Emission Tomography using 11C-PK11195 could provide a novel approach to the diagnosis and assessment of the extent of thalamic damage due to thiamine deficiency in humans with Wernicke's Encephalopathy. ..
  29. Ostuni M, Péranzi G, Ducroc R, Fasseu M, Vidic B, Dumont J, et al. Distribution, pharmacological characterization and function of the 18 kDa translocator protein in rat small intestine. Biol Cell. 2009;101:573-86 pubmed publisher
    The TSPO (18 kDa translocator protein) is a mitochondrial transmembrane protein involved in cholesterol transport in organs that synthesize steroids and bile salts...
  30. Fukaya T, Ishiyama T, Baba S, Masumoto S. Identification of a novel benzoxazolone derivative as a selective, orally active 18 kDa translocator protein (TSPO) ligand. J Med Chem. 2013;56:8191-5 pubmed publisher
    ..Investigation into the cause of this unexpected side effect and management of 9b off-target binding affinity led to the identification of 10d, which showed oral anxiolytic effect in the rat model with improved safety profile. ..
  31. Paradis S, Leoni V, Caccia C, Berdeaux A, Morin D. Cardioprotection by the TSPO ligand 4'-chlorodiazepam is associated with inhibition of mitochondrial accumulation of cholesterol at reperfusion. Cardiovasc Res. 2013;98:420-7 pubmed publisher
    The translocator protein (TSPO) is located on the outer mitochondrial membrane where it is responsible for the uptake of cholesterol into mitochondria of steroidogenic organs...
  32. Ostuni M, Issop L, Péranzi G, Walker F, Fasseu M, Elbim C, et al. Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value. Inflamm Bowel Dis. 2010;16:1476-87 pubmed publisher
    ..The mitochondrial translocator protein (TSPO) is a high-affinity drug- and cholesterol-binding protein expressed in the colon and its expression ..
  33. Doorduin J, Klein H, Dierckx R, James M, Kassiou M, de Vries E. [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis. Mol Imaging Biol. 2009;11:386-98 pubmed publisher
    ..Therefore, both tracers warrant further investigation in animal models and in a clinical setting. ..
  34. Mills C, Bitler J, Woolf C. Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mol Cell Neurosci. 2005;30:228-37 pubmed
    Peripheral benzodiazepine receptor (PBR) expression increases in small dorsal root ganglion (DRG) sensory neurons after peripheral nerve injury...
  35. Manku G, Wang Y, Thuillier R, Rhodes C, Culty M. Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells. Curr Mol Med. 2012;12:467-75 pubmed
    b>Translocator protein (TSPO) is a high affinity 18 kDa drug- and cholesterol-binding protein strongly expressed in steroidogenic tissues where it mediates cholesterol transport into mitochondria and steroid formation...
  36. Culty M, Luo L, Yao Z, Chen H, Papadopoulos V, Zirkin B. Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl. 2002;23:439-47 pubmed
    ..With this in mind, we turned our attention to peripheral benzodiazepine receptor (PBR), a mitochondrial cholesterol-binding protein known to be involved in mediating cholesterol transport...
  37. Midzak A, Akula N, Lecanu L, Papadopoulos V. Novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis. J Biol Chem. 2011;286:9875-87 pubmed publisher
    ..The 18-kDa translocator protein (TSPO) plays an integral part in this mitochondrial cholesterol transport...
  38. Samuelson L, Dukes M, Hunt C, Casey J, Bornhop D. TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization. Bioconjug Chem. 2009;20:2082-9 pubmed publisher
    ..we have delivered small molecule imaging agents into glioma and breast cancer cells by targeting the translocator protein (TSPO; formerly known as the peripheral benzodiazepine receptor or PBR) with a family of high-affinity ..
  39. Palzur E, Sharon A, Shehadeh M, Soustiel J. Investigation of the mechanisms of neuroprotection mediated by Ro5-4864 in brain injury. Neuroscience. 2016;329:162-70 pubmed publisher
    Increasing evidence has established the involvement of the 18-kDa translocator protein (TSPO) in the process of mitochondrial membrane permeabilization and subsequent apoptosis through modulation of the mitochondrial permeability ..
  40. Hazell A, Normandin L, Nguyen B, Kennedy G. Upregulation of 'peripheral-type' benzodiazepine receptors in the globus pallidus in a sub-acute rat model of manganese neurotoxicity. Neurosci Lett. 2003;349:13-6 pubmed
    ..These results indicate that PTBRs, and possibly neurosteroids, are an early response to manganese exposure and may play a major role in the pathophysiology of MN. ..
  41. Danovich L, Veenman L, Leschiner S, Lahav M, Shuster V, Weizman A, et al. The influence of clozapine treatment and other antipsychotics on the 18 kDa translocator protein, formerly named the peripheral-type benzodiazepine receptor, and steroid production. Eur Neuropsychopharmacol. 2008;18:24-33 pubmed
    ..The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been demonstrated to be involved ..
  42. Coronel M, Sánchez Granel M, Raggio M, Adler N, De Nicola A, Labombarda F, et al. Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5α-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration. Neurosci Lett. 2016;624:23-8 pubmed publisher
    ..In this study we explored temporal changes in the spinal expression of the 18kDa translocator protein TSPO, the steroidogenic acute regulatory protein (StAr) and the steroidogenic enzyme 5α-reductase (5α-..
  43. Lacor P, Benavides J, Ferzaz B. Enhanced expression of the peripheral benzodiazepine receptor (PBR) and its endogenous ligand octadecaneuropeptide (ODN) in the regenerating adult rat sciatic nerve. Neurosci Lett. 1996;220:61-5 pubmed
    In this study we have investigated the expression of the peripheral benzodiazepine receptor (PBR) and its endogenous ligand octadecaneuropeptide (ODN) in the sciatic nerve of the adult rat by immunohistochemistry...
  44. Dimitrova Shumkovska J, Veenman L, Ristoski T, Leschiner S, Gavish M. Decreases in binding capacity of the mitochondrial 18 kda translocator protein accompany oxidative stress and pathological signs in rat liver after DMBA exposure. Toxicol Pathol. 2010;38:957-68 pubmed publisher
    ..was to study the effects of DMBA administration on oxidative stress, histopathological signs, and 18 kDa translocator protein (TSPO) binding characteristics in rat liver...
  45. Zulian A, Sileikyte J, Petronilli V, Bova S, Dabbeni Sala F, Cargnelli G, et al. The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. Biochim Biophys Acta. 2011;1807:1600-5 pubmed publisher
    ..effect of NRB on the PT (i) is inhibited by the selective ligands of the 18kDa outer membrane (OMM) translocator protein (TSPO, formerly peripheral benzodiazepine receptor) protoporphyrin IX, N,N-dihexyl-2-(4-fluorophenyl)indole-..
  46. Ostuni M, Tumilasci O, Péranzi G, Cardoso E, Contreras L, Arregger A, et al. Effect of translocator protein (18 kDa)-ligand binding on neurotransmitter-induced salivary secretion in rat submandibular glands. Biol Cell. 2008;100:427-39 pubmed publisher
    TSPO (translocator protein), previously known as PBR (peripheral-type benzodiazepine receptor), is a ubiquitous 18 kDa transmembrane protein that participates in diverse cell functions...
  47. Arlicot N, Petit E, Katsifis A, Toutain J, Divoux D, Bodard S, et al. Detection and quantification of remote microglial activation in rodent models of focal ischaemia using the TSPO radioligand CLINDE. Eur J Nucl Med Mol Imaging. 2010;37:2371-80 pubmed publisher
    ..is involved in stroke pathophysiology and might be imaged using radioligands targeting the 18 kDa translocator protein (TSPO)...
  48. Owen D, Fan J, Campioli E, Venugopal S, Midzak A, Daly E, et al. TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. Biochem J. 2017;474:3985-3999 pubmed publisher
    The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial membrane protein implicated in numerous cell and tissue functions, including steroid hormone biosynthesis, respiration, cell proliferation, and ..
  49. Chelli B, Lena A, Vanacore R, Da Pozzo E, Costa B, Rossi L, et al. Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. Biochem Pharmacol. 2004;68:125-34 pubmed
    The peripheral benzodiazepine receptor (PBR) is a component of a multiprotein complex, located at the contact site between the inner and outer mitochondrial membranes, which constitutes the mitochondrial permeability transition (MPT)-..
  50. Kurumaji A, Nomoto H, Yoshikawa T, Okubo Y, Toru M. An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample. J Neural Transm (Vienna). 2000;107:491-500 pubmed
    The benzodiazepine receptor (peripheral) (BZRP) mainly localized on glial cells plays a role in neurosteroid synthesis, and increases with glial proliferation...
  51. Venneti S, Lopresti B, Wang G, Slagel S, Mason N, Mathis C, et al. A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation. J Neurochem. 2007;102:2118-2131 pubmed publisher
    ..PK11195), a ligand that binds the peripheral benzodiazepine receptor (PBR)...
  52. Barupala D, Dzul S, RIGGS GELASCO P, Stemmler T. Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors. Arch Biochem Biophys. 2016;592:60-75 pubmed publisher
  53. Azarashvili T, Grachev D, Krestinina O, Evtodienko Y, Yurkov I, Papadopoulos V, et al. The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. Cell Calcium. 2007;42:27-39 pubmed
    The peripheral-type benzodiazepine receptor (PBR) is an 18 kDa mitochondrial membrane protein with still elusive function in cell death...
  54. Lacor P, Gandolfo P, Tonon M, Brault E, Dalibert I, Schumacher M, et al. Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis. Brain Res. 1999;815:70-80 pubmed
    Peripheral benzodiazepine receptors (PBR) and their endogenous ligands, the diazepam-binding inhibitor derived-peptides, are present in Schwann cells in the peripheral nervous system...
  55. Yanamoto K, Zhang M, Kumata K, Hatori A, Okada M, Suzuki K. In vitro and ex vivo autoradiography studies on peripheral-type benzodiazepine receptor binding using [11C]AC-5216 in normal and kainic acid-lesioned rats. Neurosci Lett. 2007;428:59-63 pubmed
    AC-5216 was reported as a novel ligand for peripheral-type benzodiazepine receptor (PBR) with a different chemical structure from DAA1106 analogues...
  56. Avital A, Richter Levin G, Leschiner S, Spanier I, Veenman L, Weizman A, et al. Acute and repeated swim stress effects on peripheral benzodiazepine receptors in the rat hippocampus, adrenal, and kidney. Neuropsychopharmacology. 2001;25:669-78 pubmed
    Peripheral benzodiazepine receptor (PBR) density has been found to be sensitive to stress. We set out to compare the influences of acute and repeated swim stress on behavior and PBR density...