Trdn

Summary

Gene Symbol: Trdn
Description: triadin
Alias: triadin, triadin 1, triadin 32 kDa (TRISK 32), triadin 49 kDa (TRISK 49), triadin 95
Species: rat
Products:     Trdn

Top Publications

  1. Chopra N, Yang T, Asghari P, Moore E, Huke S, Akin B, et al. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc Natl Acad Sci U S A. 2009;106:7636-41 pubmed publisher
    ..Although studies suggest that the jSR protein triadin anchors cardiac calsequestrin (Casq2) to RyR2, its contribution to E-C coupling remains unclear...
  2. Terentyev D, Viatchenko Karpinski S, Vedamoorthyrao S, Oduru S, Gyorke I, Williams S, et al. Protein protein interactions between triadin and calsequestrin are involved in modulation of sarcoplasmic reticulum calcium release in cardiac myocytes. J Physiol. 2007;583:71-80 pubmed
    ..release is controlled by a number of proteins including the ryanodine receptor (RyR2), calsequestrin (CASQ2), triadin-1 (Trd) and junctin (Jn) which form a complex in the junctional sarcoplasmic reticulum (SR) membrane...
  3. Gyorke I, Hester N, Jones L, Gyorke S. The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium. Biophys J. 2004;86:2121-8 pubmed
    ..study, we investigated the potential role of the cardiac SR luminal auxiliary proteins calsequestrin (CSQ), triadin 1, and junctin in forming the luminal calcium sensor for the cardiac RyR...
  4. Vassilopoulos S, Thevenon D, Rezgui S, Brocard J, Chapel A, Lacampagne A, et al. Triadins are not triad-specific proteins: two new skeletal muscle triadins possibly involved in the architecture of sarcoplasmic reticulum. J Biol Chem. 2005;280:28601-9 pubmed
    We have cloned two new triadin isoforms from rat skeletal muscle, Trisk 49 and Trisk 32, which were named according to their theoretical molecular masses (49 and 32 kDa, respectively)...
  5. Zhang L, Kelley J, Schmeisser G, Kobayashi Y, Jones L. Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane. J Biol Chem. 1997;272:23389-97 pubmed
    ..These include the ryanodine receptor, triadin, and calsequestrin, which may associate into a stable complex at the junctional membrane...
  6. Fourest Lieuvin A, Rendu J, Osseni A, Pernet Gallay K, Rossi D, Oddoux S, et al. Role of triadin in the organization of reticulum membrane at the muscle triad. J Cell Sci. 2012;125:3443-53 pubmed publisher
    ..Here we explore the intrinsic molecular properties of the longest triadin isoform Trisk 95. We show that when ectopically expressed, Trisk 95 can modulate reticulum membrane morphology...
  7. Gergs U, Berndt T, Buskase J, Jones L, Kirchhefer U, Müller F, et al. On the role of junctin in cardiac Ca2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol. 2007;293:H728-34 pubmed
    ..cardiac junctional sarcoplasmic reticulum (SR) and forms a quaternary complex with the Ca(2+) release channel, triadin and calsequestrin...
  8. Rezgui S, Vassilopoulos S, Brocard J, Platel J, Bouron A, Arnoult C, et al. Triadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes. J Biol Chem. 2005;280:39302-8 pubmed
    To identify the function of triadin in skeletal muscle, adenovirus-mediated overexpression of Trisk 95 or Trisk 51, the two major skeletal muscle isoforms, was induced in rat skeletal muscle primary cultures, and the physiological ..
  9. Vassilopoulos S, Brocard J, Garcia L, Marty I, Bouron A. Retrograde regulation of store-operated calcium channels by the ryanodine receptor-associated protein triadin 95 in rat skeletal myotubes. Cell Calcium. 2007;41:179-85 pubmed
    The 95kDa triadin (or T95), the main skeletal muscle triadin isoform, negatively regulates the mechanism of excitation-contraction coupling...

More Information

Publications19

  1. Milstein M, McFarland T, Marsh J, Cala S. Inefficient glycosylation leads to high steady-state levels of actively degrading cardiac triadin-1. J Biol Chem. 2008;283:1929-35 pubmed
    In junctional sarcoplasmic reticulum, binding to cardiac triadin-1 provides a mechanism by which the Ca(2+)-release channel/ryanodine receptor may link with calsequestrin to regulate Ca(2+) release...
  2. Royland J, Kodavanti P. Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action. Toxicol Appl Pharmacol. 2008;231:179-96 pubmed publisher
    ..Functional analysis suggests that pathways related to calcium homeostasis (Gng3, Ryr2, Trdn, Cacna1a), intracellular signaling (Camk2d, Stk17b, Pacsin2, Ryr2, Trio, Fert2, Ptk2b), axonal guidance (Lum, Mxd3, ..
  3. Fodor J, Gönczi M, Sztretye M, Dienes B, Oláh T, Szabo L, et al. Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture. J Physiol. 2008;586:5803-18 pubmed publisher
    The 95 kDa triadin (Trisk 95), an integral protein of the sarcoplasmic reticular membrane in skeletal muscle, interacts with both the ryanodine receptor (RyR) and calsequestrin...
  4. Marty I, Thevenon D, Scotto C, Groh S, Sainnier S, Robert M, et al. Cloning and characterization of a new isoform of skeletal muscle triadin. J Biol Chem. 2000;275:8206-12 pubmed
    We have shown that several isoforms of triadin, a protein involved in calcium release process through the ryanodine receptor, are expressed in rat skeletal muscle, and we have cloned two of these isoforms...
  5. Terentyev D, Cala S, Houle T, Viatchenko Karpinski S, Gyorke I, Terentyeva R, et al. Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes. Circ Res. 2005;96:651-8 pubmed
    b>Triadin 1 (TRD) is an integral membrane protein that associates with the ryanodine receptor (RyR2), calsequestrin (CASQ2) and junctin to form a macromolecular Ca signaling complex in the cardiac junctional sarcoplasmic reticulum (SR)...
  6. Bach A, Beier J, Stark G. Expression of Trisk 51, agrin and nicotinic-acetycholine receptor epsilon-subunit during muscle development in a novel three-dimensional muscle-neuronal co-culture system. Cell Tissue Res. 2003;314:263-74 pubmed
    ..Our results suggest the existence of an alternative pathway for the maturation of the nAChR gamma-subunit to the epsilon-subunit without neural agrin activity. ..
  7. Qin J, Valle G, Nani A, Nori A, Rizzi N, Priori S, et al. Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants. J Gen Physiol. 2008;131:325-34 pubmed publisher
    ..The key Ca2+-sensitive step in this mechanism may be the Ca2+-dependent CSQ2 interaction with triadin. The CSQ2-dependent mechanism alters the cytosolic Ca2+ sensitivity of the channel...
  8. Oláh T, Fodor J, Oddoux S, Ruzsnavszky O, Marty I, Csernoch L. Trisk 32 regulates IP(3) receptors in rat skeletal myoblasts. Pflugers Arch. 2011;462:599-610 pubmed publisher
    ..Thus, Trisk 32 not only co-localizes with, but directly contributes to, the regulation of Ca(2+) release via IP(3)R. ..
  9. Roux Buisson N, Cacheux M, Fourest Lieuvin A, Fauconnier J, Brocard J, Denjoy I, et al. Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Hum Mol Genet. 2012;21:2759-67 pubmed publisher
    ..Based on a candidate gene approach, we focused our investigations on triadin and junctin, two proteins that link RyR2 and CSQ2...
  10. Carl S, Felix K, Caswell A, Brandt N, Brunschwig J, Meissner G, et al. Immunolocalization of triadin, DHP receptors, and ryanodine receptors in adult and developing skeletal muscle of rats. Muscle Nerve. 1995;18:1232-43 pubmed
    ..Recently, a newly discovered 95-kDa protein, triadin, has been purified from rabbit skeletal muscle heavy sarcoplasmic reticulum (SR) vesicles...