Trpv4

Summary

Gene Symbol: Trpv4
Description: transient receptor potential cation channel, subfamily V, member 4
Alias: Otrpc4, Vroac, transient receptor potential cation channel subfamily V member 4, VR-OAC, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential cation channel, subfamily 5, member 4, vanilloid receptor-related osmotically activated channel (Vroac), vanilloid receptor-related osmotically-activated channel
Species: rat

Top Publications

  1. pmc A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy
    Hideki Shigematsu
    Division of Nano Structure Physiology, Okazaki Institute for Integrative Bioscience, Higashiyama, Myodaiji, Okazaki 444 8787 Japan
    J Biol Chem 285:11210-8. 2010
  2. pmc Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication
    Feng Gao
    Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 53:228-35. 2009
  3. pmc Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion
    Sergio A Gradilone
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 104:19138-43. 2007
  4. ncbi Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes
    V Benfenati
    Department of Human and General Physiology, University of Bologna, Via S Donato 19 2, 40127 Bologna, Italy
    Neuroscience 148:876-92. 2007
  5. ncbi Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation
    Ralf Köhler
    Department of Internal Medicine Nephrology, Philipps University, Baldingerstrasse, 35033 Marburg, Germany
    Arterioscler Thromb Vasc Biol 26:1495-502. 2006
  6. ncbi A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators
    Nicole Alessandri-Haber
    Division of Neurosciences, Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 26:3864-74. 2006
  7. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
  8. ncbi TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels
    Scott Earley
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Circ Res 97:1270-9. 2005
  9. ncbi Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat
    Nicole Alessandri-Haber
    Division of Neurosciences, University of California San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 24:4444-52. 2004
  10. pmc Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans
    Wolfgang Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:14531-6. 2003

Scientific Experts

  • Stephen Loukin
  • Kevin S Thorneloe
  • Masayo Koide
  • Ming Shi
  • Christian Chabbert
  • Hidetaka Kumagami
  • Chandan Goswami
  • Sean P Marrelli
  • Hiromi Tsushima
  • Ralf Köhler
  • De Shou Cao
  • Scott Earley
  • Wolfgang Liedtke
  • Yang Zhang
  • Thomas Ducret
  • Feng Gao
  • Juan Huai
  • Shou Wei Yue
  • Diana Dahan
  • Jean Pierre Savineau
  • W Schierling
  • Roger Marthan
  • Nicole Alessandri-Haber
  • Juan Du
  • Xin Chen
  • Yu Juan Qu
  • Maria Grazia Mola
  • Lihua Ying
  • Kevin Monaghan
  • W S V Ho
  • P D Cabral
  • Lei Zhan
  • LiMin Zhao
  • Pablo D Cabral
  • Hidemoto Yamawaki
  • Jae Chul Lee
  • Gisela Segond von Banchet
  • Daniel P Poole
  • Bing Shen
  • Oleg Zaika
  • Ravi K Adapala
  • Susanth V Sukumaran
  • Yongwoo Jang
  • Makoto Tominaga
  • Naoki Aizawa
  • Alexandre Denadai-Souza
  • Elodie Martin
  • Luciano Galizia
  • E S Albert
  • Liping Ning
  • Y Zhao
  • Xiao ru Yang
  • Olena Butenko
  • Liana Merrill
  • Lars Arendt-Nielsen
  • Hong You Ge
  • Xiaomei Wei
  • Chao Wang
  • Jeffrey L Garvin
  • W Schaper
  • K Troidl
  • H Apfelbeck
  • T Schmitz-Rixen
  • Arun K Shukla
  • A Sayed
  • Xin Ma
  • Wouter Everaerts
  • Hideki Shigematsu
  • Donna H Wang
  • Wenzhong Yang
  • F Aura Kullmann
  • Michiko Nakatsuka
  • Flávia Regina Carreño
  • Guillermo B Silva
  • Jun Yin
  • Ryoichi Tanaka
  • Takatoshi Karasawa
  • Sergio A Gradilone
  • V Benfenati
  • Huai Peng Wang
  • Olayinka A Dina
  • Jon D Levine
  • Lu Kang Wang
  • Jinhang Zhu
  • Yong Bo Teng
  • Hui Yang
  • Zhen Zhen Fan
  • Eliana Scemes
  • Concetta Domenica Gargano
  • David C Spray

Detail Information

Publications69

  1. pmc A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy
    Hideki Shigematsu
    Division of Nano Structure Physiology, Okazaki Institute for Integrative Bioscience, Higashiyama, Myodaiji, Okazaki 444 8787 Japan
    J Biol Chem 285:11210-8. 2010
    The transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel responsive to various stimuli including cell swelling, warm temperatures (27-35 degrees C), and chemical compounds such as phorbol ester derivatives...
  2. pmc Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication
    Feng Gao
    Department of Medicine, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 53:228-35. 2009
    To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sodium (0...
  3. pmc Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion
    Sergio A Gradilone
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 104:19138-43. 2007
    ..b>TRPV4, a Ca(2+)-permeable ion channel, has been implicated in signal transduction of osmotic stimuli...
  4. ncbi Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes
    V Benfenati
    Department of Human and General Physiology, University of Bologna, Via S Donato 19 2, 40127 Bologna, Italy
    Neuroscience 148:876-92. 2007
    ..b>TRPV4 was functional because the selective TRPV4 agonist 4-alpha-phorbol 12,13-didecanoate (4alphaPDD) activated an ..
  5. ncbi Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation
    Ralf Köhler
    Department of Internal Medicine Nephrology, Philipps University, Baldingerstrasse, 35033 Marburg, Germany
    Arterioscler Thromb Vasc Biol 26:1495-502. 2006
    ..Here, we investigated the role of the putatively mechanosensitive TRPV4 channel in the mechanisms of endothelium-dependent vasodilatation.
  6. ncbi A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators
    Nicole Alessandri-Haber
    Division of Neurosciences, Department of Oral and Maxillofacial Surgery, University of California, San Francisco, California 94143 0440, USA
    J Neurosci 26:3864-74. 2006
    The transient receptor potential vanilloid 4 (TRPV4) is a primary afferent transducer that plays a crucial role in neuropathic hyperalgesia for osmotic and mechanical stimuli, as well as in inflammatory mediator-induced hyperalgesia for ..
  7. pmc Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
    W Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 103:525-35. 2000
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells...
  8. ncbi TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels
    Scott Earley
    Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Circ Res 97:1270-9. 2005
    ..b>TRPV4 message was detected in RNA from cerebral artery smooth muscle cells...
  9. ncbi Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat
    Nicole Alessandri-Haber
    Division of Neurosciences, University of California San Francisco, San Francisco, California 94143 0440, USA
    J Neurosci 24:4444-52. 2004
    ..We recently showed that the polymodal receptor transient receptor potential vanilloid 4 (TRPV4), a member of the transient receptor potential (TRP) family of ion channels, may play a role in inflammatory pain (..
  10. pmc Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans
    Wolfgang Liedtke
    Laboratory of Molecular Genetics, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:14531-6. 2003
    ..The vertebrate transient receptor potential channel vanilloid subfamily 4 (TRPV4) (VR-OAC) cation channel has been suggested to be an osmo/mechanosensory channel...
  11. pmc Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion
    Yu Juan Qu
    Department of Physical Medicine and Rehabilitation, Qilu Hospital of Shandong University, No 107 Wenhuaxi Road, Jinan, Shandong 250012, China
    Biomed Res Int 2016:6978923. 2016
    The aim of this study was to investigate the relationships among TRPV4, p38, and neuropathic pain in a rat model of chronic compression of the dorsal root ganglion...
  12. doi An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
    Kevin S Thorneloe
    Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area Unit, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA
    Sci Transl Med 4:159ra148. 2012
    ..edema is driven by activation of pulmonary capillary endothelial transient receptor potential vanilloid 4 (TRPV4) channels...
  13. pmc Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4
    Arun K Shukla
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:30115-25. 2010
    ..the angiotensin receptor (AT1aR) and a member of the transient receptor potential (TRP) ion channel family, TRPV4. AT1aR and TRPV4 form a constitutive complex in the plasma membrane, and angiotensin stimulation leads to ..
  14. doi TRPV4 channel activation leads to endothelium-dependent relaxation mediated by nitric oxide and endothelium-derived hyperpolarizing factor in rat pulmonary artery
    Susanth V Sukumaran
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243122, Bareilly, Uttar Pradesh, India
    Pharmacol Res 78:18-27. 2013
    The purpose of the present study was to characterize TRPV4 channels in the rat pulmonary artery and examine their role in endothelium-dependent relaxation...
  15. pmc Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferation
    LiMin Zhao
    1 Vascular Physiology Research Group, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado
    Am J Respir Cell Mol Biol 50:1064-75. 2014
    ..We found that synthetic and endogenous TRPV4 agonists increase proliferation of primary ASMCs...
  16. doi Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage
    Hidemoto Yamawaki
    Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Am J Physiol Gastrointest Liver Physiol 307:G33-40. 2014
    ..Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel expressed throughout the gastrointestinal tract epithelium that is activated by ..
  17. doi Age-related changes in the distribution of transient receptor potential vanilloid 4 channel (TRPV4) in the central nervous system of rats
    Jae Chul Lee
    Department of Biology, School of Life Sciences, Chungbuk National University, Gaeshin dong, Heungduk gu, Cheongju, 361 763, Republic of Korea
    J Mol Histol 45:497-505. 2014
    Transient receptor potential vanilloid type 4 (TRPV4) channels are expressed in the central nervous system, but their role in regulating the aging process under physiological and pathological conditions is still largely unknown...
  18. pmc TRPV4 activation mediates flow-induced nitric oxide production in the rat thick ascending limb
    Pablo D Cabral
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio and Universidad de Buenos Aires, Facultad de Medicina, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
    Am J Physiol Renal Physiol 307:F666-72. 2014
    ..Transient receptor potential vanilloid 4 (TRPV4) is a mechano-sensitive channel activated by luminal flow in different types of cells...
  19. pmc Activation of TRPV4 channels does not mediate inversion of neurovascular coupling after SAH
    Masayo Koide
    Department of Pharmacology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA
    Acta Neurochir Suppl 120:111-6. 2015
    ..Here, we examined the role of TRPV4 channels in the development of high-amplitude spontaneous Ca²⁺ oscillations in astrocyte endfeet and the ..
  20. doi Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy
    Lei Zhan
    The Key Laboratory of Anti inflammatory and Immune Medicine, Ministry of Education, Anhui Medical University, Hefei, China
    Mol Cell Biochem 402:9-22. 2015
    ..Transient receptor potential vanilloid 4 (TRPV4), another member of the transient receptor potential (TRP) channel, is proved to be a vital modulator in ..
  21. doi TRPV4 mediates flow-induced increases in intracellular Ca in medullary thick ascending limbs
    P D Cabral
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA
    Acta Physiol (Oxf) 214:319-28. 2015
    Medullary thick ascending limbs (mTAL) regulate Na balance and therefore blood pressure. We previously showed that cell swelling and luminal flow activates the mechanosensitive channel TRPV4 in mTAL.
  22. pmc Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium
    Kevin Monaghan
    Centre for Experimental Medicine, Queen s University of Belfast
    PLoS ONE 10:e0128359. 2015
    ..Numerous studies have shown that TRPV4 channels are critically involved in maintaining normal endothelial cell function...
  23. pmc Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol
    W S V Ho
    Vascular Biology Research Centre, Institute of Cardiovascular and Cell Sciences, St George s University of London, Cranmer Terrace, London, SW17 0RE, UK
    Br J Pharmacol 172:5251-64. 2015
    ..of the endocannabinoid, 2-arachidonoylglycerol (2-AG) have been postulated to act as endogenous activators of TRPV4, a Ca(2+) -permeable cation channel that plays a critical role in endothelium-dependent relaxation...
  24. pmc The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins
    Maria Grazia Mola
    Department of Bioscience, Biotechnology, and Biopharmaceutics, University of Bari Aldo Moro, Bari, Italy
    Glia 64:139-54. 2016
    ..inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium...
  25. doi The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy
    Lihua Ying
    Center for Excellence in Pulmonary Biology, Stanford University Medical School, Stanford, CA 94305, USA
    Sci Transl Med 7:319ra204. 2015
    ..whether uterine contractility might be modulated by calcium entry via transient receptor potential vanilloid 4 (TRPV4) channels...
  26. doi Increased Expression of Transient Receptor Potential Vanilloid 4 in Cortical Lesions of Patients with Focal Cortical Dysplasia
    Xin Chen
    Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    CNS Neurosci Ther 22:280-90. 2016
    ..Studies found that transient receptor potential vanilloid receptor 4 (TRPV4) may participate in the occurrence of seizures...
  27. pmc Increasing TRPV4 expression restores flow-induced dilation impaired in mesenteric arteries with aging
    Juan Du
    Department of Physiology, School of Basic Medicine, Anhui Medical University, Hefei, Anhui 230032, China
    Sci Rep 6:22780. 2016
    ..Transient receptor potential vanilloid subtype 4 (TRPV4), a Ca(2+)-permeable cation channel, facilitates the flow-stimulated [Ca(2+)]i rise...
  28. doi Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx
    Xin Ma
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Arterioscler Thromb Vasc Biol 30:851-8. 2010
    The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx...
  29. pmc Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth
    Yongwoo Jang
    Sensory Research Center, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    J Biol Chem 287:6014-24. 2012
    ..Recent advances in genetics have resulted in the identification of missense mutations in TRPV4 in patients with these hereditary neuropathies...
  30. pmc TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals
    Ravi K Adapala
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA
    J Mol Cell Cardiol 54:45-52. 2013
    ..Here, we show that the mechanosensitve ion channel TRPV4 is required for TGF-β1-induced differentiation of cardiac fibroblasts into myofibroblasts...
  31. pmc Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat
    Y Zhao
    Department of Physiology and Pathophysiology, Capital Medical University, Beijing, China
    Eur J Histochem 56:e32. 2012
    b>TRPV4 protein forms a Ca2+-permeable channel that is sensitive to osmotic and mechanical stimuli and responds to warm temperatures, and expresses widely in various kinds of tissues...
  32. doi Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats
    Diana Dahan
    Universite de Bordeaux, Centre de Recherche Cardio Thoracique de Bordeaux, France
    Am J Physiol Lung Cell Mol Physiol 303:L824-33. 2012
    ..the expression, functional role, and coupling to reticulum calcium channels of the type 4 vanilloid TRP subfamily (TRPV4) in the pulmonary artery from both normoxic (Nx) and chronically hypoxic (CH) rats...
  33. pmc Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation
    Liana Merrill
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 48:744-56. 2012
    ..transcriptional and translational plasticity of three transient receptor potential (TRP) channels (TRPA1, TRPV1, TRPV4) with established neuronal and non-neuronal expression and functional roles in the lower urinary tract...
  34. doi Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells
    Elodie Martin
    Centre de Recherche Cardio Thoracique de Bordeaux, Univ Bordeaux, 33076, Bordeaux, France
    Pflugers Arch 464:261-72. 2012
    ..we thus investigated in rat intrapulmonary arteries (1) the expression and the functional activity of TRPV1 and TRPV4, (2) the PASMC migration triggered by these TRPV channels, and (3) the associated reorganization of the ..
  35. doi Functional interaction of TRPV4 channel protein with annexin A2 in DRG
    Liping Ning
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Shandong University, Jinan, China
    Neurol Res 34:685-93. 2012
    Transient receptor potential vanilloid 4 (TRPV4) is a Ca(2+)-permeable, non-selective cation channel that is involved in the transmission of pain signals mediated by dorsal root ganglion (DRG)...
  36. pmc The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia
    Olena Butenko
    Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 7:e39959. 2012
    The polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by various stimuli such as cell swelling, low pH and high temperature...
  37. doi TRPV4 channels mediate the infrared laser-evoked response in sensory neurons
    E S Albert
    U 1051, INSERM Institut des Neurosciences de Montpellier, Montpellier, France
    J Neurophysiol 107:3227-34. 2012
    ..These results have the potential to facilitate greatly the design of future prosthetic devices aimed at restoring neurosensory capacities in disabled patients...
  38. doi Interaction of transient receptor potential vanilloid 4 with annexin A2 and tubulin beta 5
    Juan Huai
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Shandong University, Jinan 250012, China
    Neurosci Lett 512:22-7. 2012
    The aim of the present study was to investigate if there exists an interaction of TRPV4 with annexin A2 and with tubulin beta 5 in transfected human embryonic kidney (HEK293) cells in vitro...
  39. pmc Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension
    Xiao ru Yang
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 302:L555-68. 2012
    ..Here we found that TRPV4 was the only member of the TRPV and TRPM subfamilies upregulated in PAs of chronic hypoxic rats...
  40. doi Role of transient receptor potential vanilloid 4 in rat joint inflammation
    Alexandre Denadai-Souza
    University of Sao Paulo, Sao Paulo, Brazil
    Arthritis Rheum 64:1848-58. 2012
    ....
  41. pmc Activation of TRPV4 on dural afferents produces headache-related behavior in a preclinical rat model
    Xiaomei Wei
    University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Cephalalgia 31:1595-600. 2011
    ..Based on the sensitivity to these stimuli we hypothesized that dural afferents express the osmo/mechano-sensitive channel transient receptor-potential vanilloid 4 (TRPV4).
  42. doi Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat
    Naoki Aizawa
    Department of Continence Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Neurourol Urodyn 31:148-55. 2012
    Transient receptor potential vanilloid 4 (TRPV4) may affect afferent pathways innervating the bladder...
  43. doi Functional interaction between AQP2 and TRPV4 in renal cells
    Luciano Galizia
    Laboratorio de Biomembranas, Departamento de Fisiologia y Biofisica, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Cell Biochem 113:580-9. 2012
    ..Since the calcium permeable nonselective cation channel TRPV4 plays a crucial role in the response to mechanical and osmotic perturbations in a wide range of cell types, the ..
  44. doi Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia
    Gisela Segond von Banchet
    Institute of Physiology 1, Jena University Hospital, Friedrich Schiller University Jena, Teichgraben 8, 07743 Jena, Germany
    Mol Cell Neurosci 52:152-60. 2013
    ..However, we found a pronounced upregulation of transient receptor potential vanilloid 4 (TRPV4) which is considered a candidate transduction molecule for mechanical hyperalgesia...
  45. pmc Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
    Daniel P Poole
    Monash Institute of Pharmaceutical Sciences, Parkville, Victoria 3052, Australia
    J Biol Chem 288:5790-802. 2013
    ..We investigated the signaling mechanisms by which PAR(2) regulates TRPV4 and determined the importance of tyrosine phosphorylation in this process...
  46. pmc TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease
    Oleg Zaika
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA
    J Am Soc Nephrol 24:604-16. 2013
    ..The activity of the mechanosensitive Ca(2+)-permeable TRPV4 channel underlies flow-dependent Ca(2+) signaling in murine collecting duct (CD) cells, suggesting that this ..
  47. pmc Functional TRP and ASIC-like channels in cultured urothelial cells from the rat
    F Aura Kullmann
    Dept of Pharmacology and Chemical Biology, Univ of Pittsburgh School of Medicine, E 1340 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Am J Physiol Renal Physiol 296:F892-901. 2009
    ..The TRPV4 agonist 4alpha-phorbol-12,13 didecanoate (4alpha-PDD; 1-5 microM) and the TRPA1/TRPM8 agonist icilin (50-100 ..
  48. ncbi TRPV4-like non-selective cation currents in cultured aortic myocytes
    Ryoichi Tanaka
    Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, Nagoya, Japan
    J Pharmacol Sci 108:179-89. 2008
    ..A selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate (4alphaPDD), had little effect on membrane currents and intracellular Ca(..
  49. doi Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac
    H Kumagami
    Department of Otolaryngology, Nagasaki University, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
    Audiol Neurootol 14:190-7. 2009
    ..b>TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 ..
  50. pmc Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats
    Flávia Regina Carreño
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Am J Physiol Regul Integr Comp Physiol 296:R454-66. 2009
    ..We tested the hypothesis that changes in the expression or trafficking of TRPV4 in the central nervous system may contribute to inappropriate AVP release in the bile duct ligation (BDL) model of ..
  51. ncbi Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle
    Hiromi Tsushima
    Department of Cellular and Molecular Pharmacology, Nagoya City University, Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1736-41. 2006
    Transient receptor potential vanilloid 4 (TRPV4) is one member of the TRP superfamily of nonselective cation channels...
  52. pmc TRPV4 mediates hypotonicity-induced ATP release by the thick ascending limb
    Guillermo B Silva
    Division of Hypertension and Vascular Research, Henry Ford Hospital, and Department of Physiology, School of Medicine, Wayne State University, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 295:F1090-5. 2008
    ..9+/-7.2 vs. 2.4+/-1.0 pmol/mg protein; n=6, P<0.01). To examine the role of TRPV4, we used 1) Ca-free solutions, 2) a TRPV4 inhibitor, 3) small interfering (si) RNA against TRPV4, and 4) a TRPV4 ..
  53. pmc TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 121:2871-9. 2008
    The cochlea and kidney are susceptible to aminoglycoside-induced toxicity. The non-selective cation channel TRPV4 is expressed in kidney distal tubule cells, and hair cells and the stria vascularis in the inner ear...
  54. doi Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4
    Jun Yin
    Institute of Physiology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin, Germany
    Circ Res 102:966-74. 2008
    ..pressure was shown to increase endothelial [Ca(2+)](i) via activation of transient receptor potential vanilloid 4 (TRPV4) channels...
  55. ncbi Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat
    Huai Peng Wang
    Department of Urology, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    Asian J Androl 9:634-40. 2007
    ..To investigate the expression and distribution of the members of the transient receptor potential (TRP) channel members of TRP melastatin (TRPM) and TRP vanilloid (TRPV) subfamilies in rat prostatic tissue...
  56. ncbi Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells
    Thomas Ducret
    Universite Bordeaux 2, Laboratoire de Physiologie Cellulaire Respiratoire, 146 rue Leo Saignat, F 33076 Bordeaux, France
    Cell Calcium 43:315-23. 2008
    ..and to ruthenium red, a TRPV channel blocker, and mimicked by 4alpha-phorbol-12,13-didecanoate (4alpha-PDD), a TRPV4 channel agonist...
  57. ncbi PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries
    Sean P Marrelli
    Department of Anesthesiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 292:H1390-7. 2007
    ..dilation, specifically whether PLA(2) is involved in endothelial Ca(2+) regulation through stimulation of TRPV4 channels...
  58. doi Exercise linked to transient increase in expression and activity of cation channels in newly formed hind-limb collaterals
    A Sayed
    Department of General Surgery, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt
    Eur J Vasc Endovasc Surg 40:81-7. 2010
    This study aimed to compare arteriogenesis after femoral artery occlusion as influenced by exercise or arteriovenous shunt and follow changes in collateral transient receptor potential cation channel, subfamily V, member 4 (Trpv4).
  59. pmc Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids
    Stephen H Loukin
    Laboratory of Molecular Biology, University of Wisconsin Madison, 1525 Linden Drive Madison, WI 53706, USA
    FEBS Lett 583:754-8. 2009
    ..We expressed the rat TRPV1 and TRPV4 subtypes in yeast and monitored their activities in vivo as Ca(2+) rise using transgenic aequorin...
  60. pmc Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C
    De Shou Cao
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
    Mol Pain 5:5. 2009
    ..In this study, the expression and function of TRPV4 have been characterized and compared with those of TRPV1.
  61. ncbi Expression of TRPV4 in the stimulated rat oral mucous membrane--nociceptive mechanisms of lingual conical papillae
    Michiko Nakatsuka
    Dept of Oral Anatomy, Osaka Dental University, Kuzuha Hanazono cho 8 1, Hirakata, Osaka 573 1121, Japan
    Okajimas Folia Anat Jpn 86:45-54. 2009
    ..We studied the function of TRPV4 expression and its neuronal activation in response to noxious stimulation of oral mucosa...
  62. ncbi Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells
    Wenzhong Yang
    Surface Physics Laboratory National Key Laboratory, Department of Physics, Fudan University, Shanghai, China
    J Environ Pathol Toxicol Oncol 28:223-30. 2009
    ..Because histamine is a well-known mediator of microvascular tissue dilation, these results may have an important impact on understanding the mechanism involved in massage therapy...
  63. doi Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats
    Chao Wang
    Department of Physical Medicine and Rehabilitation, Qilu Hospital, Medical School of Shandong University, Jinan 250012, China
    Behav Brain Res 221:19-24. 2011
    The aim of this study was to test the hypothesis that nuclear factor-kappa B (NF-κB) is involved in TRPV4-NO pathway in thermal hyperalgesia following chronic compression of the dorsal root ganglion (DRG) (the procedure hereafter termed ..
  64. doi Cerebral arteriogenesis is enhanced by pharmacological as well as fluid-shear-stress activation of the Trpv4 calcium channel
    W Schierling
    Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
    Eur J Vasc Endovasc Surg 41:589-96. 2011
    ..channels Trpc1, Trpm7, Trpp2, Trpv2 (transient receptor potential cation channel, subfamily V, member 2) and Trpv4 for cerebral arteriogenesis...
  65. pmc Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
    Wouter Everaerts
    Laboratory of Ion Channel Research, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 107:19084-9. 2010
    ..Recent work has demonstrated that the cation channel TRPV4 is highly expressed in urothelial cells and plays a role in sensing the normal filling state of the bladder...
  66. pmc Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells
    Chandan Goswami
    Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e11654. 2010
    b>TRPV4 and the cellular cytoskeleton have each been reported to influence cellular mechanosensitive processes as well as the development of mechanical hyperalgesia...
  67. pmc Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism
    Feng Gao
    Department of Medicine, Michigan State University, East Lansing, Mich 48824, USA
    Hypertension 55:1018-25. 2010
    To examine the role of transient receptor potential vanilloid type 4 (TRPV4) channels in the development of salt-sensitive hypertension, male Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a low-salt (LS) or high-salt (HS) ..
  68. pmc Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force
    Stephen Loukin
    Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 285:27176-81. 2010
    ..b>TRPV4, a key molecular model, can be activated by hypotonicity, but the mechanism of activation is unclear...
  69. pmc Forward genetic analysis reveals multiple gating mechanisms of TRPV4
    Stephen Loukin
    Laboratory of Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 285:19884-90. 2010
    b>TRPV4 is a polymodal cation channel gain-of-function (GOF) allele which causes skeletal dysplasia in humans. To better understand its gating, we screened for additional GOF alleles based on their ability to block yeast proliferation...