Gene Symbol: Tollip
Description: toll interacting protein
Alias: toll-interacting protein
Species: rat
Products:     Tollip

Top Publications

  1. Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2000;2:346-51 pubmed
    ..and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip. Here we show that, before IL-1beta treatment, Tollip is present in a complex with IRAK, and that recruitment of ..
  2. Bulut Y, Faure E, Thomas L, Equils O, Arditi M. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like recepto. J Immunol. 2001;167:987-94 pubmed
    ..Moreover, we show that Toll-interacting protein (Tollip) coimmunoprecipitates with TLR2 and TLR4 using HEK 293 cells, and overexpression of Tollip inhibits NF-kappaB ..
  3. Katoh Y, Imakagura H, Futatsumori M, Nakayama K. Recruitment of clathrin onto endosomes by the Tom1-Tollip complex. Biochem Biophys Res Commun. 2006;341:143-9 pubmed
    ..We have previously shown that the GAT domain of Tom1 interacts with Tollip (Toll-interacting protein), which is associated with endosomes, to which it recruits Tom1...
  4. Verstrepen L, Bekaert T, Chau T, Tavernier J, Chariot A, Beyaert R. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol Life Sci. 2008;65:2964-78 pubmed publisher
    ..In this review, we will discuss our current knowledge of NF-kappaB signaling in response to TLR-4, TNF-R and IL-1R stimulation, with a special focus on the similarities and dissimilarities among these pathways. ..
  5. Ciarrocchi A, D Angelo R, Cordiglieri C, Rispoli A, Santi S, Riccio M, et al. Tollip is a mediator of protein sumoylation. PLoS ONE. 2009;4:e4404 pubmed publisher
    b>Tollip is an interactor of the interleukin-1 receptor involved in its activation. The endosomal turnover of ubiquitylated IL-1RI is also controlled by Tollip...
  6. Wu W, Wang Y, Zou J, Long F, Yan H, Zeng L, et al. Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats. BMC Pediatr. 2017;17:1 pubmed publisher
    ..All rats were sacrificed 72 h after birth and intestinal injury and mRNA expression of TLR4, TOLLIP and SIGIRR were assessed. B. adolescentis significantly increased the 72-h survival rate from 56...
  7. Nilsen K. Malignant lymphoma and rheumatic symptoms. N Z Med J. 1976;83:320-2 pubmed
    ..The progress of her illness suggests that she is suffering from a connective tissue disease, too, or possibly secondary immune complex disease. ..
  8. Xu N, Yu Z, Yao Q, Wang Z, Qu H, Sun Y, et al. PPAR-? and tollip are associated with toll-like receptors in colitis rats. J Immunoassay Immunochem. 2013;34:219-31 pubmed publisher
    To elucidate the significance of Toll-like receptors and their negative regulating factors PPAR-? and Tollip on the pathogenesis of colitis. Colitis model was induced by TNBS in rat...
  9. Liu M, Wang Y, Qian C, Li H. Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis. Int J Mol Med. 2014;34:1492-504 pubmed publisher
    ..chain reaction (PT-PCR) and western blot analysis were used to examine the expression of Toll-interacting protein (Tollip), interleukin-1 receptor-associated kinase 1 (IRAK1), Toll-like receptor 4 (TLR4), nuclear factor-κB65 (NF-κ..

More Information


  1. Li M, Feng B, Wang L, Guo S, Zhang P, Gong J, et al. Tollip is a critical mediator of cerebral ischaemia-reperfusion injury. J Pathol. 2015;237:249-62 pubmed publisher
    ..Toll-interacting protein (Tollip) is an endogenous negative modulator of TLR signalling that is involved in several inflammatory diseases...