Gene Symbol: TOM22
Description: translocase of outer mitochondrial membrane 22
Alias: TOM22, rTOM22, mitochondrial import receptor subunit TOM22 homolog, translocase of outer membrane 22 kDa subunit homolog, translocase of outer mitochondrial membrane 22 homolog
Johnston A, Hoogenraad J, Dougan D, Truscott K, Yano M, Mori M, et al
. Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem. 2002;277:42197-204 pubmed
..intermediate can be chased to the stable approximately 380-kDa mammalian TOM complex that additionally contains Tom22. Overexpression of Tom22 in HeLa cells results in the rapid assembly of Tom7 into the 380-kDa complex indicating ..
Humphries A, Streimann I, Stojanovski D, Johnston A, Yano M, Hoogenraad N, et al
. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005;280:11535-43 pubmed
..Nevertheless, we show that Tom40 assembly is reduced in mitochondria depleted of human Sam50. These findings are discussed in context with current models from fungal studies. ..
Dagda R, Barwacz C, Cribbs J, Strack S. Unfolding-resistant translocase targeting: a novel mechanism for outer mitochondrial membrane localization exemplified by the Bbeta2 regulatory subunit of protein phosphatase 2A. J Biol Chem. 2005;280:27375-82 pubmed
..is not detectably cleaved and is retained at the outer mitochondrial membrane, even though it interacts with the TOM22 import receptor, as shown by luciferase complementation in intact cells...
Cartron P, Bellot G, Oliver L, Grandier Vazeille X, Manon S, Vallette F. Bax inserts into the mitochondrial outer membrane by different mechanisms. FEBS Lett. 2008;582:3045-51 pubmed publisher
..We have recently shown that TOM22, a mitochondrial outer membrane receptor, is important for insertion, although other reports have suggested that ..
Wenz L, OpaliÅ„ski Å, Wiedemann N, Becker T. Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 2015;1853:1119-29 pubmed publisher
..Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis. ..
Ellenrieder L, MÃ¥rtensson C, Becker T. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Biol Chem. 2015;396:1199-213 pubmed publisher
..We summarize current models and open questions of biogenesis of mitochondrial outer membrane proteins and discuss the impact of malfunctions of protein sorting on the development of diseases. ..
Nakamura Y, Suzuki H, Sakaguchi M, Mihara K. Targeting and assembly of rat mitochondrial translocase of outer membrane 22 (TOM22) into the TOM complex. J Biol Chem. 2004;279:21223-32 pubmed
..Rat Tom22 (rTOM22) is a 142-residue protein, embedded in the outer membrane through the internal transmembrane domain (TMD) with 82 ..
HÃ¶hr A, Straub S, Warscheid B, Becker T, Wiedemann N. Assembly of Î²-barrel proteins in the mitochondrial outer membrane. Biochim Biophys Acta. 2015;1853:74-88 pubmed publisher
Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..