Gene Symbol: Tnfrsf1a
Description: TNF receptor superfamily member 1A
Alias: TNFR-1, Tnfr1, tumor necrosis factor receptor superfamily member 1A, TNF-R1, TNF-RI, TNFR-I, p55, p60, tumor necrosis factor receptor 1, tumor necrosis factor receptor superfamily, member 1a, tumor necrosis factor receptor type I
Species: rat
Products:     Tnfrsf1a

Top Publications

  1. Williams Skipp C, Raman T, Valuck R, Watkins H, Palmer B, Scheinman R. Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model. Arthritis Rheum. 2009;60:408-18 pubmed publisher
    ..To examine the relative importance of tumor necrosis factor receptor I (TNFRI) signaling in the hematopoietic tissue compartment in the progression of collagen-induced arthritis (CIA), a model of rheumatoid arthritis (RA)...
  2. TEZEL G, Yang X, Yang J, Wax M. Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice. Brain Res. 2004;996:202-12 pubmed
    ..Since secondarily degenerating neurons are viable targets for neuroprotection, inhibition of TNF death receptor signaling may be an effective strategy to protect RGCs in several neurodegenerative injuries. ..
  3. Qin Y, Cheng C, Wang H, Shao X, Gao Y, Shen A. TNF-alpha as an autocrine mediator and its role in the activation of Schwann cells. Neurochem Res. 2008;33:1077-84 pubmed publisher
    ..TNF-alpha exhibits its biological effect through two distinct surface receptors, TNF receptor 1 (TNFR1) and TNFR2...
  4. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003;10:45-65 pubmed
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed. ..
  5. Costa G, Vindeirinho J, Cavadas C, Ambrósio A, Santos P. Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose. Mol Cell Neurosci. 2012;50:113-23 pubmed publisher the breakdown of the blood-retinal barrier, we set out to investigate whether TNF-? acting through tumor necrosis factor receptor 1 (TNFR1), the major receptor responsible for mediating TNF-induced cell death, could also be ..
  6. Dorr A, Wilson M, Wakabayashi K, Waite A, Patel B, Van Rooijen N, et al. Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies. J Appl Physiol (1985). 2011;111:177-84 pubmed publisher
    ..inflammation, but minimal alveolar epithelial permeability changes, with increased BALF sTNFR p75, but not p55. Increased p75 levels were markedly attenuated by alveolar macrophage depletion...
  7. Zwiech R, Kacprzyk F, Szuflet A, Nowicki M. [Prognostic values of serum concentration and urinary excretion of interleukin-1 receptor antagonist and tumor necrosis factor receptors type I and II in patients with IGA nephropathy]. Pol Arch Med Wewn. 2005;113:326-33 pubmed
    ..Those assessments may be helpful as a part of initial screening in patients with IgA nephritis and heavy proteinuria. In contrast the evaluation of both serum and urinary TNF RI and II seems to have no predictive value.
  8. Raina N, Jeejeebhoy K. Effect of low-protein diet and protein supplementation on the expressions of TNF-alpha, TNFR-I, and TNFR-II in organs and muscle of LPS-injected rats. Am J Physiol Endocrinol Metab. 2004;286:E481-7 pubmed
    ..This increase is suppressed by refeeding protein. A differential pattern between translation and transcription of TNF-alpha and its receptors is present. Our data suggest that protein restriction may be deleterious in sepsis. ..
  9. Mavri A, Bastelica D, Poggi M, Morange P, Peiretti F, Verdier M, et al. Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women. Thromb Haemost. 2007;97:62-6 pubmed
    ..The aim of this study was to investigate the influence of polymorphism A36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, ..

More Information


  1. Qin J, Shang L, Ping A, Li J, Li X, Yu H, et al. TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1?-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther. 2012;14:R242 pubmed publisher
  2. Szretter K, Gangappa S, Lu X, Smith C, Shieh W, Zaki S, et al. Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol. 2007;81:2736-44 pubmed
    ..interleukin-6 (IL-6), macrophage inflammatory protein 1 alpha (MIP-1alpha), IL-1 receptor (IL-1R), or tumor necrosis factor receptor 1 (TNFR1) by the use of two avian influenza A viruses isolated from humans, A/Hong Kong/483/97 (HK/483) ..
  3. Yue H, Mills P, Ancoli Israel S, Loredo J, Ziegler M, Dimsdale J. The roles of TNF-alpha and the soluble TNF receptor I on sleep architecture in OSA. Sleep Breath. 2009;13:263-9 pubmed publisher
    ..These findings suggest that sTNF-RI is associated with arousals during sleep, but not with other measures in patients with OSA. ..
  4. Figueras M, Busquets S, Carbó N, Almendro V, Argiles J, Lopez Soriano F. Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. Int J Oncol. 2005;27:855-60 pubmed
    The mRNA content of both TNF-alpha and its receptors (TNFR1 and TNFR2) in skeletal muscle and adipose tissue from cachectic rats has been assessed...
  5. Nagarkar D, Wang Q, Shim J, Zhao Y, Tsai W, Lukacs N, et al. CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection. J Immunol. 2009;183:6698-707 pubmed publisher
    ..The requirement of TNF-alpha for RV1B-induced airway responses was tested using TNFR1(-/-) mice...
  6. Yan P, Liu N, Kim G, Xu J, Xu J, Li Q, et al. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Exp Neurol. 2003;183:286-97 pubmed
    ..The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whether these two receptors are expressed after SCI has not been demonstrated...
  7. White L, Santora R, Cui Y, Moore F, Hassoun H. TNFR1-dependent pulmonary apoptosis during ischemic acute kidney injury. Am J Physiol Lung Cell Mol Physiol. 2012;303:L449-59 pubmed publisher
    ..b>Tumor necrosis factor receptor 1 (TNFR1) has been identified as a prominent death receptor activated in the lungs during ischemic AKI...
  8. Eum H, Vallabhaneni R, Wang Y, Loughran P, Stolz D, Billiar T. Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-?-treated hepatocytes. Am J Pathol. 2011;179:1221-9 pubmed publisher
    b>Tumor necrosis factor receptor 1 (TNFR1) activation in hepatocytes can trigger apoptotic or inflammatory signaling...
  9. Ishikawa T, Miyagi M, Kamoda H, Orita S, Eguchi Y, Arai G, et al. Differences between tumor necrosis factor-? receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model. Spine (Phila Pa 1976). 2013;38:11-6 pubmed publisher
    ..the rat neuropathic pain model were investigated to clarify the function of tumor necrosis factor (TNF)-? receptors p55 type 1 and p75 type 2...
  10. Sanchez E, Singru P, Wittmann G, Nouriel S, Barrett P, Fekete C, et al. Contribution of TNF-alpha and nuclear factor-kappaB signaling to type 2 iodothyronine deiodinase activation in the mediobasal hypothalamus after lipopolysaccharide administration. Endocrinology. 2010;151:3827-35 pubmed publisher
    ..We hypothesize that in addition to TSH, other factors derived from the pars tuberalis may contribute to LPS-induced D2 activation in tanycytes. ..
  11. Nemec A, Pavlica Z, Svete A, Erzen D, Crossley D, Petelin M. Lack of soluble tumor necrosis factor alpha receptor 1 and 2 and interleukin-1beta compartmentalization in lungs of mice after a single intratracheal inoculation with live Porphyromonas gingivalis. Exp Lung Res. 2009;35:605-20 pubmed
    ..Development of pneumonia is dependent on the P. gingivalis dose; however, part of the cytokine response is unique to the systemic compartment, even in animals that do not develop pneumonia. ..
  12. Lotocki G, de Rivero Vaccari J, Perez E, Alonso O, Curbelo K, Keane R, et al. Therapeutic hypothermia modulates TNFR1 signaling in the traumatized brain via early transient activation of the JNK pathway and suppression of XIAP cleavage. Eur J Neurosci. 2006;24:2283-90 pubmed
    ..Here, TNFR1 signaling pathways were investigated in the cerebral cortex of adult male Sprague-Dawley rats subjected to ..
  13. Yu Y, Wei S, Weiss R, Felder R. TNF-? receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats. Am J Physiol Heart Circ Physiol. 2017;313:H744-H756 pubmed publisher
    ..We hypothesized that the tumor necrosis factor-? (TNF-?) receptor 1 (TNFR1) in the SFO contributes to sympathetic excitation and cardiac dysfunction in HF rats...
  14. Geis C, Graulich M, Wissmann A, Hagenacker T, Thomale J, Sommer C, et al. Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain. Neuroscience. 2010;169:463-74 pubmed publisher
    ..Mechanisms by which TNF, through its receptor subtypes, TNF receptor 1 (TNFR1) and -2 (TNFR2), elicits altered sensation and pain behavior, are still incompletely understood...
  15. Zhang M, Qian J, Xing X, Kong F, Zhao L, Chen M, et al. Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung. Clin Cancer Res. 2008;14:1868-76 pubmed publisher
    ..Lung toxicity was measured by apoptosis and pulmonary function testing. TNF receptor 1 (TNFR1) inhibition, achieved by genetic knockout or antisense oligonucleotide (ASO) silencing, was tested for selective ..
  16. Idasiak Piechocka I, Oko A, Pawliczak E, Kaczmarek E, Czekalski S. Urinary excretion of soluble tumour necrosis factor receptor 1 as a marker of increased risk of progressive kidney function deterioration in patients with primary chronic glomerulonephritis. Nephrol Dial Transplant. 2010;25:3948-56 pubmed publisher
    ..factor ? (TNF ?), a potent proinflammatory cytokine, in the kidneys are mediated by two membrane receptors (TNFR), TNFR1 and TNFR2...
  17. Kuwata K, Shibutani M, Hayashi H, Shimamoto K, Hayashi S, Suzuki K, et al. Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by ?-naphthoflavone involving TNF?-signaling due to oxidative cellular stress in rats. Toxicology. 2011;283:8-17 pubmed publisher
    ..Furthermore, BNF increased HO-1-expressing Kupffer cells and liver cells expressing tumor necrosis factor receptor 1 (TNFR1) and the TNFR1-associated death domain...
  18. Hosono K, Yamada E, Endo H, Takahashi H, Inamori M, Hippo Y, et al. Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas. World J Gastroenterol. 2012;18:5360-8 pubmed publisher
    ..TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis. ..
  19. Shimizu T, Tomita Y, Son K, Nishinarita S, Sawada S, Horie T. Elevation of serum soluble tumour necrosis factor receptors in patients with polymyositis and dermatomyositis. Clin Rheumatol. 2000;19:352-9 pubmed
  20. Shubayev V, Myers R. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. J Neuroimmunol. 2001;114:48-56 pubmed
    ..These findings highlight a dynamic process of TNF-alpha protein and receptor regulation throughout the peripheral neural axis that bears on both the normal function of DRG neurons and the pathogenesis of painful neuropathies. ..
  21. Catalano M, Fortunati N, Arena K, Costelli P, Aragno M, Danni O, et al. Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia. Int J Oncol. 2003;23:429-36 pubmed
    ..This is the first demonstration of a selective up-regulation of TNF-RI in cancer cachexia and suggests that local production of TNF-alpha and IL-6 is a corner-stone in the induction/maintenance of this syndrome. ..
  22. Wang Y, Zhou D, Shen Q, Cheng C, Liu H, Qin Y, et al. Lipopolysaccharide-induced upregulation of tumor necrosis factor-alpha (TNF-alpha) and TNF receptors in rat sciatic nerve. J Mol Neurosci. 2007;32:207-16 pubmed
    ..Therefore, we focused our study on TNF-alpha, TNFR1, and TNFR2 protein synthesis and expression patterns in sciatic nerve of controls and rats under systemic ..
  23. Guo G, Morrissey J, McCracken R, Tolley T, Klahr S. Role of TNFR1 and TNFR2 receptors in tubulointerstitial fibrosis of obstructive nephropathy. Am J Physiol. 1999;277:F766-72 pubmed
    ..Mice in which individual TNF-alpha receptors TNFR1 or TNFR2 had been genetically knocked out were used, and results were compared with mice of C57Bl/6 background ..
  24. Raveney B, Copland D, Dick A, Nicholson L. TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis. J Immunol. 2009;183:2321-9 pubmed publisher
    ..depends on activation by T cell-produced IFN-gamma and autocrine TNF-alpha signaling in the myeloid cells via TNFR1. In the absence of TNFR1 signaling, relative T cell expansion in the retina is increased, indicating that ..
  25. Zhou J, Zhang M, Atherton S. Tumor necrosis factor-alpha-induced apoptosis in murine cytomegalovirus retinitis. Invest Ophthalmol Vis Sci. 2007;48:1691-700 pubmed
    ..To explore the mechanism underlying retinal apoptosis in MCMV retinitis, this study was initiated to determine whether the tumor necrosis factor receptor (TNFR)1-TNF pathway is involved in apoptosis during MCMV retinitis...
  26. Liu Z, Swindall A, Kesterson R, Schoeb T, Bullard D, Bellis S. ST6Gal-I regulates macrophage apoptosis via ?2-6 sialylation of the TNFR1 death receptor. J Biol Chem. 2011;286:39654-62 pubmed publisher
    ..Herein we describe a novel apoptotic pathway involving ?2-6 sialylation of the TNFR1 death receptor by the ST6Gal-I sialyltransferase...
  27. Fujita M, Ikegame S, Harada E, Ouchi H, Inoshima I, Watanabe K, et al. TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice. Cytokine. 2008;44:298-303 pubmed publisher
    ..pneumophila. In the case of TNFR1-knock-out mice and TNFR2-knock-out mice, a high mortality rate was observed after inoculation of 1x10(7)CFU/head ..
  28. Jeon S, Sung J, Cho H. Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain. Neuroscience. 2011;190:354-66 pubmed publisher
    ..Extensive colocalization of tumor necrosis factor receptor 1 (TNFR1) and MCP-1 was observed in the L5 DRG following L5 VR, and treatment with TNFR1 antisense ..
  29. Lind M, Rozell B, Wallin R, van Hogerlinden M, Ljunggren H, Toftgard R, et al. Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. Proc Natl Acad Sci U S A. 2004;101:4972-7 pubmed
    ..We now show that by crossing K5-IkappaBalpha mice onto a tumor necrosis factor receptor 1(Tnfr1)-null background, both the inflammatory and the tumorigenic responses are blocked...
  30. Pradillo J, Hurtado O, Romera C, Cardenas A, Fernandez Tome P, Alonso Escolano D, et al. TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning. Neuroscience. 2006;138:1171-8 pubmed
    ..Intracerebral administration of either anti-TNF-alpha antibody or of a TNFR1 antisense oligodeoxynucleotide also inhibited ischemic preconditioning-induced EAAT3 up-regulation...
  31. Maury C, Liljestrom M, Laiho K, Tiitinen S, Kaarela K, Hurme M. Tumor necrosis factor alpha, its soluble receptor I, and -308 gene promoter polymorphism in patients with rheumatoid arthritis with or without amyloidosis: implications for the pathogenesis of nephropathy and anemia of chronic disease in reactive amy. Arthritis Rheum. 2003;48:3068-76 pubmed
  32. Eagan T, Ueland T, Wagner P, Hardie J, Mollnes T, Damas J, et al. Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. Eur Respir J. 2010;35:540-8 pubmed publisher
    ..05). The present study confirms that certain circulating inflammatory mediators are an important phenotypic feature of COPD. ..
  33. Tian L, Xie H, Yang T, Hu Y, Li J, Wang W. TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: a case-control study. J Huazhong Univ Sci Technolog Med Sci. 2010;30:408-11 pubmed publisher
    ..588; P=0.018; OR=1.838; 95% CI: 1.105-3.057). It was concluded that the high frequency of 196R allele in the functional M196R polymorphism of TNFR2 is a risk factor for acne vulgaris in Han Chinese. ..
  34. Nakazawa T, Kayama M, Ryu M, Kunikata H, Watanabe R, Yasuda M, et al. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci. 2011;52:1384-91 pubmed publisher
    ..the role of TNF? in photoreceptor degeneration, RD was induced in mice deficient in TNF? or its receptors (TNFR1, TNFR2, and TNFR1 and -2), or in wild-type (WT) mice by using a functionally blocking antibody to TNF?...
  35. Kim D, Hong G, Ro J. Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L. J Neuroinflammation. 2011;8:25 pubmed publisher
    ..Express Kit; small GTPases by GTP-pull down assay; PKCs, MAPKs, CD40, CD40L, Jak1/2, STAT1, TNF receptor 1 (TNFR1) by Western blot; NF-?B and AP-1 by EMSA; cytokines by RT-PCR...
  36. Carballo E, Blackshear P. Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood. 2001;98:2389-95 pubmed
    ..were generated that were deficient in TTP and either or both of the known TNF-alpha receptors (TNFRs), type 1 (TNFR1) and type 2 (TNFR2)...
  37. Molina A, Vendrell J, Gutierrez C, Simon I, Masdevall C, Soler J, et al. Insulin resistance, leptin and TNF-alpha system in morbidly obese women after gastric bypass. Obes Surg. 2003;13:615-21 pubmed
    ..This pattern of variation of the leptin TNF-alpha axis suggests a disregulation of the system after dramatic weight loss and also that insulin and leptin up-regulate TNF-alpha production irrespective of insulin resistance status. ..
  38. Zwiech R. Predictive value of conjointly examined IL-1ra, TNF-R I, TNF-R II, and RANTES in patients with primary glomerulonephritis. J Korean Med Sci. 2013;28:261-7 pubmed publisher
    ..In conclusion, the urinary excretion of IL-1ra, TNF-R I and R II, and RANTES examined conjointly are effective in predicting favorable response to immunosuppressive treatment in patients with GN. ..
  39. Roy D, Mandal S, Sen G, Mukhopadhyay S, Biswas T. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010;160:1823-43 pubmed publisher
    ..Events associated with 14-DAG-induced TNFRSF1A release from hepatocytes were determined using immunoblotting, biochemical assay and fluorimetric studies...
  40. Gong Q, Wang Q, Pan L, Liu X, Xin H, Zhu Y. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-?B pathway in rats. Brain Behav Immun. 2011;25:110-9 pubmed publisher
    ..Furthermore, SPRC afforded beneficial actions in inhibitions tumor necrosis factor (TNF)-?, TNF-? receptor 1 (TNFR1) and A? generation, as well as I?B-? degradation and phospho-transcription factors of the nuclear factor ?B p65 (p-..
  41. Selinsky C, Howell M. Soluble tumor necrosis factor receptor type I enhances tumor development and persistence in vivo. Cell Immunol. 2000;200:81-7 pubmed
    Secretion of human soluble tumor necrosis factor receptor type I (sTNFRI) by the mouse fibrosarcoma cell line, L929, previously has been demonstrated to confer resistance to in vitro lysis by TNF and to LAK- and CTL-mediated cytolysis...
  42. Ingaramo P, Ronco M, Francés D, Monti J, Pisani G, Ceballos M, et al. Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus. Mol Immunol. 2011;48:1397-407 pubmed publisher
    ..Overall, we demonstrated that in the diabetes enhances TNF-? in the liver, which may be a fundamental key leading to apoptotic cell death, through activation of caspase-8, NF?B and JNK pathways. ..
  43. Harrington J, Messier A, Levine A, Szmydynger Chodobska J, Chodobski A. Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury. J Neurotrauma. 2005;22:919-28 pubmed
    ..These CSF samples were analyzed by ELISA for the presence of TNF-alpha and soluble TNFR1 and TNFR2 (sTNFR1 and sTNFR2, respectively)...
  44. Shinoda S, Skradski S, Araki T, Schindler C, Meller R, Lan J, et al. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci. 2003;17:2065-76 pubmed
    The consequences of activation of tumour necrosis factor receptor 1 (TNFR1) during neuronal injury remain controversial...
  45. Ito Y, Nomura S, Ueda H, Sakurai T, Kizaki T, Ohno H, et al. Exercise training increases membrane bound form of tumor necrosis factor-alpha receptors with decreases in the secretion of soluble forms of receptors in rat adipocytes. Life Sci. 2002;71:601-9 pubmed
    ..These alterations may induce enhanced the autocrine effects of TNF-alpha within adipocytes in exercise-trained rats. ..
  46. Parada C, Yeh J, Joseph E, Levine J. Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur J Neurosci. 2003;17:1847-52 pubmed
    ..Intrathecal administration of antisense to tumour necrosis factor receptor type-1 (TNFR1) reduced the level of TNFR1 transported toward the peripheral terminals of sensory neurons, and attenuated both ..
  47. Aderka D, Wysenbeek A, Engelmann H, Cope A, Brennan F, Molad Y, et al. Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus. Arthritis Rheum. 1993;36:1111-20 pubmed
    ..The mean +/- SD concentrations of both the p55 (type I) and p75 (type II) soluble receptors were significantly higher in a group of 46 SLE patients than in ..
  48. Baier P, Wolf Vorbeck G, Hempel S, Hopt U, von Dobschuetz E. Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors. World J Gastroenterol. 2006;12:3835-40 pubmed
    ..In immunohistochemistry, EGFR, HGFR, FGFR and TNFR1 showed biphasic kinetics after partial hepatectomy with a peak up to 12 h, a nadir after 24 h and another weak ..
  49. Liu K, Glidden D, Eisner M, Parsons P, Ware L, Wheeler A, et al. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007;35:2755-61 pubmed
    ..The combination of these biological and clinical risk factors may have important and additive value in predictive models for acute kidney injury. ..
  50. Chen B, Tong Z, Ye Q, Nakamura S, Costabel U, Guzman J. Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis. Eur Respir J. 2005;25:1039-43 pubmed
    ..In conclusion, this study shows evidence of altered expression of tumour necrosis factor superfamily receptors in hypersensitivity pneumonitis. ..
  51. Robertson M, Liversidge J, Forrester J, Dick A. Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci. 2003;44:3034-41 pubmed
    ..sTNFr-IgG-mediated suppression of NO production results in reduced levels of apoptosis of inflammatory cells and reduction in photoreceptor damage. ..
  52. Works M, Koenig J, Sapolsky R. Soluble TNF receptor 1-secreting ex vivo-derived dendritic cells reduce injury after stroke. J Cereb Blood Flow Metab. 2013;33:1376-85 pubmed publisher
    ..These studies indicate that cell-mediated delivery of proteins may be a promising new approach to reduce brain damage after acute neurologic insult. ..
  53. Lee K, Jeon S, Cho H. Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model. Eur J Pain. 2009;13:794-806 pubmed publisher
    ..pain induces the upregulation of interleukin (IL)-6 and tumor necrosis factor-alpha, which binds to tumor necrosis factor receptor 1 (TNFR1) and induces NF-kappaB and p38 MAPK activation in the spinal cord and dorsal root ganglia (DRG)..