Gene Symbol: Tlr5
Description: toll-like receptor 5
Alias: toll-like receptor 5
Species: rat
Products:     Tlr5

Top Publications

  1. Hawn T, Verbon A, Lettinga K, Zhao L, Li S, Laws R, et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med. 2003;198:1563-72 pubmed
    ..We demonstrated recently that TLR5 recognizes flagellin, a potent inflammatory stimulus present in the flagellar structure of many bacteria...
  2. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2003;4:920-7 pubmed
    ..Finally, biochemical analysis indicated that SIGIRR binds to the TLR-IL-1R signaling components in a ligand-dependent way. Our data show that SIGIRR functions as a biologically important modulator of TLR-IL-1R signaling. ..
  3. Hasan U, Trinchieri G, Vlach J. Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts. J Biol Chem. 2005;280:20620-7 pubmed
    ..We show that stimulation of fibroblasts with a TLR5 ligand, flagellin, can induce proliferation of serum-starved cells or prevent cell cycle exit upon serum withdrawal ..
  4. Das N, Dewan V, Grace P, Gunn R, Tamura R, Tzarum N, et al. HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia. Cell Rep. 2016;17:1128-1140 pubmed publisher
    ..Here, we find that TLR5 is also an HMGB1 receptor that was previously overlooked due to lack of functional expression in the cell lines ..
  5. Oshikawa K, Sugiyama Y. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Biochem Biophys Res Commun. 2003;305:649-55 pubmed
    ..acute lung injury model; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli...
  6. Zhou R, Zhang R, Sun Y, Platt S, Szczotka Flynn L, Pearlman E. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012;53:7382-8 pubmed publisher
    ..S. marcescens induces corneal inflammation by activation of TLR4/MD-2/MyD88 and the IL-1R1/MyD88 pathways, which are potential therapeutic targets for inhibition of S. marcescens-induced corneal inflammation. ..
  7. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30:16-34 pubmed publisher
    ..In this review, we comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated by PRRs. ..
  8. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..53 (0.29-0.96)). These results provide the first evidence of associations of TLR5 and TLR1 variants with altered risks of acquiring rUTI and pyelonephritis, respectively...
  9. Masamune A, Kikuta K, Watanabe T, Satoh K, Satoh A, Shimosegawa T. Pancreatic stellate cells express Toll-like receptors. J Gastroenterol. 2008;43:352-62 pubmed publisher
    ..acid (a ligand for TLR3), lipopolysaccharide (a ligand for TLR4), or flagellin (a ligand for TLR5). The effects of the TLR ligands on key cell functions and activation of signaling pathways were examined...

More Information


  1. Hartl D, Lehmann N, Hoffmann F, Jansson A, Hector A, Notheis G, et al. Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease. J Allergy Clin Immunol. 2008;121:375-382.e9 pubmed
    ..Neutrophils from patients with CGD had lower expression levels of TLR5, TLR9, CD11b, CD18, CD35, and CXCR1 compared with those from healthy control subjects, whereas similar or increased ..
  2. Hirayama T, Tamaki Y, Takakubo Y, Iwazaki K, Sasaki K, Ogino T, et al. Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles. J Orthop Res. 2011;29:984-92 pubmed publisher
    ..mRNA levels of TNF-?, IL-1?, and IL-6 increased in Ti/LPS+ than Ti/LPS-. In contrast, mRNA levels of TLR4, TLR5, and TLR9 decreased in Ti/LPS+ compared to Ti/LPS-...
  3. Lee J, Mo J, Katakura K, Alkalay I, Rucker A, Liu Y, et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006;8:1327-36 pubmed
    ..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation. ..
  4. Aplin A, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia R. Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors. Angiogenesis. 2014;17:147-61 pubmed publisher
    ..Expression of TLR5, 7 and 9 steadily increases over time and is highest during vascular regression...
  5. Kauppila J, Mattila A, Karttunen T, Salo T. Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue. Br J Cancer. 2013;108:638-43 pubmed publisher
    Toll-like receptor 5 (TLR5) is an immune receptor recognising bacterial flagellin. Activation of TLR5 results in cancer invasion and cytokine release...
  6. Morris A, Liggitt H, Hawn T, Skerrett S. Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1112-9 pubmed publisher
    ..The contribution of Toll-like receptor 5 (TLR5) to the innate immune response to this organism is incompletely understood...
  7. Rolli J, Rosenblatt Velin N, Li J, Loukili N, Levrand S, Pacher P, et al. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. PLoS ONE. 2010;5:e12687 pubmed publisher
    ..Here, we determined the ability of bacterial flagellin, the ligand of mammalian TLR5, to trigger myocardial inflammation and contractile dysfunction...
  8. Banas M, Banas B, Hudkins K, Wietecha T, Iyoda M, Bock E, et al. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol. 2008;19:704-13 pubmed publisher
    ..b>TLR5 through 9 and 11 were upregulated to similar degrees in TSLP transgenic and TSLP transgenic FcgammaRIIb-deficient ..
  9. Assassi S, Reveille J, Arnett F, Weisman M, Ward M, Agarwal S, et al. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. J Rheumatol. 2011;38:87-98 pubmed publisher
    ..Many of the differentially expressed genes belonged to Toll-like receptor (TLR) and related pathways. TLR4 and TLR5 were the only dysregulated TLR subtypes among AS patients...
  10. Posadas S, Caz V, Caballero I, Cendejas E, Quilez I, Largo C, et al. Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium. BMC Gastroenterol. 2010;10:58 pubmed publisher
    ..This study investigates the effects of mannoprotein administration via a liquid diet on inflammatory response and TLR5 expression during intestinal tissue injury in a rat model of infection with Salmonella typhimurium...
  11. Koller B, Kappler M, Latzin P, Gaggar A, Schreiner M, Takyar S, et al. TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease. J Immunol. 2008;181:2753-63 pubmed
    ..TLR2, TLR4, TLR5, and TLR9 expression was increased on airway neutrophils compared with circulating neutrophils in CF and ..
  12. Hawn T, Berrington W, Smith I, Uematsu S, Akira S, Aderem A, et al. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J Immunol. 2007;179:6981-7 pubmed
    ..We examined the role of TLR5 during the murine response to aerosolized Lp infection...
  13. Biswas B, Narmadha G, Choudhary M, French F, Hall S, Yenugu S. Identification of Toll-like receptors in the rat (Rattus norvegicus): messenger RNA expression in the male reproductive tract under conditions of androgen variation. Am J Reprod Immunol. 2009;62:243-52 pubmed publisher
    ..Rat Tlr5, Tlr10, and Tlr11 transcript sequences were submitted to GenBank and in silico characterization carried out using ..
  14. Blohmke C, Park J, Hirschfeld A, Victor R, Schneiderman J, Stefanowicz D, et al. TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis. J Immunol. 2010;185:7731-8 pubmed publisher
    ..By combining cellular immunology with a population-based genetic modifier study, we examined TLR5 as an anti-inflammatory target and modifier gene in CF...
  15. Wiersinga W, Wieland C, Dessing M, Chantratita N, Cheng A, Limmathurotsakul D, et al. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). PLoS Med. 2007;4:e248 pubmed
    ..the cell surfaces of monocytes and granulocytes, and increased CD14, TLR1, TLR2, TLR4, LY96 (also known as MD-2), TLR5, and TLR10 mRNA levels in purified monocytes and granulocytes when compared with healthy controls...
  16. Guo L, Guo K, Wendel H, Schluesener H. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Biochem Biophys Res Commun. 2006;349:1156-62 pubmed
    ..Thus TLRs and NOD2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation. ..
  17. Yu F, Cornicelli M, Kovach M, Newstead M, Zeng X, Kumar A, et al. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J Immunol. 2010;185:1142-9 pubmed publisher
    ..In this study, we evaluated the effect of the TLR5 ligand flagellin on stimulation of antibacterial mucosal immunity in a lethal murine Pseudomonas aeruginosa ..
  18. Liu Y, Zhu L, Fatheree N, Liu X, Pacheco S, Tatevian N, et al. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2009;297:G442-50 pubmed publisher
    ..01); TLR5 was downregulated (P < 0.01). All TLR changes started at 48 h, before any histological evidence of NEC...
  19. Weile C, Josefsen K, Buschard K. Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection. Clin Exp Immunol. 2011;166:251-7 pubmed publisher
    ..We have found that the expression of TLR5 is up-regulated by glucose activation of isolated islets of Langerhans, in contrast to other investigated TLRs (TLR-..
  20. Bambou J, Giraud A, Menard S, Begue B, Rakotobe S, Heyman M, et al. In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain. J Biol Chem. 2004;279:42984-92 pubmed
    ..MG1655 flagellin was necessary and sufficient to trigger this pro-inflammatory pathway via its interaction with TLR5 and the subsequent recruitment of the adaptor protein MyD88...