Gene Symbol: Tomm70
Description: translocase of outer mitochondrial membrane 70
Alias: TOM70, Tomm70a, mitochondrial import receptor subunit TOM70, mitochondrial precursor proteins import receptor, translocase of outer membrane 70 kDa subunit, translocase of outer mitochondrial membrane protein 70
Species: rat
Products:     Tomm70

Top Publications

  1. Suzuki H, Maeda M, Mihara K. Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane. J Cell Sci. 2002;115:1895-905 pubmed
    ..1% and 20.1% with N. crassa and S. cerevisiae Tom70, respectively...
  2. Höhr A, Straub S, Warscheid B, Becker T, Wiedemann N. Assembly of β-barrel proteins in the mitochondrial outer membrane. Biochim Biophys Acta. 2015;1853:74-88 pubmed publisher
  3. Wenz L, OpaliÅ„ski Å, Wiedemann N, Becker T. Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 2015;1853:1119-29 pubmed publisher
    ..Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis. ..
  4. Giorgianni F, Usman Khan M, Weber K, Gerling I, Beranova Giorgianni S. Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure. Mol Cell Biochem. 2014;389:159-67 pubmed publisher
    ..for example, long-chain specific acyl-CoA dehydrogenase, Complex III subunit 6, and mitochondrial import receptor TOM70. Collectively, the characterized phosphoproteins belong to diverse functional modules, including bioenergetic ..
  5. Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
    ..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..
  6. Ellenrieder L, MÃ¥rtensson C, Becker T. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Biol Chem. 2015;396:1199-213 pubmed publisher
    ..We summarize current models and open questions of biogenesis of mitochondrial outer membrane proteins and discuss the impact of malfunctions of protein sorting on the development of diseases. ..
  7. Kang C, Qin J, Osei W, Hu K. Regulation of protein kinase C-epsilon and its age-dependence. Biochem Biophys Res Commun. 2017;482:1201-1206 pubmed publisher
    ..the basal condition and in response to adenosine treatment, along with largely decreased mitochondrial HSP90 and TOM70 protein expression...
  8. Santos J, Kowluru R. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes Metab Res Rev. 2013;29:204-13 pubmed publisher
    ..Components of the membrane transport system, Tom70, Tom40, Tim23, and Tim44, were analysed in the retina from streptozotocin-induced diabetic rats maintained in poor ..
  9. Deane E, Ilie A, Sizdahkhani S, Das Gupta M, Orlowski J, McKinney R. Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci. 2013;33:595-610 pubmed publisher
    ..These data suggest that NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory...

More Information


  1. Li J, Qi M, Li C, Shi D, Zhang D, Xie D, et al. Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Res. 2014;24:977-93 pubmed publisher
    ..Here, we showed that Tom70 was downregulated in pathological hypertrophic hearts from humans and experimental animals...
  2. Alvarez Dolado M, Gonzalez Moreno M, Valencia A, Zenke M, Bernal J, Munoz A. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. J Neurochem. 1999;73:2240-9 pubmed
    ..S2 was identified as KIAA0719, the first human gene distantly homologous to the fungal Tom70, which encodes a member of the translocase mitochondrial outer membrane complex involved in the import of ..