Tlr4

Summary

Gene Symbol: Tlr4
Description: toll-like receptor 4
Alias: toll-like receptor 4, toll4
Species: rat
Products:     Tlr4

Top Publications

  1. Mohammad M, Morran M, Slotterbeck B, Leaman D, Sun Y, Grafenstein H, et al. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Int Immunol. 2006;18:1101-13 pubmed
    ..Expression levels of TLR3 correlated with poly(I)poly(C)-triggered IFN activity. LPS triggered down-regulation of TLR4 in pre-diabetic NOD, NOR and BALB/c, while levels of TLR4 remained consistently elevated in type 1 diabetic NOD and ..
  2. Holland W, Bikman B, Wang L, Yuguang G, Sargent K, Bulchand S, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest. 2011;121:1858-70 pubmed publisher
    ..increased inflammation associated with obesity is activation of the innate immune signaling pathway triggered by TLR4 recognition of saturated fatty acids, an event that is essential for lipid-induced insulin resistance...
  3. Hutchinson M, Zhang Y, Brown K, Coats B, Shridhar M, Sholar P, et al. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci. 2008;28:20-9 pubmed publisher
    ..It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 (TLR4) may be a key receptor for initiating microglial activation following L5 spinal nerve injury...
  4. Reyna S, Ghosh S, Tantiwong P, Meka C, Eagan P, Jenkinson C, et al. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes. 2008;57:2595-602 pubmed publisher
    ..However, it is not known whether insulin-resistant subjects have abnormal TLR4 signaling...
  5. Liu N, Liu J, Ji Y, Lu P. C-reactive protein triggers inflammatory responses partly via TLR4/IRF3/NF-?B signaling pathway in rat vascular smooth muscle cells. Life Sci. 2010;87:367-74 pubmed publisher
    ..Toll-like receptor 4 (TLR4) participates in atherogenesis by mediating the inflammatory responses...
  6. Zhang X, Shan P, Jiang G, Cohn L, Lee P. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest. 2006;116:3050-9 pubmed
    ..Here we show Tlr4(-/-) mice exhibited emphysema as they aged...
  7. Wu F, Bian J, Miao X, Huang S, Xu X, Gong D, et al. Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. Int J Med Sci. 2010;7:251-9 pubmed
    ..Recent studies have suggested that Toll-like receptor 4 (TLR4) might play a role in neuropathic pain...
  8. He Z, Zhu Y, Jiang H. Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study. Respir Res. 2009;10:126 pubmed publisher
    Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced fibroblast activation and collagen secretion in vitro...
  9. El Achkar T, Plotkin Z, Marcic B, Dagher P. Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent. Am J Physiol Renal Physiol. 2007;293:F1187-96 pubmed
    ..Recently, we demonstrated that sepsis upregulates the endotoxin receptor Toll-like receptor 4 (TLR4) in rat kidney...
  10. Lubbad A, Oriowo M, Khan I. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Mol Cell Biochem. 2009;322:127-35 pubmed publisher
    ..These findings demonstrate that signaling pathway of curcumin-induced inhibition of inflammation involves TLR-4 and MyD88, and therefore may serve as an important therapeutic target in IBD. ..

Detail Information

Publications69

  1. Mohammad M, Morran M, Slotterbeck B, Leaman D, Sun Y, Grafenstein H, et al. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Int Immunol. 2006;18:1101-13 pubmed
    ..Expression levels of TLR3 correlated with poly(I)poly(C)-triggered IFN activity. LPS triggered down-regulation of TLR4 in pre-diabetic NOD, NOR and BALB/c, while levels of TLR4 remained consistently elevated in type 1 diabetic NOD and ..
  2. Holland W, Bikman B, Wang L, Yuguang G, Sargent K, Bulchand S, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest. 2011;121:1858-70 pubmed publisher
    ..increased inflammation associated with obesity is activation of the innate immune signaling pathway triggered by TLR4 recognition of saturated fatty acids, an event that is essential for lipid-induced insulin resistance...
  3. Hutchinson M, Zhang Y, Brown K, Coats B, Shridhar M, Sholar P, et al. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). Eur J Neurosci. 2008;28:20-9 pubmed publisher
    ..It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 (TLR4) may be a key receptor for initiating microglial activation following L5 spinal nerve injury...
  4. Reyna S, Ghosh S, Tantiwong P, Meka C, Eagan P, Jenkinson C, et al. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes. 2008;57:2595-602 pubmed publisher
    ..However, it is not known whether insulin-resistant subjects have abnormal TLR4 signaling...
  5. Liu N, Liu J, Ji Y, Lu P. C-reactive protein triggers inflammatory responses partly via TLR4/IRF3/NF-?B signaling pathway in rat vascular smooth muscle cells. Life Sci. 2010;87:367-74 pubmed publisher
    ..Toll-like receptor 4 (TLR4) participates in atherogenesis by mediating the inflammatory responses...
  6. Zhang X, Shan P, Jiang G, Cohn L, Lee P. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest. 2006;116:3050-9 pubmed
    ..Here we show Tlr4(-/-) mice exhibited emphysema as they aged...
  7. Wu F, Bian J, Miao X, Huang S, Xu X, Gong D, et al. Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain. Int J Med Sci. 2010;7:251-9 pubmed
    ..Recent studies have suggested that Toll-like receptor 4 (TLR4) might play a role in neuropathic pain...
  8. He Z, Zhu Y, Jiang H. Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study. Respir Res. 2009;10:126 pubmed publisher
    Toll-like receptor 4 (TLR4) is essential in lipopolysaccharide (LPS)-induced fibroblast activation and collagen secretion in vitro...
  9. El Achkar T, Plotkin Z, Marcic B, Dagher P. Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent. Am J Physiol Renal Physiol. 2007;293:F1187-96 pubmed
    ..Recently, we demonstrated that sepsis upregulates the endotoxin receptor Toll-like receptor 4 (TLR4) in rat kidney...
  10. Lubbad A, Oriowo M, Khan I. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Mol Cell Biochem. 2009;322:127-35 pubmed publisher
    ..These findings demonstrate that signaling pathway of curcumin-induced inhibition of inflammation involves TLR-4 and MyD88, and therefore may serve as an important therapeutic target in IBD. ..
  11. Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, et al. Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci. 2008;38:65-74 pubmed
    ..Brain samples were extracted at 5 days after trauma. We measured mRNA expression of TLR2 and TLR4 by reverse-transcriptase polymerase chain reaction (RT-PCR), NF-kappaB binding activity by electrophoretic mobility ..
  12. Zhou Z, Zhu X, Chen J, Yang S, Sun R, Yang G. The interaction between Toll-like receptor 4 signaling pathway and hypoxia-inducible factor 1? in lung ischemia-reperfusion injury. J Surg Res. 2014;188:290-7 pubmed publisher
    ..Toll-like receptor 4 (TLR4) signaling pathway and hypoxia-inducible factor-1? (HIF-1?) are intimately involved in the development and ..
  13. Dange R, Agarwal D, Masson G, Vila J, Wilson B, Nair A, et al. Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension. Cardiovasc Res. 2014;103:17-27 pubmed publisher
    ..Although brain has been implicated in the pathogenesis of hypertension, the role of brain TLR4 in hypertension is largely unexplored...
  14. Bettoni I, Comelli F, Rossini C, Granucci F, Giagnoni G, Peri F, et al. Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice. Glia. 2008;56:1312-9 pubmed publisher
    ..involved in the development and maintenance of neuropathic pain, with a pivotal role of toll-like receptor 4 (TLR4)...
  15. Hu J, Wang Y, Xie L. Potential role of macrophages in experimental keratomycosis. Invest Ophthalmol Vis Sci. 2009;50:2087-94 pubmed publisher
    ..Cytokine mRNA levels were detected by real-time polymerase chain reaction. Toll-like receptor 4 (TLR4) expression and mRNA levels were also examined...
  16. Jilling T, Simon D, Lu J, Meng F, Li D, Schy R, et al. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol. 2006;177:3273-82 pubmed
    ..Our aims were to determine whether bacteria and intestinal epithelial TLR4 play roles in a well-established neonatal rat model and a novel neonatal murine model of NEC...
  17. Moreno L, McMaster S, Gatheral T, Bailey L, Harrington L, Cartwright N, et al. Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages. Br J Pharmacol. 2010;160:1997-2007 pubmed publisher
    ..Lipopolysaccharide (LPS) activates TLR4, while peptidoglycan products activate NOD1...
  18. Zhang J, Niu N, Wang M, McNutt M, Zhang D, Zhang B, et al. Neuron-derived IgG protects dopaminergic neurons from insult by 6-OHDA and activates microglia through the Fc?R I and TLR4 pathways. Int J Biochem Cell Biol. 2013;45:1911-20 pubmed publisher
    ..in microglia was elevated to protective levels by neuron-derived IgG at a physiologic level via the Fc?R I and TLR4 pathways and microglial activation could be attenuated by IgG blocking...
  19. Chen W, Hu X, Zhao L, Li S, Lu H. Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Mol Vis. 2009;15:619-28 pubmed
    To investigate the dynamics and distribution of toll-like receptor 4 (TLR4)-positive cells and resident tissue macrophages in the uvea during endotoxin-induced uveitis (EIU) in Wistar rats.
  20. Castoldi A, Braga T, Correa Costa M, Aguiar C, Bassi E, Correa Silva R, et al. TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis. PLoS ONE. 2012;7:e37584 pubmed publisher
    The aim of this study was to investigate the role of TLR2, TLR4 and MyD88 in sepsis-induced AKI. C57BL/6 TLR2(-/-), TLR4(-/-) and MyD88(-/-) male mice were subjected to sepsis by cecal ligation and puncture (CLP)...
  21. Devaraj S, Dasu M, Rockwood J, Winter W, Griffen S, Jialal I. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. J Clin Endocrinol Metab. 2008;93:578-83 pubmed
    ..The toll-like receptors (TLRs) are pattern recognition receptors, expressed abundantly on monocytes. TLR2 and TLR4 are important in atherosclerosis...
  22. Yao L, Kan E, Lu J, Hao A, Dheen S, Kaur C, et al. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation. 2013;10:23 pubmed publisher
    ..Microglia derived inflammatory mediators may contribute to this process. Toll-like receptor 4 (TLR4) has been reported to induce microglial activation and cytokines production in brain injuries; however, its role in ..
  23. Aoki T, Nishimura M, Ishibashi R, Kataoka H, Takagi Y, Hashimoto N. Toll-like receptor 4 expression during cerebral aneurysm formation. Laboratory investigation. J Neurosurg. 2010;113:851-8 pubmed publisher
    ..Because Toll-like receptor 4 (TLR4) stimulates NF-?B activation in arterial walls in atherosclerosis, the authors hypothesize that TLR4 expresses in ..
  24. Bomfim G, dos Santos R, Oliveira M, Giachini F, Akamine E, Tostes R, et al. Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats. Clin Sci (Lond). 2012;122:535-43 pubmed publisher
    Activation of TLRs (Toll-like receptors) induces gene expression of proteins involved in the immune system response. TLR4 has been implicated in the development and progression of CVDs (cardio-vascular diseases)...
  25. Yuan F, Marks K, Wong M, Watson S, de Leon E, McIntyre P, et al. Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol. 2008;86:268-70 pubmed publisher
    ..In the present study, polymorphisms in several candidate genes, including TLR2-Arg/Gln753, TLR4-Asp/Gly299, TLR4-Thr/Ile399, CD14-159C/T and FcgammaRIIA-R/H131, were examined in 85 children with pneumococcal ..
  26. Sarangi P, Kim B, Kurt Jones E, Rouse B. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. J Virol. 2007;81:11128-38 pubmed
    ..The susceptibility of TLR4(-/-) animals was also evaluated...
  27. Eissler R, Schmaderer C, Rusai K, Kühne L, Sollinger D, Lahmer T, et al. Hypertension augments cardiac Toll-like receptor 4 expression and activity. Hypertens Res. 2011;34:551-8 pubmed publisher
    ..We hypothesized that hypertension is accompanied by enhanced TLR4 expression and activity...
  28. Sheth P, Delos Santos N, Seth A, LaRusso N, Rao R. Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2007;293:G308-18 pubmed
    ..Reduced expression of c-Src, TLR4, or LBP by specific small interfering RNA attenuated lipopolysaccharide-induced permeability and redistribution of ..
  29. Zhang Z, Li W, Sun D, Zhao L, Zhang R, Wang Y, et al. Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia/reoxygenation. Inflamm Res. 2011;60:37-45 pubmed publisher
    This study was designed to detect the role of Toll-like receptor 4 (TLR4) signaling in the dysfunction of cardiac microvascular endothelial cells (CMECs) after hypoxia/reoxygenation (H/R)...
  30. Wu Y, Bai M, Zhang J, Jin Y, Zhang L, Bao B. [The effect of nitric oxide inhalation on the expression of COX-2 and toll-like receptor 4 in rat acute lung injury induced by lipopolysaccharide]. Zhonghua Jie He He Hu Xi Za Zhi. 2009;32:111-4 pubmed
    To study the effect of nitric oxide (NO) on the expression of cyclo-oxygenase 2 (COX-2) and toll-like receptor 4 (TLR4) in a rat model of acute lung injury (ALI) induced by lipopolysaccharide (LPS)...
  31. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra D, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci. 2009;29:359-70 pubmed publisher
  32. van Well G, Sanders M, Ouburg S, van Furth A, Morre S. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. PLoS ONE. 2012;7:e35837 pubmed publisher
    ..Eleven SNPs in seven genes (TLR2, TLR4, TLR9, NOD1, NOD2, CASP1, and TRAIL) were genotyped in 393 survivors of childhood bacterial meningitis (BM) (327 MM ..
  33. Gao Q, Ma L, Gao X, Yan W, Williams P, Yin D. TLR4 mediates early graft failure after intraportal islet transplantation. Am J Transplant. 2010;10:1588-96 pubmed publisher
    ..Deficiency of TLR4 in donor, but not in recipient, inhibited NF-kappaB activation, reduced proinflammatory cytokines and improved ..
  34. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
    ..Our results identify CD36-TLR4-TLR6 activation as a common molecular mechanism by which atherogenic lipids and amyloid-beta stimulate sterile ..
  35. Chang J, Hampartzoumian T, Everett B, Lloyd A, McCluskey P, Wakefield D. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Invest Ophthalmol Vis Sci. 2007;48:1711-7 pubmed
    ..To investigate the expression and polymorphisms of Toll-like receptor (TLR)-2 and -4 in the peripheral neutrophils and monocytes of patients with acute anterior uveitis (AAU)...
  36. Yu M, Shao D, Yang J, Feng S, Xu J. Ketamine suppresses intestinal TLR4 expression and NF-kappaB activity in lipopolysaccharide-treated rats. Croat Med J. 2006;47:825-31 pubmed
    To investigate whether ketamine suppresses lipopolysaccharide (LPS)-induced increase in Toll-like receptor 4 (TLR4) expression and nuclear factor-kappa B (NF-kappaB) activity in the intestines of rats...
  37. Shi H, Kokoeva M, Inouye K, Tzameli I, Yin H, Flier J. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015-25 pubmed
    b>TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types...
  38. Tanga F, Nutile McMenemy N, DeLeo J. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A. 2005;102:5856-61 pubmed
    ..first time, to our knowledge, a critical role for CNS innate immunity by means of microglial Toll-like receptor 4 (TLR4) in the induction phase of behavioral hypersensitivity in a mouse and rat model of neuropathy...
  39. Jeyaseelan S, Chu H, Young S, Freeman M, Worthen G. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 2005;73:1754-63 pubmed
    ..LPS binding and signaling involves CD14 and Toll-like receptor 4 (TLR4)...
  40. Maslinska D, Laure Kamionowska M, Maśliński S. Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcal alpha-toxin. Folia Neuropathol. 2004;42:125-32 pubmed
    ..In such vessels the spectrum of ultrastructural lesions was found. The presence of TLR4 detected in the nerve cells of the subcortical gray matter of the brain is particularly of interest, but requires ..
  41. Gagro A, Tominac M, Krsulović Hresić V, Bace A, Matic M, Drazenovic V, et al. Increased Toll-like receptor 4 expression in infants with respiratory syncytial virus bronchiolitis. Clin Exp Immunol. 2004;135:267-72 pubmed
    The fusion protein of the respiratory syncytial virus (RSV) binds to the pattern recognition receptors, TLR4 and CD14, and initiates innate immunity response to the virus...
  42. Wolfs T, Buurman W, van Schadewijk A, de Vries B, Daemen M, Hiemstra P, et al. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol. 2002;168:1286-93 pubmed
    ..receptor (TLR)4 for resistance to Gram-negative pyelonephritis prompted us to localize the expression of TLR2 and TLR4 mRNA in the kidney at the cellular level by in situ hybridization...
  43. Frantz S, Kobzik L, Kim Y, Fukazawa R, Medzhitov R, Lee R, et al. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest. 1999;104:271-80 pubmed
    ..in the fly, now termed human Toll-like receptor 4 (hTLR4), appeared to be relatively high in the heart, we examined TLR4 mRNA and protein abundance in isolated cellular constituents of cardiac muscle and in normal and abnormal murine, ..
  44. Minoretti P, Gazzaruso C, Vito C, Emanuele E, Bianchi M, Coen E, et al. Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease. Neurosci Lett. 2006;391:147-9 pubmed
    Experimental data have shown an upregulated expression of toll-like receptors, particularly toll-like receptor 4 (TLR4), in neurodegeneration...
  45. Kim Y, Romero R, Oh S, Kim C, Kilburn B, Armant D, et al. Toll-like receptor 4: a potential link between "danger signals," the innate immune system, and preeclampsia?. Am J Obstet Gynecol. 2005;193:921-7 pubmed
    ..This suggests a novel mechanism that links the activation of the innate immune system through TLR-4 and preeclampsia. ..
  46. Böttcher T, von Mering M, Ebert S, Meyding Lamade U, Kuhnt U, Gerber J, et al. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Neurosci Lett. 2003;344:17-20 pubmed
    ..Streptococcus pneumoniae meningitis led to an enhanced expression of TLR2, TLR4 and TLR9 mRNA...
  47. Abel B, Thieblemont N, Quesniaux V, Brown N, Mpagi J, Miyake K, et al. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol. 2002;169:3155-62 pubmed
    ..tb.) preferentially use TLR2 signaling. We asked whether TLR4 plays any role in host resistance to M.tb. infection in vivo...
  48. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11:443-51 pubmed
    Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice...
  49. Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol. 2000;164:558-61 pubmed
    ..Both the induction of TNF-alpha and NO formation were found dependent on a functional Tlr4 whereas stimulation of macrophages by CpG DNA was Tlr4 independent. We conclude that Tlr4 mediates hsp60 signaling...
  50. Tanga F, Raghavendra V, DeLeo J. Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain. Neurochem Int. 2004;45:397-407 pubmed
    ..lumbar mRNA levels of glial fibrillary acidic protein (GFAP), integrin alpha M (ITGAM), toll-like receptor 4 (TLR4) and cluster determinant 14 (CD14) were assayed using real-time reverse transcription polymerase chain reaction (RT-..
  51. Rudofsky G, Reismann P, Witte S, Humpert P, Isermann B, Chavakis T, et al. Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Diabetes Care. 2004;27:179-83 pubmed
    ..Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduced prevalence of diabetic neuropathy in type 2, but not in type 1, diabetes...
  52. Fan J, Kapus A, Marsden P, Li Y, Oreopoulos G, Marshall J, et al. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol. 2002;168:5252-9 pubmed
    The Toll-like receptor 4 (TLR4) has recently been shown to function as the major upstream sensor for LPS...
  53. Peng Y, Gong J, Liu C, Li X, Gan L, Li S. Expression of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after ischemia-reperfusion in rat liver graft. World J Gastroenterol. 2004;10:2890-3 pubmed
    To investigate the expression of toll-like receptor 4 (TLR4) and MD-2 gene and protein in Kupffer cells (KCs) and their role in ischemia-reperfusion (IR) injury of rat liver graft...
  54. Arbour N, Lorenz E, Schutte B, Zabner J, Kline J, Jones M, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000;25:187-91 pubmed
    ..To address this, we investigated whether TLR4 (encoding the toll-like receptor-4), which has been shown to affect lipopolysaccharide (LPS) responsiveness in mice,..
  55. Lehnardt S, Massillon L, Follett P, Jensen F, Ratan R, Rosenberg P, et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci U S A. 2003;100:8514-9 pubmed
    ..We show that in the CNS, specific activation of innate immunity through a Toll-like receptor 4 (TLR4)-dependent pathway leads to neurodegeneration...
  56. Sun Y, Chandra J, Mukherjee P, Szczotka Flynn L, Ghannoum M, Pearlman E. A murine model of contact lens-associated fusarium keratitis. Invest Ophthalmol Vis Sci. 2010;51:1511-6 pubmed publisher
    ..of either untreated or cyclophosphamide-treated C57BL/6 mice or of IL-1R1(-/-), MyD88(-/-), TLR2(-/-), or TLR4(-/-) mice...
  57. Ostadhadi S, Rezayat S, Ejtemaei Mehr S, Tavangar S, Nikoui V, Jazaeri F, et al. Mesenteric artery responsiveness to acetylcholine and phenylephrine in cirrhotic rats challenged with endotoxin: the role of TLR4. Can J Physiol Pharmacol. 2015;93:475-83 pubmed publisher
    ..to bile-duct ligation (BDL), and to determine whether LPS initiates changes in vascular Toll-like receptor 4 (TLR4) expression. Four weeks after BDL, the animals were given an intraperitoneal injection of either saline or LPS (1...
  58. Xiao Z, Ren P, Chao Y, Wang Q, Kuai J, Lv M, et al. Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism. Mol Med Rep. 2015;12:675-83 pubmed publisher
    Inflammation and immunity are important in the pathogenesis of cerebral ischemia. Toll-like receptor 4 (TLR4) is involved in the inflammatory responses of injured brain tissues...
  59. Galbo T, Perry R, Jurczak M, Camporez J, Alves T, Kahn M, et al. Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo. Proc Natl Acad Sci U S A. 2013;110:12780-5 pubmed publisher
    ..These data demonstrate that saturated fat-induced insulin resistance is independent of TLR-4 activation and ceramides. ..
  60. Yang X, Fu Y, Liu J, Ren H. Impact of probiotics on toll-like receptor 4 expression in an experimental model of ulcerative colitis. J Huazhong Univ Sci Technolog Med Sci. 2013;33:661-665 pubmed publisher
    ..This study aimed to investigate the impact of probiotics (Lactobacillus, Bifidobacterium) on the expression of TLR4 and tumor necrosis factor-alpha (TNF-?) in the colon mucosa of rat experimental ulcerative colitis model induced by ..
  61. Lartigue A, Colliou N, Calbo S, François A, Jacquot S, Arnoult C, et al. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J Immunol. 2009;183:6207-16 pubmed publisher
    ..The recognition of these factors is mediated by TLRs, in particular TLR2 and TLR4 which bind pathogen-associated molecular patterns of Gram(+) and Gram(-) bacteria, respectively...
  62. Richter J, Schanbacher B, Huang H, Xue J, Bauer J, Giannone P. LPS-binding protein enables intestinal epithelial restitution despite LPS exposure. J Pediatr Gastroenterol Nutr. 2012;54:639-44 pubmed publisher
    ..We sought to determine how LBP would affect wound healing in an in vitro model of intestinal cell restitution and protect against intestinal injury in a rodent model of NEC...
  63. Zhou R, Zhang R, Sun Y, Platt S, Szczotka Flynn L, Pearlman E. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012;53:7382-8 pubmed publisher
    ..Conversely, CFU was significantly lower by 48 hours post infection. In contrast, MyD88(-/-), IL-1R(-/-), TLR4(-/-), and TLR4/5(-/-) corneas infected with S...
  64. Theodoropoulos G, Saridakis V, Karantanos T, Michalopoulos N, Zagouri F, Kontogianni P, et al. Toll-like receptors gene polymorphisms may confer increased susceptibility to breast cancer development. Breast. 2012;21:534-8 pubmed publisher
    Toll-like receptor (TLR) activation may be an important event in tumor cell immune evasion. TLR2 and TLR4 gene polymorphisms have been related to increased susceptibility to cancer development in various organs...
  65. Shimamoto A, Pohlman T, Shomura S, Tarukawa T, Takao M, Shimpo H. Toll-like receptor 4 mediates lung ischemia-reperfusion injury. Ann Thorac Surg. 2006;82:2017-23 pubmed
    ..Because Toll-like receptor 4 (TLR4) activates NF-kappaB-dependent transcription of inflammatory cytokine genes during myocardial ischemia-reperfusion ..
  66. Fu Y, Xie Y, Shi J, Zhou N, Guo G. [Study on the expression of TLR4 on splenocytes and its relation with CD4(+) CD25(+) regulatory T cells in peripheral blood in severely burnt rats]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007;23:523-6 pubmed
    To investigate the expression of Toll like receptor 4(TLR4) on splenocytes and TNF-alpha mRNA, the dynamic changes of CD4(+) CD25(+) regulatory T cell(Treg) and endotoxin(ET) in peripheral blood of burnt rats during the early phase, and ..
  67. Deng Y, Zhou W. Expression of TLR4 and TLR9 mRNA in Lewis rats with experimental allergic neuritis. Neuroimmunomodulation. 2007;14:337-43 pubmed publisher
    ..In this study, we observed the expression of mRNA of TLR4 and TLR9 in EAN rats...