Trpa1

Summary

Gene Symbol: Trpa1
Description: transient receptor potential cation channel, subfamily A, member 1
Alias: Anktm1, transient receptor potential cation channel subfamily A member 1, ankyrin-like with transmembrane domains protein 1
Species: rat
Products:     Trpa1

Top Publications

  1. Eid S, Crown E, Moore E, Liang H, Choong K, Dima S, et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain. 2008;4:48 pubmed publisher
    ..The recent discovery and description of the transient receptor potential family of receptors including TRPV1 and TRPA1 has provided a number of potential new therapeutic targets for treating chronic pain...
  2. Salas M, Hargreaves K, Akopian A. TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci. 2009;29:1568-78 pubmed publisher
    ..Previous studies have characterized the properties of TRPA1 in heterologous expression systems...
  3. Obata K, Katsura H, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, et al. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest. 2005;115:2393-401 pubmed
    ..Here we report that the pharmacological blockade of TRPA1 in primary sensory neurons reversed cold hyperalgesia caused by inflammation and nerve injury...
  4. Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, et al. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol. 2005;493:596-606 pubmed
    ..Recently, two other members of this superfamily, TRPA1 and TRPM8, have been cloned and characterized as possible candidates for cold transducers in primary afferent ..
  5. Trevisan G, Hoffmeister C, Rossato M, Oliveira S, Silva M, Silva C, et al. TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout. Free Radic Biol Med. 2014;72:200-9 pubmed publisher
    ..The transient potential receptor ankyrin 1 (TRPA1) is expressed by a subpopulation of peptidergic nociceptors and, via its activation by endogenous reactive oxygen ..
  6. Sawada Y, Hosokawa H, Hori A, Matsumura K, Kobayashi S. Cold sensitivity of recombinant TRPA1 channels. Brain Res. 2007;1160:39-46 pubmed
    TRPM8 and TRPA1, members of the transient receptor potential (TRP) channel family, are candidates for cooling-activated receptors...
  7. Frederick J, Buck M, Matson D, Cortright D. Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury. Biochem Biophys Res Commun. 2007;358:1058-64 pubmed
    ..We developed a multiplex ribonuclease protection assay (RPA) to quantify rat TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, and TRPM8 RNA levels in DRG...
  8. Ji G, Zhou S, Carlton S. Intact Adelta-fibers up-regulate transient receptor potential A1 and contribute to cold hypersensitivity in neuropathic rats. Neuroscience. 2008;154:1054-66 pubmed publisher
    ..Recent data indicate both transient receptor potential (TRP) M8 and TRPA1 play a role. In relation to TRPA1, there are reported increases in mRNA...
  9. Caspani O, Zurborg S, Labuz D, Heppenstall P. The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain. PLoS ONE. 2009;4:e7383 pubmed publisher
    ..Recently the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been identified and proposed to be molecular sensors for cold...

More Information

Publications85

  1. Katsura H, Obata K, Mizushima T, Yamanaka H, Kobayashi K, Dai Y, et al. Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol. 2006;200:112-23 pubmed
    ..In the present study, we precisely examined the incidence of cold hyperalgesia and the changes of TRPA1 and TRPM8 expression in the L4 and L5 DRG following L5 spinal nerve ligation (SNL), because it is likely that the ..
  2. Akopian A, Ruparel N, Jeske N, Hargreaves K. Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol. 2007;583:175-93 pubmed
    ..The TRPA1 channel plays a key role in the processing of noxious information and can undergo functional desensitization by ..
  3. Jordt S, Bautista D, Chuang H, McKemy D, Zygmunt P, Hogestatt E, et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature. 2004;427:260-5 pubmed
    ..Both allyl isothiocyanate and THC mediate their excitatory effects by activating ANKTM1, a member of the TRP ion channel family recently implicated in the detection of noxious cold...
  4. Salazar H, Llorente I, Jara Oseguera A, García Villegas R, Munari M, Gordon S, et al. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci. 2008;11:255-61 pubmed publisher
    ..Although it is well known that TRPA1 channels are activated by pungent compounds found in garlic, onion, mustard and cinnamon extracts, activation of ..
  5. Wang Y, Chang R, Liman E. TRPA1 is a component of the nociceptive response to CO2. J Neurosci. 2010;30:12958-63 pubmed publisher
    ..Here we show that CO(2) specifically activates a subpopulation of trigeminal neurons that express TRPA1, a mustard oil- and cinnamaldehyde-sensitive channel, and that these responses are dependent on a functional TRPA1 ..
  6. Story G, Peier A, Reeve A, Eid S, Mosbacher J, Hricik T, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:819-29 pubmed
    ..Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8...
  7. Raisinghani M, Zhong L, Jeffry J, Bishnoi M, Pabbidi R, Pimentel F, et al. Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception. Am J Physiol Cell Physiol. 2011;301:C587-600 pubmed publisher
    Transient receptor potential (TRP) ankyrin 1 (TRPA1) is a Ca(2+)-permeant, nonselective cationic channel...
  8. Nagata K, Duggan A, Kumar G, Garcia Anoveros J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci. 2005;25:4052-61 pubmed
    Mechanosensory channels of sensory cells mediate the sensations of hearing, touch, and some forms of pain. The TRPA1 (a member of the TRP family of ion channel proteins) channel is activated by pain-producing chemicals, and its ..
  9. Peterlin Z, Chesler A, Firestein S. A painful trp can be a bonding experience. Neuron. 2007;53:635-8 pubmed
    The receptive field of the TRPA1 nociceptor is remarkably expansive when compared to other chemodetectors such as odorant receptors...
  10. Dai Y, Wang S, Tominaga M, Yamamoto S, Fukuoka T, Higashi T, et al. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest. 2007;117:1979-87 pubmed
    ..Transient receptor potential A1 (TRPA1) is an excitatory ion channel on primary sensory nerves of pain pathway...
  11. Nozawa K, Kawabata Shoda E, Doihara H, Kojima R, Okada H, Mochizuki S, et al. TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proc Natl Acad Sci U S A. 2009;106:3408-13 pubmed publisher
    ..Here, we demonstrate that the transient receptor potential (TRP) cation channel TRPA1, which is activated by pungent compounds or cold temperature, is highly expressed in EC cells...
  12. Kim Y, Son J, Kim T, Paik S, Dai Y, Noguchi K, et al. Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn. J Comp Neurol. 2010;518:687-98 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1), responding to noxious cold and pungent compounds, is implicated in the mediation of nociception, but little is known about the processing of the TRPA1-mediated nociceptive information ..
  13. Chen J, Zhang X, Kort M, Huth J, Sun C, Miesbauer L, et al. Molecular determinants of species-specific activation or blockade of TRPA1 channels. J Neurosci. 2008;28:5063-71 pubmed publisher
    b>TRPA1 is an excitatory, nonselective cation channel implicated in somatosensory function, pain, and neurogenic inflammation...
  14. Del Camino D, Murphy S, Heiry M, Barrett L, Earley T, Cook C, et al. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010;30:15165-74 pubmed publisher
    b>TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial...
  15. Bianchi B, Zhang X, Reilly R, Kym P, Yao B, Chen J. Species comparison and pharmacological characterization of human, monkey, rat, and mouse TRPA1 channels. J Pharmacol Exp Ther. 2012;341:360-8 pubmed publisher
    The transient receptor potential ankyrin-1 (TRPA1) channel has emerged as an attractive target for development of analgesic and anti-inflammatory drugs...
  16. Cao D, Zhong L, Hsieh T, Abooj M, Bishnoi M, Hughes L, et al. Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells. PLoS ONE. 2012;7:e38005 pubmed publisher
    ..Here, we demonstrate the expression of the transient receptor potential ankyrin 1 (TRPA1) ion channel in the pancreatic beta cells and its role in insulin release...
  17. Kwan K, Allchorne A, Vollrath M, Christensen A, Zhang D, Woolf C, et al. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006;50:277-89 pubmed
    b>TRPA1, a member of the transient receptor potential (TRP) family of ion channels, is expressed by dorsal root ganglion neurons and by cells of the inner ear, where it has proposed roles in sensing sound, painful cold, and irritating ..
  18. Corey D, Garcia Anoveros J, Holt J, Kwan K, Lin S, Vollrath M, et al. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 2004;432:723-30 pubmed
    ..we investigate TRP (transient receptor potential) ion channels as candidates and find one, TRPA1 (also known as ANKTM1), that meets criteria for the transduction channel...
  19. Zhang X, Chen J, Faltynek C, Moreland R, Neelands T. Transient receptor potential A1 mediates an osmotically activated ion channel. Eur J Neurosci. 2008;27:605-11 pubmed publisher
    ..A recent study of TRPA1 knockout mice demonstrated deficits in sensing mechanical stimuli, suggesting a role for TRPA1 also in somatic ..
  20. Dunham J, Kelly S, Donaldson L. Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat. Eur J Neurosci. 2008;27:3151-60 pubmed publisher
    ..The transient receptor potential channel A1 (TRPA1) is a receptor localized to putative nociceptive neurones and is implicated in mechanical and thermal nociception...
  21. Andrade E, Luiz A, Ferreira J, Calixto J. Pronociceptive response elicited by TRPA1 receptor activation in mice. Neuroscience. 2008;152:511-20 pubmed publisher
    Ankyrin-repeat transient receptor potential 1 (TRPA1) is a member of the transient receptor potential (TRP) channel family and it is found in sensory neurons...
  22. Bessac B, Sivula M, von Hehn C, ESCALERA J, Cohn L, Jordt S. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest. 2008;118:1899-910 pubmed publisher
    ..These responses were absent in neurons from mice lacking TRPA1, an ion channel of the transient receptor potential (TRP) gene family...
  23. Bautista D, Jordt S, Nikai T, Tsuruda P, Read A, Poblete J, et al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124:1269-82 pubmed
    b>TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic. TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) nociception, hearing, and inflammatory pain...
  24. Doihara H, Nozawa K, Kawabata Shoda E, Kojima R, Yokoyama T, Ito H. TRPA1 agonists delay gastric emptying in rats through serotonergic pathways. Naunyn Schmiedebergs Arch Pharmacol. 2009;380:353-7 pubmed publisher
    Our recent study found that TRPA1 is highly expressed in enterochromaffin cells and that stimulation of these cells with TRPA1 agonists enhances 5-hydroxytryptamine (5-HT) secretion in vitro...
  25. Kremeyer B, Lopera F, Cox J, Momin A, Rugiero F, Marsh S, et al. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron. 2010;66:671-80 pubmed publisher
    ..Candidate gene sequencing identified a point mutation (N855S) in the S4 transmembrane segment of TRPA1, a key sensor for environmental irritants...
  26. McGaraughty S, Chu K, Perner R, Didomenico S, Kort M, Kym P. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain. 2010;6:14 pubmed publisher
    There is growing evidence supporting a role for TRPA1 receptors in the neurotransmission of peripheral mechanical stimulation...
  27. Paulsen C, Armache J, Gao Y, Cheng Y, Julius D. Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature. 2015;520:511-7 pubmed publisher
    The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism...
  28. Weller K, Reeh P, Sauer S. TRPV1, TRPA1, and CB1 in the isolated vagus nerve--axonal chemosensitivity and control of neuropeptide release. Neuropeptides. 2011;45:391-400 pubmed publisher
    Vagal sensory afferents innervating airways and abdominal tissues express TRPV1 and TRPA1, two depolarizing calcium permeable ion channels playing a major role in sensing environmental irritants and endogenous metabolites which cause ..
  29. Perin Martins A, Teixeira J, Tambeli C, Parada C, Fischer L. Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema. J Peripher Nerv Syst. 2013;18:62-74 pubmed publisher
    The aim of this study was to investigate the mechanisms that contribute to hyperalgesia and edema induced by TRPA1 activation...
  30. Hayashi S, Nakamura E, Endo T, Kubo Y, Takeuchi K. Impairment by activation of TRPA1 of gastric epithelial restitution in a wound model using RGM1 cell monolayer. Inflammopharmacology. 2007;15:218-22 pubmed
    We examined the influence of TRPA1 on the epithelial restitution using a rat gastric epithelial cell line RGM1 monolayer...
  31. Green D, Ruparel S, Gao X, Ruparel N, Patil M, AKOPIAN A, et al. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. Mol Pain. 2016;12: pubmed publisher
    ..The transient receptor potential channels, TRPV1 and TRPA1, are expressed by a subset of nociceptive sensory neurons and contribute to inflammatory hypersensitivity...
  32. Hsu C, Lin R, Lee L, Lin Y. Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors. Am J Physiol Regul Integr Comp Physiol. 2013;305:R769-79 pubmed publisher
    ..sulfide (H2S) is an endogenous mediator inducing hyperalgesia through transient receptor potential ankyrin 1 (TRPA1) receptors located on nociceptors...
  33. Pozsgai G, Hajna Z, Bagoly T, Boros M, Kemeny A, Materazzi S, et al. The role of transient receptor potential ankyrin 1 (TRPA1) receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation. Eur J Pharmacol. 2012;689:56-64 pubmed publisher
    Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP)...
  34. Huang K, Bian D, Jiang B, Zhai Q, Gao N, Wang R. TRPA1 contributed to the neuropathic pain induced by docetaxel treatment. Cell Biochem Funct. 2017;35:141-143 pubmed publisher
    ..We further revealed that the transient receptor potential ankyrin subtype 1 protein (TRPA1) protein level is upregulated and the TRPA1 activator allyl isothiocyanate induced larger ion currents in the ..
  35. Piao L, Fujita T, Yu T, Kumamoto E. Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels. Brain Res. 2017;1657:245-252 pubmed publisher
    The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial ..
  36. Kondo T, Oshima T, Obata K, Sakurai J, Knowles C, Matsumoto T, et al. Role of transient receptor potential A1 in gastric nociception. Digestion. 2010;82:150-5 pubmed publisher
    ..b>TRPA1 was coexpressed with ERK1/2 in gastric primary afferent neurons, and attenuation of TRPA1 activation using ..
  37. Pohóczky K, Kun J, Szalontai B, SzÅ‘ke Ã, Sághy Ã, Payrits M, et al. Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium. J Mol Endocrinol. 2016;56:135-49 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors expressed predominantly in sensory nerves are activated by inflammatory stimuli and mediate inflammation and pain...
  38. Kondo T, Sakurai J, Miwa H, Noguchi K. Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain. Neuroreport. 2013;24:68-72 pubmed publisher
    ..On the basis of these results, the aim of this study was to investigate the involvement of p38 and TRPA1 in acute visceral pain. Male Sprague-Dawley rats were used...
  39. Yamamoto K, Chiba N, Chiba T, Kambe T, Abe K, Kawakami K, et al. Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration. Mol Pain. 2015;11:69 pubmed publisher
    ..In the present study, we investigated the effects of oxaliplatin on transient receptor potential ankyrin 1 (TRPA1) in dorsal root ganglion (DRG) neurons of rats...
  40. Andrade E, Forner S, Bento A, Leite D, Dias M, Leal P, et al. TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. Am J Physiol Renal Physiol. 2011;300:F1223-34 pubmed publisher
    The ankyrin-repeat transient receptor potential 1 (TRPA1) has been implicated in pathological conditions of the bladder, but its role in overactive bladder (OAB) following spinal cord injury (SCI) remains unknown...
  41. Kaji I, Yasuoka Y, Karaki S, Kuwahara A. Activation of TRPA1 by luminal stimuli induces EP4-mediated anion secretion in human and rat colon. Am J Physiol Gastrointest Liver Physiol. 2012;302:G690-701 pubmed publisher
    ..The transient receptor potential A1 (TRPA1) channel is considered to be a chemosensor in several sensory tissues...
  42. Staruschenko A, Jeske N, Akopian A. Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem. 2010;285:15167-77 pubmed publisher
    Several lines of evidence suggest that TRPA1 and TRPV1 mutually control the transduction of inflammation-induced noxious stimuli in sensory neurons. It was recently shown that certain TRPA1 properties are modulated by TRPV1...
  43. Uta D, Furue H, Pickering A, Rashid M, Mizuguchi Takase H, Katafuchi T, et al. TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord. Eur J Neurosci. 2010;31:1960-73 pubmed publisher
    The TRPA1 channel has been proposed to be a molecular transducer of cold and inflammatory nociceptive signals...
  44. Camacho S, Michlig S, de Senarclens Bezençon C, Meylan J, Meystre J, Pezzoli M, et al. Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying. Sci Rep. 2015;5:7919 pubmed publisher
    ..flavor to cinnamon and is known to be the main agonist of transient receptor potential-ankyrin receptor 1 (TRPA1). Here, expression of TRPA1 in epithelial mouse stomach cells is described...
  45. Kojima R, Nozawa K, Doihara H, Keto Y, Kaku H, Yokoyama T, et al. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur J Pharmacol. 2014;723:288-93 pubmed publisher
    ..We previously reported that transient receptor potential ankyrin 1 (TRPA1) is highly expressed in enterochromaffin (EC) cells, which are 5-hydroxytryptamine (5-HT)-releasing cells, and ..
  46. Gu Q, Lin R. Heavy metals zinc, cadmium, and copper stimulate pulmonary sensory neurons via direct activation of TRPA1. J Appl Physiol (1985). 2010;108:891-7 pubmed publisher
    ..Transient receptor potential A1 (TRPA1) is selectively expressed in a subpopulation of pulmonary C-fiber afferents and has been considered as a major ..
  47. Thornton P, Hatcher J, Robinson I, Sargent B, Franzén B, Martino G, et al. Artemin-GFR?3 interactions partially contribute to acute inflammatory hypersensitivity. Neurosci Lett. 2013;545:23-8 pubmed publisher
    ..Anti-ARTN antibodies had no effect on hypersensitivity in response to partial nerve ligation in mice. These data suggest that ARTN-GFR?3 interactions partially mediate early stage nociceptive signalling following an inflammatory insult. ..
  48. Bonet I, Fischer L, Parada C, Tambeli C. The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia. Neuropharmacology. 2013;65:206-12 pubmed publisher
    Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel important in setting nociceptive threshold. It is expressed in nociceptive C-fibers and in non-neuronal cells involved in pro-inflammatory mediators' release...
  49. Wang S, Zhai C, Zhang Y, Yu Y, Zhang Y, Ma L, et al. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016;21: pubmed publisher
    ..The current study aimed to find anti-nociceptive candidates targeting transient receptor potential ankyrin 1 (TRPA1), a receptor that implicates in hyperalgesia and neurogenic inflammation...
  50. Yamanaka M, Taniguchi W, Nishio N, Hashizume H, Yamada H, Yoshida M, et al. In vivo patch-clamp analysis of the antinociceptive actions of TRPA1 activation in the spinal dorsal horn. Mol Pain. 2015;11:20 pubmed publisher
    ..We investigated the function of one key member of the TRP superfamily, TRPA1, in the spinal dorsal horn using in vivo patch-clamp recordings...
  51. Tsumura M, Sobhan U, Sato M, Shimada M, Nishiyama A, Kawaguchi A, et al. Functional expression of TRPM8 and TRPA1 channels in rat odontoblasts. PLoS ONE. 2013;8:e82233 pubmed publisher
    ..of transient receptor potential (TRP) melastatin subfamily member 8 (TRPM8) and ankyrin subfamily member 1 (TRPA1) channels in odontoblasts remain to be clarified...
  52. Minagawa T, Aizawa N, Igawa Y, Wyndaele J. The role of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat. Neurourol Urodyn. 2014;33:544-9 pubmed publisher
    We investigated the role of transient receptor potential ankyrin 1 (TRPA1) channel on the single unit mechanosensitive afferent activities (SAAs) primarily originating from the bladder in the rat. Female Sprague-Dawley rats were used...
  53. Ikeda Miyagawa Y, Kobayashi K, Yamanaka H, Okubo M, Wang S, Dai Y, et al. Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons. Mol Pain. 2015;11:8 pubmed publisher
    ..Artemin-induced p38 MAPK pathway regulated the TRPV1 channel expression, however TRPA1 upregulation by artemin is not mediated through p38 MAPK...
  54. Wang S, Lee J, Ro J, Chung M. Warmth suppresses and desensitizes damage-sensing ion channel TRPA1. Mol Pain. 2012;8:22 pubmed publisher
    ..Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of substances that are released following tissue damage to evoke ..
  55. Sun B, Bang S, Jin Y. Transient receptor potential A1 increase glutamate release on brain stem neurons. Neuroreport. 2009;20:1002-6 pubmed publisher
    ..b>TRPA1 ligands are found as common ingredients of pungent spices and can trigger autonomic reflexes and alter blood ..
  56. Ujike A, Otsuguro K, Miyamoto R, Yamaguchi S, Ito S. Bidirectional effects of hydrogen sulfide via ATP-sensitive K(+) channels and transient receptor potential A1 channels in RIN14B cells. Eur J Pharmacol. 2015;764:463-70 pubmed publisher
    ..H2S can activate both KATP and TRPA1 channels at a similar concentration range...
  57. Mizushima T, Obata K, Katsura H, Yamanaka H, Kobayashi K, Dai Y, et al. Noxious cold stimulation induces mitogen-activated protein kinase activation in transient receptor potential (TRP) channels TRPA1- and TRPM8-containing small sensory neurons. Neuroscience. 2006;140:1337-48 pubmed
    Two cold-sensitive transient receptor potential (TRP) channels, TRPA1 and TRPM8, have been identified and considered interesting because of their possible roles in thermosensation, nociception and other functions...
  58. Sugiyama D, Kang S, Arpey N, Arunakul P, Usachev Y, Brennan T. Hydrogen Peroxide Induces Muscle Nociception via Transient Receptor Potential Ankyrin 1 Receptors. Anesthesiology. 2017;127:695-708 pubmed publisher
    ..The greater response of muscle tissue to H2O2 may help explain why incision that includes deep muscle but not skin incision alone produces spontaneous activity in nociceptive pathways. ..
  59. Merrill L, Girard B, May V, Vizzard M. Transcriptional and translational plasticity in rodent urinary bladder TRP channels with urinary bladder inflammation, bladder dysfunction, or postnatal maturation. J Mol Neurosci. 2012;48:744-56 pubmed
    ..examined the transcriptional and translational plasticity of three transient receptor potential (TRP) channels (TRPA1, TRPV1, TRPV4) with established neuronal and non-neuronal expression and functional roles in the lower urinary ..
  60. Philyppov I, Paduraru O, Gulak K, Skryma R, Prevarskaya N, Shuba Y. TRPA1-dependent regulation of bladder detrusor smooth muscle contractility in normal and type I diabetic rats. J Smooth Muscle Res. 2016;52:1-17 pubmed publisher
    b>TRPA1 is a Ca(2+)-permeable cation channel that is activated by painful low temperatures (<17°C), irritating chemicals, reactive metabolites and mediators of inflammation...
  61. Asgar J, Zhang Y, Saloman J, Wang S, Chung M, Ro J. The role of TRPA1 in muscle pain and mechanical hypersensitivity under inflammatory conditions in rats. Neuroscience. 2015;310:206-15 pubmed publisher
    Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is expressed in muscle afferents and direct activation of these receptors induces acute mechanical hypersensitivity...
  62. Park C, Kim M, Fang Z, Li H, Jung S, Choi S, et al. Functional expression of thermo-transient receptor potential channels in dental primary afferent neurons: implication for tooth pain. J Biol Chem. 2006;281:17304-11 pubmed
    ..Single cell reverse transcription-PCR and immunohistochemistry revealed expression of TRPV1, TRPM8, and TRPA1 in subsets of such neurons...
  63. Sugiyama D, Kang S, Brennan T. Muscle Reactive Oxygen Species (ROS) Contribute to Post-Incisional Guarding via the TRPA1 Receptor. PLoS ONE. 2017;12:e0170410 pubmed publisher
    ..b>TRPA1 has been shown to mediate pain-related responses in inflammation- and nerve injury-induced pain models...
  64. Edelmayer R, Le L, Yan J, Wei X, Nassini R, Materazzi S, et al. Activation of TRPA1 on dural afferents: a potential mechanism of headache pain. Pain. 2012;153:1949-58 pubmed publisher
    Activation of transient receptor potential ankyrin-1 (TRPA1) on meningeal nerve endings has been suggested to contribute to environmental irritant-induced headache, but this channel may also contribute to other forms of headache, such as ..
  65. Choi M, Jin Z, Park Y, Rhee Y, Jin Y. Transient receptor potential (TRP) A1 activated currents in TRPV1 and cholecystokinin-sensitive cranial visceral afferent neurons. Brain Res. 2011;1383:36-42 pubmed publisher
    ..b>TRPA1 channel have also been identified on cranial visceral afferent neurons but their distribution and functional ..
  66. Eberhardt M, Filipović M, Leffler A, de la Roche J, Kistner K, Fischer M, et al. Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies. J Biol Chem. 2012;287:28291-306 pubmed publisher
    ..The electrophilic structure of this cytotoxic ketoaldehyde suggests TRPA1, a receptor channel deeply involved in inflammatory and neuropathic pain, as a molecular target...
  67. Yu Y, Yang J, Zuo X, Gao L, Wang P, Li Y. Transient receptor potential vanilloid-1 (TRPV1) and ankyrin-1 (TRPA1) participate in visceral hyperalgesia in chronic water avoidance stress rat model. Neurochem Res. 2010;35:797-803 pubmed publisher
    ..In the present study, we aimed to examine the involvement of TRPV1 and TRPA1 in the stress-induced visceral hyperalgesia...
  68. Voronova I, Tuzhikova A, Kozyreva T. [Thermosensitive TRP channels gene expression in hypothalamus of normal rats and rats adapted to cold]. Ross Fiziol Zh Im I M Sechenova. 2012;98:1101-10 pubmed
    ..it was made a comparison of the gene expression of the 6 thermosensitive ion channels (TRPV1, TRPV2, TRPV3, TRPV4, TRPA1, TRPM8) and found that there was rather high expression of the genes of thermosensitive ion channels activated at ..
  69. Chen J, Kang D, Xu J, Lake M, Hogan J, Sun C, et al. Species differences and molecular determinant of TRPA1 cold sensitivity. Nat Commun. 2013;4:2501 pubmed publisher
    b>TRPA1 is an ion channel and has been proposed as a thermosensor across species...
  70. Bang S, Hwang S. Polymodal ligand sensitivity of TRPA1 and its modes of interactions. J Gen Physiol. 2009;133:257-62 pubmed publisher
  71. Katagiri A, Thompson R, Rahman M, Okamoto K, Bereiter D. Evidence for TRPA1 involvement in central neural mechanisms in a rat model of dry eye. Neuroscience. 2015;290:204-13 pubmed publisher
    ..exorbital gland removal, to assess the effects of mustard oil (MO), a transient receptor potential ankyrin (TRPA1) agonist, on eyeblink and eyewipe behavior and Fos-like immunoreactivity (Fos-LI) in the trigeminal brainstem of ..
  72. Dall Acqua M, Bonet I, Zampronio A, Tambeli C, Parada C, Fischer L. The contribution of transient receptor potential ankyrin 1 (TRPA1) to the in vivo nociceptive effects of prostaglandin E?. Life Sci. 2014;105:7-13 pubmed publisher
    Although evidence suggest that TRPA1 mediates some effects of prostaglandins, it is not known whether TRPA1 contributes to the in vivo nociceptive effects of prostaglandin E2 (PGE2), a key mediator of inflammatory pain...
  73. Nishio N, Taniguchi W, Sugimura Y, Takiguchi N, Yamanaka M, Kiyoyuki Y, et al. Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels. Neuroscience. 2013;247:201-12 pubmed publisher
    ..Furthermore, in the presence of a transient receptor potential ankyrin 1 (TRPA1) channel antagonist (HC-030031) or a transient receptor potential vanilloid 1 (TRPV1) channel antagonist (..
  74. Takahashi K, Ohta T. Inflammatory acidic pH enhances hydrogen sulfide-induced transient receptor potential ankyrin 1 activation in RIN-14B cells. J Neurosci Res. 2013;91:1322-7 pubmed publisher
    ..we have shown that H2 S elicits acute pain through the activation of transient receptor potential ankyrin 1 (TRPA1), which is expressed mainly in primary nociceptive neurons...
  75. Lu Y, Piplani H, McAllister S, Hurt C, Gross E. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016;125:1171-1180 pubmed
    ..Here, the authors address whether the transient receptor potential ankyrin 1 (TRPA1) channel, important in pain signaling, is present in cardiac myocytes and regulates cardiac ischemia-reperfusion ..
  76. Wei H, Saarnilehto M, Falck L, Viisanen H, Lasierra M, Koivisto A, et al. Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A. J Physiol Pharmacol. 2013;64:331-40 pubmed
    ..and cutaneous blood flow response induced by activation of the spinal transient receptor potential ankyrin 1 (TRPA1) channel using intrathecal drug administrations in the rat...