Tnfsf10

Summary

Gene Symbol: Tnfsf10
Description: TNF superfamily member 10
Alias: Tnlg6a, Trail, tumor necrosis factor ligand superfamily member 10, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor ligand 6a, tumor necrosis factor superfamily member 10
Species: rat
Products:     Tnfsf10

Top Publications

  1. Mi Q, Ly D, Lamhamedi Cherradi S, Salojin K, Zhou L, Grattan M, et al. Blockade of tumor necrosis factor-related apoptosis-inducing ligand exacerbates type 1 diabetes in NOD mice. Diabetes. 2003;52:1967-75 pubmed
    Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including pancreas and lymphocytes, and can induce apoptosis in various tumor cells but not in most normal cells...
  2. Pennarun B, Meijer A, de Vries E, Kleibeuker J, Kruyt F, de Jong S. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Biochim Biophys Acta. 2010;1805:123-40 pubmed publisher
    ..DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2...
  3. Huang Z, Song L, Wang C, Liu J, Chen C. Hypoxia-ischemia upregulates TRAIL and TRAIL receptors in the immature rat brain. Dev Neurosci. 2011;33:519-30 pubmed publisher
    ..Recently, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors (death receptor DR4/5 and decoy receptor DcR1/2) were reported to mediate various ..
  4. Tang Y, Yang S, Zhu B, Cui J. [Therapeutic effects of recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand on non-small lung cell cancer: an experimental with rats]. Zhonghua Yi Xue Za Zhi. 2005;85:2021-5 pubmed
    ..rmhTRAIL dose-dependently inhibit the growth of NSCLC cells, primarily by inducing apoptosis of tumor cells. ..
  5. Bangert A, Cristofanon S, Eckhardt I, Abhari B, Kolodziej S, Hacker S, et al. Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. Oncogene. 2012;31:4677-88 pubmed publisher
    ..inhibitors (HDACI) prime glioblastoma cells for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) -induced apoptosis at least in part by c-myc-mediated downregulation of cellular FLICE-inhibitory protein (cFLIP)...
  6. Grataroli R, Vindrieux D, Gougeon A, Benahmed M. Expression of tumor necrosis factor-alpha-related apoptosis-inducing ligand and its receptors in rat testis during development. Biol Reprod. 2002;66:1707-15 pubmed
    Tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor-alpha family of cytokines that is known to induce apoptosis upon binding to its death domain-containing receptors, DR4/TRAIL-..
  7. Lorz C, Benito Martin A, Boucherot A, Ucero A, Rastaldi M, Henger A, et al. The death ligand TRAIL in diabetic nephropathy. J Am Soc Nephrol. 2008;19:904-14 pubmed publisher
    ..in regulation were two death receptors, OPG (the gene encoding osteoprotegerin) and Fas, and the death ligand TRAIL. Glomerular and proximal tubular TRAIL expression, assessed by immunohistochemistry, was higher in DN kidneys than ..
  8. Salehi E, Vodjgani M, Massoud A, Keyhani A, Rajab A, Shafaghi B, et al. Increased expression of TRAIL and its receptors on peripheral T-cells in type 1 diabetic patients. Iran J Immunol. 2007;4:197-205 pubmed
    ..TNF-related apoptosis-inducing ligand (TRAIL) is a type-II membrane protein of the TNF superfamily which is expressed in different tissues, including pancreas ..
  9. Corallini F, Celeghini C, Rizzardi C, Pandolfi A, Di Silvestre S, Vaccarezza M, et al. Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro. J Cell Physiol. 2007;212:89-95 pubmed
    To dissect the effect of hyperinsulinemia versus hyperglycemia on TNF-related apoptosis inducing ligand (TRAIL) expression in the macrovascular district, we measured TRAIL mRNA and protein in four groups of animals: streptozotocin (SZT)-..

More Information

Publications34

  1. Vaccarezza M, Bortul R, Fadda R, Zweyer M. Increased OPG expression and impaired OPG/TRAIL ratio in the aorta of diabetic rats. Med Chem. 2007;3:387-91 pubmed
    Despite accumulating evidence showing that TNF-related apoptosis inducing ligand (TRAIL) plays a role in vascular biology and that its decoy receptor osteoprotegerin (OPG) is expressed in the vessel wall, modulation of these TNF and TNF-..
  2. Jiang Y, Chen X, Fan M, Li H, Zhu W, Chen X, et al. TRAIL facilitates cytokine expression and macrophage migration during hypoxia/reoxygenation via ER stress-dependent NF-?B pathway. Mol Immunol. 2017;82:123-136 pubmed publisher
    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which is known as a key molecule to induce cancer cell apoptosis, has also been found to participate in the process of ischemia/reperfusion (I/R) injury...
  3. Mader I, Wabitsch M, Debatin K, Fischer Posovszky P, Fulda S. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB J. 2010;24:1997-2009 pubmed publisher
    ..We demonstrate for the first time that resveratrol enhances TNF-related apoptosis-inducing ligand (TRAIL)- or CD95-induced apoptosis of human preadipocytes in a highly synergistic manner (EC(50) at 72 h: resveratrol, &..
  4. Tang X, Yang J, Li J. Accelerative effect of leflunomide on recovery from hepatic fibrosis involves TRAIL-mediated hepatic stellate cell apoptosis. Life Sci. 2009;84:552-7 pubmed
    ..PCR (Q-PCR) analysis showed increased expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Kupffer cells during the spontaneous recovery phase...
  5. Falschlehner C, Emmerich C, Gerlach B, Walczak H. TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39:1462-75 pubmed
    The TNF-related apoptosis-inducing ligand, TRAIL, has been shown to selectively kill tumour cells...
  6. Vindrieux D, Devonec M, Benahmed M, Grataroli R. Identification of tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) and its receptors in adult rat ventral prostate. Mol Cell Endocrinol. 2002;198:115-21 pubmed
    Tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor-alpha (TNF-alpha) family of cytokines that is known to induce apoptosis upon binding to its death domain-containing receptors, ..
  7. Na H, Hwang J, Lee K, Choi Y, Choe J, Kim J, et al. TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions. Angiogenesis. 2014;17:179-94 pubmed publisher
    ..We here investigated the effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on VEGF-induced angiogenesis...
  8. Chiu T, Wang M, Su C. The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model. J Biomed Sci. 2012;19:45 pubmed publisher
    ..of microglia was determined by expressions of ED1 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) which were evaluated by Western blotting and immunohistochemistry...
  9. Lee S, Lee H, Chung W, Choi S, Rhyu S, Kim D, et al. TRAIL induces apoptosis of chondrocytes and influences the pathogenesis of experimentally induced rat osteoarthritis. Arthritis Rheum. 2004;50:534-42 pubmed
    To investigate whether TRAIL influences the pathogenesis of osteoarthritis (OA). A recombinant adenoviral vector system (Ad-TRAIL) was used. Expression of TRAIL in a rat chondrocyte cell line (RCJ3.1C...
  10. Unterkircher T, Cristofanon S, Vellanki S, Nonnenmacher L, Karpel Massler G, Wirtz C, et al. Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis. Clin Cancer Res. 2011;17:4019-30 pubmed publisher
    ..The effect of bortezomib on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis signaling pathways was analyzed in glioblastoma cell lines, primary glioblastoma cultures, and ..
  11. Naumann I, Kappler R, Von Schweinitz D, Debatin K, Fulda S. Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway. Clin Cancer Res. 2011;17:3204-18 pubmed publisher
    ..The effect of bortezomib on TRAIL (TNF-related apoptosis-inducing ligand)-induced apoptosis signaling pathways was analyzed in neuroblastoma cell ..
  12. Secchiero P, Candido R, Corallini F, Zacchigna S, Toffoli B, Rimondi E, et al. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation. 2006;114:1522-30 pubmed
    Although in vitro studies have suggested that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) might be involved in vascular biology, its potential role in the pathogenesis and/or treatment of atherosclerosis has not been ..
  13. Cantarella G, Pignataro G, Di Benedetto G, Anzilotti S, Vinciguerra A, Cuomo O, et al. Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype. Cell Death Dis. 2014;5:e1331 pubmed publisher
    TNF-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily released by microglia, appears to be involved in the induction of apoptosis following focal brain ischemia...
  14. Lamhamedi Cherradi S, Zheng S, Maguschak K, Peschon J, Chen Y. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Nat Immunol. 2003;4:255-60 pubmed
    b>TRAIL, the tumor necrosis factor-related apoptosis-inducing ligand, selectively induces apoptosis of tumor cells, but not most normal cells. Its role in normal, nontransformed tissues is not clear...
  15. Harith H, Di Bartolo B, Cartland S, Genner S, Kavurma M. Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand. J Diabetes. 2016;8:568-78 pubmed publisher
    ..Recently, we showed that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) stimulates intimal thickening via accelerated growth of VSMCs...
  16. Xu F, Zhou D, Meng X, Wang X, Liu C, Huang C, et al. Smad2 increases the apoptosis of activated human hepatic stellate cells induced by TRAIL. Int Immunopharmacol. 2016;32:76-86 pubmed publisher
    ..Furthermore, TGF-β1-activated HSCs were treated with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) following the silencing or overexpression of Smad2...
  17. Dirice E, Sanlioglu A, Kahraman S, Ozturk S, Balci M, Omer A, et al. Adenovirus-mediated TRAIL gene (Ad5hTRAIL) delivery into pancreatic islets prolongs normoglycemia in streptozotocin-induced diabetic rats. Hum Gene Ther. 2009;20:1177-89 pubmed publisher
    ..For this reason, a novel gene therapy approach involving adenovirus-mediated TRAIL gene delivery into pancreatic islets was tested to determine whether this approach would defy autoreactive T cell ..
  18. Sayan A, Sayan B, Gogvadze V, Dinsdale D, Nyman U, Hansen T, et al. P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis. Oncogene. 2008;27:4363-72 pubmed publisher
    ..vivo during apoptosis elicited by DNA-damaging drugs and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor ligation. TAp73 and some of its cleavage products are localized to mitochondria...
  19. Zhang J, Zhu G, Wang X, Xu B, Hu L. Apoptosis and expression of protein TRAIL in granulosa cells of rats with polycystic ovarian syndrome. J Huazhong Univ Sci Technolog Med Sci. 2007;27:311-4 pubmed
    ..ovarian syndrome (PCOS) rats, and the contribution of tumor necrosis factor related apoptosis inducing ligand (TRAIL) in apoptosis of granulosa cells were explored. By using sodium prasterone sulfate rat PCOS model was induced...
  20. Song Y, Jacob C. The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. J Biol Chem. 2005;280:9618-26 pubmed
    ..Furthermore, we have expressed mTOSO in transgenic mice and show that mTOSO overexpressing primary T lymphocytes are resistant to Fas/Fas ligand-induced apoptosis. ..
  21. Song C, Jin B. TRAIL (CD253), a new member of the TNF superfamily. J Biol Regul Homeost Agents. 2005;19:73-7 pubmed
  22. Chen B, Zhang Y, Liu G, Guan G, Hou X, Li X, et al. [Effects of valsartan, mycophenolate mofetil and their combined application on TRAIL and nuclear factor-kappaB expression in the kidneys of diabetic rats]. Zhonghua Yi Xue Za Zhi. 2008;88:540-5 pubmed
    To evaluate the expression of TNF-related apoptosis inducing ligand (TRAIL) and nuclear factor (NF)-kappaB in the kidney tissues of diabetic rats and the effects of valsartan, mycophenolate mofetil (MMF), and their combined application ..
  23. Ramamurthy V, Yamniuk A, Lawrence E, Yong W, Schneeweis L, Cheng L, et al. The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. Acta Crystallogr F Struct Biol Commun. 2015;71:1273-81 pubmed publisher
    The structure of death receptor 4 (DR4) in complex with TNF-related apoptosis-inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with those of previously determined DR5-TRAIL complexes...
  24. Celik O, Kutlu O, Tekcan M, Celik Ozenci C, Koksal I. Role of TNF-related apoptosis-inducing ligand (TRAIL) in the pathogenesis of varicocele-induced testicular dysfunction. Asian J Androl. 2013;15:269-74 pubmed publisher
    ..aim of this study was to investigate the role of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and its receptors in varicocele-induced testicular dysfunction in an experimental rat model...
  25. Schneider P, Olson D, Tardivel A, Browning B, Lugovskoy A, Gong D, et al. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2003;278:5444-54 pubmed
    ..mTNFRH1, -2 and -3, are most homologous to those of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors...