Gene Symbol: Trak1
Description: trafficking kinesin protein 1
Alias: OIP106, RGD1307844, trafficking kinesin-binding protein 1, trafficking protein, kinesin binding 1
Brickley K, Smith M, Beck M, Stephenson F. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem. 2005;280:14723-32 pubmed
..44% amino acid sequence identity with O-linked N-acetylglucosamine transferase interacting protein 106, OIP106. Both proteins contain predicted coiled-coil domains and probably constitute a novel gene family...
Iyer S, Akimoto Y, Hart G. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. J Biol Chem. 2003;278:5399-409 pubmed
..L., Pollard, S., and Stephenson, F. A. (2002) J. Biol. Chem. 277, 30079-30090), and its novel homolog, OIP106 (KIAA1042), as novel OGT-interacting proteins...
Webber E, Li L, Chin L. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. J Mol Biol. 2008;382:638-51 pubmed publisher
..Recently, a spontaneous mutation in the gene encoding trafficking protein, kinesin-binding 1 (Trak1), was identified as the genetic defect that causes hypertonia in mice...
Gilbert S, Zhang L, Forster M, Anderson J, Iwase T, Soliven B, et al
. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. Nat Genet. 2006;38:245-50 pubmed
..We cloned the responsible gene, trafficking protein, kinesin binding 1 (Trak1), and showed that its protein product interacts with GABA(A) receptors...
Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff H, Rempe D. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J Cell Biol. 2009;185:1065-81 pubmed publisher
..These findings have broad implications for maintenance of neuronal viability and function during physiological and pathological states. ..
van Spronsen M, Mikhaylova M, Lipka J, Schlager M, van den Heuvel D, Kuijpers M, et al
. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron. 2013;77:485-502 pubmed publisher
..Here, we show that TRAK family adaptor proteins, TRAK1 and TRAK2, which link mitochondria to microtubule-based motors, are required for axonal and dendritic ..
Lin M, Sheng Z. Regulation of mitochondrial transport in neurons. Exp Cell Res. 2015;334:35-44 pubmed publisher
..The review focuses on microtubule (MT)-based mitochondrial trafficking and anchoring. Additional insight from different perspectives can be found in other in-depth reviews. ..
Loss O, Stephenson F. Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. J Neurosci Res. 2015;93:1056-66 pubmed publisher
..Previous work has established that trafficking kinesin proteins (TRAKs),TRAK1 and TRAK2, are kinesin adaptor proteins that link mitochondria to kinesin motor proteins via an acceptor protein ..