Gene Symbol: Trip10
Description: thyroid hormone receptor interactor 10
Alias: Cip4, STP, cdc42-interacting protein 4, TR-interacting protein 10, TRIP-10, salt tolerant protein, thyroid receptor-interacting protein 10
Species: rat
Products:     Trip10

Top Publications

  1. Holbert S, Dedeoglu A, Humbert S, Saudou F, Ferrante R, Neri C. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Proc Natl Acad Sci U S A. 2003;100:2712-7 pubmed
    ..A human homolog of K08E3.3b is the Cdc42-interacting protein 4 (CIP4), a protein involved in Cdc42 and Wiskott-Aldrich syndrome protein-dependent signal transduction...
  2. Hartig S, Ishikura S, Hicklen R, Feng Y, Blanchard E, Voelker K, et al. The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2. J Cell Sci. 2009;122:2283-91 pubmed publisher
    ..Because F-BAR proteins, including Cdc42 interacting protein-4 (CIP4), drive membrane deformation and affect endocytosis, we investigated the role of CIP4 in GLUT4 traffic by flow ..
  3. Jun H, Hwang K, Kim Y, Park T. High-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of rats. Obesity (Silver Spring). 2008;16:1226-31 pubmed publisher (HFD)-induced obesity and the expression of protein phosphatase 2A (PP2A) and Cdc42-interacting protein 4 (CIP4) proteins, potential downstream components of the IRS/PI3K/AKT and CAP/Cbl/TC10 pathway, respectively, in the ..
  4. Hsiao S, Lee K, Hsu C, Tseng M, Jin V, Sun W, et al. DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochem Biophys Res Commun. 2010;400:305-12 pubmed publisher
    ..Aberrant epigenetic modifications may lead to abnormal development, even diseases. We have found that Trip10 (thyroid hormone receptor interactor 10), an adaptor protein involved in diverse functions, is epigenetically ..
  5. Bai S, Zeng R, Zhou Q, Liao W, Zhang Y, Xu C, et al. Cdc42-interacting protein-4 promotes TGF-?1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells. Int J Biol Sci. 2012;8:859-69 pubmed publisher
    Cdc42-interacting protein-4 (CIP4) is an F-BAR (Fer/CIP4 and Bin, amphiphysin, Rvs) family member that regulates membrane deformation and endocytosis, playing a key role in extracellular matrix (ECM) deposition and invasion of cancer ..
  6. Rusconi F, Thakur H, Li J, Kapiloff M. CIP4 is required for the hypertrophic growth of neonatal cardiac myocytes. J Biomed Sci. 2013;20:56 pubmed publisher
    b>CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking...
  7. Ba W, Selten M, van der Raadt J, van Veen H, Li L, Benevento M, et al. ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function. Cell Rep. 2016;14:1355-1368 pubmed publisher
    ..ARHGAP12 negatively controls spine size via its RhoGAP activity and promotes, by interacting with CIP4, postsynaptic AMPA receptor endocytosis...
  8. Tsuji E, Tsuji Y, Misumi Y, Fujita A, Sasaguri M, Ideishi M, et al. Molecular cloning of a novel rat salt-tolerant protein by functional complementation in yeast. Biochem Biophys Res Commun. 1996;229:134-8 pubmed
    ..mitochondrial cytochrome b, a homologue of infant brain cDNA, and a novel gene, called salt-tolerant protein (STP). STP contains 1964 bp nucleotides and an open reading frame which encodes 496 amino acid residues...
  9. Morin F, Vannier B, Houdart F, Regnacq M, Berges T, Voisin P. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Mol Vis. 2003;9:449-59 pubmed
    ..This proline-rich domain also allowed Pgamma-rod to interact with Cdc42-interacting protein 4 (CIP4), another SH3-containing protein...

More Information


  1. Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa Suetsugu K, et al. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell. 2007;129:761-72 pubmed
    ..In the present study, we solved the crystal structures of the EFC domains of human FBP17 and CIP4. The structures revealed a gently curved helical-bundle dimer of approximately 220 A in length, which forms ..
  2. Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman E, et al. Structural basis of membrane invagination by F-BAR domains. Cell. 2008;132:807-17 pubmed publisher
    ..The geometric constraints and sequential assembly of the helical lattice explain how F-BAR and classical BAR domains segregate into distinct microdomains, and provide insight into the spatial regulation of membrane invagination. ..
  3. Zhang J, Bi M, Zhong F, Jiao X, Zhang D, Dong Q. Role of CIP4 in high glucose induced epithelial--mesenchymal transition of rat peritoneal mesothelial cells. Ren Fail. 2013;35:989-95 pubmed publisher
    ..Cdc42-interacting protein-4 (CIP4) is a critical regulator of cell skeleton and downstream effector of Cdc42 and participates in EMT of tubular ..
  4. Yu R, Mao J, Yang Y, Zhang Y, Tian Y, Zhu J. Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat. Int J Clin Exp Pathol. 2015;8:3503-12 pubmed modulating the expressions of transforming growth factor-beta 1 (TGF-β1) and Cdc42 interacting protein-4 (CIP4)...
  5. Xu C, Zhou Q, Liu L, Liu P, Pei G, Zeng R, et al. Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting β-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells. Int J Mol Sci. 2015;16:19170-83 pubmed publisher
    ..Catenin may act as a mediator by accumulation and translocation to the nucleus. Studies have suggested that CIP4, a Cdc42 effector protein, is associated with β-catenin...