Tp53

Summary

Gene Symbol: Tp53
Description: tumor protein p53
Alias: Trp53, p53, cellular tumor antigen p53, transformation related protein 53, tumor protein p53 (Li-Fraumeni syndrome), tumor suppressor p53
Species: rat
Products:     Tp53

Top Publications

  1. Hong M, Gao J, Cui J, Wang K, Tian Y, Li R, et al. Effect of c-Jun NH?-terminal kinase-mediated p53 expression on neuron autophagy following traumatic brain injury in rats. Chin Med J (Engl). 2012;125:2019-24 pubmed
    ..However, the underlying molecular pathway remains unclear. Our study assessed whether JNK-mediated p53 phosphorylation might be an important mechanism for enhancing neuron autophagy in response to TBI...
  2. van Boxtel R, Kuiper R, Toonen P, van Heesch S, Hermsen R, de Bruin A, et al. Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. Am J Pathol. 2011;179:1616-22 pubmed publisher
    The TP53 tumor suppressor gene is mutated in the majority of human cancers. Inactivation of p53 in a variety of animal models results in early-onset tumorigenesis, reflecting the importance of p53 as a gatekeeper tumor suppressor...
  3. Wilkinson D, Tsai W, Schumacher M, Barton M. Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol. 2008;28:1988-98 pubmed publisher
    In hepatic cells, Smad and SnoN proteins converge with p53 to repress transcription of AFP, an oncodevelopmental tumor marker aberrantly reactivated in hepatoma cells...
  4. Langley E, Pearson M, Faretta M, Bauer U, Frye R, Minucci S, et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 2002;21:2383-96 pubmed
    ..SIRT1 binds and deacetylates p53, a component of PML nuclear bodies, and it can repress p53-mediated transactivation...
  5. Kurki S, Latonen L, Laiho M. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J Cell Sci. 2003;116:3917-25 pubmed
    Mdm2 is a nucleoplasmic and nucleolar protein interacting with p53 and alternative reading frame (ARF) tumor suppressor proteins...
  6. Binet R, Ythier D, Robles A, Collado M, Larrieu D, Fonti C, et al. WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 2009;69:9183-91 pubmed publisher
    ..that is induced by several stimuli, including oncogenic signaling and telomere shortening, and controlled by the p53/p21(WAF1) signaling pathway...
  7. Kruse J, Gu W. Modes of p53 regulation. Cell. 2009;137:609-22 pubmed publisher
    The traditional view of p53 activation includes three steps-p53 stabilization, DNA binding, and transcriptional activation. However, recent studies indicate that each step of p53 activation is more complex than originally anticipated...
  8. Whibley C, Pharoah P, Hollstein M. p53 polymorphisms: cancer implications. Nat Rev Cancer. 2009;9:95-107 pubmed publisher
    The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of most human cancers and cause dramatic defects in p53 ..
  9. Li Y, Lu D, Tan W, Wang J, Li P. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Mol Cell Biol. 2008;28:564-74 pubmed
    b>p53 plays an important role in regulating apoptosis. However, the molecular mechanism by which it initiates the apoptotic program still remains to be fully understood...

More Information

Publications62

  1. Brown L, Ongusaha P, Kim H, Nuti S, Mandinova A, Lee J, et al. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. EMBO J. 2007;26:3410-22 pubmed
    We have identified a novel pro-apoptotic p53 target gene named CDIP (Cell Death Involved p53-target). Inhibition of CDIP abrogates p53-mediated apoptotic responses, demonstrating that CDIP is an important p53 apoptotic effector...
  2. Lee J, Kim H, Lee S, Kim K. Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci. 2007;120:2259-71 pubmed
    The p53 tumor suppressor protein is a key regulator of cellular functions including responses to numerous stress signals, and triggers apoptosis in many cell types, including neurons...
  3. Zhang J, Yan W, Chen X. p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death Differ. 2006;13:2118-28 pubmed
    b>p53 is necessary for the elimination of neural cells inappropriately differentiated or in response to stimuli. However, the role of p53 in neuronal differentiation is not certain...
  4. Wierød L, Rosseland C, Lindeman B, Oksvold M, Grøsvik H, Skarpen E, et al. Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes. Oncogene. 2008;27:2763-71 pubmed
    b>p53 plays a major role in the prevention of tumor development. It responds to a range of potentially oncogenic stresses by activating protective mechanisms, most notably cell-cycle arrest and apoptosis...
  5. Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine J, et al. Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005;25:8874-86 pubmed
    Nucleophosmin (NPM) is a nucleolar phosphoprotein that binds the tumor suppressors p53 and p19(Arf) and is thought to be indispensable for ribogenesis, cell proliferation, and survival after DNA damage...
  6. Lavin M, Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ. 2006;13:941-50 pubmed
    ..are activated by stress stimuli but none so spectacularly or with the degree of complexity as the tumour suppressor p53 (human p53 gene or protein)...
  7. Endo H, Kamada H, Nito C, Nishi T, Chan P. Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. J Neurosci. 2006;26:7974-83 pubmed
    Although p53 is a key modulator of cellular stress responses, the mechanism of p53-mediated apoptosis is ambiguous...
  8. Yan H, Wu H, Ashton C, Tong C, Ying Q. Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Carcinogenesis. 2012;33:2001-5 pubmed publisher
    The p53 tumor suppressor gene is highly mutated in human cancers. Individuals who inherit one p53 mutant allele are susceptible to a wide range of tumor types, including breast cancer and sarcoma...
  9. Mukhopadhyay U, Eves R, Jia L, Mooney P, Mak A. p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon. Mol Cell Biol. 2009;29:3088-98 pubmed publisher
    The tumor-suppressive role of p53 at the level of tumor initiation is well documented. It has also been shown previously that p53 acts against tumor progression/metastasis...
  10. Naito A, Okada S, Minamino T, Iwanaga K, Liu M, Sumida T, et al. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res. 2010;106:1692-702 pubmed publisher
    ..Tumor suppressor protein p53 accumulates in the myocardium after myocardial infarction, causes apoptosis of cardiomyocytes, and plays an ..
  11. Inoue Y, Tomiya T, Yanase M, Arai M, Ikeda H, Tejima K, et al. p53 May positively regulate hepatocyte proliferation in rats. Hepatology. 2002;36:336-44 pubmed
    b>p53, known as a tumor suppressor gene, is a transcription factor that regulates various cellular functions...
  12. Peters M, DeLuca C, Hirao A, Stambolic V, Potter J, Zhou L, et al. Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. Proc Natl Acad Sci U S A. 2002;99:11305-10 pubmed
    The tumor suppressor function of p53 has been attributed to its ability to regulate apoptosis and the cell cycle...
  13. Li H, Li A, Sheppard H, Liu X. Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. Mol Cell. 2004;13:867-78 pubmed
    ..Since p53 functions by inducing cell G1 arrest and apoptosis, we investigated the link between TAF1 and p53...
  14. Vaghefi H, Hughes A, Neet K. Nerve growth factor withdrawal-mediated apoptosis in naive and differentiated PC12 cells through p53/caspase-3-dependent and -independent pathways. J Biol Chem. 2004;279:15604-14 pubmed
    Programmed cell death is regulated in response to a variety of stimuli, including the tumor suppressor protein p53, that can mediate cell cycle arrest through p21/Waf1 and apoptosis through the Bcl-2/Bax equilibrium and caspases...
  15. Colombo E, Marine J, Danovi D, Falini B, Pelicci P. Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol. 2002;4:529-33 pubmed
    ..Here we show that NPM interacts directly with the tumour suppressor p53, regulates the increase in stability and transcriptional activation of p53 after different types of stress, and ..
  16. Fabian Z, Vecsernyés M, Pap M, Szeberenyi J. The effects of a mutant p53 protein on the proliferation and differentiation of PC12 rat phaeochromocytoma cells. J Cell Biochem. 2006;99:1431-41 pubmed
    ..Upon NGF treatment the p53 protein, the most commonly mutated tumor suppressor in human cancers, translocates to the nucleus and may play a ..
  17. Freed Pastor W, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012;26:1268-86 pubmed publisher
    There is now strong evidence that mutation not only abrogates p53 tumor-suppressive functions, but in some instances can also endow mutant proteins with novel activities...
  18. Okamoto K, Li H, Jensen M, Zhang T, Taya Y, Thorgeirsson S, et al. Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell. 2002;9:761-71 pubmed
    The function of cyclin G, a commonly induced p53 target, has remained elusive. We show that cyclin G forms a quaternary complex in vivo and in vitro with enzymatically active phosphatase 2A (PP2A) holoenzymes containing B' subunits...
  19. Fan B, Liu K, Wang D, Tham C, Tam P, Lam D, et al. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010;51:4110-6 pubmed publisher
    ..reductase), NOS3 (nitric oxide synthase 3), OPA1 (optic atrophy 1), TNF (tumor necrosis factor), and TP53 (tumor protein p53). One SNP (-308G>A; rs1800629) in TNF demonstrated a significant association with HTG (P = 0...
  20. Pustylnyak V, Lisachev P, Shtark M, Epstein O. Regulation of S100B gene in rat hippocampal CA1 area during long term potentiation. Brain Res. 2011;1394:33-9 pubmed publisher
    ..We analyzed the promoter region of the rat S100B gene and identified response elements for the tumor suppressor p53. ChIP assay revealed that p53 could bind to putative p53-binding sites of the S100B promoter...
  21. Vaziri H, Dessain S, Ng Eaton E, Imai S, Frye R, Pandita T, et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001;107:149-59 pubmed
    DNA damage-induced acetylation of p53 protein leads to its activation and either growth arrest or apoptosis. We show here that the protein product of the gene hSIR2(SIRT1), the human homolog of the S...
  22. Serrano M, Lin A, McCurrach M, Beach D, Lowe S. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997;88:593-602 pubmed
    ..of primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16...
  23. Walker K, Levine A. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci U S A. 1996;93:15335-40 pubmed
    Activation of the p53 tumor suppressor protein has been demonstrated to block cell growth by inducing either a transient cell cycle arrest or programmed cell death (apoptosis)...
  24. Malkin D, Li F, Strong L, Fraumeni J, Nelson C, Kim D, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250:1233-8 pubmed
    ..The alternative approach was to select the most plausible candidate gene. The tumor suppressor gene, p53, was studied because of previous indications that this gene is inactivated in the sporadic (nonfamilial) forms of ..
  25. Miyashita T, Krajewski S, Krajewska M, Wang H, Lin H, Liebermann D, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799-805 pubmed
    The p53 tumor suppressor gene product can induce apoptotic cell death through an unknown mechanism...
  26. Buschmann T, Lin Y, Aithmitti N, Fuchs S, Lu H, Resnick Silverman L, et al. Stabilization and activation of p53 by the coactivator protein TAFII31. J Biol Chem. 2001;276:13852-7 pubmed
    Regulation of the stability of p53 is key to its tumor-suppressing activities. mdm2 directly binds to the amino-terminal region of p53 and targets it for degradation through the ubiquitin-proteasome pathway...
  27. Hirao A, Kong Y, Matsuoka S, Wakeham A, Ruland J, Yoshida H, et al. DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science. 2000;287:1824-7 pubmed
    ..Chk2-/- thymocytes were resistant to DNA damage-induced apoptosis. Chk2-/- cells were defective for p53 stabilization and for induction of p53-dependent transcripts such as p21 in response to gamma irradiation...
  28. Perez Escuredo J, Martínez J, Vivanco B, Marcos C, Suarez C, Llorente J, et al. Wood dust-related mutational profile of TP53 in intestinal-type sinonasal adenocarcinoma. Hum Pathol. 2012;43:1894-901 pubmed publisher
    ..it is known that carcinogens can leave specific mutational fingerprints, we aimed to analyze the spectrum of TP53 mutations and to relate the findings to the wood dust etiology of the patients...
  29. Zhu Y, Zhang S, Ye D, Yao X, Jiang Z, Zhou X. Predicting pelvic lymph node metastases in penile cancer patients: a comparison of computed tomography, Cloquet's node, and disease burden of inguinal lymph nodes. Onkologie. 2008;31:37-41 pubmed publisher
    ..LNs, lymph node ratio (number of positive LNs/total number removed), extranodal extension and the expression of p53 - were significantly associated with pelvic LNM...
  30. Kalantari M, Ahmadnia H. P53 overexpression in bladder urothelial neoplasms: new aspect of World Health Organization/International Society of Urological Pathology classification. Urol J. 2007;4:230-3 pubmed
    The aim of this study was to investigate the probable differences in P53 expression between papillary urothelial neoplasm of low malignant potential (PUNLMP) and varying grades of transitional cell carcinoma (TCC) of the bladder...
  31. Kmet T, Tkachuk S. [Dynamics of changes of p53-positive cells morphofunctional condition in the cerebral cortex of the temporal lobe in rats affected by carotid ischemia-reperfusion]. Patol Fiziol Eksp Ter. 2015;59:19-22 pubmed
    ..Bilateral carotid ischemia with one-hour reperjusion has been indicated to increase the location density of p53+-neurocytes in this region of the cerebral cortex, increases percentage and density of p53+-nerve cells and reduces ..
  32. Hui L, Abbas T, Pielak R, Joseph T, Bargonetti J, Foster D. Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol Cell Biol. 2004;24:5677-86 pubmed
    ..Since DNA damage-induced apoptosis is often mediated by p53, we examined the effect of elevated PLD expression on the regulation of p53 stabilization...
  33. Tidow H, Melero R, Mylonas E, Freund S, Grossmann J, Carazo J, et al. Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex. Proc Natl Acad Sci U S A. 2007;104:12324-9 pubmed
    The homotetrameric tumor suppressor p53 consists of folded core and tetramerization domains, linked and flanked by intrinsically disordered segments that impede structure analysis by x-ray crystallography and NMR...
  34. Villeneuve C, Guilbeau Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, et al. p53-PGC-1? pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antioxid Redox Signal. 2013;18:5-18 pubmed publisher
    ..In the present study, we evaluated the consequences of cardiac MAO-A augmentation on chronic oxidative damage, cardiomyocyte survival, and heart function, and identified the intracellular pathways involved...
  35. He H, Multani A, Cosme Blanco W, Tahara H, Ma J, Pathak S, et al. POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J. 2006;25:5180-90 pubmed
    ..of a mutant Pot1b allele that cannot bind telomeric DNA initiated a DNA damage response at telomeres that led to p53-dependent senescence...
  36. Lasham A, Moloney S, Hale T, Homer C, Zhang Y, Murison J, et al. The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressor. J Biol Chem. 2003;278:35516-23 pubmed
    The p53 tumor suppressor plays a major role in preventing tumor development by transactivating genes to remove or repair potentially tumorigenic cells. Here we show that the Y-box-binding protein, YB1, acts as a negative regulator of p53...
  37. Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H, Tanaka Okamoto M, et al. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell. 2007;18:1701-9 pubmed
    The tumor suppressor p53 is a key transcriptional factor regulating the induction of cellular senescence by oncogenic signals...
  38. Loghavi S, Al Ibraheemi A, Zuo Z, Garcia Manero G, Yabe M, Wang S, et al. TP53 overexpression is an independent adverse prognostic factor in de novo myelodysplastic syndromes with fibrosis. Br J Haematol. 2015;171:91-9 pubmed publisher
    ..Bone marrow (BM) fibrosis is associated with poor prognosis in patients with de novo myelodysplastic syndromes (MDS). TP53 mutations and TP53 (p53) overexpression in MDS are also associated with poor patient outcomes...
  39. Herbig U, Jobling W, Chen B, Chen D, Sedivy J. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell. 2004;14:501-13 pubmed
    ..multiple DNA damage response factors were assembled in a subset of senescent cells and signaled through ATM to p53, upregulating p21 and causing G1 phase arrest...
  40. Li D, Wang Y, Zhou S, Sun W. ?-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative conditions. Mol Med Rep. 2016;14:4360-4366 pubmed publisher
    ..in the expression levels of PCNA by ALA in the MPP+?treated PC12 cells appeared to be mediated by repression of the p53 protein, as the expression of p53 was increased by MPP+?treatment and reduced by ALA...
  41. Khoury Haddad H, Guttmann Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:E728-37 pubmed publisher
    ..with an upstream role in DDR, KDM4D knockdown disrupts the damage-induced recombinase Rad51 and tumor protein P53 binding protein foci formation...
  42. Liu J, Mao W, Ding B, Liang C. ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008;295:H1956-65 pubmed publisher
    ..agent, have been linked to DNA damage, oxidative mitochondrial damage, and nuclear translocation of p53, but the exact molecular mechanisms causing p53 transactivation and doxorubicin-induced cardiomyopathy are not ..
  43. Pabla N, Huang S, Mi Q, Daniel R, Dong Z. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem. 2008;283:6572-83 pubmed
    ..Recent work has suggested a role for p53 in cisplatin-induced renal cell apoptosis and kidney injury; however, the signaling pathway leading to p53 ..
  44. Muller L, Schaupp A, Walerych D, Wegele H, Buchner J. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. J Biol Chem. 2004;279:48846-54 pubmed
    The activity and structural integrity of the tumor suppressor protein p53 is of crucial importance for the prevention of cancer...
  45. Nishimura K, Makino S, Tanaka Y, Kaneda T, Hashimoto K. Altered expression of p53 mRNA in the brain and pituitary during repeated immobilization stress: negative correlation with glucocorticoid receptor mRNA levels. J Neuroendocrinol. 2004;16:84-91 pubmed
    ..Our laboratory has also shown that the sp1 activates, whereas tumour suppressor p53 represses the promoter activity of GR gene...
  46. Shibue T, Takeda K, Oda E, Tanaka H, Murasawa H, Takaoka A, et al. Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 2003;17:2233-8 pubmed
    The tumor suppressor p53 exerts its versatile function to maintain the genomic integrity of a cell, and the life of cancerous cells with DNA damage is often terminated by induction of apoptosis...
  47. Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor E, et al. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol Cell Biol. 2010;30:3004-15 pubmed publisher
    ..We report here that ATDC increases cell proliferation via inhibition of p53 nuclear activities. ATDC represses the expression of p53-regulated genes, including p21 and NOXA...
  48. Frappart P, Lee Y, Lamont J, McKinnon P. BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J. 2007;26:2732-42 pubmed
    ..defects arose from DNA damage as Brca2(LoxP/LoxP);Nestin-cre mice showed extensive gammaH2AX in neural tissue and p53 deficiency restored brain histology but lead to rapid formation of medulloblastoma brain tumors...
  49. Sasaki T, Gan E, Wakeham A, Kornbluth S, Mak T, Okada H. HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev. 2007;21:848-61 pubmed
    In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still unclear...
  50. Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R, et al. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Genes Dev. 2006;20:1262-7 pubmed
    ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2-/- pups died before weaning. This postnatal lethality was significantly enhanced in p53+/- background and both deletions are synthetic lethal...
  51. Sugo N, Niimi N, Aratani Y, Takiguchi Hayashi K, Koyama H. p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol Cell Biol. 2004;24:9470-7 pubmed
    ..Here, we studied potential roles in the phenotype for p53, which has been implicated in DNA damage sensing, cell cycle arrest, and apoptosis...
  52. Wen Y, Zhou P, Liu L, Wang Z, Zhang Y, Liang J. Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. J Recept Signal Transduct Res. 2016;36:173-80 pubmed publisher
    ..Moreover, Cabin1 retards tumor cell apoptosis by regulating p53. This study was designed to observe the expression of Cabin1 during podocyte injury, as well as its relationship ..
  53. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-90 pubmed
    b>p53 induces apoptosis by target gene regulation and transcription-independent signaling. However, a mechanism for the latter was unknown...