Gene Symbol: Tnfrsf1b
Description: TNF receptor superfamily member 1B
Alias: Tnfr2, tumor necrosis factor receptor superfamily member 1B, TNF-R2, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, tumor necrosis factor receptor 2, tumor necrosis factor receptor superfamily, member 1b, tumor necrosis factor receptor type II
Species: rat
Products:     Tnfrsf1b

Top Publications

  1. Vielhauer V, Stavrakis G, Mayadas T. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest. 2005;115:1199-209 pubmed
    ..and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. TNFR1-deficient mice subjected to immune complex-mediated glomerulonephritis developed less proteinuria and ..
  2. Inglis J, Nissim A, Lees D, Hunt S, Chernajovsky Y, Kidd B. The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation. Arthritis Res Ther. 2005;7:R807-16 pubmed
    ..Joint inflammation was associated with increased TNFR1 and TNFR2 expression on DRG cells, which was maintained throughout the time course of the model...
  3. Hoffmann U, Bergler T, Rihm M, Pace C, Kruger B, Rümmele P, et al. Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection. Am J Transplant. 2009;9:675-86 pubmed publisher
    An important role of TNF interacting with TNFR2 has been shown in different models of ischemic, nephrotoxic and immune-mediated renal injury...
  4. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003;10:45-65 pubmed
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed. ..
  5. Shubayev V, Myers R. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. J Neuroimmunol. 2001;114:48-56 pubmed
    ..These findings highlight a dynamic process of TNF-alpha protein and receptor regulation throughout the peripheral neural axis that bears on both the normal function of DRG neurons and the pathogenesis of painful neuropathies. ..
  6. Li Y, Ji A, Weihe E, Schafer M. Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor alpha (TNFalpha) and TNF receptors in rat dorsal root ganglion. J Neurosci. 2004;24:9623-31 pubmed
    ..Therefore, we differentiated the neuronal and non-neuronal sites of TNFalpha, TNFR1, and TNFR2 mRNA synthesis in dorsal root ganglion (DRG) of control rats and evaluated how their expression is altered under ..
  7. Bader T, Nettesheim P. Tumor necrosis factor-alpha modulates the expression of its p60 receptor and several cytokines in rat tracheal epithelial cells. J Immunol. 1996;157:3089-96 pubmed
    ..These findings suggest that the airway epithelium may actively participate in the pathogenesis of airway inflammation through the production of mediators similar to those found in a Th1 response. ..
  8. Zhou Q, Sumbria R, Hui E, Lu J, Boado R, Pardridge W. Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor. J Pharmacol Exp Ther. 2011;339:618-23 pubmed publisher
    ..In conclusion, a biologic TNF inhibitor is neuroprotective after intravenous administration in a mouse model of neurodegeneration, providing that the TNF decoy receptor is reengineered to cross the BBB. ..
  9. Gadducci A, Ferdeghini M, Fanucchi A, Annicchiarico C, Prato B, Prontera C, et al. Serum levels of soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) in endometrial cancer. Anticancer Res. 1996;16:3125-8 pubmed
    The pretreatment serum levels of the soluble receptors for tumor necrosis factor (p55 and p75 sTNFr) were retrospectively measured in 38 patients with endometrial cancer and 55 patients with benign uterine diseases as controls...

More Information


  1. Fernandez R, Nardocci G, Simon F, Martin A, Becerra A, Rodriguez Tirado C, et al. Lipopolysaccharide signaling in the carotid chemoreceptor pathway of rats with sepsis syndrome. Respir Physiol Neurobiol. 2011;175:336-48 pubmed publisher
    ..These results show a novel afferent pathway to the central nervous system during endotoxemia, and could be relevant in understanding sepsis pathophysiology and therapy. ..
  2. Kong S, Liu J, Hwang T, Yu X, Lu Y, Zang W. Tumour necrosis factor-? and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. Clin Exp Pharmacol Physiol. 2011;38:300-6 pubmed publisher
    ..of LV pressure, higher LDH and CK leakage, a larger infarct size, increased TNF-? levels and an increased TNFR1/TNFR2 ratio...
  3. Aderka D, Wysenbeek A, Engelmann H, Cope A, Brennan F, Molad Y, et al. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Arthritis Rheum. 1993;36:1111-20 pubmed
    ..The mean +/- SD concentrations of both the p55 (type I) and p75 (type II) soluble receptors were significantly higher in a group of 46 SLE patients than in controls: 1.89 +/- 0...
  4. Shi Y, Zhou E, Wu H, Zhou C, Wang Q, Qi L. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn's disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2. Chin J Integr Med. 2011;17:212-7 pubmed publisher
    ..whether moxibustion regulates tumor necrosis factor alpha (TNF-?), tumor necrosis factor receptor 1 (TNFR1), and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism, to repair ..
  5. Yu B, Chen H, Lu C, Lin Q, Wang B, Qin C. [Effect of intra-articular ozone injection on serum and synovial TNF-?, TNFR I, and TNFR II contents in rats with rheumatoid arthritis]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1055-8 pubmed different concentrations on the contents of tumor necrosis factor-? (TNF-?), TNF receptor I (TNFR I), and TNFR II in the serum and synovium of rats with rheumatoid arthritis (RA) and explore the therapeutic mechanism of ozone ..
  6. Yanik G, Ho V, Levine J, White E, Braun T, Antin J, et al. The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. Blood. 2008;112:3073-81 pubmed publisher
    ..The combination of etanercept and corticosteroids is safe and is associated with high response rates and improved survival in patients with IPS. ..
  7. Hwang D, Hong S, Jeong J, Choi S, Kim H, Kim J, et al. Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. J Neurochem. 2009;111:1202-12 pubmed publisher
  8. Kang Y, Wang Y, Yang L, Elks C, Cardinale J, Yu X, et al. TNF-? in hypothalamic paraventricular nucleus contributes to sympathoexcitation in heart failure by modulating AT1 receptor and neurotransmitters. Tohoku J Exp Med. 2010;222:251-63 pubmed
  9. Guthmann F, Wissel H, Rüstow B. Early subcutaneous administration of etanercept (Enbrel) prevents from hyperoxia-induced lung injury. Exp Lung Res. 2009;35:770-80 pubmed publisher
    ..Here, the authors show that a single subcutaneous pretreatment of rat with etanercept, a recombinant p75 TNF receptor 2 human immunoglobulin G1 (IgG1) construct, inhibits the hyperoxia-induced and TNFalpha-mediated ..
  10. Peschon J, Torrance D, Stocking K, Glaccum M, Otten C, Willis C, et al. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998;160:943-52 pubmed
    ..cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types...
  11. Aderka D, Englemann H, Hornik V, Skornick Y, Levo Y, Wallach D, et al. Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Cancer Res. 1991;51:5602-7 pubmed
    ..The mean +/- SD concentrations of both the soluble type I (p55) and type II (p75) receptors were significantly higher in the cancer patients than in the healthy controls: 1.96 +/- 1.19 versus 0...
  12. Wang M, Wang L, Huang C, Wang I, Turrentine M. Regulation of myocardial stromal cell-derived factor 1α/CXCL12 by tumor necrosis factor signaling. J Surg Res. 2017;207:155-163 pubmed publisher
    ..Knockdown of TNFR1 or TNFR2 by small interfering RNAs neutralized TNF-suppressed SDF-1 in H9c2 cells...
  13. Ye Q, Dai H, Sarria R, Guzman J, Costabel U. Increased expression of tumor necrosis factor receptors in cryptogenic organizing pneumonia. Respir Med. 2011;105:292-7 pubmed publisher
    TNF receptors (TNFR1 and TNFR2) and Fas belong to the system of apoptosis-signalling receptor molecules and may play a role in the pathogenesis of interstitial lung disease...
  14. Ishikawa T, Miyagi M, Kamoda H, Orita S, Eguchi Y, Arai G, et al. Differences between tumor necrosis factor-? receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model. Spine (Phila Pa 1976). 2013;38:11-6 pubmed publisher
    ..pain model were investigated to clarify the function of tumor necrosis factor (TNF)-? receptors p55 type 1 and p75 type 2...
  15. Iglesias J, Marik P, Levine J. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Am J Kidney Dis. 2003;41:62-75 pubmed
    ..S-TNF-R level is an independent predictor for the development of ARF and mortality. We speculate that elevated S-TNF-R levels may reflect a more intense inflammatory response. ..
  16. Hadlock G, Chu P, Walters E, Hanson G, Fleckenstein A. Methamphetamine-induced dopamine transporter complex formation and dopaminergic deficits: the role of D2 receptor activation. J Pharmacol Exp Ther. 2010;335:207-12 pubmed publisher
  17. Dougados M, Braun J, Szanto S, Combe B, Elbaz M, Geher P, et al. Efficacy of etanercept on rheumatic signs and pulmonary function tests in advanced ankylosing spondylitis: results of a randomised double-blind placebo-controlled study (SPINE). Ann Rheum Dis. 2011;70:799-804 pubmed publisher
    ..The efficacy is observed for the main symptoms (pain) and on markers of inflammation (CRP), as well as disease severity in terms of spinal mobility and pulmonary function. ..
  18. Al Lamki R, Sadler T, Wang J, Reid M, Warren A, Movassagh M, et al. Tumor necrosis factor receptor expression and signaling in renal cell carcinoma. Am J Pathol. 2010;177:943-54 pubmed publisher
    ..activates apoptotic signaling kinase 1 and nuclear factor-kappaB (NF-kappaB) and induces cell death, whereas TNFR2, inducibly expressed on endothelial cells and on TECs by injury, activates endothelial/epithelial tyrosine kinase (..
  19. Pfeifer E, Polz J, Grieβl S, Mostbock S, Hehlgans T, Männel D. Mechanisms of immune complex-mediated experimental glomerulonephritis: possible role of the balance between endogenous TNF and soluble TNF receptor type 2. Eur Cytokine Netw. 2012;23:15-20 pubmed publisher
    ..Mice lacking the TNF receptor type 2 (TNFR2) were protected from early proteinuria and enhanced mortality...
  20. Qin Y, Cheng C, Wang H, Shao X, Gao Y, Shen A. TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells. Neurochem Res. 2008;33:1077-84 pubmed publisher
    ..TNF-alpha exhibits its biological effect through two distinct surface receptors, TNF receptor 1 (TNFR1) and TNFR2. We show here that cultured SCs express both TNFR1 and TNFR2, and that activation of these receptors by TNF-alpha ..
  21. Rostkowska Nadolska B, Kapral M, Mazurek U, Fraczek M, Ziolkowski P, Gamian E. Quantification of the mRNA encoding Tumor Necrosis Factor alpha (TNFalpha) and its receptors in human nasal polyps. Adv Med Sci. 2008;53:263-9 pubmed publisher
    ..The differences between ENP and NNP relating to TNFalpha and the expression of its receptors may reflect the distinct character of those diseases. ..
  22. Tian L, Xie H, Yang T, Hu Y, Li J, Wang W. Association study of tumor necrosis factor receptor type 2 M196R and toll-like receptor 2 Arg753Gln polymorphisms with acne vulgaris in a Chinese Han ethnic group. Dermatology. 2010;221:276-84 pubmed publisher
    Inflammatory cytokines such as tumor necrosis factor receptor 2 (TNFR2) and Toll-like receptor 2 (TLR2) are the main responsible mediators of inflammatory acne...
  23. Safranow K, Dziedziejko V, Rzeuski R, Czyzycka E, Wojtarowicz A, Binczak Kuleta A, et al. Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease. Tissue Antigens. 2009;74:386-92 pubmed publisher
    ..Metabolic syndrome and diabetes are associated with higher plasma concentrations of TNF-alpha and its receptors. ..
  24. Sama D, Mohmmad Abdul H, Furman J, Artiushin I, Szymkowski D, Scheff S, et al. Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats. PLoS ONE. 2012;7:e38170 pubmed publisher
    ..levels for TNF receptor 1 (TNFR1) are significantly elevated in the hippocampus relative to TNF receptor 2 (TNFR2) in aged (22 months) but not young adult (6 months) Fischer 344 rats...
  25. English W, Corvol P, Murphy G. LPS activates ADAM9 dependent shedding of ACE from endothelial cells. Biochem Biophys Res Commun. 2012;421:70-5 pubmed publisher
    ..Transient transfection of ADAM9 and ACE cDNAs into HEK293 cells demonstrated that ADAM9 requires both membrane anchorage and its catalytic domain to shed ACE. ..
  26. Constantin C, Mair N, Sailer C, Andratsch M, Xu Z, Blumer M, et al. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J Neurosci. 2008;28:5072-81 pubmed publisher
    ..Deletion of the tumor necrosis factor receptor type 2 (TNFR2) gene attenuated heat hyperalgesia and prevented TRPV1 upregulation in tumor-bearing mice, whereas TNFR1 gene ..
  27. Bruggeman L, Drawz P, Kahoud N, Lin K, Barisoni L, Nelson P. TNFR2 interposes the proliferative and NF-?B-mediated inflammatory response by podocytes to TNF-?. Lab Invest. 2011;91:413-25 pubmed publisher
    The development of proliferative podocytopathies has been linked to ligation of tumor necrosis factor receptor 2 (TNFR2) expressed on the renal parenchyma; however, the TNFR2-positive cells within the kidney responsible for podocyte ..
  28. Van Pottelberge G, Mestdagh P, Bracke K, Thas O, van Durme Y, Joos G, et al. MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011;183:898-906 pubmed publisher
    ..The concentration of tumor necrosis factor receptor type II (TNFR-II, implicated in COPD pathogenesis and a predicted target gene of let-7c) was inversely ..
  29. Weinberg M, Blake B, McCown T. Opposing actions of hippocampus TNF? receptors on limbic seizure susceptibility. Exp Neurol. 2013;247:429-37 pubmed publisher
    ..limbic seizures the rat hippocampus exhibited a rapid upregulation of TNFR1, but a simultaneous downregulation of TNFR2. These limbic seizures also evoked significant increases in measures of neuroinflammation and caused significant ..
  30. Shimizu T, Tomita Y, Son K, Nishinarita S, Sawada S, Horie T. Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. Clin Rheumatol. 2000;19:352-9 pubmed
  31. Shen C, Tsai R, Shih M, Lin S, Tai Y, Chien C, et al. Etanercept restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in morphine-tolerant rats. Anesth Analg. 2011;112:454-9 pubmed publisher
    ..The results suggest that etanercept could also be an adjuvant therapy for morphine tolerance, which extends the effectiveness of opioids in clinical pain management. ..
  32. Liu K, Glidden D, Eisner M, Parsons P, Ware L, Wheeler A, et al. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007;35:2755-61 pubmed
    ..The combination of these biological and clinical risk factors may have important and additive value in predictive models for acute kidney injury. ..
  33. Vega A, Luther J, Birren S, Morales M. Segregation of the classical transmitters norepinephrine and acetylcholine and the neuropeptide Y in sympathetic neurons: modulation by ciliary neurotrophic factor or prolonged growth in culture. Dev Neurobiol. 2010;70:913-28 pubmed publisher
    ..These data demonstrate segregation of classical transmitters in sympathetic neurons and plasticity of neurotransmitter segregation. Finally, we discuss a possible functional correlate of segregation in sympathetic neurons. ..
  34. Islimye M, Kilic S, Zulfikaroglu E, Topcu O, Zergeroglu S, Batioglu S. Regression of endometrial autografts in a rat model of endometriosis treated with etanercept. Eur J Obstet Gynecol Reprod Biol. 2011;159:184-9 pubmed publisher
    ..Endometrial explants were evaluated immunohistochemically for tumor necrosis factor receptor type 2 (TNFR2). A scoring system was used to evaluate expression grade of TNFR2...
  35. Spicka I, Masek Z, Jirsa M, Zounar R, Prochazka B, Merta M, et al. [Interleukin-6, tumor necrosis factor alpha and their soluble receptors in Bence-Jones nephropathy. Possible role in pathogenesis andthe importance in the determination of prognosis in renal insufficiency]. Cas Lek Cesk. 1998;137:267-70 pubmed
    ..We suggest that IL-6 levels could be predictive factor for renal insufficiency recovery. ..
  36. Loza M, Brodmerkel C, du Bois R, Judson M, Costabel U, Drent M, et al. Inflammatory profile and response to anti-tumor necrosis factor therapy in patients with chronic pulmonary sarcoidosis. Clin Vaccine Immunol. 2011;18:931-9 pubmed publisher
    ..This study supports the need for further exploration of anti-TNF therapy for chronic sarcoidosis patients, particularly for those expressing the highest serum levels of TNF-?. ..
  37. Erickson S, de Sauvage F, Kikly K, Carver Moore K, Pitts Meek S, Gillett N, et al. Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature. 1994;372:560-3 pubmed
    ..TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75)...
  38. Nemec A, Pavlica Z, Svete A, Erzen D, Crossley D, Petelin M. Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis. Exp Lung Res. 2009;35:605-20 pubmed
    ..Development of pneumonia is dependent on the P. gingivalis dose; however, part of the cytokine response is unique to the systemic compartment, even in animals that do not develop pneumonia. ..
  39. Hashem R, Mohamed R, Abo El matty D. Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral obstruction in rats. Nutrition. 2016;32:478-85 pubmed publisher the pathophysiology of renal obstruction through its interactions with two TNF-α receptors: TNFR1 and TNFR2. Activation of TNFR1 leads to the recruitment of the adaptor TNFR-associated death domain protein (TRADD), which ..
  40. Dubey S, Kerrigan N, Mills K, Scott D. Bronchospasm associated with anti-TNF treatment. Clin Rheumatol. 2009;28:989-92 pubmed publisher
    ..The frequency and severity of bronchospasm appears to be greater than previously anticipated, all three anti-TNF agents appear to be implicated. ..
  41. Yan M, Xia C, Niu S, Shao X, Cheng C, Zhao J, et al. The role of TNF-alpha and its receptors in the production of beta-1,4 galactosyltransferase I and V mRNAs by rat primary astrocytes. J Mol Neurosci. 2007;33:155-62 pubmed
    ..TNF-alpha and TNFR2 are not detected in control astrocytes and upregulated significantly with LPS stimulation and that activation of ..
  42. Nakazawa T, Kayama M, Ryu M, Kunikata H, Watanabe R, Yasuda M, et al. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci. 2011;52:1384-91 pubmed publisher
    ..the role of TNF? in photoreceptor degeneration, RD was induced in mice deficient in TNF? or its receptors (TNFR1, TNFR2, and TNFR1 and -2), or in wild-type (WT) mice by using a functionally blocking antibody to TNF?...
  43. Cho H, Zhang L, Kleeberger S. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors. Am J Physiol Lung Cell Mol Physiol. 2001;280:L537-46 pubmed
    ..mice with targeted disruption (knockout) of the genes for the p55 TNF receptor [TNFR1(-/-)], the p75 TNF receptor [TNFR2(-/-)], or both receptors [TNFR1/TNFR2(-/-)] were exposed to 0...
  44. Riezzo I, Cerretani D, Fiore C, Bello S, Centini F, D Errico S, et al. Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity. J Neurosci Res. 2010;88:905-16 pubmed publisher
    ..Cortical positivity, located in the most superficial layer was revealed only for heat shock protein 70 after 24 hr. ..
  45. Horii M, Orita S, Nagata M, Takaso M, Yamauchi K, Yamashita M, et al. Direct application of the tumor necrosis factor-? inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons. Spine (Phila Pa 1976). 2011;36:E80-5 pubmed publisher
    ..This finding may further elucidate the mechanism for the effectiveness of etanercept in upregulation of neuropeptide in DRG neurons innervating intervertebral discs. ..
  46. Ermert M, Pantazis C, Duncker H, Grimminger F, Seeger W, Ermert L. In situ localization of TNFalpha/beta, TACE and TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. Cytokine. 2003;22:89-100 pubmed
  47. Yang S, Wang Y, Mei K, Zhang S, Sun X, Ren F, et al. Tumor necrosis factor receptor 2 (TNFR2)·interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-κB activation. J Biol Chem. 2015;290:861-71 pubmed publisher
    TNF receptor 2 (TNFR2) exerts diverse roles in the pathogenesis of inflammatory and autoimmune diseases...
  48. Abdo M, Hisheh S, Arfuso F, Dharmarajan A. The expression of tumor necrosis factor-alpha, its receptors and steroidogenic acute regulatory protein during corpus luteum regression. Reprod Biol Endocrinol. 2008;6:50 pubmed publisher
    ..TNF-alpha mRNA increased on Day 3 post-partum. TNFR were immunolocalized to luteal cells, and an increase in TNFR2 mRNA observed on Day 3 post-partum whilst no change was detected in TNFR1 mRNA relative to Day 16...
  49. Yan P, Liu N, Kim G, Xu J, Xu J, Li Q, et al. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Exp Neurol. 2003;183:286-97 pubmed
    ..The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whether these two receptors are expressed after SCI has not been demonstrated...
  50. Niewczas M, Gohda T, Skupien J, Smiles A, Walker W, Rosetti F, et al. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012;23:507-15 pubmed publisher
    ..Of the examined markers, only TNF receptors 1 and 2 (TNFR1 and TNFR2) associated with risk for ESRD...
  51. Caulin C, Ware C, Magin T, Oshima R. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol. 2000;149:17-22 pubmed
    ..produced by macrophages and T lymphocytes that acts through two distinct receptors, TNFR1 (60 kD, CD120a) and TNFR2 (80 kD, CD120b), to affect cellular proliferation, differentiation, survival, and cell death...
  52. Cayci T, Akgul E, Kurt Y, Ceyhan T, Aydin I, Onguru O, et al. The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model. J Obstet Gynaecol Res. 2011;37:1041-7 pubmed publisher
    ..6 ± 3.8, 19.8 ± 4.4, 39.3 ± 6.1, 80.5 ± 5.3, and 91.1 ± 5.0 µmol/L, respectively. Infliximab, etanercept and letrozole have regressed endometriotic implants, decreased plasma NO(x) levels, and increased plasma ADMA levels. ..
  53. Xiong D, Shen H, Zhao L, Xiao P, Yang T, Guo Y, et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res. 2006;21:1678-95 pubmed
    ..genes (CYP19, RANK, RANKL, and CYP17) highly suggestive for hip BMD/OP; and four genes (CYP19, BMP2, RANK, and TNFR2) highly suggestive for UD BMD/OP...
  54. Stoelcker B, Hehlgans T, Weigl K, Bluethmann H, Grau G, Männel D. Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Infect Immun. 2002;70:5857-9 pubmed
    Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue ..
  55. Ingaramo P, Ronco M, Francés D, Monti J, Pisani G, Ceballos M, et al. Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus. Mol Immunol. 2011;48:1397-407 pubmed publisher
    ..Overall, we demonstrated that in the diabetes enhances TNF-? in the liver, which may be a fundamental key leading to apoptotic cell death, through activation of caspase-8, NF?B and JNK pathways. ..
  56. Misaki T, Yamamoto T, Suzuki S, Fukasawa H, Togawa A, Ohashi N, et al. Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats. Am J Pathol. 2009;175:74-83 pubmed publisher
    ..Two TNFalpha receptors (TNFRs), TNFR1 and TNFR2, are known to exist...
  57. Dobrzycka B, Terlikowski S, Kowalczuk O, Kinalski M. Circulating levels of TNF-alpha and its soluble receptors in the plasma of patients with epithelial ovarian cancer. Eur Cytokine Netw. 2009;20:131-4 pubmed publisher
    ..Thus, the clinical value of an activated TNF system in EOC needs to be further investigated. ..
  58. Leo M, Argalski S, Schäfers M, Hagenacker T. Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats. Mediators Inflamm. 2015;2015:124942 pubmed publisher
    ..The effects of TNFR activation on VGSCs promote excitation in primary afferent neurons and this might explain the sensitization mechanisms associated with neuropathic and inflammatory pain. ..
  59. Niewczas M, Ficociello L, Johnson A, Walker W, Rosolowsky E, Roshan B, et al. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2009;4:62-70 pubmed publisher
    ..These effects are independent of those of urinary albumin excretion. Follow-up studies are needed to characterize the role of these markers in early progressive renal function decline. ..
  60. Singh P, Bahrami L, Castillo A, Majid D. TNF-? type 2 receptor mediates renal inflammatory response to chronic angiotensin II administration with high salt intake in mice. Am J Physiol Renal Physiol. 2013;304:F991-9 pubmed publisher
  61. Ramesh G, Reeves W. TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure. Am J Physiol Renal Physiol. 2003;285:F610-8 pubmed
    ..In this study, we examined the effect of cisplatin on the expression of TNF receptors TNFR1 and TNFR2 in the kidney and the role of each receptor in mediating cisplatin nephrotoxicity...
  62. Zwiech R. Predictive value of conjointly examined IL-1ra, TNF-R I, TNF-R II, and RANTES in patients with primary glomerulonephritis. J Korean Med Sci. 2013;28:261-7 pubmed publisher
    ..In conclusion, the urinary excretion of IL-1ra, TNF-R I and R II, and RANTES examined conjointly are effective in predicting favorable response to immunosuppressive treatment in patients with GN. ..
  63. Hasegawa M, Nishii C, Ohashi A, Tomita M, Nakai S, Murakami K, et al. Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Nephron Clin Pract. 2009;113:c222-33 pubmed publisher
    ..vasculitis, we evaluated the cell surface expression of TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2)...
  64. Hao S, Liu S, Zheng X, Zheng W, Ouyang H, Mata M, et al. The role of TNF? in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats. Neuropsychopharmacology. 2011;36:664-76 pubmed publisher
    ..These results support the concept that proinflammatory cytokines expressed in astrocytes in the PAG may play an important role in the pathogenesis of morphine withdrawal response...
  65. Chen H, Yu B, Lu C, Lin Q. The effect of intra-articular injection of different concentrations of ozone on the level of TNF-?, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis. Rheumatol Int. 2013;33:1223-7 pubmed publisher
    ..In conclusion, intra-articular injection of O3 at 40 ?g/mL can effectively suppress the joint swelling caused by RA. This mechanism is probably mediated by down-regulating synovial TNF-? and TNF-R2 and up-regulating TNF-R1 in the joint. ..
  66. Goodwin R, Anderson D, Jerzy R, Davis T, Brannan C, Copeland N, et al. Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol. 1991;11:3020-6 pubmed
    ..The murine cDNAs were further used to determine the chromosomal locations of the TNF receptor genes. They are not linked, in contrast to the ligands, and map to chromosomes 4 (type 1) and 6 (type 2). ..
  67. Gohda T, Niewczas M, Ficociello L, Walker W, Skupien J, Rosetti F, et al. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012;23:516-24 pubmed publisher
    Elevated plasma concentrations of TNF receptors 1 and 2 (TNFR1 and TNFR2) predict development of ESRD in patients with type 2 diabetes without proteinuria, suggesting these markers may contribute to the pathogenesis of renal decline...
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    ..that metalloproteinase inhibition increases the proportion of ADAM17 substrates (TNF and its receptors TNFR1 and TNFR2) in lipid rafts...
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    ..localization and degree of protein and mRNA expression of the two specific TNF-alpha receptors (TNF-Rs), p55 and p75, in brain tissues from AIDS patients...
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