Trim63

Summary

Gene Symbol: Trim63
Description: tripartite motif containing 63
Alias: Murf, Murf1, Rnf28, E3 ubiquitin-protein ligase TRIM63, MURF-1, RING-type E3 ubiquitin transferase TRIM63, muscle ring finger protein 1, muscle-specific RING finger protein 1, ring finger protein 28, tripartite motif containing 63, E3 ubiquitin protein ligase, tripartite motif protein 63, tripartite motif-containing protein 63
Species: rat
Products:     Trim63

Top Publications

  1. McElhinny A, Kakinuma K, Sorimachi H, Labeit S, Gregorio C. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. J Cell Biol. 2002;157:125-36 pubmed
    ..The COOH-terminal A168-170 region of the giant sarcomeric protein titin interacts with muscle-specific RING finger-1 (MURF-1)...
  2. Bodine S, Latres E, Baumhueter S, Lai V, Nunez L, Clarke B, et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 2001;294:1704-8 pubmed
    ..Two of these genes encode ubiquitin ligases: Muscle RING Finger 1 (MuRF1), and a gene we designate Muscle Atrophy F-box (MAFbx), the latter being a member of the SCF family of E3 ..
  3. Baskin K, Taegtmeyer H. AMP-activated protein kinase regulates E3 ligases in rodent heart. Circ Res. 2011;109:1153-61 pubmed publisher
    ..enhances UPS-mediated protein degradation by directly regulating the ubiquitin ligases Atrogin-1 and muscle RING finger protein 1 (MuRF1) in the heart...
  4. Kedar V, McDonough H, Arya R, Li H, Rockman H, Patterson C. Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. Proc Natl Acad Sci U S A. 2004;101:18135-40 pubmed
    Muscle-specific RING finger protein 1 (MuRF1) is a sarcomere-associated protein that is restricted to cardiac and skeletal muscle...
  5. Polge C, Heng A, Jarzaguet M, Ventadour S, Claustre A, Combaret L, et al. Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1. FASEB J. 2011;25:3790-802 pubmed publisher
    ..The muscle-specific E3 ubiquitin ligase MuRF1 is up-regulated in catabolic conditions and polyubiquitinylates components of the thick filament...
  6. Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren P. Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem. 2008;105:353-64 pubmed publisher
    ..the naturally occurring glucocorticoid in rodents) on protein breakdown rates, myotube size, and atrogin-1 and MuRF1 mRNA levels in the two cell lines...
  7. Macpherson P, Wang X, Goldman D. Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle. J Cell Biochem. 2011;112:2149-59 pubmed publisher
    ..However, it is clear that expression of atrophy-related genes, like Atrogin-1 and MuRF-1, are intimately tied to loss of muscle mass...
  8. Delfino G, Peviani S, Durigan J, Russo T, Baptista I, Ferretti M, et al. Quadriceps muscle atrophy after anterior cruciate ligament transection involves increased mRNA levels of atrogin-1, muscle ring finger 1, and myostatin. Am J Phys Med Rehabil. 2013;92:411-9 pubmed publisher
    ..Quadriceps atrophy after ACL transection involves increased levels of myostatin, atrogin-1, and muscle ring finger 1 mRNA and the accumulation of ubiquitinated protein. ..
  9. Nordquist J, Höglund A, Norman H, Tang X, Dworkin B, Larsson L. Transcription factors in muscle atrophy caused by blocked neuromuscular transmission and muscle unloading in rats. Mol Med. 2007;13:461-70 pubmed
    ..Significant muscle wasting and upregulation of mRNA for the ubiquitin ligases MAFbx and MuRF1 followed the treatment...

More Information

Publications40

  1. Wu C, Cornwell E, Jackman R, Kandarian S. NF-?B but not FoxO sites in the MuRF1 promoter are required for transcriptional activation in disuse muscle atrophy. Am J Physiol Cell Physiol. 2014;306:C762-7 pubmed publisher
    The muscle-specific ring finger protein 1 (MuRF1) gene is required for most types of skeletal muscle atrophy yet we have little understanding of its transcriptional regulation...
  2. Lange S, Xiang F, Yakovenko A, Vihola A, Hackman P, Rostkova E, et al. The kinase domain of titin controls muscle gene expression and protein turnover. Science. 2005;308:1599-603 pubmed
    ..A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway. ..
  3. Polge C, Koulmann N, Claustre A, Jarzaguet M, Serrurier B, Combaret L, et al. UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension. Int J Biochem Cell Biol. 2016;79:488-493 pubmed publisher
    ..The E3 ligase MuRF1 is so far the only enzyme known to direct the main contractile proteins for degradation (i.e...
  4. Clavel S, Coldefy A, Kurkdjian E, Salles J, Margaritis I, Derijard B. Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle. Mech Ageing Dev. 2006;127:794-801 pubmed
    ..To test the hypothesis that the ubiquitin-proteasome pathway contributes to this phenomenon, we studied MuRF1 and atrogin-1 expression in Tibialis Anterior muscle of aged rats...
  5. McClung J, Kavazis A, Whidden M, Deruisseau K, Falk D, Criswell D, et al. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. J Physiol. 2007;585:203-15 pubmed
    ..expression of the muscle-specific ubiquitin ligases, muscle atrophy factor (MAFbx) and muscle ring finger-1 (MuRF-1)...
  6. Wray C, Mammen J, Hershko D, Hasselgren P. Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Int J Biochem Cell Biol. 2003;35:698-705 pubmed
    ..We tested the hypothesis that sepsis upregulates the gene expression of the newly described ubiquitin ligases, MuRF1 and atrogin-1/MAFbx. Sepsis was induced in rats by cecal ligation and puncture. Control rats were sham-operated...
  7. Proserpio V, Fittipaldi R, Ryall J, Sartorelli V, Caretti G. The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev. 2013;27:1299-312 pubmed publisher
  8. Wang H, Liang B, Peng C, Wang P. [Effect of Ligustrazine on expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012;26:597-600 pubmed
    To investigate the effect of Ligustrazine on the expressions of FoXO3a, MAFbx, and MuRF1 in denervated skeletal muscle atrophy rats...
  9. Gerlinger Romero F, Yonamine C, Junior D, Esteves J, Machado U. Dysregulation between TRIM63/FBXO32 expression and soleus muscle wasting in diabetic rats: potential role of miR-1-3p, -29a/b-3p, and -133a/b-3p. Mol Cell Biochem. 2017;427:187-199 pubmed publisher
    ..The present study investigated the effect of diabetes and acute muscle contraction upon the TRIM63 and FBXO32 expression as well as the potential involvement of some miRNAs...
  10. Kang S, Lee H, Kim M, Lee E, Sohn U, Kim I. Forkhead box O3 plays a role in skeletal muscle atrophy through expression of E3 ubiquitin ligases MuRF-1 and atrogin-1 in Cushing's syndrome. Am J Physiol Endocrinol Metab. 2017;312:E495-E507 pubmed publisher
    ..FOXO3a plays a role in muscle atrophy through expression of the E3 ubiquitin ligases, muscle RING finger protein-1 (MuRF-1), and atrogin-1 in Cushing's syndrome...
  11. Carvalho R, Castan E, Coelho C, Lopes F, Almeida F, Michelin A, et al. Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy. J Mol Histol. 2010;41:81-7 pubmed publisher
    ..that HF induces skeletal muscle atrophy in a fiber type-specific manner altering the expression of atrogin-1 and MuRF1 in a fast muscle of rats with monocrotaline-induced heart failure...
  12. Arya R, Kedar V, Hwang J, McDonough H, Li H, Taylor J, et al. Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. J Cell Biol. 2004;167:1147-59 pubmed
    ..We define a novel anti-hypertrophic signaling pathway regulated by muscle ring finger protein-1 (MURF1) that inhibits the agonist-stimulated PKC-mediated signaling response in neonatal rat ventricular myocytes...
  13. You J, Park M, Song W, Lee Y. Dietary fish oil alleviates soleus atrophy during immobilization in association with Akt signaling to p70s6k and E3 ubiquitin ligases in rats. Appl Physiol Nutr Metab. 2010;35:310-8 pubmed publisher
  14. Song D, Ryu J, Kim J, Kwon E, Kim D. The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1. Biochem J. 2014;457:151-62 pubmed publisher
    ..Luciferase assays revealed that miR-19a/b directly target the anti-hypertrophic genes atrogin-1 and MuRF-1 (muscle RING-finger protein-1). The endogenous expressions of the target genes were down-regulated by miR-19a/b...
  15. Balasubramaniam A, Joshi R, Su C, Friend L, Sheriff S, Kagan R, et al. Ghrelin inhibits skeletal muscle protein breakdown in rats with thermal injury through normalizing elevated expression of E3 ubiquitin ligases MuRF1 and MAFbx. Am J Physiol Regul Integr Comp Physiol. 2009;296:R893-901 pubmed publisher
    ..Expression of the muscle-specific ubiquitin-ligating enzyme (E3) ubiquitin ligases MuRF1 and MAFbx were markedly elevated in both EDL and gastrocnemius and were normalized by ghrelin...
  16. Lomonosova I, Turtikova O, Shenkman B. [Translocation of MuRF isoforms to nuclei in postural muscle during gravitational unloading]. Ross Fiziol Zh Im I M Sechenova. 2015;101:64-73 pubmed
    ..E3 ubiquitin ligases, rate limiting enzymes of the ubiquitin-proteasomal pathway, the most interesting ones are the MuRF isoforms: MuRF-1 and MuRF-2...
  17. Kamalov G, Zhao W, Zhao T, Sun Y, Ahokas R, Marion T, et al. Atrophic cardiomyocyte signaling in hypertensive heart disease. J Cardiovasc Pharmacol. 2013;62:497-506 pubmed publisher
    ..ZnSO? cotreatment in HHD with ALDOST attenuates the number of atrophic myocytes, optimizes size of atrophied and hypertrophied myocytes, and improves systolic function. ..
  18. Castillero E, Alamdari N, Lecker S, Hasselgren P. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism. 2013;62:1495-502 pubmed publisher
    The mechanistic role of the ubiquitin ligases atrogin-1 and MuRF1 in glucocorticoid-induced muscle wasting is not fully understood...
  19. Wiberg R, Jonsson S, Novikova L, Kingham P. Investigation of the Expression of Myogenic Transcription Factors, microRNAs and Muscle-Specific E3 Ubiquitin Ligases in the Medial Gastrocnemius and Soleus Muscles following Peripheral Nerve Injury. PLoS ONE. 2015;10:e0142699 pubmed publisher
    ..The muscles also showed significantly contrasting transcriptional regulation of the microRNAs miR-1 and miR-206. MuRF1 and Atrogin-1 showed the highest levels of expression in the denervated gastrocnemius muscle...
  20. Senf S, Dodd S, McClung J, Judge A. Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy. FASEB J. 2008;22:3836-45 pubmed publisher
    ..prevented disuse muscle fiber atrophy and inhibited the increased promoter activities of atrogin-1 and MuRF1. Importantly, the transcriptional activities of Foxo3a and NF-kappaB, which are implicated in the regulation of ..
  21. Sishi B, Bester D, Wergeland A, Loos B, Jonassen A, van Rooyen J, et al. Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart. Exp Biol Med (Maywood). 2012;237:219-26 pubmed publisher
    ..of specific transcription factors; however, no reports exist on the effect of DNR on the E3 ubiquitin ligases, MURF-1 (muscle ring finger 1) and MAFbx (muscle atrophy F-box)...
  22. Liu A, Yu D, Zhang Y, Zhang W, Ding W, Ren A, et al. [MAFbx and MuRF1 mRNA expression and its relationship with muscular contractility following free muscle transfer]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2009;25:217-21 pubmed
    To study muscle atrophy F-box (MAFbx) and muscle ring finger 1 (MuRF1) mRNA expression and its relationship with muscular contraction following free muscle transfer...
  23. Chen G, Mou C, Yang Y, Wang S, Zhao Z. Exercise training has beneficial anti-atrophy effects by inhibiting oxidative stress-induced MuRF1 upregulation in rats with diabetes. Life Sci. 2011;89:44-9 pubmed publisher
    b>MuRF1 E3 ubiquitin ligase has been identified as a mediator of skeletal muscle wasting in various skeletal muscle atrophy models, and its expression is upregulated by oxidative stress...
  24. Dehoux M, van Beneden R, Fernández Celemín L, Lause P, Thissen J. Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection. FEBS Lett. 2003;544:214-7 pubmed
    MafBx and Murf are two new rat E3 ubiquitin ligases induced in muscle atrophy. Our goal was to investigate whether lipopolysaccharide (LPS) injection, a model of muscle catabolism, is associated with increased expression of MafBx and Murf...
  25. DeRuisseau K, Kavazis A, Powers S. Selective downregulation of ubiquitin conjugation cascade mRNA occurs in the senescent rat soleus muscle. Exp Gerontol. 2005;40:526-31 pubmed
    ..two key UCC components in soleus muscle; ubiquitin conjugating enzyme E2(14k) (E2(14k)) and muscle ring finger-1 (MuRF1)...
  26. Maki T, Yamamoto D, Nakanishi S, Iida K, Iguchi G, Takahashi Y, et al. Branched-chain amino acids reduce hindlimb suspension-induced muscle atrophy and protein levels of atrogin-1 and MuRF1 in rats. Nutr Res. 2012;32:676-83 pubmed publisher
    Atrogin-1 and MuRF1, muscle-specific ubiquitin ligases, and autophagy play a role in protein degradation in muscles...
  27. Lecker S, Jagoe R, Gilbert A, Gomes M, Baracos V, Bailey J, et al. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004;18:39-51 pubmed
    ..involved in protein degradation, including polyubiquitins, Ub fusion proteins, the Ub ligases atrogin-1/MAFbx and MuRF-1, multiple but not all subunits of the 20S proteasome and its 19S regulator, and cathepsin L...
  28. O Neal P, Alamdari N, Smith I, Poylin V, Menconi M, Hasselgren P. Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle. J Cell Biochem. 2009;108:963-73 pubmed publisher
    ..conditions is associated with increased expression of the muscle-specific ubiquitin ligases atrogin-1 and MuRF1 but it is not known if atrogin-1 and MuRF1 are upregulated in hyperthyroidism...
  29. Mearini G, Gedicke C, Schlossarek S, Witt C, Kramer E, Cao P, et al. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. Cardiovasc Res. 2010;85:357-66 pubmed publisher
    ..ligases, we investigated whether the muscle-specific E3 ligases atrogin-1 or muscle ring finger protein-1 (MuRF1) mediate degradation of truncated cMyBP-C...
  30. Chen G, Lü K, Yang Y, Wang S, Bie M. [Effects of oxidative stress on MuRF1 expression in skeletal muscle of diabetic rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2011;42:349-52 pubmed
    To determine whether muscle-specific RING finger protein 1 (MuRF1) expression induced by oxidative stress lead to muscle wasting in diabetes rats...
  31. Chen B, Xiong Z, Zhang C, Ma Y, Meng R, Chen G, et al. [Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:2419-22 pubmed
    ..To investigate the effects of AICAR on the activity of transcription factor FOXO1 and expression of ubiquitin ligase MuRF1 in rat cardiomyocytes, and explore the possible role of AMP-activated protein kinase (AMPK) in proteolysis ..