Gene Symbol: Tnr
Description: tenascin R
Alias: J1NRM, tenascin-R, TN-R, Tenascin-R (Restrictin, janusin, J1-160/180), janusin, neural recognition molecule J1-160/180, restrictin, tenascin R (restrictin, janusin)
Species: rat
Products:     Tnr

Top Publications

  1. Fuss B, Wintergerst E, Bartsch U, Schachner M. Molecular characterization and in situ mRNA localization of the neural recognition molecule J1-160/180: a modular structure similar to tenascin. J Cell Biol. 1993;120:1237-49 pubmed
    ..Sequence comparison analysis revealed highest homology of rat J1-160/180 to mouse tenascin and chicken restrictin with a similarity of 66% and 85%, respectively. The J1-160/180-coding mRNA is derived from a single copy gene...
  2. Bukalo O, Schachner M, Dityatev A. Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. J Neurosci. 2007;27:6019-28 pubmed
    ..of a molecular mechanism underlying metaplasticity, we investigated mice deficient in the glycoprotein tenascin-R (TNR), based on the observations that this mutant exhibits elevated basal excitatory synaptic transmission and reduced ..
  3. Lundell A, Olin A, Morgelin M, Al Karadaghi S, Aspberg A, Logan D. Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins. Structure. 2004;12:1495-506 pubmed
    ..Comparison of the protein interaction surface with that of P-selectin in complex with the PGSL-1 peptide suggests that direct protein-protein interactions of Ca(2+)-binding CLDs may be more widespread than previously appreciated. ..
  4. Montag Sallaz M, Montag D. Severe cognitive and motor coordination deficits in tenascin-R-deficient mice. Genes Brain Behav. 2003;2:20-31 pubmed
    ..Our results support important functions of TN-R in vivo in the central nervous system, in particular in the cerebellum and the hippocampus. ..
  5. Bekku Y, Rauch U, Ninomiya Y, Oohashi T. Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. J Neurochem. 2009;108:1266-76 pubmed publisher
    ..Our results revealed that brevican plays a crucial role in determining the specialization of the hyaluronan-binding nodal matrix assemblies in large diameter nodes. ..
  6. Liao H, Huang W, Schachner M, Guan Y, Guo J, Yan J, et al. Beta 1 integrin-mediated effects of tenascin-R domains EGFL and FN6-8 on neural stem/progenitor cell proliferation and differentiation in vitro. J Biol Chem. 2008;283:27927-36 pubmed publisher
    ..The influence of EGFL or FN6-8 on NSCs differentiation was inhibited by beta 1 integrin antibody application, implicating beta 1 integrin in proliferation and differentiation induced by EGFL and FN6-8 mediated triggering of NSCs. ..
  7. Apostolova I, Irintchev A, Schachner M. Tenascin-R restricts posttraumatic remodeling of motoneuron innervation and functional recovery after spinal cord injury in adult mice. J Neurosci. 2006;26:7849-59 pubmed
    Tenascin-R (TNR) is an extracellular glycoprotein in the CNS implicated in neural development and plasticity...
  8. Sykova E, Vorisek I, Mazel T, Antonova T, Schachner M. Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice. Eur J Neurosci. 2005;22:1873-80 pubmed
    ..The altered diffusion of neuroactive substances in the brain will inevitably affect extrasynaptic transmission, neuron-glia interactions and synaptic efficacy. ..
  9. Liao H, Bu W, Wang T, Ahmed S, Xiao Z. Tenascin-R plays a role in neuroprotection via its distinct domains that coordinate to modulate the microglia function. J Biol Chem. 2005;280:8316-23 pubmed
    ..These results suggest that TN-R plays a role in neuroprotection through distinct domains coordinating to modulate microglia function. ..

Scientific Experts

More Information


  1. Saghatelyan A, Dityatev A, Schmidt S, Schuster T, Bartsch U, Schachner M. Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R. Mol Cell Neurosci. 2001;17:226-40 pubmed
  2. Bruckner G, Grosche J, Schmidt S, Hartig W, Margolis R, Delpech B, et al. Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J Comp Neurol. 2000;428:616-29 pubmed
    ..This may interfere with the development of the specific micromilieu of the ensheathed neurons and adjacent glial cells and may also permanently change their functional properties. ..
  3. Xiao Z, Taylor J, Montag D, Rougon G, Schachner M. Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11. Eur J Neurosci. 1996;8:766-82 pubmed
    ..They further suggest the existence of multiple neuronal tenascin-R receptors which influence the response of neurons to their extracellular matrix environment. ..
  4. Weber P, Bartsch U, Rasband M, Czaniera R, Lang Y, Bluethmann H, et al. Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J Neurosci. 1999;19:4245-62 pubmed
    ..These observations indicate an essential role for TN-R in the formation of perineuronal nets and in normal conduction velocity of optic nerve. ..
  5. Srinivasan J, Schachner M, Catterall W. Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R. Proc Natl Acad Sci U S A. 1998;95:15753-7 pubmed
  6. Probstmeier R, Stichel C, Muller H, Asou H, Pesheva P. Chondroitin sulfates expressed on oligodendrocyte-derived tenascin-R are involved in neural cell recognition. Functional implications during CNS development and regeneration. J Neurosci Res. 2000;60:21-36 pubmed
    ..e., suppression of axon regeneration after CNS injury. ..
  7. Czopka T, von Holst A, Schmidt G, Ffrench Constant C, Faissner A. Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway. Glia. 2009;57:1790-801 pubmed publisher
    ..Here, we compared the roles of the two related extracellular matrix (ECM) glycoproteins Tenascin C (Tnc) and Tenascin R (Tnr) in oligodendrocyte differentiation...
  8. Kappler J, Baader S, Franken S, Pesheva P, Schilling K, Rauch U, et al. Tenascins are associated with lipid rafts isolated from mouse brain. Biochem Biophys Res Commun. 2002;294:742-7 pubmed
    ..The reported interactions of several raft-associated proteins (such as, e.g., F3) with tenascin C and tenascin R prompted us to consider that these oligomeric multidomain glycoproteins of the extracellular matrix (ECM) could ..
  9. Woodworth A, Fiete D, Baenziger J. Spatial and temporal regulation of tenascin-R glycosylation in the cerebellum. J Biol Chem. 2002;277:50941-7 pubmed
    ..The spatially and temporally regulated addition of this unique sulfated carbohydrate to tenascin-R may serve to modulate its adhesive/anti-adhesive or other biological properties in vivo. ..
  10. Schachner M, Taylor J, Bartsch U, Pesheva P. The perplexing multifunctionality of janusin, a tenascin-related molecule. Perspect Dev Neurobiol. 1994;2:33-41 pubmed
    The extracellular matrix glycoprotein janusin, closely related to tenascin in its repeated motifs of epidermal growth factor, fibronectin type III, and fibrinogen-like domains, displays in vitro a broad spectrum of functional diversity...
  11. Woodworth A, Pesheva P, Fiete D, Baenziger J. Neuronal-specific synthesis and glycosylation of tenascin-R. J Biol Chem. 2004;279:10413-21 pubmed
    ..In addition, the 160-kDa form of TN-R is particularly enriched for terminal GalNAc-4-SO(4) later in development and in the adult, suggesting additional levels of regulation. ..
  12. Gurevicius K, Gureviciene I, Valjakka A, Schachner M, Tanila H. Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R. Mol Cell Neurosci. 2004;25:515-23 pubmed
    ..In addition, response habituation to repeated sound stimuli was significantly attenuated in TN-R-/- mice. These findings indicate that tenascin-R is involved in the regulation of certain inhibitory mechanisms in the intact brain. ..
  13. Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegard D, Schachner M, et al. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Proc Natl Acad Sci U S A. 1997;94:10116-21 pubmed
    ..These results demonstrate that the C-type lectin domain can interact with fibronectin type III domains through protein-protein interactions, and suggest that brevican is a physiological tenascin-R ligand in the adult brain. ..
  14. Xiao Z, Bartsch U, Margolis R, Rougon G, Montag D, Schachner M. Isolation of a tenascin-R binding protein from mouse brain membranes. A phosphacan-related chondroitin sulfate proteoglycan. J Biol Chem. 1997;272:32092-101 pubmed
    ..These observations indicate that TN-R can interact with a phosphacan-related molecule and thereby modulate its inhibitory influence on neuritogenesis. ..
  15. Cowley A, Moreno C, Jacob H, Peterson C, Stingo F, Ahn K, et al. Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats. Physiol Genomics. 2014;46:398-410 pubmed publisher
    ..filled genomic gaps and provided identification of five genes in this region, Rfwd2, Fam5b, Astn1, Pappa2, and Tnr. A cross-platform normalization of transcriptome data sets obtained from our previously published Affymetrix ..
  16. Galtrey C, Kwok J, Carulli D, Rhodes K, Fawcett J. Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord. Eur J Neurosci. 2008;27:1373-90 pubmed publisher
    ..During postnatal development the expression of link protein and aggrecan mRNA is up-regulated at the time of PNN formation, and these molecules may therefore trigger their formation. ..
  17. Milev P, Chiba A, Haring M, Rauvala H, Schachner M, Ranscht B, et al. High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule. J Biol Chem. 1998;273:6998-7005 pubmed
  18. Pesheva P, Probstmeier R, Lang D, McBride R, Hsu N, Gennarini G, et al. Early coevolution of adhesive but not antiadhesive tenascin-R ligand-receptor pairs in vertebrates: a phylogenetic study. Mol Cell Neurosci. 2006;32:366-86 pubmed
  19. Leprini A, Gherzi R, Vecchi E, Borsi L, Zardi L, Siri A. Rat tenascin-R gene: structure, chromosome location and transcriptional activity of promoter and exon 1. Cytogenet Cell Genet. 1998;83:115-23 pubmed
  20. Saghatelyan A, de Chevigny A, Schachner M, Lledo P. Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrain. Nat Neurosci. 2004;7:347-56 pubmed
  21. Freitag S, Schachner M, Morellini F. Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav Brain Res. 2003;145:189-207 pubmed
    ..TN-R deficient mice showed motor coordination impairments in the wire hanging, Rotarod and pole test. Thus TN-R ablation leads to an altered behavioral phenotype in mice that may negatively affect their fitness under natural conditions. ..
  22. Wintergerst E, Rathjen F, Schwaller B, Eggli P, Celio M. Tenascin-R associates extracellularly with parvalbumin immunoreactive neurones but is synthesised by another neuronal population in the adult rat cerebral cortex. J Neurocytol. 2001;30:293-301 pubmed
    ..Using immunohistochemical methods, we observed that the large extracellular matrix-protein, tenascin-R (Restrictin, J1-160-180, Janusin), associates preferentially with the parvalbumin-positive subpopulation of interneurones ..
  23. Bukalo O, Schachner M, Dityatev A. Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience. 2001;104:359-69 pubmed
    ..Our data demonstrate that tenascin-R and chondroitin sulfate proteoglycans differentially modulate several forms of synaptic plasticity, suggesting that different mechanisms are involved. ..
  24. Brenneke F, Schachner M, Elger C, Lie A. Up-regulation of the extracellular matrix glycoprotein tenascin-R during axonal reorganization and astrogliosis in the adult rat hippocampus. Epilepsy Res. 2004;58:133-43 pubmed