Tnrc6a

Summary

Gene Symbol: Tnrc6a
Description: trinucleotide repeat containing 6a
Alias: Tnrc6, trinucleotide repeat-containing gene 6A protein, trinucleotide repeat containing 6
Species: rat
Products:     Tnrc6a

Top Publications

  1. Wakiyama M, Takimoto K, Ohara O, Yokoyama S. Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev. 2007;21:1857-62 pubmed
    ..Our work suggests that let-7 miRNPs containing Argonaute and GW182 impair the synergistic enhancement of translation by the 5'-cap and 3'-poly(A) tail, resulting in translational repression. ..
  2. Yang Z, Jakymiw A, Wood M, Eystathioy T, Rubin R, Fritzler M, et al. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J Cell Sci. 2004;117:5567-78 pubmed
  3. Ender C, Meister G. Argonaute proteins at a glance. J Cell Sci. 2010;123:1819-23 pubmed publisher
  4. Huntzinger E, Kuzuoğlu Öztürk D, Braun J, Eulalio A, Wohlbold L, Izaurralde E. The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Res. 2013;41:978-94 pubmed publisher
    ..melanogaster and human cells indicate that miRNA-mediated translational repression and degradation are mechanistically linked and are triggered through the interactions of GW182 proteins with PABP and deadenylases. ..
  5. James V, Zhang Y, Foxler D, de Moor C, Kong Y, Webb T, et al. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2010;107:12499-504 pubmed publisher