Tnfrsf11b

Summary

Gene Symbol: Tnfrsf11b
Description: TNF receptor superfamily member 11B
Alias: Opg, tumor necrosis factor receptor superfamily member 11B, Osteoprotegerin
Species: rat
Products:     Tnfrsf11b

Top Publications

  1. Simonet W, Lacey D, Dunstan C, Kelley M, Chang M, Luthy R, et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. 1997;89:309-19 pubmed
    A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily...
  2. Ueland T, Yndestad A, Øie E, Florholmen G, Halvorsen B, Frøland S, et al. Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure. Circulation. 2005;111:2461-8 pubmed
    Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) are newly discovered members of the tumor ..
  3. El Shehaby A, Darweesh H, El Khatib M, Momtaz M, Marzouk S, El Shaarawy N, et al. Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis. J Clin Immunol. 2011;31:848-56 pubmed publisher
    ..study was designed to correlate urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and interleukin-8 (IL-8) levels, with renal involvement in ..
  4. Charoenphandhu N, Teerapornpuntakit J, Methawasin M, Wongdee K, Thongchote K, Krishnamra N. Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats. Can J Physiol Pharmacol. 2008;86:240-8 pubmed publisher
    ..for 48 h to 1000 ng/mL PRL, but not to 10 or 100 ng/mL PRL, showed decreases in the mRNA expression of Runx2, osteoprotegerin (OPG), and receptor activator of nuclear factor kappaBeta ligand (RANKL) by 60.49%, 72.74%, and 87...
  5. Gu S, Zhang Y, Wu S, Diao T, Gebru Y, Deng H. Early molecular responses of bone to obstructive nephropathy induced by unilateral ureteral obstruction in mice. Nephrology (Carlton). 2012;17:767-73 pubmed publisher
    ..This study was performed to address the bone injury and the early molecular responses of bone to obstructive nephropathy induced by unilateral ureteral obstruction in mice...
  6. Siomou E, Challa A, Printza N, Giapros V, Petropoulou F, Mitsioni A, et al. Serum osteoprotegerin, RANKL and fibroblast growth factor-23 in children with chronic kidney disease. Pediatr Nephrol. 2011;26:1105-14 pubmed publisher
    b>Osteoprotegerin (OPG), receptor activator of the nuclear factor ?B ligand (RANKL) and fibroblast growth factor-23 (FGF-23) play a central role in renal osteodystrophy...
  7. Jorsal A, Tarnow L, Flyvbjerg A, Parving H, Rossing P, Rasmussen L. Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy. Diabetologia. 2008;51:2100-7 pubmed publisher
    The bone-related peptide osteoprotegerin is produced by vascular cells and is involved in the process of vascular calcification...
  8. Schrader J, Rennekamp W, Niebergall U, Schoppet M, Jahr H, Brendel M, et al. Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death. Diabetologia. 2007;50:1243-7 pubmed
    ..Microarray analysis recently identified osteoprotegerin (OPG; now known as tumour necrosis factor receptor superfamily, member 11b [TNFRSF11B]) as a cytokine-induced ..
  9. Akat K, Kaden J, Schmitz F, Ewering S, Anton A, Klomfass S, et al. Calcium metabolism in adults with severe aortic valve stenosis and preserved renal function. Am J Cardiol. 2010;105:862-4 pubmed publisher
    ..renal function: calcium, phosphate, 1,25(OH(2))-vitamin D(3), intact parathyroid hormone (iPTH), and osteoprotegerin. Patients with AS had significantly higher serum levels of calcium (2.63 +/- 0.28 vs 2.48 +/- 0...

More Information

Publications62

  1. Wang Q, Wang K, Dang X, Shi Z, Pei X, Bai C, et al. [Effect of estrogen on osteoprotegerin, osteoclast differentiation factor and macrophage colony stimulating factor mRNA expressions in ovariectomized rat bone tissue]. Nan Fang Yi Ke Da Xue Xue Bao. 2006;26:532-4 pubmed
    To observe the effect of the estrogen on the mRNA expression of osteoprotegerin (OPG), osteoclast differentiation factor (ODF) and macrophage colony stimulating factor (M-CSF) in bone tissue of ovariectomized rats, and investigate the ..
  2. Jin Q, Cirelli J, Park C, Sugai J, Taba M, Kostenuik P, et al. RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis. J Periodontol. 2007;78:1300-8 pubmed
    ..The receptor activator of nuclear factor-kappa B ligand (RANKL) inhibitor osteoprotegerin (OPG) inhibits osteoclastogenesis and suppresses bone resorption...
  3. Zhou J, Chen S, Guo H, Xia L, Liu H, Qin Y, et al. Pulsed electromagnetic field stimulates osteoprotegerin and reduces RANKL expression in ovariectomized rats. Rheumatol Int. 2013;33:1135-41 pubmed publisher
    ..Receptor activator of nuclear factor ?B ligand (RANKL) and osteoprotegerin (OPG) are cytokines predominantly secreted by osteoblasts and play a central role in differentiation and ..
  4. Wang J, Gao H, Wang K, Zhou R, Li X, Guo J, et al. [Effect of Epimedium extract on osteoprotegerin and RANKL mRNA expressions in glucocorticoid-induced femoral head necrosis in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:1714-7 pubmed
    To investigate the effect of glucocorticoid on the expression levels of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) mRNAs in rat femoral head and the antagonistic effect of Epimedium, and explore ..
  5. Ziegler S, Kudlacek S, Luger A, Minar E. Osteoprotegerin plasma concentrations correlate with severity of peripheral artery disease. Atherosclerosis. 2005;182:175-80 pubmed
    b>Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor family, is involved in the process of bone turnover and also in the pathogenesis of osteoporosis and premature calcification of the vascular system...
  6. Ferreira E, Bortolin R, Freire Neto F, Souza K, Bezerra J, Ururahy M, et al. Zinc supplementation reduces RANKL/OPG ratio and prevents bone architecture alterations in ovariectomized and type 1 diabetic rats. Nutr Res. 2017;40:48-56 pubmed publisher
    ..The RANKL/OPG ratio was similar between the control and OVX/T1DM+Zn groups, whereas it was higher in the OVX/T1DM group...
  7. Li Y, Wang H. [Serum osteoprotegerin level in children with nephrotic syndrome and the effect of glucocorticoid on it]. Zhongguo Dang Dai Er Ke Za Zhi. 2012;14:653-6 pubmed
    To observe serum osteoprotegerin (OPG) level in children with nephrotic syndrome (NS) and changes in serum OPG level after glucocorticoid therapy, with the aim of studying the role of OPG in the bone metabolism of children with NS...
  8. Blázquez Medela A, Garcia Ortiz L, Gomez Marcos M, Recio Rodriguez J, Sánchez Rodríguez A, Lopez Novoa J, et al. Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes. Eur J Clin Invest. 2012;42:548-56 pubmed publisher
    b>Osteoprotegerin (OPG), a secreted member of the tumour necrosis factor receptor superfamily of cytokines, has been associated with endothelial dysfunction...
  9. Wise G, Yao S, Liu D. Injections of osteoprotegerin and PMA delay tooth eruption. Clin Anat. 2006;19:19-24 pubmed
    ..subsequent alveolar bone resorption for eruption, we have hypothesized that a reduction in gene expression of osteoprotegerin (OPG) in the follicle of the first mandibular molar of the rat at Day 3 is needed...
  10. Zhao N, Lin J, Chen Z, Liu Y. [Indication of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) in gingival crevicular fluid to remodeling of alveolar bone during retention]. Beijing Da Xue Xue Bao Yi Xue Ban. 2012;44:108-12 pubmed
    To investigate the level of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) in gingival crevicular fluid (GCF) during orthodontic retention and corresponding expression of OPG and RANKL in ..
  11. Ugur Altun B, Altun A, Gerenli M, Tugrul A. The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity. Diabetes Res Clin Pract. 2005;68:217-22 pubmed
    We investigated the relationship between insulin resistance and serum osteoprotegerin (OPG) levels in healthy obese subjects and healthy lean controls...
  12. Silvestrini G, Ballanti P, Patacchioli F, Leopizzi M, Gualtieri N, Monnazzi P, et al. Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat. J Mol Histol. 2005;36:59-67 pubmed
    b>Osteoprotegerin (OPG) and the receptor activator of nuclear factor (NF)-kB ligand (RANKL) are key regulators of osteoclastogenesis...
  13. Xu Y, Wu T, Chen Y, Zhang Z. Regulation of the response of the adult rat condyle to intermaxillary asymmetric force by the RANKL-OPG system. Angle Orthod. 2009;79:646-51 pubmed publisher
    To test the hypothesis that the RANKL-OPG system in the subchondral bone of adult rat condyles does not vary in response to different values of intermaxillary asymmetrical forces...
  14. Vijayan V, Khandelwal M, Manglani K, Singh R, Gupta S, Surolia A. Homocysteine alters the osteoprotegerin/RANKL system in the osteoblast to promote bone loss: pivotal role of the redox regulator forkhead O1. Free Radic Biol Med. 2013;61:72-84 pubmed publisher
    ..of how homocysteine differentially affects receptor activator of nuclear factor-?B ligand (RANKL) and osteoprotegerin (OPG) synthesis in the bone...
  15. Wise G, Yao S, Zhang Q, Ren Y. Inhibition of osteoclastogenesis by the secretion of osteoprotegerin in vitro by rat dental follicle cells and its implications for tooth eruption. Arch Oral Biol. 2002;47:247-54 pubmed
    ..Recent studies have shown that the osteoprotegerin (OPG) gene is expressed in the dental follicle, but in the first mandibular molar of the rat, that expression ..
  16. Rauner M, Stupphann D, Haas M, Fert I, Glatigny S, Sipos W, et al. The HLA-B27 transgenic rat, a model of spondyloarthritis, has decreased bone mineral density and increased RANKL to osteoprotegerin mRNA ratio. J Rheumatol. 2009;36:120-6 pubmed publisher
    ..P1NP), and osteocalcin, as well as receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG), were measured...
  17. Kurnatowska I, Grzelak P, Kaczmarska M, Stefanczyk L, Nowicki M. Serum osteoprotegerin is a predictor of progression of atherosclerosis and coronary calcification in hemodialysis patients. Nephron Clin Pract. 2011;117:c297-304 pubmed publisher
    ..e. serum osteoprotegerin (OPG) and fibroblast growth factor 23 (FGF-23)...
  18. Ndip A, Williams A, Jude E, Serracino Inglott F, Richardson S, Smyth J, et al. The RANKL/RANK/OPG signaling pathway mediates medial arterial calcification in diabetic Charcot neuroarthropathy. Diabetes. 2011;60:2187-96 pubmed publisher
    The receptor activator of nuclear factor-?B (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) signaling pathway (RANKL/RANK/OPG signaling) is implicated in the osteolysis associated with diabetic Charcot neuroarthropathy (CN); ..
  19. Romas E, Sims N, Hards D, Lindsay M, Quinn J, Ryan P, et al. Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. Am J Pathol. 2002;161:1419-27 pubmed
    ..A decoy receptor for RANKL, osteoprotegerin, (OPG) impinges on this system and regulates osteoclast numbers and activity...
  20. Mazurkiewicz T, Matuszewski L, Matuszewska A, Jaszek M. Implanted bisphosphonates in bone cement affect bone markers in rat serum. Int Orthop. 2013;37:969-74 pubmed publisher
    ..The concentration of osteoprotegerin ligand (OPG) was higher in rats with BP implants...
  21. Li X, Ominsky M, Stolina M, Warmington K, Geng Z, Niu Q, et al. Increased RANK ligand in bone marrow of orchiectomized rats and prevention of their bone loss by the RANK ligand inhibitor osteoprotegerin. Bone. 2009;45:669-76 pubmed publisher
    ..63). The effects of RANKL inhibition were then studied by treating ORX rats for 6 weeks with OPG-Fc (10 mg/kg, twice/week SC) or with PBS, beginning immediately after surgery. Sham controls were treated with PBS...
  22. Liu Y, Zhang H, Zang H, Cheng J, Li Y. [Effects of kangfengshi granules on expressions of osteoprotegerin, RANKL and M-CSF in bone tissues of rats with collagen-induced arthritis]. Zhong Xi Yi Jie He Xue Bao. 2006;4:307-10 pubmed
    To observe the effects of Kangfengshi Granules (KFSG) on expressions of the mRNAs of osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB ligand (RANKL) and macrophage colony stimulating factor (M-CSF) in bone tissues of ..
  23. Zhang L, Liu W, Zhao J, Ma X, Shen L, Zhang Y, et al. Mechanical stress regulates osteogenic differentiation and RANKL/OPG ratio in periodontal ligament stem cells by the Wnt/?-catenin pathway. Biochim Biophys Acta. 2016;1860:2211-9 pubmed publisher
    ..with 100kpa static pressure for 1h or 12h in vitro, and examined the phenotypic changes and expression of RANKL and OPG in these cells...
  24. Xu W, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, et al. Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells. Cell Biol Int. 2004;28:675-82 pubmed
    ..BMP-6 stimulated the expression of osteopontin, BMP-2, ALPase and osteoprotegerin. These findings show that BMP-4, -5 and -6 have different actions on the expression of bone-related proteins ..
  25. Ohazama A, Courtney J, Sharpe P. Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis. J Dent Res. 2004;83:241-4 pubmed
    b>Osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) are mediators of various cellular interactions, including bone metabolism...
  26. Jia L, Jin T. Combined effect of fluoride and arsenate on gene expression of osteoclast differentiation factor and osteoprotegerin. Biomed Environ Sci. 2006;19:375-9 pubmed
    ..and arsenate on the expression of SD rat osteoblastic osteoclast differentiation factor (ODF) mRNA and osteoprotegerin (OPG) mRNA. Osteoblasts were obtained by enzymatic isolation from newborn SD rats...
  27. Roudier M, Bain S, Dougall W. Effects of the RANKL inhibitor, osteoprotegerin, on the pain and histopathology of bone cancer in rats. Clin Exp Metastasis. 2006;23:167-75 pubmed
    ..study investigated the effects of the receptor activator for nuclear factor kappaB ligand (RANKL) inhibitor, osteoprotegerin (OPG), on tumor-induced allodynia, osteolysis, and bone histology in the mammary tumor (MRMT-1) rat model for ..
  28. Cao F, Liu X, Cao X, Wang S, Fu K, Zhao Y, et al. Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system. Biochem Biophys Res Commun. 2017;491:578-586 pubmed publisher
    ..factor(RUNX)-2 and nuclear factor-kappa B ligand (RANKL) were down-regulated, whereas the expression of osteoprotegerin (OPG) increased...
  29. Wang T, Zhang X, Li S. [Effect of different types of jumps on the expressions of IL-6, OPG and RANKL in rat tibia]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014;30:909-12 pubmed
    To investigate the effect of different types of jumps on the expressions of interleukin 6 (IL-6), osteoprotegerin(OPG), ligand of receptor activator of NF-κB(RANKL) genes related to bone metabolism in rat tibia, and explore the ..
  30. Kiechl S, Schett G, Wenning G, Redlich K, Oberhollenzer M, Mayr A, et al. Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease. Circulation. 2004;109:2175-80 pubmed
    b>Osteoprotegerin is a novel member of the tumor necrosis factor receptor superfamily and a soluble decoy receptor of the receptor activator of nuclear factor-kappaB ligand...
  31. Zhang Z, Song C, Fu X, Liu M, Li Y, Pan J, et al. High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratio. Int J Mol Sci. 2014;15:17130-47 pubmed publisher
    ..Levels of protein and mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) in tibia were evaluated by ..
  32. Chen Z, Xue J, Shen T, Mu S, Fu Q. Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway. Int J Mol Med. 2016;37:329-38 pubmed publisher
    ..The mRNA and protein expression levels of osteoprotegerin (OPG) and receptor activator for nuclear factor-kappa B ligand (RANKL) were detected to assess cytokine-..
  33. Chen X, Wang G, Li X, Gan C, Zhu G, Jin T, et al. Environmental level of cadmium exposure stimulates osteoclasts formation in male rats. Food Chem Toxicol. 2013;60:530-5 pubmed publisher
    ..showed that Cd could enhance receptor-activated nuclear factor kappa B ligand expression (RANKL) and inhibit osteoprotegerin (OPG) expression...
  34. Aihara N, Yamaguchi M, Kasai K. Low-energy irradiation stimulates formation of osteoclast-like cells via RANK expression in vitro. Lasers Med Sci. 2006;21:24-33 pubmed
    ..The present results suggest that low-energy laser irradiation facilitates differentiation and activation of osteoclasts via RANK expression. ..
  35. Fernandes M, Yanai M, Martins G, Iano F, Leite A, Cestari T, et al. Effects of fluoride in bone repair: an evaluation of RANKL, OPG and TRAP expression. Odontology. 2014;102:22-30 pubmed publisher
    ..the effect of fluoride in the expression of the receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG) and tartrate-resistant acid phosphatase (TRAP) in alveolar bone repair in rats...
  36. Cundy T, Hegde M, Naot D, Chong B, King A, Wallace R, et al. A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype. Hum Mol Genet. 2002;11:2119-27 pubmed
    ..The gene TNFRSF11B encoding osteoprotegerin (OPG), which lies within this locus, was an obvious candidate, given the critical role of OPG in regulating ..
  37. Aydin H, Deyneli O, Yavuz D, Yuksel M, Tarcin O, Yazici D, et al. Effect of oxidative stress on aorta and tibia osteoprotegerin gene expression in ovariectomized rats. Minerva Endocrinol. 2011;36:107-15 pubmed
    ..Tissue oxidative stress was determined via measurement of malondialdehyde levels and osteoprotegerin gene expression with RT-PCR...
  38. Zhu W, Wang X, Wang X, Wang Z. [Molecular mechanism of bone remodelling during mandibular distraction osteogenesis in rats]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2007;42:729-32 pubmed
    To study the expression profiles of osteoprotegerin (OPG) and receptor activator of nuclear factor-KB ligand (RANKL) in the distraction region and to investigate the mechanism of bone remodelling during mandibular distraction ..
  39. Bilgin E, Yasasever V, Soydinc H, Yasasever C, Ozturk N, Duranyildiz D. Markers of bone metastases in breast and lung cancers. Asian Pac J Cancer Prev. 2012;13:4331-4 pubmed
    The aim of the present study was to evaluate correlations between serum osteocalcin, osteoprotegerin and NTX (Cross-linked N-telopeptides of Type I Collagen) and urinary NTX in breast and lung cancer patients with bone metastases...
  40. McGonigle J, Giachelli C, Scatena M. Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function. Angiogenesis. 2009;12:35-46 pubmed publisher
    b>Osteoprotegerin (OPG) a soluble tumor necrosis factor receptor family molecule protects endothelial cells from apoptosis in vitro and promotes neovascularization in vivo...
  41. Liu X, Xu L, Wang Y, Li J, Zhang Y, Zhang C, et al. Protective effects of total flavonoids of Astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-?B pathway. Int Immunopharmacol. 2017;44:105-114 pubmed publisher
    ..The levels of serum tumor necrosis factor (TNF)-?, interleukin (IL)-1?, prostaglandin (PG)E2, osteoprotegerin (OPG) and receptor activator of nuclear factor-?B ligand (RANKL) were determined using ELISA...
  42. Shao B, Yu Y, Fu X, Xue H, Qi M, Shuai Y, et al. [RANKL and OPG expression in bone marrow-derived mesenchymal stem cells of ovariectomied promotes osteoclast development and enhances its function]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:1262-6 pubmed
    To investigate the expression of receptor activator of nuclear factor-kappa B lig (RANKL), osteoprotegerin (OPG) in bone marrow mesenchymal stem cells (BMSCs) and its impact on osteoclast formation and function in the ovariectomied mice...
  43. Liu Z, Xu J, E L, Wang D, Bei D. [Effect of ultrasound on osteoprotegerin and receptor activator nuclear factor kappaB ligand expression during root resorption in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31:813-6 pubmed
    To evaluate the effect of pulsed ultrasound on the expressions of osteoprotegerin (OPG) and receptor activator nuclear factor kappaB ligand (RANKL) during root resorption in a mouse model of orthodontic tooth movement...
  44. Altun A, Ugur Altun B, Tatli E. Decreased serum osteoprotegerin levels in patients with cardiac syndrome X. J Endocrinol Invest. 2004;27:839-43 pubmed
    Receptor activator of nuclear factor KB (RANK) and osteoprotegerin (OPG) represent the ligand and decoy receptor, respectively, of a pleiotropic cytokine system that regulates bone metabolism and vascular biology...
  45. Yang X, Halladay D, Onyia J, Martin T, Chandrasekhar S. Protein Kinase C is a mediator of the synthesis and secretion of osteoprotegerin in osteoblast-like cells. Biochem Biophys Res Commun. 2002;290:42-6 pubmed
    b>Osteoprotegerin (OPG) is a member of the TNF receptor superfamily and plays a critical role in the development of osteoclasts from precursor cells...
  46. Nie B, Zhou S, Fang X, Zhang S, Guan S. The function and meaning of receptor activator of NF-?B ligand in arterial calcification. J Huazhong Univ Sci Technolog Med Sci. 2015;35:666-671 pubmed publisher
    ..During arterial calcification, in vivo and in vitro expression of RANKL and its inhibitor, osteoprotegerin (OPG), was detected by real-time PCR. The extent of osteoclast-like cell differentiation was also assessed...
  47. Gold B, Zeleny Pooley M, Chaturvedi P, Wang M. Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration. Neuroreport. 1998;9:553-8 pubmed
    ..Orally active nonimmunosuppressant FKBP-12 ligands may be useful for the treatment of human peripheral nerve disorders. ..
  48. Liu W, Feng W, Wang F, Li W, Gao C, Zhou B, et al. Osteoprotegerin/RANK/RANKL axis in cardiac remodeling due to immuno-inflammatory myocardial disease. Exp Mol Pathol. 2008;84:213-7 pubmed publisher
    b>Osteoprotegerin (OPG) and the receptor activator of nuclear factor-kappaB ligand (RANKL) are inflammatory cytokines traditionally linked to the regulation of bone remodeling...
  49. Guldiken B, Guldiken S, Turgut B, Turgut N, Demir M, Celik Y, et al. Serum osteoprotegerin levels in patients with acute atherothrombotic stroke and lacunar infarct. Thromb Res. 2007;120:511-6 pubmed
    Arterial calcification is associated with increased risk of cardiovascular events. Osteoprotegerin (OPG) is a cytokine involved in the bone metabolism and vascular calcification...
  50. Valdes A, Hart D, Jones K, Surdulescu G, Swarbrick P, Doyle D, et al. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Arthritis Rheum. 2004;50:2497-507 pubmed
    ..10 years in the K/L score, osteophyte grade, and JSN grade), we found significant associations with ADAM12, CILP, OPG, and TNA. Overall, we observed 15 associations with nominal significance (P < 0...
  51. Nezami N, Safa J, Eftekhar Sadat A, Salari B, Ghorashi S, Sakhaee K, et al. Lovastatin raises serum osteoprotegerin level in people with type 2 diabetic nephropathy. Clin Biochem. 2010;43:1294-9 pubmed publisher
    b>Osteoprotegerin (OPG), a glycoprotein, is a member of the tumor necrotizing factor alpha receptor super-family...
  52. Seriwatanachai D, Thongchote K, Charoenphandhu N, Pandaranandaka J, Tudpor K, Teerapornpuntakit J, et al. Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio. Bone. 2008;42:535-46 pubmed publisher
    ..The ratios of receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OPG) proteins were increased, indicating an increase in the osteoclastic bone resorption...
  53. Wang Q, Wang K, Wang G. [Effects of soybean isoflavones on expression levels of osteoprotegerin and osteoprotegerin ligand mRNAs in bone tissues of ovariectomized rats]. Zhong Xi Yi Jie He Xue Bao. 2006;4:303-6 pubmed
    To investigate the effects of soybean isoflavones (SI) on expression levels of osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) mRNAs in bone tissues of ovariectomized rats, and to discuss the mechanism of soybean isoflavaones in ..