Gene Symbol: Trpc4
Description: transient receptor potential cation channel, subfamily C, member 4
Alias: Trp4, Trrp4, short transient receptor potential channel 4, CCE1, capacitative calcium entry channel 1, transient receptor potential channel 4, transient receptor potential protein 4
Species: rat
Products:     Trpc4

Top Publications

  1. Strübing C, Krapivinsky G, Krapivinsky L, Clapham D. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 2001;29:645-55 pubmed
    ..In contrast to the more common view of the TRP family as comprising store-operated channels, we propose that many TRPC heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain. ..
  2. Wu D, Huang W, Richardson P, Priestley J, Liu M. TRPC4 in rat dorsal root ganglion neurons is increased after nerve injury and is necessary for neurite outgrowth. J Biol Chem. 2008;283:416-26 pubmed
    ..profile of TRPC channels in adult rat dorsal root ganglia (DRG) after nerve injury and examined the role of TRPC4 in neurite outgrowth in cultured DRG neurons...
  3. Nedungadi T, Cunningham J. Differential regulation of TRPC4 in the vasopressin magnocellular system by water deprivation and hepatic cirrhosis in the rat. Am J Physiol Regul Integr Comp Physiol. 2014;306:R304-14 pubmed publisher
    Transient receptor potential canonical subtype 4 (TRPC4) is expressed in the magnocellular paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus...
  4. Yuan J, Kiselyov K, Shin D, Chen J, Shcheynikov N, Kang S, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-89 pubmed
    ..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function. ..
  5. Hofmann T, Schaefer M, Schultz G, Gudermann T. Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J. 2000;351:115-22 pubmed
    ..We conclude that TRPC2 may form functional channels in the cellular context of the VNO, but is unlikely to have a physiological function in other tissues. ..
  6. Miehe S, Bieberstein A, Arnould I, Ihdene O, Rütten H, Strübing C. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. J Biol Chem. 2010;285:12426-34 pubmed publisher
    b>TRPC4 and TRPC5 are two closely related members of the mammalian transient receptor potential cation channel family that have been implicated in important physiological functions, such as growth cone guidance and smooth muscle ..
  7. Graziani A, Poteser M, Heupel W, Schleifer H, Krenn M, Drenckhahn D, et al. Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. J Biol Chem. 2010;285:4213-23 pubmed publisher
    b>TRPC4 is well recognized as a prominent cation channel in the vascular endothelium, but its contribution to agonist-induced endothelial Ca(2+) entry is still a matter of controversy...
  8. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, et al. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem. 2000;275:37559-64 pubmed
    ..Here we show that murine Trp4 and Trp5, as well as phospholipase C beta1 and beta2 interact with the first PDZ domain of NHERF, regulatory factor ..
  9. Satoh E, Ono K, Xu F, Iijima T. Cloning and functional expression of a novel splice variant of rat TRPC4. Circ J. 2002;66:954-8 pubmed
    b>Transient receptor potential protein 4 (TRPC4) has been identified as a candidate for the capacitative calcium entry (CCE) channels, but its functional role is still controversial...

More Information


  1. Munsch T, Freichel M, Flockerzi V, Pape H. Contribution of transient receptor potential channels to the control of GABA release from dendrites. Proc Natl Acad Sci U S A. 2003;100:16065-70 pubmed
    ..channels in the plasma membrane but that is critically dependent on the transient receptor potential (TRP) protein TRPC4. These data ascribe a functional role of agonist-activated TRP channels to the release of transmitters from ..
  2. Fowler M, Sidiropoulou K, Ozkan E, Phillips C, Cooper D. Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS ONE. 2007;2:e573 pubmed
    ..Quantitative real-time PCR of the seven TRPC channels in the rodent brain revealed that TRPC4 and TRPC5 channels were the predominant TRPC subtypes in the adult rat brain...
  3. Sabourin J, Bartoli F, Antigny F, Gomez A, Benitah J. Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem. 2016;291:13394-409 pubmed publisher
    ..Our study provides the first evidence that aldosterone promotes TRPC1-, -C4-, -C5-, and Orai1-mediated SOCE in cardiomyocytes through an MR and serum- and glucocorticoid-regulated kinase 1 pathway. ..
  4. Alzoubi A, Almalouf P, Toba M, O Neill K, Qian X, Francis M, et al. TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension. Am J Pathol. 2013;183:1779-1788 pubmed publisher
    ..b>TRPC4 is a ubiquitously expressed store-operated calcium entry channel, but its role in PAH is unknown...
  5. Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh S, et al. Conserved gating elements in TRPC4 and TRPC5 channels. J Biol Chem. 2013;288:19471-83 pubmed publisher
    b>TRPC4 and TRPC5 proteins share 65% amino acid sequence identity and form Ca(2+)-permeable nonselective cation channels. They are activated by stimulation of receptors coupled to the phosphoinositide signaling cascade...
  6. Huang W, Young J, Glitsch M. Changes in TRPC channel expression during postnatal development of cerebellar neurons. Cell Calcium. 2007;42:1-10 pubmed
    ..TRPC3 expression is significantly up-regulated whereas TRPC4 and TRPC6 expression are significantly down-regulated over this period of time...
  7. Schaefer M, Plant T, Stresow N, Albrecht N, Schultz G. Functional differences between TRPC4 splice variants. J Biol Chem. 2002;277:3752-9 pubmed
    Functional characterizations of heterologously expressed TRPC4 have revealed diverse regulatory mechanisms and permeation properties...
  8. Lindsey S, Tribe R, Songu Mize E. Cyclic stretch decreases TRPC4 protein and capacitative calcium entry in rat vascular smooth muscle cells. Life Sci. 2008;83:29-34 pubmed publisher
    We investigated whether cyclic stretch affects TRPC4 or TRPC6 expression and calcium mobilization in cultured vascular smooth muscle cells...
  9. Murata T, Lin M, Stan R, Bauer P, Yu J, Sessa W. Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. J Biol Chem. 2007;282:16631-43 pubmed
    ..Thus, Cav-1 is required for calcium entry in vascular endothelial cells and perhaps other specialized cell types containing caveolae. ..
  10. Cioffi D, Wu S, Alexeyev M, Goodman S, Zhu M, Stevens T. Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4. Circ Res. 2005;97:1164-72 pubmed is a Ca2+-selective SOC entry channel to which the transient receptor potential (TRP) proteins TRPC1 and TRPC4 contribute subunits...
  11. Cooley N, Grubb D, Luo J, Woodcock E. The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4? is critical for its contribution to cardiomyocyte hypertrophy. Mol Pharmacol. 2014;86:399-405 pubmed publisher
    ..b>TrpC4 exists as two splice variants (TrpC4? and TrpC4?) that differ only in an 84-residue sequence that binds to ..
  12. Westlund K, Zhang L, Ma F, Nesemeier R, Ruiz J, Ostertag E, et al. A rat knockout model implicates TRPC4 in visceral pain sensation. Neuroscience. 2014;262:165-75 pubmed publisher
    ..This study focuses on the transient receptor potential canonical subfamily 4 (TRPC4) ion channel, which is involved in the tissue-specific and stimulus-dependent regulation of intracellular Ca²? ..
  13. Boudes M, Uvin P, Pinto S, Freichel M, Birnbaumer L, Voets T, et al. Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity. PLoS ONE. 2013;8:e69550 pubmed publisher
    ..Repeated cyclophosphamide injections induce a specific increase in the expression of TRPC1 and TRPC4 in bladder-innervating sensory neurons and the sprouting of sensory fibers in the bladder mucosa...
  14. Funayama M, Goto K, Kondo H. Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel. Brain Res Mol Brain Res. 1996;43:259-66 pubmed
    ..This limited spatiotemporal expression of this novel molecule. TRP-R, suggests that it is involved in some specific functions related to the neuronal differentiation. ..
  15. Wang X, Pluznick J, Wei P, Padanilam B, Sansom S. TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells. Am J Physiol Cell Physiol. 2004;287:C357-64 pubmed
    ..Using TRPC-specific primers and RT-PCR, we found that cultured MMC contained mRNA for TRPC1 and TRPC4 but not for TRPC2, TRPC3, TRPC5, TRPC6, and TRPC7...
  16. Lindsey S, Songu Mize E. Stretch-induced TRPC4 downregulation is accompanied by reduced capacitative Ca2+ entry in WKY but not SHR mesenteric smooth muscle cells. Clin Exp Hypertens. 2010;32:288-92 pubmed publisher
    Our previous work showed that a 6-hour cyclic stretch significantly decreases TRPC4 protein expression and capacitative Ca(2+) entry in vascular smooth muscle cells from Sprague-Dawley rats...
  17. Torihashi S, Fujimoto T, Trost C, Nakayama S. Calcium oscillation linked to pacemaking of interstitial cells of Cajal: requirement of calcium influx and localization of TRP4 in caveolae. J Biol Chem. 2002;277:19191-7 pubmed
    ..We further demonstrated the presence of transient receptor potential-like channel 4 (TRP4) in caveolae of ICC...
  18. Klipec W, Burrow K, O Neill C, Cao J, Lawyer C, Ostertag E, et al. Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards. Behav Brain Res. 2016;306:117-27 pubmed publisher
    Among the canonical transient receptor potential (TRPC) channels, the TRPC4 non-selective cation channel is one of the most abundantly expressed subtypes within mammalian corticolimbic brain regions, but its functional and behavioral ..
  19. Cioffi D, Wu S, Chen H, Alexeyev M, St Croix C, Pitt B, et al. Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Circ Res. 2012;110:1435-44 pubmed publisher
    Canonical transient receptor potential 4 (TRPC4) contributes to the molecular composition of a channel encoding for a calcium selective store-operated current, I(SOC), whereas Orai1 critically comprises a channel encoding for the highly ..
  20. Li X, Lu W, Fu X, Zhang Y, Yang K, Zhong N, et al. BMP4 increases canonical transient receptor potential protein expression by activating p38 MAPK and ERK1/2 signaling pathways in pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol. 2013;49:212-20 pubmed publisher
    ..The induction of TRPC1, TRPC4, and TRPC6 expression, and the increases of [Ca(2+)]i caused by BMP4 in distal PASMCs, were inhibited by treatment ..
  21. Li W, Ehrich M. Transient alterations of the blood-brain barrier tight junction and receptor potential channel gene expression by chlorpyrifos. J Appl Toxicol. 2013;33:1187-91 pubmed publisher
    ..proteins claudin5, scaffold proteins zona occludens (ZO1) and transient receptor potential (canonical) channels (TRPC4). Gene expression decreased 2?h after exposure to CPF, especially TRPC4, but the effects were reversed 12?h later...
  22. Francis M, Xu N, Zhou C, Stevens T. Transient Receptor Potential Channel 4 Encodes a Vascular Permeability Defect and High-Frequency Ca(2+) Transients in Severe Pulmonary Arterial Hypertension. Am J Pathol. 2016;186:1701-9 pubmed publisher
    The canonical transient receptor potential channel 4 (TRPC4) comprises an endothelial store-operated Ca(2+) entry channel, and TRPC4 inactivation confers a survival benefit in pulmonary arterial hypertension (PAH)...
  23. Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
    ..Oligodendrocytic differentiation feedback loops may therefore yield pharmacological targets to treat disease related to dysfunctional myelin deposition. ..