Trpv4

Summary

Gene Symbol: Trpv4
Description: transient receptor potential cation channel, subfamily V, member 4
Alias: Otrpc4, Vroac, transient receptor potential cation channel subfamily V member 4, VR-OAC, osm-9-like TRP channel 4, osmosensitive transient receptor potential channel 4, transient receptor potential cation channel, subfamily 5, member 4, vanilloid receptor-related osmotically activated channel (Vroac), vanilloid receptor-related osmotically-activated channel
Species: rat
Products:     Trpv4

Top Publications

  1. Adapala R, Thoppil R, Luther D, Paruchuri S, Meszaros J, Chilian W, et al. TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol. 2013;54:45-52 pubmed publisher
    ..Here, we show that the mechanosensitve ion channel TRPV4 is required for TGF-?1-induced differentiation of cardiac fibroblasts into myofibroblasts...
  2. Everaerts W, Zhen X, Ghosh D, Vriens J, Gevaert T, Gilbert J, et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A. 2010;107:19084-9 pubmed publisher
    ..Recent work has demonstrated that the cation channel TRPV4 is highly expressed in urothelial cells and plays a role in sensing the normal filling state of the bladder...
  3. Butenko O, Dzamba D, Benesova J, Honsa P, Benfenati V, Rusnakova V, et al. The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. PLoS ONE. 2012;7:e39959 pubmed publisher
    The polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by various stimuli such as cell swelling, low pH and high temperature...
  4. Gradilone S, Masyuk A, Splinter P, Banales J, Huang B, Tietz P, et al. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A. 2007;104:19138-43 pubmed
    ..b>TRPV4, a Ca(2+)-permeable ion channel, has been implicated in signal transduction of osmotic stimuli...
  5. Gao F, Sui D, Garavito R, Worden R, Wang D. Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication. Hypertension. 2009;53:228-35 pubmed publisher
    To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sodium (0...
  6. Teilmann S, Byskov A, Pedersen P, Wheatley D, Pazour G, Christensen S. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev. 2005;71:444-52 pubmed
    ..Further, the Ca2+ permeable cation channel, TRP vaniloid 4 (TRPV4), localizes to a sub-population of motile cilia on the epithelial cells of the ampulla and isthmus with high ..
  7. Earley S, Heppner T, Nelson M, Brayden J. TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res. 2005;97:1270-9 pubmed
    ..b>TRPV4 message was detected in RNA from cerebral artery smooth muscle cells...
  8. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant T. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000;2:695-702 pubmed
    ..Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart...
  9. Benfenati V, Caprini M, Dovizio M, Mylonakou M, Ferroni S, Ottersen O, et al. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc Natl Acad Sci U S A. 2011;108:2563-8 pubmed publisher
    ..Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes...
  10. Strotmann R, Schultz G, Plant T. Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem. 2003;278:26541-9 pubmed
    ..that currents through the osmo-, heat- and phorbol ester-sensitive, Ca2+-permeable nonselective cation channel TRPV4 are potentiated by intracellular Ca2+...

Detail Information

Publications80

  1. Adapala R, Thoppil R, Luther D, Paruchuri S, Meszaros J, Chilian W, et al. TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals. J Mol Cell Cardiol. 2013;54:45-52 pubmed publisher
    ..Here, we show that the mechanosensitve ion channel TRPV4 is required for TGF-?1-induced differentiation of cardiac fibroblasts into myofibroblasts...
  2. Everaerts W, Zhen X, Ghosh D, Vriens J, Gevaert T, Gilbert J, et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A. 2010;107:19084-9 pubmed publisher
    ..Recent work has demonstrated that the cation channel TRPV4 is highly expressed in urothelial cells and plays a role in sensing the normal filling state of the bladder...
  3. Butenko O, Dzamba D, Benesova J, Honsa P, Benfenati V, Rusnakova V, et al. The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. PLoS ONE. 2012;7:e39959 pubmed publisher
    The polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by various stimuli such as cell swelling, low pH and high temperature...
  4. Gradilone S, Masyuk A, Splinter P, Banales J, Huang B, Tietz P, et al. Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion. Proc Natl Acad Sci U S A. 2007;104:19138-43 pubmed
    ..b>TRPV4, a Ca(2+)-permeable ion channel, has been implicated in signal transduction of osmotic stimuli...
  5. Gao F, Sui D, Garavito R, Worden R, Wang D. Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication. Hypertension. 2009;53:228-35 pubmed publisher
    To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sodium (0...
  6. Teilmann S, Byskov A, Pedersen P, Wheatley D, Pazour G, Christensen S. Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol Reprod Dev. 2005;71:444-52 pubmed
    ..Further, the Ca2+ permeable cation channel, TRP vaniloid 4 (TRPV4), localizes to a sub-population of motile cilia on the epithelial cells of the ampulla and isthmus with high ..
  7. Earley S, Heppner T, Nelson M, Brayden J. TRPV4 forms a novel Ca2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res. 2005;97:1270-9 pubmed
    ..b>TRPV4 message was detected in RNA from cerebral artery smooth muscle cells...
  8. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant T. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000;2:695-702 pubmed
    ..Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart...
  9. Benfenati V, Caprini M, Dovizio M, Mylonakou M, Ferroni S, Ottersen O, et al. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Proc Natl Acad Sci U S A. 2011;108:2563-8 pubmed publisher
    ..Here we show that a complex containing aquaporin-4 (AQP4) and transient receptor potential vanilloid 4 (TRPV4) is essential for RVD in astrocytes...
  10. Strotmann R, Schultz G, Plant T. Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site. J Biol Chem. 2003;278:26541-9 pubmed
    ..that currents through the osmo-, heat- and phorbol ester-sensitive, Ca2+-permeable nonselective cation channel TRPV4 are potentiated by intracellular Ca2+...
  11. Yang X, Lin A, Hughes J, Flavahan N, Cao Y, Liedtke W, et al. Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012;302:L555-68 pubmed publisher
    ..Here we found that TRPV4 was the only member of the TRPV and TRPM subfamilies upregulated in PAs of chronic hypoxic rats...
  12. Alessandri Haber N, Dina O, Joseph E, Reichling D, Levine J. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci. 2006;26:3864-74 pubmed
    The transient receptor potential vanilloid 4 (TRPV4) is a primary afferent transducer that plays a crucial role in neuropathic hyperalgesia for osmotic and mechanical stimuli, as well as in inflammatory mediator-induced hyperalgesia for ..
  13. Benfenati V, Amiry Moghaddam M, Caprini M, Mylonakou M, Rapisarda C, Ottersen O, et al. Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes. Neuroscience. 2007;148:876-92 pubmed
    ..b>TRPV4 was functional because the selective TRPV4 agonist 4-alpha-phorbol 12,13-didecanoate (4alphaPDD) activated an ..
  14. D hoedt D, Owsianik G, Prenen J, Cuajungco M, Grimm C, Heller S, et al. Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem. 2008;283:6272-80 pubmed publisher
    b>TRPV4, a member of the vanilloid subfamily of the transient receptor potential (TRP) channels, is activated by a variety of stimuli, including cell swelling, moderate heat, and chemical compounds such as synthetic 4alpha-phorbol esters...
  15. Andrade Y, Fernandes J, Vazquez E, Fernández Fernández J, Arniges M, Sánchez T, et al. TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol. 2005;168:869-74 pubmed
    ..Hamster oviductal ciliated cells express the transient receptor potential vanilloid 4 (TRPV4) channel, which is activated by increased viscous load involving a phospholipase A(2)-dependent pathway...
  16. Köhler R, Heyken W, Heinau P, Schubert R, Si H, Kacik M, et al. Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arterioscler Thromb Vasc Biol. 2006;26:1495-502 pubmed
    ..Here, we investigated the role of the putatively mechanosensitive TRPV4 channel in the mechanisms of endothelium-dependent vasodilatation...
  17. Fernández Fernández J, Andrade Y, Arniges M, Fernandes J, Plata C, Rubio Moscardo F, et al. Functional coupling of TRPV4 cationic channel and large conductance, calcium-dependent potassium channel in human bronchial epithelial cell lines. Pflugers Arch. 2008;457:149-59 pubmed publisher
    ..We now show molecular evidence for the presence of TRPV4, a calcium permeable channel sensitive to osmotic and mechanical stress, and its functional coupling to the large ..
  18. Shigematsu H, Sokabe T, Danev R, Tominaga M, Nagayama K. A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy. J Biol Chem. 2010;285:11210-8 pubmed publisher
    The transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel responsive to various stimuli including cell swelling, warm temperatures (27-35 degrees C), and chemical compounds such as phorbol ester derivatives...
  19. Liedtke W, Choe Y, Martí Renom M, Bell A, Denis C, Sali A, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell. 2000;103:525-35 pubmed
    ..The channel also occurs in other neurosensory cells, including inner-ear hair cells, sensory neurons, and Merkel cells. ..
  20. Carreño F, Ji L, Cunningham J. Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R454-66 pubmed publisher
    ..We tested the hypothesis that changes in the expression or trafficking of TRPV4 in the central nervous system may contribute to inappropriate AVP release in the bile duct ligation (BDL) model of ..
  21. Alessandri Haber N, Dina O, Yeh J, Parada C, Reichling D, Levine J. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci. 2004;24:4444-52 pubmed
    ..We recently showed that the polymodal receptor transient receptor potential vanilloid 4 (TRPV4), a member of the transient receptor potential (TRP) family of ion channels, may play a role in inflammatory pain (..
  22. Liedtke W, Tobin D, Bargmann C, Friedman J. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2003;100 Suppl 2:14531-6 pubmed
    ..The vertebrate transient receptor potential channel vanilloid subfamily 4 (TRPV4) (VR-OAC) cation channel has been suggested to be an osmo/mechanosensory channel...
  23. Suzuki M, Hirao A, Mizuno A. Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4). J Biol Chem. 2003;278:51448-53 pubmed
    ..Transient receptor potential vanilloid 4 (TRPV4) is a candidate in the calcium-permeable, swelling-activated mechanosensitive channel in heterogeneously expressed ..
  24. Mizuno A, Matsumoto N, Imai M, Suzuki M. Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol. 2003;285:C96-101 pubmed
    The Ca2+-permeable cation channel TRPV4, which is part of the Trp family located in the circumventricular organs, is activated by cell swelling...
  25. Merrill L, Girard B, May V, Vizzard M. Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation. J Mol Neurosci. 2012;48:744-56 pubmed
    ..transcriptional and translational plasticity of three transient receptor potential (TRP) channels (TRPA1, TRPV1, TRPV4) with established neuronal and non-neuronal expression and functional roles in the lower urinary tract...
  26. Cabral P, Capurro C, Garvin J. TRPV4 mediates flow-induced increases in intracellular Ca in medullary thick ascending limbs. Acta Physiol (Oxf). 2015;214:319-28 pubmed publisher
    ..We previously showed that cell swelling and luminal flow activates the mechanosensitive channel TRPV4 in mTAL. We hypothesized that TRPV4 mediates flow-induced increases in intracellular Ca (Cai) in rat mTALs...
  27. Yang W, Chen J, Zhou L. Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J Environ Pathol Toxicol Oncol. 2009;28:223-30 pubmed
    ..Because histamine is a well-known mediator of microvascular tissue dilation, these results may have an important impact on understanding the mechanism involved in massage therapy...
  28. Loukin S, Su Z, Zhou X, Kung C. Forward genetic analysis reveals multiple gating mechanisms of TRPV4. J Biol Chem. 2010;285:19884-90 pubmed publisher
    b>TRPV4 is a polymodal cation channel gain-of-function (GOF) allele which causes skeletal dysplasia in humans. To better understand its gating, we screened for additional GOF alleles based on their ability to block yeast proliferation...
  29. Ma X, Qiu S, Luo J, Ma Y, Ngai C, Shen B, et al. Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx. Arterioscler Thromb Vasc Biol. 2010;30:851-8 pubmed publisher
    The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx...
  30. Tanaka R, Muraki K, Ohya S, Yamamura H, Hatano N, Itoh Y, et al. TRPV4-like non-selective cation currents in cultured aortic myocytes. J Pharmacol Sci. 2008;108:179-89 pubmed
    ..A selective TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate (4alphaPDD), had little effect on membrane currents and intracellular Ca(..
  31. Loukin S, Su Z, Kung C. Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids. FEBS Lett. 2009;583:754-8 pubmed publisher
    ..We expressed the rat TRPV1 and TRPV4 subtypes in yeast and monitored their activities in vivo as Ca(2+) rise using transgenic aequorin...
  32. Ye L, Kleiner S, Wu J, Sah R, Gupta R, Banks A, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012;151:96-110 pubmed publisher
    ..In particular, TRPV4 negatively regulated the expression of PGC1?, UCP1, and cellular respiration...
  33. Sokabe T, Fukumi Tominaga T, Yonemura S, Mizuno A, Tominaga M. The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem. 2010;285:18749-58 pubmed publisher
    Transient receptor potential vanilloid 4 (TRPV4) channel is a physiological sensor for hypo-osmolarity, mechanical deformation, and warm temperature. The channel activation leads to various cellular effects involving Ca(2+) dynamics...
  34. Hurd L, Kirwin S, Boggs M, MacKenzie W, Bober M, Funanage V, et al. A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. Am J Med Genet A. 2015;167A:2286-93 pubmed publisher
    Transient receptor potential cation channel, subfamily V, member 4 (TRPV4) is a polymodal modulated non-selective cation channel required for normal development and maintenance of bone and cartilage...
  35. Martin E, Dahan D, Cardouat G, Gillibert Duplantier J, Marthan R, Savineau J, et al. Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells. Pflugers Arch. 2012;464:261-72 pubmed publisher
    ..we thus investigated in rat intrapulmonary arteries (1) the expression and the functional activity of TRPV1 and TRPV4, (2) the PASMC migration triggered by these TRPV channels, and (3) the associated reorganization of the ..
  36. Du J, Ma X, Shen B, Huang Y, Birnbaumer L, Yao X. TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel. FASEB J. 2014;28:4677-85 pubmed publisher
    ..The analysis demonstrated the formation of a heteromeric TRPV4-C1-P2 complex in primary cultured rat mesenteric artery endothelial cells (MAECs) and HEK293 cells that were ..
  37. Zhao Y, Huang H, Jiang Y, Wei H, Liu P, Wang W, et al. Unusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat. Eur J Histochem. 2012;56:e32 pubmed publisher
    b>TRPV4 protein forms a Ca2+-permeable channel that is sensitive to osmotic and mechanical stimuli and responds to warm temperatures, and expresses widely in various kinds of tissues...
  38. Mola M, Sparaneo A, Gargano C, Spray D, Svelto M, Frigeri A, et al. The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins. Glia. 2016;64:139-54 pubmed publisher
    ..inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium...
  39. Cabral P, Garvin J. TRPV4 activation mediates flow-induced nitric oxide production in the rat thick ascending limb. Am J Physiol Renal Physiol. 2014;307:F666-72 pubmed publisher
    ..Transient receptor potential vanilloid 4 (TRPV4) is a mechano-sensitive channel activated by luminal flow in different types of cells...
  40. Xu H, Zhao H, Tian W, Yoshida K, Roullet J, Cohen D. Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem. 2003;278:11520-7 pubmed
    The recently identified transient receptor potential (TRP) channel family member, TRPV4 (formerly known as OTRPC4, VR-OAC, TRP12, and VRL-2) is activated by hypotonicity...
  41. Wu Q, Qian C, Zhao N, Dong Q, Li J, Wang B, et al. Activation of transient receptor potential vanilloid 4 involves in hypoxia/reoxygenation injury in cardiomyocytes. Cell Death Dis. 2017;8:e2828 pubmed publisher
    Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels and can be activated during myocardial ischemia/reperfusion (I/R)...
  42. Karasawa T, Wang Q, Fu Y, Cohen D, Steyger P. TRPV4 enhances the cellular uptake of aminoglycoside antibiotics. J Cell Sci. 2008;121:2871-9 pubmed publisher
    The cochlea and kidney are susceptible to aminoglycoside-induced toxicity. The non-selective cation channel TRPV4 is expressed in kidney distal tubule cells, and hair cells and the stria vascularis in the inner ear...
  43. Merrill L, Vizzard M. Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats. Am J Physiol Regul Integr Comp Physiol. 2014;307:R471-80 pubmed publisher
    ..One member of the transient receptor potential ion channel vanilloid family, TRPV4, has recently been implicated in urinary bladder dysfunction disorders including OAB and IC/BPS...
  44. Gebremedhin D, Zhang D, Weihrauch D, Uche N, Harder D. Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells. PLoS ONE. 2017;12:e0176796 pubmed publisher
    The transient receptor potential vallinoid type 4 (TRPV4) is a calcium entry channel known to modulate vascular function by mediating endothelium-dependent vasodilation...
  45. Segond von Banchet G, Boettger M, König C, Iwakura Y, Bräuer R, Schaible H. Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia. Mol Cell Neurosci. 2013;52:152-60 pubmed publisher
    ..However, we found a pronounced upregulation of transient receptor potential vanilloid 4 (TRPV4) which is considered a candidate transduction molecule for mechanical hyperalgesia...
  46. Silva G, Garvin J. TRPV4 mediates hypotonicity-induced ATP release by the thick ascending limb. Am J Physiol Renal Physiol. 2008;295:F1090-5 pubmed publisher
    ..9+/-7.2 vs. 2.4+/-1.0 pmol/mg protein; n=6, P<0.01). To examine the role of TRPV4, we used 1) Ca-free solutions, 2) a TRPV4 inhibitor, 3) small interfering (si) RNA against TRPV4, and 4) a TRPV4 ..
  47. Goswami C, Kuhn J, Heppenstall P, Hucho T. Importance of non-selective cation channel TRPV4 interaction with cytoskeleton and their reciprocal regulations in cultured cells. PLoS ONE. 2010;5:e11654 pubmed publisher
    b>TRPV4 and the cellular cytoskeleton have each been reported to influence cellular mechanosensitive processes as well as the development of mechanical hyperalgesia...
  48. Dryn D, Melnyk M, Kizub I, Hu H, Soloviev A, Zholos A. THE ROLE OF TRPV4 CATION CHANNELS IN THE REGULATION OF PHENYLEPHRINE-INDUCED CONTRACTION OF RAT PULMONARY ARTER. Fiziol Zh. 2016;62:79-86 pubmed
    The aim of our study was to investigate the role of mechanosensitive TRPV4 channels in the regulation of rat pulmonary artery smooth muscle (PASM) contractile activity induced by the activation of α-adrenoceptors and the possibility ..
  49. Hu F, Hui Z, Wei W, Yang J, Chen Z, Guo B, et al. Hypotonic stress promotes ATP release, reactive oxygen species production and cell proliferation via TRPV4 activation in rheumatoid arthritis rat synovial fibroblasts. Biochem Biophys Res Commun. 2017;486:108-115 pubmed publisher
    ..mechanosensitive Ca2+ channel blocker) and ruthenium red (a transient receptor potential vanilloid 4 (TRPV4) blocker)...
  50. Sayed A, Schierling W, Troidl K, Rüding I, Nelson K, Apfelbeck H, et al. Exercise linked to transient increase in expression and activity of cation channels in newly formed hind-limb collaterals. Eur J Vasc Endovasc Surg. 2010;40:81-7 pubmed publisher
    ..shunt and follow changes in collateral transient receptor potential cation channel, subfamily V, member 4 (Trpv4)...
  51. Ho W, Zheng X, Zhang D. Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol. Br J Pharmacol. 2015;172:5251-64 pubmed publisher
    ..of the endocannabinoid, 2-arachidonoylglycerol (2-AG) have been postulated to act as endogenous activators of TRPV4, a Ca(2+) -permeable cation channel that plays a critical role in endothelium-dependent relaxation...
  52. Sukumaran S, Singh T, Parida S, Narasimha Reddy C, Thangamalai R, Kandasamy K, et al. TRPV4 channel activation leads to endothelium-dependent relaxation mediated by nitric oxide and endothelium-derived hyperpolarizing factor in rat pulmonary artery. Pharmacol Res. 2013;78:18-27 pubmed publisher
    The purpose of the present study was to characterize TRPV4 channels in the rat pulmonary artery and examine their role in endothelium-dependent relaxation...
  53. Koide M, Wellman G. Activation of TRPV4 channels does not mediate inversion of neurovascular coupling after SAH. Acta Neurochir Suppl. 2015;120:111-6 pubmed publisher
    ..Here, we examined the role of TRPV4 channels in the development of high-amplitude spontaneous Ca²? oscillations in astrocyte endfeet and the ..
  54. Feetham C, Nunn N, Lewis R, Dart C, Barrett Jolley R. TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus. Br J Pharmacol. 2015;172:1753-68 pubmed publisher
    Transient receptor potential vanilloid type 4 (TRPV4) and calcium-activated potassium channels (KCa ) mediate osmosensing in many tissues...
  55. Yin J, Hoffmann J, Kaestle S, Neye N, Wang L, Baeurle J, et al. Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circ Res. 2008;102:966-74 pubmed publisher
    ..pressure was shown to increase endothelial [Ca(2+)](i) via activation of transient receptor potential vanilloid 4 (TRPV4) channels...
  56. Nakatsuka M, Iwai Y. Expression of TRPV4 in the stimulated rat oral mucous membrane--nociceptive mechanisms of lingual conical papillae. Okajimas Folia Anat Jpn. 2009;86:45-54 pubmed
    ..We studied the function of TRPV4 expression and its neuronal activation in response to noxious stimulation of oral mucosa...
  57. Yang F, Zhou L, Wang D, Yang L, Yuan G, Huang Q. Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats. Sci Rep. 2016;6:30168 pubmed publisher
    ..The transient receptor potential vanilloid (TRPV) channels, including TRPV1 and TRPV4, are located in the subfornical organ (SFO)...
  58. Shukla A, Kim J, Ahn S, Xiao K, Shenoy S, Liedtke W, et al. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. J Biol Chem. 2010;285:30115-25 pubmed publisher
    ..the angiotensin receptor (AT1aR) and a member of the transient receptor potential (TRP) ion channel family, TRPV4. AT1aR and TRPV4 form a constitutive complex in the plasma membrane, and angiotensin stimulation leads to ..
  59. Huai J, Zhang Y, Liu Q, Ge H, Arendt Nielsen L, Jiang H, et al. Interaction of transient receptor potential vanilloid 4 with annexin A2 and tubulin beta 5. Neurosci Lett. 2012;512:22-7 pubmed publisher
    The aim of the present study was to investigate if there exists an interaction of TRPV4 with annexin A2 and with tubulin beta 5 in transfected human embryonic kidney (HEK293) cells in vitro...
  60. Poole D, Amadesi S, Veldhuis N, Abogadie F, Lieu T, Darby W, et al. Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. J Biol Chem. 2013;288:5790-802 pubmed publisher
    ..We investigated the signaling mechanisms by which PAR(2) regulates TRPV4 and determined the importance of tyrosine phosphorylation in this process...
  61. Albert E, Bec J, Desmadryl G, Chekroud K, Travo C, Gaboyard S, et al. TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. J Neurophysiol. 2012;107:3227-34 pubmed publisher
    ..These results have the potential to facilitate greatly the design of future prosthetic devices aimed at restoring neurosensory capacities in disabled patients. ..
  62. Schierling W, Troidl K, Apfelbeck H, Troidl C, Kasprzak P, Schaper W, et al. Cerebral arteriogenesis is enhanced by pharmacological as well as fluid-shear-stress activation of the Trpv4 calcium channel. Eur J Vasc Endovasc Surg. 2011;41:589-96 pubmed publisher
    ..channels Trpc1, Trpm7, Trpp2, Trpv2 (transient receptor potential cation channel, subfamily V, member 2) and Trpv4 for cerebral arteriogenesis...
  63. Zhan L, Yang Y, Ma T, Huang C, Meng X, Zhang L, et al. Transient receptor potential vanilloid 4 inhibits rat HSC-T6 apoptosis through induction of autophagy. Mol Cell Biochem. 2015;402:9-22 pubmed publisher
    ..Transient receptor potential vanilloid 4 (TRPV4), another member of the transient receptor potential (TRP) channel, is proved to be a vital modulator in ..
  64. Kamakura T, Kondo M, Koyama Y, Hanada Y, Ishida Y, Nakamura Y, et al. Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia. Audiol Neurootol. 2016;21:268-274 pubmed
    ..b>TRPV4 is activated by mechanical stress, heat, low osmotic pressure, low pH, and phorbol derivatives such as 4α-..
  65. Wei X, Edelmayer R, Yan J, Dussor G. Activation of TRPV4 on dural afferents produces headache-related behavior in a preclinical rat model. Cephalalgia. 2011;31:1595-600 pubmed publisher
    ..that dural afferents express the osmo/mechano-sensitive channel transient receptor-potential vanilloid 4 (TRPV4)...
  66. Dahan D, Ducret T, Quignard J, Marthan R, Savineau J, Esteve E. Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol. 2012;303:L824-33 pubmed publisher
    ..the expression, functional role, and coupling to reticulum calcium channels of the type 4 vanilloid TRP subfamily (TRPV4) in the pulmonary artery from both normoxic (Nx) and chronically hypoxic (CH) rats...
  67. Jang Y, Jung J, Kim H, Oh J, Jeon J, Jung S, et al. Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. J Biol Chem. 2012;287:6014-24 pubmed publisher
    ..Recent advances in genetics have resulted in the identification of missense mutations in TRPV4 in patients with these hereditary neuropathies...
  68. Loukin S, Zhou X, Su Z, Saimi Y, Kung C. Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem. 2010;285:27176-81 pubmed publisher
    ..b>TRPV4, a key molecular model, can be activated by hypotonicity, but the mechanism of activation is unclear...
  69. Galizia L, Pizzoni A, Fernandez J, Rivarola V, Capurro C, Ford P. Functional interaction between AQP2 and TRPV4 in renal cells. J Cell Biochem. 2012;113:580-9 pubmed publisher
    ..Since the calcium permeable nonselective cation channel TRPV4 plays a crucial role in the response to mechanical and osmotic perturbations in a wide range of cell types, the ..
  70. Cao D, Yu S, Premkumar L. Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C. Mol Pain. 2009;5:5 pubmed publisher
    ..In this study, the expression and function of TRPV4 have been characterized and compared with those of TRPV1...
  71. Shi M, Du F, Liu Y, Li L, Cai J, Zhang G, et al. Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment. Acta Neuropathol. 2013;126:725-39 pubmed publisher
    ..Here, we showed that glial cell-expressed TRPV4, a Ca(2+)-permeable mechanosensitive channel, mediated infrasound-induced neuronal injury...
  72. Zaika O, Mamenko M, Berrout J, Boukelmoune N, O Neil R, Pochynyuk O. TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease. J Am Soc Nephrol. 2013;24:604-16 pubmed publisher
    ..The activity of the mechanosensitive Ca(2+)-permeable TRPV4 channel underlies flow-dependent Ca(2+) signaling in murine collecting duct (CD) cells, suggesting that this ..
  73. Gao F, Wang D. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010;55:1018-25 pubmed publisher
    To examine the role of transient receptor potential vanilloid type 4 (TRPV4) channels in the development of salt-sensitive hypertension, male Dahl salt-sensitive (DS) and -resistant (DR) rats were fed a low-salt (LS) or high-salt (HS) ..
  74. Qu Y, Zhang X, Fan Z, Huai J, Teng Y, Zhang Y, et al. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. Biomed Res Int. 2016;2016:6978923 pubmed publisher
    The aim of this study was to investigate the relationships among TRPV4, p38, and neuropathic pain in a rat model of chronic compression of the dorsal root ganglion...
  75. Ying L, Becard M, Lyell D, Han X, Shortliffe L, Husted C, et al. The transient receptor potential vanilloid 4 channel modulates uterine tone during pregnancy. Sci Transl Med. 2015;7:319ra204 pubmed publisher
    ..whether uterine contractility might be modulated by calcium entry via transient receptor potential vanilloid 4 (TRPV4) channels...
  76. Wang C, Ning L, Wang Y, Zhang Y, Ding X, Ge H, et al. Nuclear factor-kappa B mediates TRPV4-NO pathway involved in thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behav Brain Res. 2011;221:19-24 pubmed publisher
    The aim of this study was to test the hypothesis that nuclear factor-kappa B (NF-?B) is involved in TRPV4-NO pathway in thermal hyperalgesia following chronic compression of the dorsal root ganglion (DRG) (the procedure hereafter termed ..