Gene Symbol: Tlr2
Description: toll-like receptor 2
Alias: toll-like receptor 2, toll-like receptor 2 variant 1, toll-like receptor 2 variant 2
Species: rat
Products:     Tlr2

Top Publications

  1. Böttcher T, von Mering M, Ebert S, Meyding Lamade U, Kuhnt U, Gerber J, et al. Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections. Neurosci Lett. 2003;344:17-20 pubmed
    ..Streptococcus pneumoniae meningitis led to an enhanced expression of TLR2, TLR4 and TLR9 mRNA...
  2. Triantafilou M, Gamper F, Haston R, Mouratis M, Morath S, Hartung T, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002-11 pubmed
    ..b>TLR2 seems to be the most promiscuous TLR receptor able to recognize the most diverse set of pathogen-associated ..
  3. Kim D, Kim M, Cho I, Kim M, Lee S, Jo E, et al. A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem. 2007;282:14975-83 pubmed
    ..These data demonstrate that toll-like receptor 2 contributes to the nerve injury-induced spinal cord glial cell activation and subsequent pain hypersensitivity. ..
  4. Yim J, Kim H, Kwon O, Koh W. Association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a Korean population. Hum Immunol. 2008;69:572-6 pubmed publisher
    ..the association between the guanine-thymine (GT) repeat polymorphism in intron II of the Toll-like receptor 2 (TLR2) gene and lung disease caused by nontuberculous mycobacteria (NTM)...
  5. Li F, Yang N, Zhang L, Tan H, Huang B, Liang Y, et al. Increased expression of toll-like receptor 2 in rat diabetic nephropathy. Am J Nephrol. 2010;32:179-86 pubmed publisher
    ..This study examined the role of Toll-like receptor 2 (TLR2) in the progression of renal injury in a model of rat DN...
  6. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 1999;11:443-51 pubmed
    ..To investigate in vivo roles of TLR2, we generated TLR2-deficient mice...
  7. Schröder N, Morath S, Alexander C, Hamann L, Hartung T, Zahringer U, et al. Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem. 2003;278:15587-94 pubmed
    ..However, the involvement of TLR-4 and MD-2 in this process was ruled out. ..
  8. Wolfs T, Buurman W, van Schadewijk A, de Vries B, Daemen M, Hiemstra P, et al. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. J Immunol. 2002;168:1286-93 pubmed
    ..Toll-like receptor (TLR)4 for resistance to Gram-negative pyelonephritis prompted us to localize the expression of TLR2 and TLR4 mRNA in the kidney at the cellular level by in situ hybridization...
  9. Sun Y, Hise A, Kalsow C, Pearlman E. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun. 2006;74:5325-32 pubmed
    ..The current study examined the role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid differentiation factor 88 (MyD88) in a Staphylococcus ..

More Information

Publications102 found, 100 shown here

  1. Sarangi P, Kim B, Kurt Jones E, Rouse B. Innate recognition network driving herpes simplex virus-induced corneal immunopathology: role of the toll pathway in early inflammatory events in stromal keratitis. J Virol. 2007;81:11128-38 pubmed
    ..outcomes of infection in wild-type (WT) mice and those lacking TLR function, it was apparent that the absence of TLR2 and, to a lesser extent, TLR9 resulted in significantly diminished lesions...
  2. Matsumura N, Takeyama Y, Ueda T, Yasuda T, Shinzeki M, Sawa H, et al. Decreased expression of Toll-like receptor 2 and 4 on macrophages in experimental severe acute pancreatitis. Kobe J Med Sci. 2007;53:219-27 pubmed
    ..b>TLR2 recognizes lipoteichoic acid (LTA) of gram-positive bacteria, and TLR4 recognizes lipopolysaccharide (LPS) of gram-..
  3. Kumar A, Singh C, Glybina I, Mahmoud T, Yu F. Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis. J Infect Dis. 2010;201:255-63 pubmed publisher
    ..whether Toll-like receptors (TLRs) are involved in retinal innate response and explored the prophylactic use of TLR2 ligand in preventing bacterial endophthalmitis...
  4. Mita Y, Dobashi K, Shimizu Y, Nakazawa T, Mori M. Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol Lett. 2001;78:97-101 pubmed
    Human Toll-like receptor 2 (TLR2) and TLR4 are recently identified receptors...
  5. Jin X, Lin Z, Xie X. The delayed response of Toll-like receptors may relate to Pseudomonas aeruginosa keratitis exacerbating rapidly at the early stages of infection. Eur J Clin Microbiol Infect Dis. 2010;29:231-8 pubmed publisher
    ..In this study, in late cases of corneal P. aeruginosa infection, the expression of TLR2, 4, 5 and 9 mRNA were all upregulated. In early infection cases, only TLR9 mRNA expression was upregulated...
  6. Fujimoto T, Sonoda K, Hijioka K, Sato K, Takeda A, Hasegawa E, et al. Choroidal neovascularization enhanced by Chlamydia pneumoniae via Toll-like receptor 2 in the retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2010;51:4694-702 pubmed publisher
    ..pneumoniae antigen. RPE cells from either MyD88 KO mice or TLR2 KO mice did not respond to the C. pneumoniae antigen...
  7. van Well G, Sanders M, Ouburg S, van Furth A, Morre S. Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. PLoS ONE. 2012;7:e35837 pubmed publisher
    ..Eleven SNPs in seven genes (TLR2, TLR4, TLR9, NOD1, NOD2, CASP1, and TRAIL) were genotyped in 393 survivors of childhood bacterial meningitis (BM) (..
  8. Brown R, Gralewski J, Eid A, Knoll B, Finberg R, Razonable R. R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins. Transplantation. 2010;89:811-5 pubmed publisher
    ..Individuals with the R753Q single-nucleotide polymorphism (SNP) in the TLR2 gene have increased the risk of allograft failure after liver transplantation for chronic hepatitis C...
  9. Dziarski R, Gupta D. Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J Endotoxin Res. 2000;6:401-5 pubmed
    MD-2 is associated with TLR4 on the cell surface and enables TLR4 to respond to LPS. TLR2 without MD-2 does not respond to pure protein-free endotoxic LPS, ReLPS, and lipid A...
  10. Froy O, Hananel A, Chapnik N, Madar Z. Differential effect of insulin treatment on decreased levels of beta-defensins and Toll-like receptors in diabetic rats. Mol Immunol. 2007;44:796-802 pubmed
    ..These findings may lay the grounds for future design of novel treatments that will induce defensins and TLRs and, as a result, bolster the immune system in diabetic patients. ..
  11. Mackern Oberti J, Maccioni M, Cuffini C, Gatti G, Rivero V. Susceptibility of prostate epithelial cells to Chlamydia muridarum infection and their role in innate immunity by recruitment of intracellular Toll-like receptors 4 and 2 and MyD88 to the inclusion. Infect Immun. 2006;74:6973-81 pubmed
    ..Moreover, we analyzed the expression of Toll-like receptor 4 (TLR4), TLR2, and related molecules on PEC and the effect of C. muridarum infection on their expression...
  12. Chen X, Zhang M, Zhu X, Deng Q, Liu H, Larmonier N, et al. Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. J Infect Dis. 2009;200:399-408 pubmed publisher
    Although it has been recognized that Mycobacterium tuberculosis contains large amounts of Toll-like receptor 2 (TLR2) ligands, their direct effects on CD4(+) T cells and the clinical implications have not been determined...
  13. Schröder N, Heine H, Alexander C, Manukyan M, Eckert J, Hamann L, et al. Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol. 2004;173:2683-91 pubmed
    ..These results support that LBP is a pattern recognition receptor transferring a variety of bacterial ligands including the two major types of lipopeptides to CD14 present in different receptor complexes. ..
  14. Ikeda H, Sasaki M, Ishikawa A, Sato Y, Harada K, Zen Y, et al. Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture. Lab Invest. 2007;87:559-71 pubmed
    ..Intraluminal bacteria and the expression of TLR2 and TLR4 in BECs were demonstrated in the bile ducts, showing chronic suppurative cholangitis...
  15. Devaraj S, Dasu M, Rockwood J, Winter W, Griffen S, Jialal I. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. J Clin Endocrinol Metab. 2008;93:578-83 pubmed
    ..The toll-like receptors (TLRs) are pattern recognition receptors, expressed abundantly on monocytes. TLR2 and TLR4 are important in atherosclerosis...
  16. Vanhinsbergh L, Powe D, Jones N. Reduction of TLR2 gene expression in allergic and nonallergic rhinitis. Ann Allergy Asthma Immunol. 2007;99:509-16 pubmed publisher the localization and distribution of protein for alpha-defensins 1 through 3, HBD2, neutrophil elastase, and TLR2 in sections of nasal turbinate tissue from adults with persistent allergic and idiopathic rhinitis, healthy nasal ..
  17. Chung S, Nam K, Kweon M. Staphylococcus aureus accelerates an experimental allergic conjunctivitis by Toll-like receptor 2-dependent manner. Clin Immunol. 2009;131:170-7 pubmed
    ..aureus had more IL-4, IL-5, IL-13 and eotaxin secretion than non-inoculated group. In contrast, inoculation of TLR2(-/-) mice with S. aureus had no effect on severity of allergic conjunctivitis...
  18. Paun A, Fox J, Balloy V, Chignard M, Qureshi S, Haston C. Combined Tlr2 and Tlr4 deficiency increases radiation-induced pulmonary fibrosis in mice. Int J Radiat Oncol Biol Phys. 2010;77:1198-205 pubmed publisher
    ..The lung phenotype of Tlr4-deficient and Tlr2-deficient mice did not differ from that of wild-type mice in terms of survival time postirradiation, or by ..
  19. Shi X, Zekki H, Zhang J. The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response. Glia. 2011;59:231-41 pubmed publisher
    ..We sought to determine whether peripheral nerve injury could induce the expression of TLR2 on the site of injury-damaged nerves and/or in the central nervous system and to investigate whether TLR2 is ..
  20. Cook E, Stahl J, Esnault S, Barney N, Graziano F. Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses. Ann Allergy Asthma Immunol. 2005;94:486-97 pubmed
    ..Conjunctival epithelial cells express TLR-2 and may play an active role in the chronic ocular inflammatory response to S aureus through pathways that involve TLR-2 and PAFR. ..
  21. Koh J, Lee Y, Kim Y, Park S, Lee S, Kim H, et al. Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency. Bone. 2009;45:650-60 pubmed publisher
    ..In conclusion, HSP60 and TLR-2 are novel mediators of estrogen-deficiency-induced bone loss. ..
  22. Ekman A, Virtala R, Fransson M, Adner M, Benson M, Jansson L, et al. Systemic up-regulation of TLR4 causes lipopolysaccharide-induced augmentation of nasal cytokine release in allergic rhinitis. Int Arch Allergy Immunol. 2012;159:6-14 pubmed publisher
    ..The present study examines how TLR2 and TLR4 expression is affected by symptomatic allergic rhinitis, and if LPS added upon allergen affects nasal ..
  23. Tu C, Yao Q, Xu B, Wang J, Zhou C, Zhang S. Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression. Food Chem Toxicol. 2012;50:3343-51 pubmed publisher
    ..matrix deposition, reduced the number of activated stellate cells, and decreased the levels of HMGB1, TLR4 and TLR2 expression in the rat model of fibrogenesis...
  24. Bagchi A, Akolkar G, Mandal S, Ayyappan P, Yang X, Singal P. Toll-like receptor 2 dominance over Toll-like receptor 4 in stressful conditions for its detrimental role in the heart. Am J Physiol Heart Circ Physiol. 2017;312:H1238-H1247 pubmed publisher
    ..suggested that Toll-like receptor (TLR)4 promotes IL-10-mediated cardiac cell survival, whereas another receptor, TLR2, from the same family, is detrimental...
  25. Le Mandat Schultz A, Bonnard A, Barreau F, Aigrain Y, Pierre Louis C, Berrebi D, et al. Expression of TLR-2, TLR-4, NOD2 and pNF-kappaB in a neonatal rat model of necrotizing enterocolitis. PLoS ONE. 2007;2:e1102 pubmed
  26. Silva M, Jury J, Porras M, Vergara P, Perdue M. Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage. Inflamm Bowel Dis. 2008;14:632-44 pubmed publisher
    ..Furthermore, we showed that TLR-2 and -4 blockade regulates CD103+DC distribution during early phases in this experimental model. ..
  27. Leendertse M, Willems R, Giebelen I, van den Pangaart P, Wiersinga W, de Vos A, et al. TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis. J Immunol. 2008;180:4865-74 pubmed
    ..We here sought to determine the roles of MyD88, the common adaptor protein involved in TLR signaling, TLR2, TLR4, and CD14 in host defense against E. faecium peritonitis...
  28. Du Q, Min S, Chen L, Ma Y, Guo X, Wang Z, et al. Major stress hormones suppress the response of macrophages through down-regulation of TLR2 and TLR4. J Surg Res. 2012;173:354-61 pubmed publisher
    ..glucocorticoid (corticosterone (CORT)), epinephrine (E), and norepinephrine (NE) on the expression and response of TLR2 and TLR4 in macrophages...
  29. Tian J, Guo X, Liu X, Liu L, Weng Q, Dong S, et al. Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res. 2013;98:391-401 pubmed publisher
    ..Further study revealed up-regulated expression of both TLR2 and TLR4 by exHSP60, which was dependent on the activation of TLR4, MyD88, c-Jun NH2-terminal kinase (JNK), and NF-?..
  30. Park Y, Park S, Yoo E, Kim D, Shin H. Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility. Ann N Y Acad Sci. 2004;1037:170-4 pubmed
    ..We investigated the association of the genes for toll-like receptor 2 (TLR2), one of the key surface receptors on innate effectors, with T1DM in Korean patients...
  31. Fransson M, Adner M, Erjefalt J, Jansson L, Uddman R, Cardell L. Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis. Respir Res. 2005;6:100 pubmed
    ..The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation. ..
  32. Chen J, Rao J, Zou T, Liu L, Marasa B, Xiao L, et al. Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2007;293:G568-76 pubmed
    ..b>TLR2 and TLR4 have been identified in intestinal epithelial cells (IECs) as fundamental components of the innate immune ..
  33. Kim Y, Park J, Shaw M, Franchi L, Inohara N, Nunez G. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity. 2008;28:246-57 pubmed publisher
    ..monocytogenes was critically dependent on Nod1 and Nod2 when mice were previously stimulated with lipopolysaccharide or E. coli. Thus, Nod1 and Nod2 are important for microbial recognition and host defense after TLR stimulation. ..
  34. Nara K, Kurokawa M, Chiba S, Yoshikawa H, Tsukikawa S, Matsuda T, et al. Involvement of innate immunity in the pathogenesis of intestinal Behçet's disease. Clin Exp Immunol. 2008;152:245-51 pubmed publisher
    ..IL-12 produced by TLR-2-expressing cells may contribute to the induction of Th1-dominant immune responses in intestinal BD. ..
  35. Puliti M, Uematsu S, Akira S, Bistoni F, Tissi L. Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease. Infect Immun. 2009;77:1524-31 pubmed publisher
    ..Toll-like receptor-2 (TLR2) mediates host responses to gram-positive bacteria...
  36. Rusai K, Sollinger D, Baumann M, Wagner B, Strobl M, Schmaderer C, et al. Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury. Pediatr Nephrol. 2010;25:853-60 pubmed publisher
    ..b>TLR2 and TLR4 are constitutively expressed on renal epithelium, and their expression is enhanced following renal ..
  37. Sloane J, Batt C, Ma Y, Harris Z, Trapp B, Vartanian T. Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci U S A. 2010;107:11555-60 pubmed publisher
    ..However, the mechanism behind this inhibition is unclear. We report here that Toll-like receptor 2 (TLR2) is expressed by oligodendrocytes and is up-regulated in MS lesions...
  38. Zhang P, Cheng G, Chen L, Zhou W, Sun J. Cerebral hypoxia-ischemia increases toll-like receptor 2 and 4 expression in the hippocampus of neonatal rats. Brain Dev. 2015;37:747-52 pubmed publisher
    ..In this study, we investigated the expression of TLR2 and TLR4 in the hippocampus of the neonatal rats. Postnatal day 7 Sprague-Dawley rats were used...
  39. Kurt Jones E, Chan M, Zhou S, Wang J, Reed G, Bronson R, et al. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A. 2004;101:1315-20 pubmed
    ..Here, we demonstrate that TLR2 mediates the inflammatory cytokine response to HSV-1 by using both transfected cell lines and knockout mice...
  40. Tokairin Y, Shibata Y, Sata M, Abe S, Takabatake N, Igarashi A, et al. Enhanced immediate inflammatory response to Streptococcus pneumoniae in the lungs of mice with pulmonary emphysema. Respirology. 2008;13:324-32 pubmed publisher
    ..This may be partly attributed to the increased expression of TLR in the alveolar macrophages of emphysema mice. ..
  41. Koc M, Toprak A, Arikan H, Odabasi Z, Elbir Y, Tulunay A, et al. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Nephrol Dial Transplant. 2011;26:955-63 pubmed publisher
    ..Conclusions. Our study demonstrates that TLR-2 is associated with the inflammatory response of non-dialysed and dialysed CKD patients. ..
  42. Welsch J, Hübschle T, Murgott J, Kirschning C, Rummel C, Gerstberger R, et al. Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36. Innate Immun. 2012;18:541-59 pubmed publisher
    This study was designed to test the responses of TLR2-knockout mice (TLR2-KO) and wild- type mice (C57/BL-6), and of CD36 deficient spontaneously hypertensive rats (SHR) and their genetic controls [Wistar Kyoto (WKY) rats] to systemic ..
  43. Vivot K, Langlois A, Jeandidier N, Bietiger W, Pinget M, Gies J, et al. Instant blood-mediated inflammatory reaction during islet transplantation: the role of Toll-like receptors signaling pathways. Transplant Proc. 2011;43:3192-4 pubmed publisher
    ..3 after 24 hours. Finally, the cyclo-oxygenase-2 gene expression was up-regulated to 509 ± 67.1-fold (P < .05) after 12 hours of culture. These data confirmed the implication of TLR signaling pathways in early inflammatory events. ..
  44. Forte A, Rinaldi B, Sodano L, Berrino L, Rossi F, Finicelli M, et al. Stem cell therapy for arterial restenosis: potential parameters contributing to the success of bone marrow-derived mesenchymal stromal cells. Cardiovasc Drugs Ther. 2012;26:9-21 pubmed publisher
    ..The MSC immunomodulatory activity was confirmed by the decreased expression of TLR2 and TLR4 in injured carotids...
  45. Femia A, Swidsinski A, Dolara P, Salvadori M, Amedei A, Caderni G. Mucin depleted foci, colonic preneoplastic lesions lacking Muc2, show up-regulation of Tlr2 but not bacterial infiltration. PLoS ONE. 2012;7:e29918 pubmed publisher
    ..b>Tlr2, as well as other downstream genes (Map4k4, Hspd1, Irak1, Ube2n), was significantly up-regulated...
  46. Matsui T, Tasaki M, Yoshioka T, Motoki Y, Tsuneoka H, Nojima J. Temperature- and time-dependent changes in TLR2-activated microglial NF-?B activity and concentrations of inflammatory and anti-inflammatory factors. Intensive Care Med. 2012;38:1392-9 pubmed publisher
    ..We have examined the effects of culture temperature on the TLR2-activated microglial production of cytokines and nitric oxide (NO), which are known to be associated with CNS ..
  47. Amura C, Renner B, Lyubchenko T, Faubel S, Simonian P, Thurman J. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Mol Immunol. 2012;52:249-57 pubmed publisher
    ..deletion of complement factor B (fB(-/-) mice), or mice with targeted deletion of factor B and TLR-2 (fB(-/-)TLR2(-/-) mice)...
  48. Tabel Y, Berdeli A, Mir S. Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. Int J Immunogenet. 2007;34:399-405 pubmed
    The aim of this study is to investigate Arg753Gln allele polymorphisms of toll-like receptor-2 (TLR2) gene distribution, allele frequency in urinary tract infection (UTI) and genotype-phenotype association of TLR2 gene in children with ..
  49. Buckland K, O CONNOR E, Murray L, Hogaboam C. Toll like receptor-2 modulates both innate and adaptive immune responses during chronic fungal asthma in mice. Inflamm Res. 2008;57:379-87 pubmed publisher
    We investigated the effect of TLR2 gene deletion in a murine model of chronic fungal asthma. TLR2 wildtype (TLR2(+/+)) and TLR2 deficient (TLR2(-/-)) mice were sensitized to soluble A. fumigatus antigens and challenged with live A...
  50. Winnall W, Muir J, Hedger M. Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides. Innate Immun. 2011;17:123-36 pubmed publisher
    ..were stimulated with either unextracted or phenol re-extracted LPS, and analysed for Toll-like receptor (TLR) 4, TLR2 and inflammatory cytokine gene expression by quantitative reverse transcription polymerase chain reaction (RT-PCR)...
  51. Sun Y, Zhou B, Wang C, Huang Q, Zhang Q, Han Y, et al. Biofilm formation and Toll-like receptor 2, Toll-like receptor 4, and NF-kappaB expression in sinus tissues of patients with chronic rhinosinusitis. Am J Rhinol Allergy. 2012;26:104-9 pubmed publisher
    ..The relative levels of TLR2, TLR4, and NF-kappaB expression in those sinus tissues were determined by quantitative real-time reverse-..
  52. Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, et al. Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal toll-like receptors in rats. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00205.2017 pubmed publisher
    ..Sham-operated rats served as no-MI controls. Renal mRNA levels of TLR2 and MyD88 were significantly higher in sham-operated OLETF than in sham-operated LETO, though levels of TLR1, TLR3, ..
  53. Zhang L, Wu H, Chen Y, Guo X, Wang L, Wang C, et al. Role of nitric oxide in Toll-like receptor 2 and 4 mRNA expression in liver of acute hemorrhagic necrotizing pancreatitis rats. World J Gastroenterol. 2006;12:485-8 pubmed
    To investigate the role of nitric oxide (NO) in Toll-like receptor 2 (TLR2)/4mRNA expression in livers of acute hemorrhagic necrotizing pancreatitis (AHNP) rats...
  54. Gao H, Yin Z, Zhang R, Zhang J, Gao F, Wang H. GSK-3beta inhibitor modulates TLR2/NF-kappaB signaling following myocardial ischemia-reperfusion. Inflamm Res. 2009;58:377-83 pubmed publisher
    The present study defines the expression of Toll-like Receptor 2 (TLR2), and the modulatory role of Glycogen synthase kinase (GSK)-3beta inhibitor on TLR2/Nuclear Factor-kappa B (NF-kappaB) signaling following myocardial ischemia-..
  55. Huang H, Zeng Z, Wang K, Zhang H, Wang S, Zhou W, et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol. 2015;21:2937-48 pubmed publisher
    ..In addition, pretreatment with CoPP reduced the expression levels of TLR2, TLR4, IL-1R-associated kinase (IRAK)-1 and tumor necrosis factor receptor-associated factor 6 in MyD88-..
  56. Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen R, et al. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 2002;8:878-84 pubmed
    ..lower cell-surface expression of Toll-like receptor (TLR) 1 as compared to normal cells, but normal expression of TLR2. TLRs activate innate responses to pathogens, and TLR2 recognizes lipoproteins and peptidoglycan (PGN)...
  57. Claeys S, Van Hoecke H, Holtappels G, Gevaert P, De Belder T, Verhasselt B, et al. Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators. Clin Exp Allergy. 2005;35:467-72 pubmed
    ..We here demonstrate that CF-NP and non-CF-NP not only differ in terms of inflammatory mediator profile, but also in terms of innate markers. ..
  58. Yoon H, Jeon S, Suk K, Choi D, Hong Y, Park E. Contribution of TLR2 to the initiation of ganglioside-triggered inflammatory signaling. Mol Cells. 2008;25:99-104 pubmed
    ..Here we report that TLR2 participates in the initiation of ganglioside-triggered inflammatory signaling responses...
  59. Dessing M, Hirst R, de Vos A, van der Poll T. Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in mice. PLoS ONE. 2009;4:e7993 pubmed publisher
    ..The primary objective of the present study was to determine the role of TLR2 and TLR4 in lung inflammation induced by intrapulmonary delivery of PLN...
  60. Seidl S, Pessolano L, Bishop C, Best M, Rich C, Stone P, et al. Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix. PLoS ONE. 2017;12:e0171711 pubmed publisher
    ..cell Toll-like receptor (TLR)2 has been linked to vascular disease, little is known about smooth muscle cell TLR2 in atherosclerosis...
  61. Tanne A, Ma B, Boudou F, Tailleux L, Botella H, Badell E, et al. A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med. 2009;206:2205-20 pubmed publisher
    ..SIGNR3 signaling was dependent on an intracellular tyrosine-based motif and the tyrosine kinase Syk. Thus, the mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen. ..
  62. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30:16-34 pubmed publisher
    ..In this review, we comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated by PRRs. ..
  63. Karaca N, Ozturk G, Gerceker B, Turkmen M, Berdeli A. TLR2 and TLR4 gene polymorphisms in Turkish vitiligo patients. J Eur Acad Dermatol Venereol. 2013;27:e85-90 pubmed publisher
    ..The TLR2 gene Arg753Gln and TLR4 gene Asp299Gly and Thr399Ile polymorphisms were genotyped by using polymerase chain ..
  64. Xu N, Yu Z, Yao Q, Wang Z, Qu H, Sun Y, et al. PPAR-? and tollip are associated with toll-like receptors in colitis rats. J Immunoassay Immunochem. 2013;34:219-31 pubmed publisher
    ..Colitis model was induced by TNBS in rat. The expression of TLR2, TLR4, NF-?Bp65, PPAR-? and Tollip was examined by immunohistochemistry (IHC) and reverse-transcription polymerase ..
  65. Kajiya T, Orihara K, Hamasaki S, Oba R, Hirai H, Nagata K, et al. Toll-like receptor 2 expression level on monocytes in patients with viral infections: monitoring infection severity. J Infect. 2008;57:249-59 pubmed publisher
    ..In this study, by using flow-cytometric quantification system, Toll-like receptor 2 (TLR2) expression levels on monocytes of influenza patients (n=47) were compared with those of healthy volunteers (n=50)...
  66. Kim G, Cho M, Park Y, Yoo W, Kim J, Oh H, et al. Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis. Clin Rheumatol. 2010;29:273-9 pubmed publisher
    ..The expressions of TLR2, TLR4, TLR9, IFNgamma, IL4, IL17, and TNFalpha were measured by real-time reverse transcription-polymerase chain ..
  67. Good D, George T, Watts B. Toll-like receptor 2 is required for LPS-induced Toll-like receptor 4 signaling and inhibition of ion transport in renal thick ascending limb. J Biol Chem. 2012;287:20208-20 pubmed publisher
    ..Here we report that the response of the MTAL to basolateral LPS requires TLR2 in addition to TLR4...
  68. Garcia Rodriguez S, Arias Santiago S, Perandrés López R, Castellote L, Zumaquero E, Navarro P, et al. Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis. J Eur Acad Dermatol Venereol. 2013;27:242-50 pubmed
    ..To evaluate TLR2 and TLR4 gene expression levels in peripheral blood mononuclear cells from psoriatic patients...
  69. Yoshimura A, Lien E, Ingalls R, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol. 1999;163:1-5 pubmed
    ..We hypothesized that Gram-positive bacteria might also be recognized by TLRs. Heterologous expression of human TLR2, but not TLR4, in fibroblasts conferred responsiveness to Staphylococcus aureus and Streptococcus pneumoniae as ..
  70. Masamune A, Kikuta K, Watanabe T, Satoh K, Satoh A, Shimosegawa T. Pancreatic stellate cells express Toll-like receptors. J Gastroenterol. 2008;43:352-62 pubmed publisher
    ..PSCs were treated with lipoteichoic acid (a ligand for TLR2), polyinosinic-polycytidylic acid (a ligand for TLR3), lipopolysaccharide (a ligand for TLR4), or flagellin (a ..
  71. Tuon F, Fernandes E, Duarte M, Amato V. The expression of TLR2, TLR4 and TLR9 in the epidermis of patients with cutaneous leishmaniasis. J Dermatol Sci. 2010;59:55-7 pubmed publisher
  72. Khan A, Li M, Abdulnour Nakhoul S, Maderdrut J, Simon E, Batuman V. Delayed administration of pituitary adenylate cyclase-activating polypeptide 38 ameliorates renal ischemia/reperfusion injury in mice by modulating Toll-like receptors. Peptides. 2012;38:395-403 pubmed publisher
    ..With PCR arrays, 59 of 83 TLR-related genes significantly changed their expression after IR. TLR2 increased 162 fold, followed by Fas-associated death domain (37 fold) and TLR6 (24 fold), while ubiquitin-..
  73. Liu X, Wang C, Ye Z, Kijlstra A, Yang P. Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. Invest Ophthalmol Vis Sci. 2013;54:6012-7 pubmed publisher
    ..Total RNA was isolated from PBMCs to determine mRNA levels of TLRs, including TLR2, TLR3, TLR4, and TLR8. Cell surface receptor activity of these TLRs was investigated by FACS analysis...
  74. da Silva Correia J, Soldau K, Christen U, Tobias P, Ulevitch R. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J Biol Chem. 2001;276:21129-35 pubmed
    ..These data support the contention that LPS is in close proximity to the three known proteins of its membrane receptor complex. Thus, LPS binds directly to each of the members of the tripartite LPS receptor complex. ..
  75. Lee H, Jo E, Choi S, Oh S, Park K, Kim J, et al. Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degeneration. Biochem Biophys Res Commun. 2006;350:742-7 pubmed
    ..In addition, NNC-induced proinflammatory gene expression was reduced in mouse Schwann cells derived from TLR2 or TLR3 knockout mice...
  76. Murawski M, Bowen G, Cerny A, Anderson L, Haynes L, Tripp R, et al. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. J Virol. 2009;83:1492-500 pubmed publisher
    ..Leukocytes express TLRs, including TLR2, TLR6, TLR3, TLR4, and TLR7, that can interact with RSV and promote immune responses following infection...
  77. Covacu R, Arvidsson L, Andersson A, Khademi M, Erlandsson Harris H, Harris R, et al. TLR activation induces TNF-alpha production from adult neural stem/progenitor cells. J Immunol. 2009;182:6889-95 pubmed publisher
    ..In this study, we determine how different proinflammatory cytokines modulate the expression of TLR2 and TLR4 in NSCs and how these cells respond to TLR2 and TLR4 agonists...
  78. Bai L, Lu X, Zhong Y, Zhou J, Zhang J, Wu H. [Role of Toll-like receptor 2 in corneal graft rejection following penetrating keratoplasty]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:2051-4 pubmed
    To gain insight into the role of Toll-like receptor 2 (TLR2) in graft rejection following penetrating keratoplasty, and investigate the expression of TLR2 mRNA in the corneal graft...
  79. Kerkhof M, Postma D, Brunekreef B, Reijmerink N, Wijga A, de Jongste J, et al. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Thorax. 2010;65:690-7 pubmed publisher
    ..A study was undertaken to determine whether the Toll-like receptor 2 and 4 genes (TLR2 and TLR4) influence the susceptibility to adverse effects of traffic-related air pollution with respect to the ..
  80. Bsibsi M, Nomden A, van Noort J, Baron W. Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation. J Neurosci Res. 2012;90:388-98 pubmed publisher
    ..Primary cultures of rat oligodendrocytes at different maturation stages were found to express TLR2 and, to lesser extent, TLR3...
  81. Bochud P, Hawn T, Siddiqui M, Saunderson P, Britton S, Abraham I, et al. Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis. 2008;197:253-61 pubmed publisher
    ..The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy...
  82. Huang D, Fang F, Xu F. [The role of expression of Toll-like receptor 2 and Toll-like receptor 4 in hyperoxia-induced acute lung injury in rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009;21:644-7 pubmed
    ..The severity of lung injury was assessed by lung histopathology scores, the expression of TLR2 mRNA and TLR4 mRNA in lung tissue was assessed by real-time reverse transcription-polymerase chain reaction (RT-PCR)..
  83. Li D, Wang X, Lan X, Li Y, Liu L, Yi J, et al. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Mol Cell Endocrinol. 2015;402:1-12 pubmed publisher
    To analyze regulatory microRNA(s) leading to increased TLR2 expression in livers of high-fat-diet induced metabolic syndrome (HFD-MetS) in rats with non-alcoholic steatohepatitis (NASH)...
  84. Li H, Yao Y, Yao S, Dong N, Yu Y, Sheng Z. [Potential role of JAK/STAT in regulating Toll-like receptor 2 gene expression in rats with postburn Staphylococcus aureus sepsis]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003;15:139-42 pubmed
    ..and activators of transcription (JAK/STAT) signal transduction pathway in regulating Toll-like receptor 2 (TLR2) gene expression in postburn Staphylococcus aureus infection...
  85. Bjørnvold M, Munthe Kaas M, Egeland T, Joner G, Dahl Jørgensen K, Njølstad P, et al. A TLR2 polymorphism is associated with type 1 diabetes and allergic asthma. Genes Immun. 2009;10:181-7 pubmed publisher
    ..test whether there exist common or inverse associations between polymorphisms in the pattern recognition receptors TLR2, TLR4 and CD14 and T1D and allergic asthma...
  86. Wikén M, Idali F, Al Hayja M, Grunewald J, Eklund A, Wahlstrom J. No evidence of altered alveolar macrophage polarization, but reduced expression of TLR2, in bronchoalveolar lavage cells in sarcoidosis. Respir Res. 2010;11:121 pubmed publisher
    ..IL-23p19, CCR2, CCR7, iNOS, CXCL10, CXCL11, CXCL16, CCL18, CCL20, CD80, and CD86, and innate immune receptors TLR2, TLR4, and TLR9, was quantified in sorted AMs, and for selected genes in total BAL cells, while IL-17A was ..
  87. Jing K, Sun M. [Effects of intestinal trefoil factor on Toll-like receptors 2 and 4 expression in intestinal tissue in young rats with endotoxemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2011;13:985-8 pubmed
    ..The mRNA expressions of TLR2 and TLR4 were detected by reverse transcriptase polymerase chain reaction (RT-PCR)...
  88. Jesic S, Jotic A, Tomanovic N, Zivkovic M. Expression of toll-like receptors 2, 4 and nuclear factor kappa B in mucosal lesions of human otitis: pattern and relationship in a clinical immunohistochemical study. Ann Otol Rhinol Laryngol. 2014;123:434-41 pubmed
    ..Kruskal-Wallis, Mann-Whitney, and Kendall's tau rank correlation tests were used. Stronger expression of TLR2, 4 was found in inflamed mucosa than in the control for children and adults (TLR2: H = 23.86, P < ...
  89. Balloy V, Si Tahar M, Takeuchi O, Philippe B, Nahori M, Tanguy M, et al. Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect Immun. 2005;73:5420-5 pubmed
    ..fumigatus infection. In the current study, we looked for the involvement of Toll-like receptor 2 (TLR2) in the recognition of A...
  90. Andersson A, Covacu R, Sunnemark D, Danilov A, Dal Bianco A, Khademi M, et al. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. J Leukoc Biol. 2008;84:1248-55 pubmed publisher
    ..Furthermore, the expression of the innate HMGB1 receptors--receptor for advanced glycation end products, TLR2, and TLR4--was also highly increased in MS and rodent EAE...
  91. Bereczky Veress B, Abdelmagid N, Piehl F, Bergstrom T, Olsson T, Sköldenberg B, et al. Influence of perineurial cells and Toll-like receptors 2 and 9 on Herpes simplex type 1 entry to the central nervous system in rat encephalitis. PLoS ONE. 2010;5:e12350 pubmed publisher
    ..genetically encoded properties of the host nerve and perineurial cells, recruitment of phagocyting cells together with the low expression of Tlr2 and -9 in the periphery define the susceptibility to HSV-1 entry into the nervous system.
  92. Kwok Y, Tuke J, Nicotra L, Grace P, Rolan P, Hutchinson M. TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers. PLoS ONE. 2013;8:e77799 pubmed publisher
    Chronic pain patients have increased peripheral blood mononuclear cell Interkeukin-1? production following TLR2 and TLR4 simulation...