Tspan2

Summary

Gene Symbol: Tspan2
Description: tetraspanin 2
Alias: Tspan-2, tetraspanin-2, tetraspan 2
Species: rat
Products:     Tspan2

Top Publications

  1. Birling M, Tait S, Hardy R, Brophy P. A novel rat tetraspan protein in cells of the oligodendrocyte lineage. J Neurochem. 1999;73:2600-8 pubmed
    ..These data indicate that Tspan-2 is likely to play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath. ..
  2. Wansleeben C, Feitsma H, Montcouquiol M, Kroon C, Cuppen E, Meijlink F. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development. 2010;137:1067-73 pubmed publisher
  3. De Monasterio Schrader P, Patzig J, Mobius W, Barrette B, Wagner T, Kusch K, et al. Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia. 2013;61:1832-47 pubmed publisher
    ..Here, we demonstrate that the abundance of the structurally related tetraspanin-2 (TSPAN2) is highly increased in CNS myelin of Plp1(null) -mice...
  4. Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
    ..Oligodendrocytic differentiation feedback loops may therefore yield pharmacological targets to treat disease related to dysfunctional myelin deposition. ..