Trpv1

Summary

Gene Symbol: Trpv1
Description: transient receptor potential cation channel, subfamily V, member 1
Alias: TRPV1_SON, VR.5'sv, Vr1, Vr1l1, transient receptor potential cation channel subfamily V member 1, OTRPC1, capsaicin receptor, deltaN-TRPV1, osm-9-like TRP channel 1, transient receptor potential vanilloid 1 supraoptic nucleus, vanilloid receptor 1, vanilloid receptor subtype 1, vanilloid receptor type 1 like protein 1, vanilloid type 1 receptor
Species: rat
Products:     Trpv1

Top Publications

  1. Jeske N, Patwardhan A, Ruparel N, Akopian A, Shapiro M, Henry M. A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain. 2009;146:301-7 pubmed publisher
    ..For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation ..
  2. Patwardhan A, Akopian A, Ruparel N, Diogenes A, Weintraub S, Uhlson C, et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest. 2010;120:1617-26 pubmed publisher
    The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous system...
  3. Xing J, Li J. TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons. J Neurophysiol. 2007;97:503-11 pubmed
    The purpose of this study was to determine the role of transient receptor potential vanilloid type 1 (TRPV1) receptor in modulating neuronal activity of the dorsolateral periaqueductal gray (dl-PAG) through excitatory and inhibitory ..
  4. Bohlen C, Priel A, Zhou S, King D, Siemens J, Julius D. A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell. 2010;141:834-45 pubmed publisher
    ..the Earth Tiger tarantula that selectively and irreversibly activates the capsaicin- and heat-sensitive channel, TRPV1. This high-avidity interaction derives from a unique tandem repeat structure of the toxin that endows it with an ..
  5. Papakosta M, Dalle C, Haythornthwaite A, Cao L, Stevens E, Burgess G, et al. The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation. J Biol Chem. 2011;286:39663-72 pubmed publisher
    The capsaicin-, heat-, and proton-activated ion channel TRPV1, a member of the transient receptor potential cation channel family is a polymodal nociceptor...
  6. Zhang N, Inan S, Inan S, Cowan A, Sun R, Wang J, et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci U S A. 2005;102:4536-41 pubmed
    ..cotransfected into human embryonic kidney (HEK)293 cells together with transient receptor potential vanilloid 1 (TRPV1), a cation channel required for certain types of thermal hyperalgesia...
  7. Jung J, Shin J, Lee S, Hwang S, Koo J, Cho H, et al. Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem. 2004;279:7048-54 pubmed
    b>Vanilloid receptor 1 (VR1), a capsaicin receptor, is known to play a major role in mediating inflammatory thermal nociception...
  8. Shinoda M, Ogino A, Ozaki N, Urano H, Hironaka K, Yasui M, et al. Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain. J Pain. 2008;9:687-99 pubmed publisher
    ..Intraplantar administration of the TRPV1 antagonist capsazepine or TRP channels antagonist ruthenium red did not inhibit spontaneous nocifensive behavior ..
  9. Pabbidi R, Cao D, Parihar A, Pauza M, Premkumar L. Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons. Mol Pharmacol. 2008;73:995-1004 pubmed
    ..While studying the influence of transient receptor potential vanilloid 1 (TRPV1) on DPN in the STZ-induced diabetic mouse model, we found that a proportion of STZ-treated mice was nondiabetic ..
  10. Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A. 2003;100:8002-6 pubmed
    The capsaicin receptor, TRPV1 (VR1), is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli...

Detail Information

Publications80

  1. Jeske N, Patwardhan A, Ruparel N, Akopian A, Shapiro M, Henry M. A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain. 2009;146:301-7 pubmed publisher
    ..For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation ..
  2. Patwardhan A, Akopian A, Ruparel N, Diogenes A, Weintraub S, Uhlson C, et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest. 2010;120:1617-26 pubmed publisher
    The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous system...
  3. Xing J, Li J. TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons. J Neurophysiol. 2007;97:503-11 pubmed
    The purpose of this study was to determine the role of transient receptor potential vanilloid type 1 (TRPV1) receptor in modulating neuronal activity of the dorsolateral periaqueductal gray (dl-PAG) through excitatory and inhibitory ..
  4. Bohlen C, Priel A, Zhou S, King D, Siemens J, Julius D. A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell. 2010;141:834-45 pubmed publisher
    ..the Earth Tiger tarantula that selectively and irreversibly activates the capsaicin- and heat-sensitive channel, TRPV1. This high-avidity interaction derives from a unique tandem repeat structure of the toxin that endows it with an ..
  5. Papakosta M, Dalle C, Haythornthwaite A, Cao L, Stevens E, Burgess G, et al. The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation. J Biol Chem. 2011;286:39663-72 pubmed publisher
    The capsaicin-, heat-, and proton-activated ion channel TRPV1, a member of the transient receptor potential cation channel family is a polymodal nociceptor...
  6. Zhang N, Inan S, Inan S, Cowan A, Sun R, Wang J, et al. A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci U S A. 2005;102:4536-41 pubmed
    ..cotransfected into human embryonic kidney (HEK)293 cells together with transient receptor potential vanilloid 1 (TRPV1), a cation channel required for certain types of thermal hyperalgesia...
  7. Jung J, Shin J, Lee S, Hwang S, Koo J, Cho H, et al. Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem. 2004;279:7048-54 pubmed
    b>Vanilloid receptor 1 (VR1), a capsaicin receptor, is known to play a major role in mediating inflammatory thermal nociception...
  8. Shinoda M, Ogino A, Ozaki N, Urano H, Hironaka K, Yasui M, et al. Involvement of TRPV1 in nociceptive behavior in a rat model of cancer pain. J Pain. 2008;9:687-99 pubmed publisher
    ..Intraplantar administration of the TRPV1 antagonist capsazepine or TRP channels antagonist ruthenium red did not inhibit spontaneous nocifensive behavior ..
  9. Pabbidi R, Cao D, Parihar A, Pauza M, Premkumar L. Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons. Mol Pharmacol. 2008;73:995-1004 pubmed
    ..While studying the influence of transient receptor potential vanilloid 1 (TRPV1) on DPN in the STZ-induced diabetic mouse model, we found that a proportion of STZ-treated mice was nondiabetic ..
  10. Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A. 2003;100:8002-6 pubmed
    The capsaicin receptor, TRPV1 (VR1), is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli...
  11. Ro J, Lee J, Zhang Y. Activation of TRPV1 and TRPA1 leads to muscle nociception and mechanical hyperalgesia. Pain. 2009;144:270-7 pubmed publisher
    The involvement of TRPV1 and TRPA1 in mediating craniofacial muscle nociception and mechanical hyperalgesia was investigated in male Sprague-Dawley rats...
  12. Fernihough J, Gentry C, Bevan S, Winter J. Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Neurosci Lett. 2005;388:75-80 pubmed
    ..Expression of calcitonin gene-related peptide (CGRP) and the vanilloid receptor TRPV1 was quantified in these backlabelled cells and was enriched in the knee afferents in all animals studied, compared ..
  13. Varga A, Bölcskei K, Szoke E, Almási R, Czéh G, Szolcsanyi J, et al. Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo. Neuroscience. 2006;140:645-57 pubmed
    ..activity of protein kinase C and cAMP-dependent protein kinase in transient receptor potential vanilloid type 1 receptor responsiveness in the rat in vitro by measurement of the intracellular calcium concentration in cultured ..
  14. Steiner A, Turek V, Almeida M, Burmeister J, Oliveira D, Roberts J, et al. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci. 2007;27:7459-68 pubmed
    ..We synthesized a new TRPV1 antagonist, AMG0347 [(E)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)..
  15. Kasama S, Kawakubo M, Suzuki T, Nishizawa T, Ishida A, Nakayama J. RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat. Eur J Neurosci. 2007;25:2956-63 pubmed
    ..b>TRPV1 plays an essential role in development of inflammatory thermal hyperalgesia after tissue injury and its expression ..
  16. Kido M, Muroya H, Yamaza T, Terada Y, Tanaka T. Vanilloid receptor expression in the rat tongue and palate. J Dent Res. 2003;82:393-7 pubmed
    Capsaicin, the pungent substance in hot peppers, evokes a sensation of burning pain by stimulating the vanilloid receptor 1 (VR1) on primary afferent neurons...
  17. McIntyre P, McLatchie L, Chambers A, Phillips E, Clarke M, Savidge J, et al. Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). Br J Pharmacol. 2001;132:1084-94 pubmed
    Vanilloid receptors (VR1) were cloned from human and rat dorsal root ganglion libraries and expressed in Xenopus oocytes or Chinese Hamster Ovary (CHO) cells...
  18. Phillips E, Reeve A, Bevan S, McIntyre P. Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1. J Biol Chem. 2004;279:17165-72 pubmed
    The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. The antagonist, capsazepine is more effective at inhibiting the human TRPV1 response to pH 5...
  19. Gibson H, Edwards J, Page R, Van Hook M, Kauer J. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 2008;57:746-59 pubmed publisher
    b>TRPV1 receptors have classically been defined as heat-sensitive, ligand-gated, nonselective cation channels that integrate nociceptive stimuli in sensory neurons...
  20. Zhang X, Li L, McNaughton P. Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron. 2008;59:450-61 pubmed publisher
    ..Here, we show that modulation of the sensitivity of the heat-activated ion channel TRPV1 by the protein kinases PKA and PKC and by the phosphatase calcineurin depends on the formation of a signaling ..
  21. Cao D, Yu S, Premkumar L. Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C. Mol Pain. 2009;5:5 pubmed publisher
    ..b>TRPV1, a non-selective cation channel has been extensively studied and is responsible for inflammatory thermal ..
  22. Puntambekar P, Van Buren J, Raisinghani M, Premkumar L, Ramkumar V. Direct interaction of adenosine with the TRPV1 channel protein. J Neurosci. 2004;24:3663-71 pubmed
    b>Vanilloid receptor 1 (TRPV1), a nonspecific cation channel expressed primarily in small sensory neurons, mediates inflammatory thermal pain sensation...
  23. Neelands T, Jarvis M, Han P, Faltynek C, Surowy C. Acidification of rat TRPV1 alters the kinetics of capsaicin responses. Mol Pain. 2005;1:28 pubmed
    TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C...
  24. Premkumar L, Ahern G. Induction of vanilloid receptor channel activity by protein kinase C. Nature. 2000;408:985-90 pubmed
    Capsaicin or vanilloid receptors (VRs) participate in the sensation of thermal and inflammatory pain. The cloned (VR1) and native VRs are non-selective cation channels directly activated by harmful heat, extracellular protons and ..
  25. Westlund K, Kochukov M, Lu Y, McNearney T. Impact of central and peripheral TRPV1 and ROS levels on proinflammatory mediators and nociceptive behavior. Mol Pain. 2010;6:46 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) channels are important membrane sensors on peripheral nerve endings and on supportive non-neuronal synoviocytes in the knee joint...
  26. Kamakura T, Ishida Y, Nakamura Y, Yamada T, Kitahara T, Takimoto Y, et al. Functional expression of TRPV1 and TRPA1 in rat vestibular ganglia. Neurosci Lett. 2013;552:92-7 pubmed publisher
    Both TRPV1 and TRPA1 are non-selective cation channels...
  27. Amaya F, Shimosato G, Nagano M, Ueda M, Hashimoto S, Tanaka Y, et al. NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia. Eur J Neurosci. 2004;20:2303-10 pubmed
    The transient receptor potential ion channel, TRPV1 plays an essential role in the development of inflammatory thermal hyperalgesia. We investigated the dependence of inflammatory TRPV1 induction on neurotrophic factor...
  28. De Schepper H, de Winter B, van Nassauw L, Timmermans J, Herman A, Pelckmans P, et al. TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats. J Physiol. 2008;586:5247-58 pubmed publisher
    ..The aim of the current study was to investigate the role of transient receptor potential of the vanilloid type 1 (TRPV1) receptors in the pathophysiology of colitis-induced pelvic afferent nerve sensitization...
  29. Kim S, Patapoutian A, GRANDL J. Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations. PLoS ONE. 2013;8:e59593 pubmed publisher
    ..We screened over 50 amino acids in the predicted outer pore domains of the heat-activated ion channels TRPV1 and TRPV3...
  30. Liao M, Cao E, Julius D, Cheng Y. Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature. 2013;504:107-12 pubmed publisher
    ..Here we exploit advances in electron cryo-microscopy to determine the structure of a mammalian TRP channel, TRPV1, at 3.4?Å resolution, breaking the side-chain resolution barrier for membrane proteins without crystallization...
  31. Kim A, Tang Z, Liu Q, Patel K, Maag D, Geng Y, et al. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell. 2008;133:475-85 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of noxious heat and capsaicin. Its channel activity can be modulated by several mechanisms. Here we identify a membrane protein, Pirt, as a regulator of TRPV1...
  32. Moiseenkova Bell V, Stanciu L, Serysheva I, Tobe B, Wensel T. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2008;105:7451-5 pubmed publisher
    The transient receptor potential (TRP) family of ion channels participate in many signaling pathways. TRPV1 functions as a molecular integrator of noxious stimuli, including heat, low pH, and chemical ligands...
  33. Shin J, Cho H, Hwang S, Jung J, Shin C, Lee S, et al. Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A. 2002;99:10150-5 pubmed
    The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown...
  34. Mohapatra D, Nau C. Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem. 2005;280:13424-32 pubmed
    The vanilloid receptor TRPV1 is a polymodal nonselective cation channel of nociceptive sensory neurons involved in the perception of inflammatory pain...
  35. García Sanz N, Fernández Carvajal A, Morenilla Palao C, Planells Cases R, Fajardo Sanchez E, Fernandez Ballester G, et al. Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci. 2004;24:5307-14 pubmed
    TRPV1 (transient receptor potential vanilloid receptor subtype 1) is a member of the TRP channel family gated by vanilloids, protons, and heat...
  36. Woodbury C, Zwick M, Wang S, Lawson J, Caterina M, Koltzenburg M, et al. Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. J Neurosci. 2004;24:6410-5 pubmed
    b>Vanilloid receptor 1 (TRPV1) has been proposed to be the principal heat-responsive channel for nociceptive neurons...
  37. Numazaki M, Tominaga T, Toyooka H, Tominaga M. Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem. 2002;277:13375-8 pubmed
    The capsaicin receptor, VR1, is a sensory neuron-specific ion channel that serves as a polymodal detector of pain-producing chemical and physical stimuli...
  38. Chu C, Zavala K, Fahimi A, Lee J, Xue Q, Eilers H, et al. Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons. Mol Pain. 2011;7:44 pubmed publisher
    The capsaicin receptor, transient receptor potential vanilloid type -1 (TRPV1) directs complex roles in signal transduction including the detection of noxious stimuli arising from cellular injury and inflammation...
  39. Bishnoi M, Bosgraaf C, Abooj M, Zhong L, Premkumar L. Streptozotocin-induced early thermal hyperalgesia is independent of glycemic state of rats: role of transient receptor potential vanilloid 1(TRPV1) and inflammatory mediators. Mol Pain. 2011;7:52 pubmed publisher
    ..a direct effect on neurons through expression and function of the Transient receptor potential vanilloid 1 (TRPV1) channel in sensory neurons resulting in thermal hyperalgesia, even in non-diabetic STZ-treated mice...
  40. Doly S, Fischer J, Salio C, Conrath M. The vanilloid receptor-1 is expressed in rat spinal dorsal horn astrocytes. Neurosci Lett. 2004;357:123-6 pubmed
    The vanilloid receptor-1 (TRPV1), expressed by nociceptive fibers, is a transducer of thermal and chemical nociceptive messages...
  41. Salazar H, Llorente I, Jara Oseguera A, García Villegas R, Munari M, Gordon S, et al. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci. 2008;11:255-61 pubmed publisher
    ..channels are activated by pungent compounds found in garlic, onion, mustard and cinnamon extracts, activation of TRPV1 by these extracts remains controversial...
  42. Sekino Y, Nakano J, Hamaue Y, Chuganji S, Sakamoto J, Yoshimura T, et al. Sensory hyperinnervation and increase in NGF, TRPV1 and P2X3 expression in the epidermis following cast immobilization in rats. Eur J Pain. 2014;18:639-48 pubmed publisher
    ..profiles and to examine the expression of the nerve growth factor (NGF), transient receptor potential vanilloid 1 (TRPV1) and P2X3 in the epidermis...
  43. Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, et al. TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J Neurosci. 2006;26:9385-93 pubmed
    Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH...
  44. Fukuoka T, Tokunaga A, Tachibana T, Dai Y, Yamanaka H, Noguchi K. VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation. Pain. 2002;99:111-20 pubmed
    ..We investigated the expression of two candidate transducers of noxious stimuli in peripheral tissues, the vanilloid receptor subtype 1 (VR1) and the P2X(3), a subunit of the ionotropic P2X receptor for ATP, in spared L4 DRG neurons ..
  45. Wirkner K, Hognestad H, Jahnel R, Hucho F, Illes P. Characterization of rat transient receptor potential vanilloid 1 receptors lacking the N-glycosylation site N604. Neuroreport. 2005;16:997-1001 pubmed
    ..on HEK293 cells transiently transfected with the rat (r) wild-type transient receptor potential vanilloid 1 (TRPV1) (rTRPV1) receptor or with a mutant that lacks the potential N-glycosylation site at position N604 (rTRPV1-N604T)...
  46. Salazar H, Jara Oseguera A, Hernández García E, Llorente I, Arias Olguin I, Soriano García M, et al. Structural determinants of gating in the TRPV1 channel. Nat Struct Mol Biol. 2009;16:704-10 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) channels mediate several types of physiological responses...
  47. Jin X, Morsy N, Winston J, Pasricha P, Garrett K, Akbarali H. Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase. Am J Physiol Cell Physiol. 2004;287:C558-63 pubmed
    The capsaicin receptor TRPV1 is a nonselective cation channel that is expressed in sensory neurons. In this study, we examined the role of the nonreceptor cellular tyrosine kinase c-Src kinase in the modulation of the rat TRPV1...
  48. Chung M, Guler A, Caterina M. TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat Neurosci. 2008;11:555-64 pubmed publisher
    Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious heat, capsaicin and other diverse stimuli. It is a nonselective cation channel that prefers Ca2+ over Na+...
  49. Gavva N, Klionsky L, Qu Y, Shi L, Tamir R, Edenson S, et al. Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem. 2004;279:20283-95 pubmed
    b>Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by ..
  50. Jin Y, Bailey T, Li B, Schild J, Andresen M. Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius. J Neurosci. 2004;24:4709-17 pubmed
    Vanilloid (VR1) and purinergic (P2X) receptors are found in cranial afferent neurons in nodose ganglia and their central terminations within the solitary tract nucleus (NTS), but little is known about their function...
  51. Xiao L, Cheng J, Zhuang Y, Qu W, Muir J, Liang H, et al. Botulinum toxin type A reduces hyperalgesia and TRPV1 expression in rats with neuropathic pain. Pain Med. 2013;14:276-86 pubmed publisher
    ..type A (BTX-A) on the thresholds of pain and the expression of transient receptor potential vanilloid type 1 (TRPV1) in the dorsal root ganglion (DRG) in rats with neuropathic pain induced by selective ventral root transection (..
  52. Xue Q, Jong B, Chen T, Schumacher M. Transcription of rat TRPV1 utilizes a dual promoter system that is positively regulated by nerve growth factor. J Neurochem. 2007;101:212-22 pubmed
    The capsaicin receptor, also known as 'transient receptor potential vanilloid receptor subtype 1' (TRPV1, VR1), is an ion channel subunit expressed in primary afferent nociceptors, which plays a critical role in pain transduction and ..
  53. Yu L, Yang F, Luo H, Liu F, Han J, Xing G, et al. The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant. Mol Pain. 2008;4:61 pubmed publisher
    The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical allodynia...
  54. Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, Armati P, et al. Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain. 2006;123:106-16 pubmed
    Important mechanisms that regulate inhibitory and facilitatory effects on TRPV1-mediated nociception are desensitization and phosphorylation, respectively...
  55. Movahed P, Jonsson B, Birnir B, Wingstrand J, Jørgensen T, Ermund A, et al. Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem. 2005;280:38496-504 pubmed
    ..This study shows that several endogenous non-cannabinoid NAEs, many of which are more abundant than anandamide in rat tissues, activate TRPV(1) and thus may play a role as endogenous TRPV(1) modulators. ..
  56. Xing J, Gao Z, Lu J, Sinoway L, Li J. Femoral artery occlusion augments TRPV1-mediated sympathetic responsiveness. Am J Physiol Heart Circ Physiol. 2008;295:H1262-H1269 pubmed publisher
    ..Previous studies reported that chemically sensitive transient receptor potential vanilloid type 1 (TRPV1) channels present on sensory muscle afferent neurons have an important impact on sympathetically mediated ..
  57. Jung J, Lee S, Hwang S, Cho H, Shin J, Kang Y, et al. Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem. 2002;277:44448-54 pubmed
    b>Vanilloid receptor 1 (VR1), a ligand-gated ion channel activated by vanilloids, acid, and heat, is a molecular detector that integrates multiple modes of pain...
  58. Jeffry J, Yu S, Sikand P, Parihar A, Evans M, Premkumar L. Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS ONE. 2009;4:e7021 pubmed publisher
    ..Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous ..
  59. Kim S, Kang C, Shin C, Hwang S, Yang Y, Shim W, et al. TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1. J Neurosci. 2006;26:2403-12 pubmed
    TRPV1, a cloned capsaicin receptor, is a molecular sensor for detecting adverse stimuli and a key element for inflammatory nociception and represents biophysical properties of native channel...
  60. Picazo Juárez G, Romero Suarez S, Nieto Posadas A, Llorente I, Jara Oseguera A, Briggs M, et al. Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel. J Biol Chem. 2011;286:24966-76 pubmed publisher
    The TRPV1 ion channel serves as an integrator of noxious stimuli with its activation linked to pain and neurogenic inflammation. Cholesterol, a major component of cell membranes, modifies the function of several types of ion channels...
  61. Brauchi S, Orta G, Mascayano C, Salazar M, Raddatz N, Urbina H, et al. Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A. 2007;104:10246-51 pubmed
    ..we have exchanged different segments of the C-terminal region between cold-sensitive (TRPM8) and heat-sensitive (TRPV1) channels, trying to understand the role of the segment in PIP2 and temperature activation...
  62. Kim H, Park C, Cho I, Jung S, Kim J, Oh S. Differential Changes in TRPV1 expression after trigeminal sensory nerve injury. J Pain. 2008;9:280-8 pubmed publisher
    ..In this study, we examined changes of transient receptor potential vanilloid 1 (TRPV1) expression in the injured and uninjured TG neurons using immunohistochemical analysis at 3 days after surgery, ..
  63. Lishko P, Procko E, Jin X, Phelps C, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron. 2007;54:905-18 pubmed
    b>TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as capsaicin, leading to a burning pain sensation...
  64. Hellwig N, Plant T, Janson W, Schafer M, Schultz G, Schaefer M. TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem. 2004;279:34553-61 pubmed
    ..pH of inflamed or ischemic tissues enhances painful sensations by sensitizing and activating the vanilloid receptor 1 (TRPV1)...
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    ..site-directed fluorescence recordings we observed that temperature change induces a significant rearrangement of TRPV1 pore turret that is coupled to channel opening...
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    b>TRPV1 and TRPM8 are sensory nerve ion channels activated by heating and cooling, respectively. A variety of physical and chemical stimuli activate these receptors in a synergistic manner but the underlying mechanisms are unclear...
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    ..We have used an expression cloning strategy based on calcium influx to isolate a functional cDNA encoding a capsaicin receptor from sensory neurons...
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    ..Acid-sensing ion channel (ASIC) and transient receptor potential/vanilloid receptor subtype-1 (TRPV1) encode proton-activated cation channels expressed by nociceptors and the opening of these channels results in ..
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    ..probes (a peptide toxin and small vanilloid agonists) to determine structures of two activated states of the capsaicin receptor, TRPV1...
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    The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid, and high temperature...
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    ..Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons...