Gene Symbol: Tlr1
Description: toll-like receptor 1
Alias: toll-like receptor 1, rCG56938-like
Species: rat
Products:     Tlr1

Top Publications

  1. Ma X, Liu Y, Gowen B, Graviss E, Clark A, Musser J. Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS ONE. 2007;2:e1318 pubmed
    ..Rare nonsynonymous polymorphisms in TLR6-TLR1-TLR10 were significantly overrepresented among African-American TB cases compared with ethnically-matched control ..
  2. Chang J, Huggett J, Dheda K, Kim L, Zumla A, Rook G. Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis. J Immunol. 2006;176:3010-8 pubmed
    ..A human splice variant of TLR1, designated hsTLR1, was found in all donors tested...
  3. Johnson C, Lyle E, Omueti K, Stepensky V, Yegin O, Alpsoy E, et al. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol. 2007;178:7520-4 pubmed
    ..In this role, TLR1 enables host responses to a variety of bacteria, including pathogenic species of mycobacteria...
  4. Jin M, Kim S, Heo J, Lee M, Kim H, Paik S, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007;130:1071-82 pubmed
    TLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response by recognizing microbial lipoproteins and lipopeptides...
  5. Kang J, Nan X, Jin M, Youn S, Ryu Y, Mah S, et al. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity. 2009;31:873-84 pubmed publisher
    ..Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6...
  6. Triantafilou M, Gamper F, Haston R, Mouratis M, Morath S, Hartung T, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002-11 pubmed
    ..Our data show that TLR2 forms heterodimers with TLR1 and TLR6 and that these heterodimer pre-exist and are not induced by the ligand...
  7. Kesh S, Mensah N, Peterlongo P, Jaffe D, Hsu K, van den Brink M, et al. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci. 2005;1062:95-103 pubmed
    ..In this preliminary study, we examined the association between single nucleotide polymorphisms (SNPs) in TLR1, TLR4, and TLR6 genes and development of invasive aspergillosis (IA) in 127 allogeneic hematopoietic stem cell ..
  8. Hawn T, Scholes D, Li S, Wang H, Yang Y, Roberts P, et al. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. PLoS ONE. 2009;4:e5990 pubmed publisher
    ..53 (0.29-0.96)). These results provide the first evidence of associations of TLR5 and TLR1 variants with altered risks of acquiring rUTI and pyelonephritis, respectively...
  9. Ben Ali M, Corre B, Manry J, Barreiro L, Quach H, Boniotto M, et al. Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Hum Mutat. 2011;32:643-52 pubmed publisher
    ..The phylogenetically conserved TLR1-2-6 family is unique in that TLR1 and TLR6 form heterodimers with TLR2 to mediate signalling in response to ..

More Information


  1. Lee J, Park H, Suh J, Hahn W, Kang S, Park H, et al. Toll-like receptor 1 gene polymorphisms in childhood IgA nephropathy: a case-control study in the Korean population. Int J Immunogenet. 2011;38:133-8 pubmed publisher
    ..b>TLR1 is expressed in renal tubular epithelial cells when the kidney is injured, but the role of TLR1 gene in ..
  2. Kormann M, Depner M, Hartl D, Klopp N, Illig T, Adamski J, et al. Toll-like receptor heterodimer variants protect from childhood asthma. J Allergy Clin Immunol. 2008;122:86-92, 92.e1-8 pubmed publisher
    ..Protective effects on atopic asthma were identified for single nucleotide polymorphisms in TLR1 (odds ratio [OR], 0.54; 95% CI, 0.37-0.81; P = .002), TLR6 (OR, 0.54; 95% CI, 0.37-0.79; P = ...
  3. Banas M, Banas B, Hudkins K, Wietecha T, Iyoda M, Bock E, et al. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol. 2008;19:704-13 pubmed publisher
    ..Expression of TLR1 through 9 and TLR11 mRNA was detectable in whole kidneys and in isolated glomeruli of wild-type mice, with TLR3 and ..
  4. Liu S, Liu Y, Hao W, Wolf L, Kiliaan A, Penke B, et al. TLR2 is a primary receptor for Alzheimer's amyloid ? peptide to trigger neuroinflammatory activation. J Immunol. 2012;188:1098-107 pubmed publisher
    ..By coexpressing TLR1 or TLR6 in TLR2-transgenic HEK293 cells or silencing tlrs genes in RAW264...
  5. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002;169:10-4 pubmed
    ..TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TLR2 and recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2...
  6. Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, et al. Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. J Neurotrauma. 2011;28:2417-27 pubmed publisher
    ..Treatment with O-1966 also caused inhibition of toll-like receptor expression (TLR1, TLR4, TLR6 and TLR7) following injury...
  7. Aplin A, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia R. Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors. Angiogenesis. 2014;17:147-61 pubmed publisher
    ..b>TLR1, 3, and 6 are transiently upregulated at 24 h whereas TLR2, 4, and 8 expression peaks at 24 h but remains ..
  8. Ohno K, Kuno A, Murase H, Muratsubaki S, Miki T, Tanno M, et al. Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal toll-like receptors in rats. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00205.2017 pubmed publisher
    ..of TLR2 and MyD88 were significantly higher in sham-operated OLETF than in sham-operated LETO, though levels of TLR1, TLR3, and TRL4 were similar...
  9. Guo L, Guo K, Wendel H, Schluesener H. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Biochem Biophys Res Commun. 2006;349:1156-62 pubmed
    ..Various TLR1-9 ligands and NOD2 agonist muramyldipeptide (MDP) were investigated...
  10. Liu Y, Zhu L, Fatheree N, Liu X, Pacheco S, Tatevian N, et al. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2009;297:G442-50 pubmed publisher
    ..We found selective induction of mRNA levels in NEC compared with dam-fed controls for TLR2 > TLR4 > TLR1 = TLR3, TLR7, and TLR9 > TLR6 (P < 0.01); TLR5 was downregulated (P < 0.01)...
  11. Schröder N, Heine H, Alexander C, Manukyan M, Eckert J, Hamann L, et al. Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol. 2004;173:2683-91 pubmed
    ..These results support that LBP is a pattern recognition receptor transferring a variety of bacterial ligands including the two major types of lipopeptides to CD14 present in different receptor complexes. ..
  12. Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen R, et al. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med. 2002;8:878-84 pubmed
    ..After OspA immunization, mice genetically deficient in either TLR2 (TLR2(-/-)) or TLR1 (TLR1(-/-)) produced low titers of antibodies against OspA...