Gene Symbol: Tln1
Description: talin 1
Alias: Tln, talin-1
Species: rat
Products:     Tln1

Top Publications

  1. Barsukov I, Prescot A, Bate N, Patel B, Floyd D, Bhanji N, et al. Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem. 2003;278:31202-9 pubmed
    ..The results suggest that ternary complex formation with a single talin FERM domain is unlikely, although both integrins and PIP kinase may bind simultaneously to the talin anti-parallel dimer. ..
  2. Luo G, Herrera A, Horowits R. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Biochemistry. 1999;38:6135-43 pubmed
  3. Bouvard D, Vignoud L, Dupe Manet S, Abed N, Fournier H, Vincent Monegat C, et al. Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. J Biol Chem. 2003;278:6567-74 pubmed
    ..Altogether, these results suggest that ICAP-1 alpha plays a key role in cell adhesion by acting as a negative regulator of beta(1) integrin avidity. ..
  4. Brzoska E, Wrobel E, Grabowska I, Moraczewski J. Talin distribution during the differentiation of satellite cells isolated from rat skeletal muscle. Cell Mol Biol Lett. 2004;9:723-37 pubmed
    ..We also demonstrated that the expression of talin during satellite cell differentiation was constant in both the control and TPA-treated cells. ..
  5. Kaneko Y, Lecce L, Murphy C. Ovarian hormones regulate expression of the focal adhesion proteins, talin and paxillin, in rat uterine luminal but not glandular epithelial cells. Histochem Cell Biol. 2009;132:613-22 pubmed publisher
    ..In particular, focal adhesion disassembly in uterine luminal epithelial cells, a key component to establish successful implantation, is predominantly under the influence of progesterone. ..
  6. Tan C, Kwok J, Heller J, Zhao R, Eva R, Fawcett J. Full length talin stimulates integrin activation and axon regeneration. Mol Cell Neurosci. 2015;68:1-8 pubmed publisher
    ..In vivo, we find that talin is present in PNS axons (sciatic nerve), and also in CNS axons of the corticospinal tract. ..
  7. van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, et al. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002;156:361-76 pubmed
    ..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins. ..
  8. Jiang G, Giannone G, Critchley D, Fukumoto E, Sheetz M. Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature. 2003;424:334-7 pubmed
  9. Izard T, Vonrhein C. Structural basis for amplifying vinculin activation by talin. J Biol Chem. 2004;279:27667-78 pubmed
    ..These findings support a model in which talin binds to and activates multiple vinculin molecules to provoke rapid reorganization of the actin cytoskeleton. ..

More Information


  1. Cerna J, Cerecedo D, Ortega A, Garcia Sierra F, Centeno F, Garrido E, et al. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. J Mol Biol. 2006;362:954-65 pubmed
    ..Our data indicate that Dp71f is a structural component of the beta1-integrin adhesion complex of PC12 cells that modulates PC12 cell adhesion by conferring proper complex assembly and/or maintenance. ..
  2. Banno A, Ginsberg M. Integrin activation. Biochem Soc Trans. 2008;36:229-34 pubmed publisher
    ..The central finding was that this Rap1-induced formation of an 'integrin activation complex' leads to the unmasking of the integrin-binding site on talin, resulting in integrin activation. ..
  3. Kaneko Y, Lindsay L, Murphy C. Focal adhesions disassemble during early pregnancy in rat uterine epithelial cells. Reprod Fertil Dev. 2008;20:892-9 pubmed
    ..This phenomenon was restricted to the period of receptivity because talin and paxillin reappeared along the basal cell surface soon after implantation. ..
  4. Goult B, Bouaouina M, Elliott P, Bate N, Patel B, Gingras A, et al. Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation. EMBO J. 2010;29:1069-80 pubmed publisher
  5. Calderwood D, Campbell I, Critchley D. Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol. 2013;14:503-17 pubmed publisher
    ..How kindlins act is less well-defined, but disease-causing mutations show that kindlins are also essential for integrin activation, adhesion, cell spreading and signalling. ..