Gene Symbol: Trio
Description: trio Rho guanine nucleotide exchange factor
Alias: triple functional domain protein, PTPRF-interacting protein, triple functional domain (PTPRF interacting)
Species: rat
Products:     Trio

Top Publications

  1. Ma X, Huang J, Eipper B, Mains R. Expression of Trio, a member of the Dbl family of Rho GEFs in the developing rat brain. J Comp Neurol. 2005;482:333-48 pubmed
    b>Trio, a member of the Dbl family of guanine nucleotide exchange factors (GEFs), has a series of spectrin repeats, two GEF domains, protein interaction domains, and a putative kinase domain, potentially important in neuronal axon guidance ..
  2. Degeer J, Kaplan A, Mattar P, Morabito M, Stochaj U, Kennedy T, et al. Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1. J Cell Biol. 2015;210:817-32 pubmed publisher
    ..The Rac1 guanine nucleotide exchange factor (GEF) Trio is essential for netrin-1-induced axon outgrowth and guidance...
  3. Xin X, Ferraro F, B├Ąck N, Eipper B, Mains R. Cdk5 and Trio modulate endocrine cell exocytosis. J Cell Sci. 2004;117:4739-48 pubmed
    ..b>Trio, a multifunctional RhoGEF expressed in pituitary cells, interacts with peptidylglycine alpha-amidating ..
  4. McPherson C, Eipper B, Mains R. Multiple novel isoforms of Trio are expressed in the developing rat brain. Gene. 2005;347:125-35 pubmed
    Mammalian Trio is a multifunctional, multidomain Rho guanine nucleotide exchange factor (GEF) closely related to Kalirin...
  5. Liu X, Bera T, Kahue C, Escobar T, Fei Z, Raciti G, et al. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. PLoS ONE. 2012;7:e38130 pubmed publisher
    ..We identified by yeast two-hybrid and immunoprecipitation assays the triple functional domain protein (TRIO), the G protein pathway suppressor 2 (GPS2), the delta-interacting protein A (DIPA) and the ..
  6. Ba W, Yan Y, Reijnders M, Schuurs Hoeijmakers J, Feenstra I, Bongers E, et al. TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function. Hum Mol Genet. 2016;25:892-902 pubmed publisher
    Recently, we marked TRIO for the first time as a candidate gene for intellectual disability (ID). Across diverse vertebrate species, TRIO is a well-conserved Rho GTPase regulator that is highly expressed in the developing brain...
  7. Degeer J, Boudeau J, Schmidt S, Bedford F, Lamarche Vane N, Debant A. Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. Mol Cell Biol. 2013;33:739-51 pubmed publisher
    ..The Rho guanine nucleotide exchange factor (GEF) Trio is essential for Rac1 activation downstream of netrin-1/DCC, but the molecular mechanisms governing Trio activity ..
  8. Moshfegh Y, Bravo Cordero J, Miskolci V, Condeelis J, Hodgson L. A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol. 2014;16:574-86 pubmed publisher
  9. Neubrand V, Thomas C, Schmidt S, Debant A, Schiavo G. Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio. J Cell Sci. 2010;123:2111-23 pubmed publisher
    ..Here, we identified Trio, a RhoGEF for Rac1, RhoG and RhoA, which is involved in neurite outgrowth and axon guidance, as a binding partner ..

More Information


  1. Sadybekov A, Tian C, Arnesano C, KATRITCH V, Herring B. An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio. Nat Commun. 2017;8:601 pubmed publisher
    The Rho guanine nucleotide exchange factor (RhoGEF) Trio promotes actin polymerization by directly activating the small GTPase Rac1...