Gene Symbol: Trpm2
Description: transient receptor potential cation channel, subfamily M, member 2
Alias: Trpm2-predicted, transient receptor potential cation channel subfamily M member 2, transient receptor potential melastatin family 2
Species: rat
Products:     Trpm2

Top Publications

  1. Hill K, Tigue N, Kelsell R, Benham C, McNulty S, Schaefer M, et al. Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. Neuropharmacology. 2006;50:89-97 pubmed
    b>TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and nitrosative stress...
  2. Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, et al. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J. 2006;25:1804-15 pubmed
    ..Here, we demonstrate that TRPM2 can be activated by exposure to warm temperatures (>35 degrees C) apparently via direct heat-evoked channel ..
  3. Song K, Wang H, Kamm G, Pohle J, Reis F, Heppenstall P, et al. The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. Science. 2016;353:1393-1398 pubmed
    ..We demonstrate that the ion channel TRPM2 [of the transient receptor potential (TRP) channel family] is a temperature sensor in a subpopulation of ..
  4. CSANADY L, Torocsik B. Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. J Gen Physiol. 2009;133:189-203 pubmed publisher
    b>TRPM2 is a tetrameric Ca(2+)-permeable channel involved in immunocyte respiratory burst and in postischaemic neuronal death...
  5. Fonfria E, Mattei C, Hill K, Brown J, Randall A, Benham C, et al. TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. J Recept Signal Transduct Res. 2006;26:179-98 pubmed
    We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery ..
  6. Li F, Abuarab N, Sivaprasadarao A. Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels. J Cell Sci. 2016;129:2016-29 pubmed publisher
    ..including H2O2 and Ca(2+) Here, we asked whether the H2O2-sensitive transient receptor potential melastatin 2 (TRPM2) Ca(2+) channel serves as a molecular link between H2O2 and Ca(2+) H2O2-mediated activation of TRPM2 channels ..
  7. Chung M, Asgar J, Lee J, Shim M, Dumler C, Ro J. The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia. Neuroscience. 2015;297:160-9 pubmed publisher
    ..cytokine and chemokine production and ROS generation within TG and that transient receptor potential melastatin (TRPM2), a well known oxidative sensor, contributes to ROS-induced gene regulation within TG...
  8. Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, et al. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell. 2002;9:163-73 pubmed
    ..Thus, LTRPC2 represents an important intrinsic mechanism that mediates Ca2+ and Na+ overload in response to disturbance of redox state in cell death. ..
  9. Lu S, Xiang L, Clemmer J, Mittwede P, Hester R. Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels. Microcirculation. 2014;21:754-60 pubmed publisher
    In vitro superoxide activates pulmonary endothelial TRPM2 channels and increases Kf ...

More Information


  1. Roedding A, Tong S, Au Yeung W, Li P, Warsh J. Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorder. Brain Res. 2013;1517:16-27 pubmed publisher
    Recent findings implicate the calcium-permeable transient receptor potential (TRP) melastatin subtype 2 (TRPM2) and canonical subtype 3 (TRPC3) channels in the pathogenesis of bipolar disorder (BD)...
  2. Kheradpezhouh E, Ma L, Morphett A, Barritt G, Rychkov G. TRPM2 channels mediate acetaminophen-induced liver damage. Proc Natl Acad Sci U S A. 2014;111:3176-81 pubmed publisher
    ..for Ca(2+) entry in hepatocytes in acetaminophen overdose is the Transient Receptor Potential Melanostatine 2 (TRPM2) cation channel...
  3. Fonfria E, Marshall I, Boyfield I, Skaper S, Hughes J, Owen D, et al. Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. J Neurochem. 2005;95:715-23 pubmed
    ..Melastatin-like transient receptor potential 2 (TRPM2) is a Ca(2+)-permeant non-selective cation channel, which responds to increases in oxidative stress levels in the ..
  4. Iordanov I, Mihályi C, Toth B, CSANADY L. The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity. elife. 2016;5: pubmed publisher
    Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death...
  5. Cook N, Vink R, Helps S, Manavis J, Van Den Heuvel C. Transient receptor potential melastatin 2 expression is increased following experimental traumatic brain injury in rats. J Mol Neurosci. 2010;42:192-9 pubmed publisher
    ..Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel, highly expressed in the brain and immune cells...
  6. Naziroglu M, Ozgül C, Ciğ B, Doğan S, Uğuz A. Glutathione modulates Ca(2+) influx and oxidative toxicity through TRPM2 channel in rat dorsal root ganglion neurons. J Membr Biol. 2011;242:109-18 pubmed publisher
    ..Because the mechanisms that lead to melastatin-like transient receptor potential 2 (TRPM2) channel activation/inhibition in response to glutathione depletion and 2-aminoethyldiphenyl borinate (2-APB) ..
  7. Chung K, Freestone P, Lipski J. Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. J Neurophysiol. 2011;106:2865-75 pubmed publisher
    Transient receptor potential melastatin 2 (TRPM2) channels are sensitive to oxidative stress, and their activation can lead to cell death...
  8. Bari M, Akbar S, Eweida M, Kühn F, Gustafsson A, Lückhoff A, et al. H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels. J Cell Mol Med. 2009;13:3260-7 pubmed publisher
    Type 2 melastatin-related transient receptor potential channel (TRPM2), a member of the melastatin-related TRP (transient receptor potential) subfamily is a Ca(2+)-permeable channel activated by hydrogen peroxide (H(2)O(2))...
  9. Ahn C, Yang H, Hong E, Jeung E. Regulation and localization of transient receptor potential melastatin 2 in rat uterus. Reprod Sci. 2014;21:1288-95 pubmed publisher
    ..transient receptor potential melastatin (TRPM) channels are implicated in nonreproductive tissues, the presence of TRPM2 has been reported in endometrium of uterus...
  10. Takahashi K, Sakamoto K, Kimura J. Hypoxic stress induces transient receptor potential melastatin 2 (TRPM2) channel expression in adult rat cardiac fibroblasts. J Pharmacol Sci. 2012;118:186-97 pubmed
    ..This current was inhibited by clotrimazole, which is an inhibitor of transient receptor potential melastatin 2 (TRPM2) channel and intermediate-conductance Ca(2+)-activated K(+) channel (KCa3.1)...
  11. Yürüker V, Nazıroğlu M, Şenol N. Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels. Metab Brain Dis. 2015;30:223-31 pubmed publisher
    ..Ca(2+) entry induced by traumatic brain injury (TBI) has deleterious effects on human hippocampal function. TRPM2 is a Ca(2+) permeable non-selective channel in hippocampal neurons, and its activation of during oxidative stress ..
  12. Kaneko S, Kawakami S, Hara Y, Wakamori M, Itoh E, Minami T, et al. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. J Pharmacol Sci. 2006;101:66-76 pubmed
    ..We have investigated a link between the H2O2-induced neuronal death and Ca2+-permeable TRPM2 channels regulated by ADP-ribose (ADPR)...
  13. Ishii M, Hagiwara T, Mori Y, Shimizu S. Involvement of TRPM2 and L-type Ca²? channels in Ca²? entry and cell death induced by hydrogen peroxide in rat ?-cell line RIN-5F. J Toxicol Sci. 2014;39:199-209 pubmed
    ..RIN-5F cells express TRPM2, which is a Ca²?-permeable channel activated by H?O?, and voltage-dependent L-type Ca²? channels, both of which ..
  14. Sumoza Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, Fleig A, et al. Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. FASEB J. 2011;25:3529-42 pubmed publisher
    ..Ca(2+) release and store-operated Ca(2+) entry (SOCE), the transient receptor potential melastatin 2 (TRPM2) channel contributes to Ca(2+) release but not Ca(2+) influx in mouse DCs...
  15. Wang H, Pu X, Wang X. Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat. Asian J Androl. 2007;9:634-40 pubmed
    ..Immunohistochemistry staining for TRPM8 and TRPV1 were also performed in rat tissues. TRPM2, TRPM3, TRPM4, TRPM6, TRPM7, TRPM8, TRPV2 and TRPV4 mRNA were detected in all rat prostatic tissues...
  16. Cakir M, Duzova H, Tekin S, Taslidere E, Kaya G, Cigremis Y, et al. ACA, an inhibitor phospholipases A2 and transient receptor potential melastatin-2 channels, attenuates okadaic acid induced neurodegeneration in rats. Life Sci. 2017;176:10-20 pubmed publisher
    In recent studies, it has been shown that the Transient Receptor Potential Melastatin-2 Channels (TRPM2) and Phospholipases A2 (PLA2) inhibitors may have a protective effect on neurons...