Trpc6

Summary

Gene Symbol: Trpc6
Description: transient receptor potential cation channel, subfamily C, member 6
Alias: Trrp6, short transient receptor potential channel 6, transient receptor protein 6
Species: rat
Products:     Trpc6

Top Publications

  1. Fellner S, Arendshorst W. Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange. Am J Physiol Renal Physiol. 2008;294:F212-9 pubmed
    ..Flufenamic acid (FFA; 50 microM), which stimulates TRPC6, caused a sustained increase of [Ca(2+)](i) of 146 nM. This response was unaffected by diltiazem or nifedipine...
  2. Yu Y, Fantozzi I, Remillard C, Landsberg J, Kunichika N, Platoshyn O, et al. Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2004;101:13861-6 pubmed
    ..Normal human PASMC expressed multiple canonical TRP (TRPC) isoforms; TRPC6 was highly expressed and TRPC3 was minimally expressed...
  3. Reiser J, Polu K, Möller C, Kenlan P, Altintas M, Wei C, et al. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet. 2005;37:739-44 pubmed
    ..Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm...
  4. Koitabashi N, Aiba T, Hesketh G, Rowell J, Zhang M, Takimoto E, et al. Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol. 2010;48:713-24 pubmed publisher
    ..activation of Cn/NFAT by calcium entering via transient receptor potential canonical (TRPC) channels (notably TRPC6)...
  5. Nishida M, Watanabe K, Sato Y, Nakaya M, Kitajima N, Ide T, et al. Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition. J Biol Chem. 2010;285:13244-53 pubmed publisher
    ..A canonical transient receptor potential protein subfamily member, TRPC6, which is activated by diacylglycerol and mechanical stretch, works as an upstream regulator of the Ca(2+) ..
  6. Wang J, Yang K, Xu L, Zhang Y, Lai N, Jiang H, et al. Sildenafil inhibits hypoxia-induced transient receptor potential canonical protein expression in pulmonary arterial smooth muscle via cGMP-PKG-PPAR? axis. Am J Respir Cell Mol Biol. 2013;49:231-40 pubmed publisher
    ..Previous results indicated that sildenafil inhibited TRPC1 and TRPC6 expression in rat distal pulmonary arteries (PAs). However, the underlying mechanisms remain unknown...
  7. Onohara N, Nishida M, Inoue R, Kobayashi H, Sumimoto H, Sato Y, et al. TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy. EMBO J. 2006;25:5305-16 pubmed
    ..Among DAG-activating TRPC channels (TRPC3, TRPC6, and TRPC7), the activities of TRPC3 and TRPC6 channels correlated with Ang II-induced NFAT activation and ..
  8. Goel M, Sinkins W, Keightley A, Kinter M, Schilling W. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Pflugers Arch. 2005;451:87-98 pubmed
    ..In the present study, affinity-purified polyclonal antibodies against TRPC5 and TRPC6 were used to immunoprecipitate signalplex components from rat brain lysates...
  9. Soboloff J, Spassova M, Xu W, He L, Cuesta N, Gill D. Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem. 2005;280:39786-94 pubmed
    ..Real time PCR and Western analyses reveal TRPC6 as the only member of the diacylglycerol-responsive TRPC3/6/7 subfamily of channels expressed at significant ..

More Information

Publications84

  1. Wang J, Chen Y, Lin C, Jia J, Tian L, Yang K, et al. Effects of chronic exposure to cigarette smoke on canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2014;306:C364-73 pubmed publisher
    ..than that in 3-mo group), accompanied with increased canonical transient receptor potential 1 (TRPC1) and TRPC6 expression at both mRNA and protein levels in isolated distal PA...
  2. Li X, Lu W, Fu X, Zhang Y, Yang K, Zhong N, et al. BMP4 increases canonical transient receptor potential protein expression by activating p38 MAPK and ERK1/2 signaling pathways in pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol. 2013;49:212-20 pubmed publisher
    ..The induction of TRPC1, TRPC4, and TRPC6 expression, and the increases of [Ca(2+)]i caused by BMP4 in distal PASMCs, were inhibited by treatment with ..
  3. Inoue R, Jensen L, Jian Z, Shi J, Hai L, Lurie A, et al. Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. Circ Res. 2009;104:1399-409 pubmed publisher
    b>TRPC6 is a non-voltage-gated Ca(2+) entry/depolarization channel associated with vascular tone regulation and remodeling...
  4. Sun Y, Li Y, Feng S, Li B, Pan Z, Xu C, et al. Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes. Biochem Biophys Res Commun. 2010;394:955-61 pubmed publisher
    ..Western blot analysis showed that GdCl(3) increased the expression of TRPC6, which was reversed by SKF96365. Additionally, SKF96365 reduced cardiomyocyte apoptosis induced by GdCl(3)...
  5. Heeringa S, Möller C, Du J, Yue L, Hinkes B, Chernin G, et al. A novel TRPC6 mutation that causes childhood FSGS. PLoS ONE. 2009;4:e7771 pubmed publisher
    b>TRPC6, encoding a member of the transient receptor potential (TRP) superfamily of ion channels, is a calcium-permeable cation channel, which mediates capacitive calcium entry into the cell...
  6. Lu W, Ran P, Zhang D, Peng G, Li B, Zhong N, et al. Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. Am J Physiol Cell Physiol. 2010;298:C114-23 pubmed publisher
    ..Ca2+ entry (SOCE); moreover, ex vivo exposure to prolonged hypoxia (4% O2 for 60 h) upregulated TRPC1 and TRPC6 expression in PASMCs...
  7. Graham S, Ding M, Sours Brothers S, Yorio T, Ma J, Ma R. Downregulation of TRPC6 protein expression by high glucose, a possible mechanism for the impaired Ca2+ signaling in glomerular mesangial cells in diabetes. Am J Physiol Renal Physiol. 2007;293:F1381-90 pubmed
    ..Western blots and real-time PCR were used to evaluate the expression level of TRPC6 protein and mRNA, respectively...
  8. Winn M, Conlon P, Lynn K, Farrington M, Creazzo T, Hawkins A, et al. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science. 2005;308:1801-4 pubmed
    ..Here we show that a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6)...
  9. Roshanravan H, Dryer S. ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species. Am J Physiol Renal Physiol. 2014;306:F1088-97 pubmed publisher
    ..b>TRPC6 channels are Ca(2+)-permeable cationic channels that have been implicated in the pathophysiology of podocyte ..
  10. Nijenhuis T, Sloan A, Hoenderop J, Flesche J, van Goor H, Kistler A, et al. Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway. Am J Pathol. 2011;179:1719-32 pubmed publisher
    The transient receptor potential channel C6 (TRPC6) is a slit diaphragm-associated protein in podocytes involved in regulating glomerular filter function...
  11. Tai Y, Feng S, Ge R, Du W, Zhang X, He Z, et al. TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci. 2008;121:2301-7 pubmed publisher
    ..Here, we report that TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth...
  12. Mani B, Brueggemann L, Cribbs L, Byron K. Opposite regulation of KCNQ5 and TRPC6 channels contributes to vasopressin-stimulated calcium spiking responses in A7r5 vascular smooth muscle cells. Cell Calcium. 2009;45:400-11 pubmed publisher
    ..Here we examine the relative contributions of KCNQ5 channels and TRPC6 non-selective cation channels to AVP-stimulated Ca(2+) spiking using patch clamp electrophysiology and fura-2 ..
  13. Wu Q, Sun M, Wu C, Li Y, Du J, Zeng J, et al. Activation of calcium-sensing receptor increases TRPC3/6 expression in T lymphocyte in sepsis. Mol Immunol. 2015;64:18-25 pubmed publisher
    ..imaging and Western blotting, we found that in septic rat peripheral blood T lymphocytes expressions of TRPC3 and TRPC6 proteins are higher...
  14. Thebault S, Zholos A, Enfissi A, Slomianny C, Dewailly E, Roudbaraki M, et al. Receptor-operated Ca2+ entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line. J Cell Physiol. 2005;204:320-8 pubmed
    ..RT-PCR and Western blotting performed on PS1 cells revealed the presence of mRNAs and the corresponding TRPC3 and TRPC6 proteins...
  15. Lin Y, Chen F, Zhang J, Wang T, Wei X, Wu J, et al. Neuroprotective effect of resveratrol on ischemia/reperfusion injury in rats through TRPC6/CREB pathways. J Mol Neurosci. 2013;50:504-13 pubmed publisher
    ..injury and whether resveratrol exerts its neuroprotective effects through inhibition of calpain proteolysis of TRPC6, a transient middle cerebral artery occlusion (MCAO) model was employed in rats...
  16. Boulay G, Zhu X, Peyton M, Jiang M, Hurst R, Stefani E, et al. Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J Biol Chem. 1997;272:29672-80 pubmed
    ..Our data support the hypothesis that mTrp6 encodes an ion channel subunit that mediates Ca2+ entry stimulated by a G-protein coupled receptor, but not Ca2+ entry stimulated by intracellular Ca2+ store depletion. ..
  17. Liu Y, Ji Z. FK506 alleviates proteinuria in rats with adriamycin-induced nephropathy by down-regulating TRPC6 and CaN expression. J Nephrol. 2012;25:918-25 pubmed publisher
    To investigate the roles of transient receptor potential cation channel 6 (TRPC6) and calcineurin (CaN) in proteinuria pathogenesis and the mechanism of action of the calcineurin inhibitor tacrolimus (FK506) in adriamycin-induced ..
  18. Graham S, Gorin Y, Abboud H, Ding M, Lee D, Shi H, et al. Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes. Am J Physiol Cell Physiol. 2011;301:C304-15 pubmed publisher
    ..oxygen species (ROS) and protein kinase C (PKC), in the diabetes-induced canonical transient receptor potential 6 (TRPC6) downregulation...
  19. Bandyopadhyay B, Swaim W, Liu X, Redman R, Patterson R, Ambudkar I. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem. 2005;280:12908-16 pubmed
    ..In contrast, TRPC1 was localized basolaterally, whereas TRPC6 was detected in both locations...
  20. Shen B, Kwan H, Ma X, Wong C, Du J, Huang Y, et al. cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem. 2011;286:19439-45 pubmed publisher
    ..In this study, we investigated the effect of cAMP on canonical TRPC6 (transient receptor potential channel 6) channels in TRPC6-expressing HEK293 cells and glomerular mesangial cells...
  21. Jung S, Strotmann R, Schultz G, Plant T. TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. Am J Physiol Cell Physiol. 2002;282:C347-59 pubmed
    ..Like TRPC6-mediated currents, cation currents in A7r5 cells were increased by flufenamate...
  22. Johansson S, Andersen X, Hansen R, Povlsen G, Edvinsson L. Cerebrovascular endothelin-1 hyper-reactivity is associated with transient receptor potential canonical channels 1 and 6 activation and delayed cerebral hypoperfusion after forebrain ischaemia in rats. Acta Physiol (Oxf). 2015;214:376-89 pubmed publisher
    ..This seems to have an important role in the enhanced cerebral vasoconstriction in the delayed post-ischaemic hypoperfusion phase after experimental forebrain ischaemia. ..
  23. Qu Z, Wang Y, Li X, Wu L, Wang Y. TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors. J Neurochem. 2017;143:282-293 pubmed publisher
    The expression of transient receptor potential canonical 6 (TRPC6) in central nervous system (CNS) is important for neuronal functions and certain neural disorders...
  24. Mita M, Ito K, Taira K, Nakagawa J, Walsh M, Shoji M. Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats. Clin Exp Pharmacol Physiol. 2010;37:670-8 pubmed publisher
    ..4. Expression of TRPC1, TRPC3 and TRPC6 mRNA and protein was found in Wistar rats...
  25. Alessandri Haber N, Dina O, Chen X, Levine J. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci. 2009;29:6217-28 pubmed publisher
    ..TRPC1 and TRPC6, two GsMTx-4-sensitive SACs, are expressed in dorsal root ganglion (DRG) neurons...
  26. Hofmann T, Schaefer M, Schultz G, Gudermann T. Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J. 2000;351:115-22 pubmed
    ..We conclude that TRPC2 may form functional channels in the cellular context of the VNO, but is unlikely to have a physiological function in other tissues. ..
  27. Yuan J, Kiselyov K, Shin D, Chen J, Shcheynikov N, Kang S, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-89 pubmed
    ..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function. ..
  28. Kiso H, Ohba T, Iino K, Sato K, Terata Y, Murakami M, et al. Sildenafil prevents the up-regulation of transient receptor potential canonical channels in the development of cardiomyocyte hypertrophy. Biochem Biophys Res Commun. 2013;436:514-8 pubmed publisher
    ..Sildenafil inhibits TRPC6 activation and expression, leading to the prevention of cardiac hypertrophy...
  29. Kim D, Ryu H, Kim J, Kang T. The reverse roles of transient receptor potential canonical channel-3 and -6 in neuronal death following pilocarpine-induced status epilepticus. Cell Mol Neurobiol. 2013;33:99-109 pubmed publisher
    ..Therefore, the present study was designated to elucidate the roles of TRPC3 and TRPC6 in neuronal death following SE...
  30. Zulian A, Baryshnikov S, Linde C, Hamlyn J, Ferrari P, Golovina V. Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats. Am J Physiol Heart Circ Physiol. 2010;299:H624-33 pubmed publisher
    ..This correlated with a threefold upregulation of transient receptor potential canonical 6 (TRPC6) protein...
  31. Yun X, Chen Y, Yang K, Wang S, Lu W, Wang J. Upregulation of canonical transient receptor potential channel in the pulmonary arterial smooth muscle of a chronic thromboembolic pulmonary hypertension rat model. Hypertens Res. 2015;38:821-8 pubmed publisher
    ..The expression of the canonical transient receptor potential channel 1 (TRPC1) and TRPC6 was determined by western blotting and real-time quantitative PCR in isolated distal pulmonary arteries (PA)...
  32. Du W, Huang J, Yao H, Zhou K, Duan B, Wang Y. Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats. J Clin Invest. 2010;120:3480-92 pubmed publisher
    ..Here, we report that suppression of proteolytic degradation of transient receptor potential canonical 6 (TRPC6) prevented ischemic neuronal cell death in a rat model of stroke...
  33. Li M, Zacharia J, Sun X, Wier W. Effects of siRNA knock-down of TRPC6 and InsP(3)R1 in vasopressin-induced Ca(2+) oscillations of A7r5 vascular smooth muscle cells. Pharmacol Res. 2008;58:308-15 pubmed publisher
    ..the roles of Type 1 inositol tris-phosphate receptors (InsP(3)R1) and transient receptor potential channel 6 (TRPC6) in Ca(2+) oscillations induced by arginine vasopressin (AVP), a typical G-protein coupled receptor agonist...
  34. Nagy G, Botond G, Borhegyi Z, Plummer N, Freund T, Hájos N. DAG-sensitive and Ca(2+) permeable TRPC6 channels are expressed in dentate granule cells and interneurons in the hippocampal formation. Hippocampus. 2013;23:221-32 pubmed publisher
    ..In this study, we investigated the localization of TRPC6 channels in the adult hippocampal formation...
  35. Li H, Huang J, Du W, Jia C, Yao H, Wang Y. TRPC6 inhibited NMDA receptor activities and protected neurons from ischemic excitotoxicity. J Neurochem. 2012;123:1010-8 pubmed publisher
    ..However, the mechanisms by which TRPC6 protects neurons are largely unknown...
  36. Liu Y, Liu C, Qin X, Zhu M, Yang Z. The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6. Behav Brain Res. 2015;294:186-93 pubmed publisher
    ..in a rat depression model along with down-regulated expression of canonical transient receptor potential 6 (TRPC6) protein. The cognitive defect could be rescued by treatment with hyperforin, which can invoke TRPC6 activation...
  37. Chu W, Wan L, Zhao D, Qu X, Cai F, Huo R, et al. Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1?-mediated TRPC signalling. J Cell Mol Med. 2012;16:2022-34 pubmed publisher
    ..Transient receptor potential canonical (TRPC) channels including TRPC3 and TRPC6, except for TRPC1, were increased, and Ca(2+)-calcineurin signals were also enhanced in a time-dependent manner ..
  38. Ichikawa J, Inoue R. TRPC6 regulates cell cycle progression by modulating membrane potential in bone marrow stromal cells. Br J Pharmacol. 2014;171:5280-94 pubmed publisher
    ..In contrast, TRPC6 expression decreased in the S phase and increased in the G1 phase...
  39. Park S, Lee S, Park E, Kang M, So I, Jeon J, et al. TGF?1 induces stress fiber formation through upregulation of TRPC6 in vascular smooth muscle cells. Biochem Biophys Res Commun. 2017;483:129-134 pubmed publisher
    ..On the other hand, deregulated transient receptor potential canonical 6 (TRPC6) channel expression shows impaired vascular physiology and wound healing...
  40. Pulina M, Zulian A, Baryshnikov S, Linde C, Karashima E, Hamlyn J, et al. Cross talk between plasma membrane Na(+)/Ca (2+) exchanger-1 and TRPC/Orai-containing channels: key players in arterial hypertension. Adv Exp Med Biol. 2013;961:365-74 pubmed publisher
    ..They thus influence vascular resistance and blood pressure (BP). For instance, upregulation of NCX1 and TRPC6 has been implicated in the pathogenesis of high BP in several models of essential hypertension...
  41. Chen R, Sun G, Ye J, Wang J, Zhang M, Sun X. Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca2+ overload in rat cardiomyocytes. Toxicol Lett. 2017;276:21-30 pubmed publisher
    ..receptor potential canonical (TRPC) channels, as characterized by inhibiting the expression of TRPC 3 and TRPC6. These results indicate that Sal B protects against DOX-induced cardiac apoptosis and ER stress via TRPC3 and ..
  42. Graham S, Ding M, Ding Y, Sours Brothers S, Luchowski R, Gryczynski Z, et al. Canonical transient receptor potential 6 (TRPC6), a redox-regulated cation channel. J Biol Chem. 2010;285:23466-76 pubmed publisher
    This study examined the effect of H(2)O(2) on the TRPC6 channel and its underlying mechanisms using a TRPC6 heterologous expression system...
  43. Zhang X, Song Z, Guo Y, Zhou M. The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats. Mol Cell Biochem. 2015;399:155-65 pubmed publisher
    ..Over expression of TRPC6 on the podocytes has been revealed to cause podocyte injury in non-diabetic states...
  44. Zhang M, Liu X, Yang N, Lin M. [TRPC6 mediates the enhancements of pulmonary arterial tone and intracellular Ca2+ concentration of pulmonary arterial smooth muscle cells in pulmonary hypertension rats]. Sheng Li Xue Bao. 2010;62:55-62 pubmed
    ..Recent studies show that canonical transient receptor potential channel 6 (TRPC6) genes, which encode receptor-operated cation channels (ROCC) in PASMCs, play an important role in Ca2+ regulation ..
  45. Selli C, Erac Y, Kosova B, Tosun M. Post-transcriptional silencing of TRPC1 ion channel gene by RNA interference upregulates TRPC6 expression and store-operated Ca2+ entry in A7r5 vascular smooth muscle cells. Vascul Pharmacol. 2009;51:96-100 pubmed publisher
    ..In siTRPC1-transfected cells, TRPC1 mRNA and protein levels were decreased by 40% and 64%; however, those of TRPC6 were drastically increased by 100% and 200%, respectively...
  46. Sonneveld R, Ferrè S, Hoenderop J, Dijkman H, Berden J, Bindels R, et al. Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease. Am J Pathol. 2013;182:1196-204 pubmed publisher
    The transient receptor potential cation channel C6 (TRPC6) is a slit diaphragm protein expressed by podocytes. TRPC6 gain-of-function mutations cause autosomal dominant focal segmental glomerulosclerosis...
  47. Giampà C, DeMarch Z, Patassini S, Bernardi G, Fusco F. Immunohistochemical localization of TRPC6 in the rat substantia nigra. Neurosci Lett. 2007;424:170-4 pubmed
    ..In this study, we examined the distribution of one particular member of TRPC superfamily, namely, TRPC6, in the substantia nigra of normal rat brain...
  48. Carrasquillo R, Tian D, Krishna S, Pollak M, Greka A, Schlondorff J. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol. 2012;13:33 pubmed publisher
    ..The canonical transient receptor potential 6 (TRPC6) has been implicated in several pathological processes, including focal segmental glomerulosclerosis (FSGS), ..
  49. Lemos V, Poburko D, Liao C, Cole W, van Breemen C. Na+ entry via TRPC6 causes Ca2+ entry via NCX reversal in ATP stimulated smooth muscle cells. Biochem Biophys Res Commun. 2007;352:130-4 pubmed
    ..In this communication we present evidence for similar functional coupling of NCX to endogenously expressed TRPC6 in rat aorta smooth muscle cells...
  50. Hu H, Gu Q, Wang C, Colton C, Tang J, Kinoshita Kawada M, et al. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem. 2004;279:35741-8 pubmed
    ..In contrast, 2APB inhibits the activity of TRPC6 and TRPM8 evoked by 1-oleolyl-2-acetyl-sn-glycerol and menthol, respectively...
  51. Huang W, Young J, Glitsch M. Changes in TRPC channel expression during postnatal development of cerebellar neurons. Cell Calcium. 2007;42:1-10 pubmed
    ..TRPC3 expression is significantly up-regulated whereas TRPC4 and TRPC6 expression are significantly down-regulated over this period of time...
  52. Liu X, Zhang T, Xia W, Wang Y, Ma K. Recombinant human erythropoietin pretreatment alleviates renal glomerular injury induced by cardiopulmonary bypass by reducing transient receptor potential channel 6-nuclear factor of activated T-cells pathway activation. J Thorac Cardiovasc Surg. 2013;146:681-7 pubmed publisher
    ..Ultra-organization of glomeruli was observed. Glomerular transient receptor potential channel 6 (TRPC6) expression was studied by immunofluorescence and Western blot...
  53. Obeidová L, Reiterova J, Lnenicka P, Stekrova J, Safránková H, Kohoutova M, et al. TRPC6 gene variants in Czech adult patients with focal segmental glomerulosclerosis and minimal change disease. Folia Biol (Praha). 2012;58:173-6 pubmed
    ..it was found that one of the proteins present in this complex was non-selective cation channel TRPC6. The aim of this work was to screen mutations and polymorphisms of the TRPC6 gene in a group ..
  54. Wang X, Teng L, Li A, Ge J, Laties A, Zhang X. TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. Invest Ophthalmol Vis Sci. 2010;51:5751-8 pubmed publisher
    To examine the potential role of transient receptor potential canonical 6 (TRPC6) in the survival of retinal ganglion cells (RGCs) in the rat retinal ischemia/reperfusion (IR) model...
  55. Fortin D, Srivastava T, Dwarakanath D, Pierre P, Nygaard S, Derkach V, et al. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci. 2012;32:8127-37 pubmed publisher
    ..Using siRNA we confirmed the involvement of TRPC5 and TRPC6 subunits in BDNF-induced AKT(T308) phosphorylation...
  56. Du Y, Fu J, Yao L, Qiao L, Liu N, Xing Y, et al. Altered expression of PPAR‑γ and TRPC in neonatal rats with persistent pulmonary hypertension. Mol Med Rep. 2017;16:1117-1124 pubmed publisher
    ..with elevated expressions of transient receptor potential cation channel, subfamily C, member 1 (TRPC1) and TRPC6 contributes to the PASMC proliferation and excessive pulmonary vascular remodeling in adult pulmonary hypertension ..
  57. He Z, Jia C, Feng S, Zhou K, Tai Y, Bai X, et al. TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKII? in rat hippocampal neurons. J Neurosci. 2012;32:9383-95 pubmed publisher
    ..cation conductance and PLC?-dependent [Ca(2+)](i) elevation, which were both blocked when TRPC5, but not TRPC6 channels, were inhibited...
  58. Zhang L, Saffen D. Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel isoforms. Molecular structures and functional characterization. J Biol Chem. 2001;276:13331-9 pubmed
  59. Shin H, Hong Y, Jang S, Chae H, Paek S, Moon H, et al. A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. PLoS ONE. 2010;5:e10359 pubmed publisher
    ..Among TRPC subtypes (TRPC1-7), marked expression of TRPC5 and TRPC6 with turned-off TRPC1 expression was observed in neuronal cells differentiated from proliferating A2B5(+) NPCs...
  60. Hofstra J, Lainez S, van Kuijk W, Schoots J, Baltissen M, Hoefsloot L, et al. New TRPC6 gain-of-function mutation in a non-consanguineous Dutch family with late-onset focal segmental glomerulosclerosis. Nephrol Dial Transplant. 2013;28:1830-8 pubmed publisher
    ..structural podocyte proteins, including the slit diaphragm-associated transient receptor potential channel C6 (TRPC6)...
  61. Xie J, Cha S, An S, Kuro O M, Birnbaumer L, Huang C. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun. 2012;3:1238 pubmed publisher
    ..Cardioprotection by Klotho in normal mice is mediated by downregulation of TRPC6 channels in the heart...
  62. Luan J, Li W, Han J, Zhang W, Gong H, Ma R. Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats. J Pharmacol Sci. 2012;119:167-76 pubmed
    ..The mRNA expression of canonical transient receptor potential 6 (TRPC6), transforming growth factor (TGF)-?1, and type IV collagen (Col IV) were examined...
  63. Nishida M, Onohara N, Sato Y, Suda R, Ogushi M, Tanabe S, et al. Galpha12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation. J Biol Chem. 2007;282:23117-28 pubmed
    ..Here, we demonstrate that Galpha(12/13)-mediated up-regulation of canonical transient receptor potential 6 (TRPC6) channels participates in sustained Ca(2+) influx and NFAT activation by endothelin (ET)-1 treatment...
  64. Suzuki F, Morishima S, Tanaka T, Muramatsu I. Snapin, a new regulator of receptor signaling, augments alpha1A-adrenoceptor-operated calcium influx through TRPC6. J Biol Chem. 2007;282:29563-73 pubmed
    ..Snapin co-immunoprecipitated with TRPC6 and alpha(1A)-AR, and these interactions were augmented upon alpha(1A)-AR activation, increasing the recruitment ..
  65. Kim Y, Kang T. The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus. Neuroscience. 2015;307:215-30 pubmed publisher
    Transient receptor potential canonical channel-6 (TRPC6) forms Ca(2+)-permeable non-selective cation channels in neurons...
  66. Wang Q, Leo M, Narayanan D, Kuruvilla K, Jaggar J. Local coupling of TRPC6 to ANO1/TMEM16A channels in smooth muscle cells amplifies vasoconstriction in cerebral arteries. Am J Physiol Cell Physiol. 2016;310:C1001-9 pubmed publisher
    ..and immunofluorescence resonance energy transfer microscopy experiments indicate that ANO1 and canonical TRP 6 (TRPC6) channels are present in the same macromolecular complex and localize in close spatial proximity in the myocyte ..
  67. Anderson M, Roshanravan H, Khine J, Dryer S. Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. J Cell Physiol. 2014;229:434-42 pubmed publisher
    ..Canonical transient receptor potential-6 (TRPC6) channels stimulate Ca(2+) influx in podocytes, and have been implicated in glomerular disease...
  68. Ma R, Liu L, Jiang W, Yu Y, Song H. FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression. Int J Clin Exp Pathol. 2015;8:14063-74 pubmed
    ..The expressions of the canonical transient receptor potential 6 (TRPC6), nuclear factor of activated T-cells (NFAT) and nephrin were detected by Western blotting and qPCR...
  69. Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, et al. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Cell. 1996;85:661-71 pubmed
    ..This identifies mammalian gene products that participate in CCE. We propose that trp homologs are subunits of CCE channels, not unlike those of classical voltage-gated ion channels. ..
  70. Shirakawa H, Katsumoto R, Iida S, Miyake T, Higuchi T, Nagashima T, et al. Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes. Glia. 2017;65:1005-1016 pubmed publisher
    ..inhibition of Ca2+ mobilization, MAPK pathway inhibitors, or knockdown of the TRPC channel isoform TRPC6. Taken together, these results demonstrate that S1P induces Ca2+ signaling in astrocytes via Gq
  71. Erac Y, Selli C, Kosova B, Akcali K, Tosun M. Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta: implications for age-related vasospastic disorders. Age (Dordr). 2010;32:223-30 pubmed publisher
    ..Therefore, the purpose of this study was to explore whether TRPC6 is also upregulated in aging rat aorta comparable to that of TRPC1 in longitudinal in vivo aging model...
  72. Jiang Q, Fu X, Tian L, Chen Y, Yang K, Chen X, et al. NOX4 mediates BMP4-induced upregulation of TRPC1 and 6 protein expressions in distal pulmonary arterial smooth muscle cells. PLoS ONE. 2014;9:e107135 pubmed publisher
    ..These results suggest that BMP4 may increase ROS level, enhance TRPC1 and 6 expression and proliferation by up-regulating NOX4 expression in PASMCs. ..
  73. Welsh D, Morielli A, Nelson M, Brayden J. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circ Res. 2002;90:248-50 pubmed
    ..In the present study, we provide evidence that a transient receptor potential channel (TRPC6) homologue has a major role in this depolarizing response to pressure...
  74. Sonneveld R, van der Vlag J, Baltissen M, Verkaart S, Wetzels J, Berden J, et al. Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner. Am J Pathol. 2014;184:1715-26 pubmed publisher
    ..Gain-of-function mutations in TRPC6, a slit diaphragm-associated ion channel, cause glomerulosclerosis; TRPC6 expression is increased in acquired ..
  75. Goel M, Sinkins W, Zuo C, Hopfer U, Schilling W. Vasopressin-induced membrane trafficking of TRPC3 and AQP2 channels in cells of the rat renal collecting duct. Am J Physiol Renal Physiol. 2007;293:F1476-88 pubmed
    The canonical transient receptor potential channels TRPC3 and TRPC6 are abundantly expressed along with the water channel aquaporin-2 (AQP2) in principal cells of the cortical and medullary collecting duct...