Gene Symbol: Tln1
Description: talin 1
Alias: Tln, talin-1
Barsukov I, Prescot A, Bate N, Patel B, Floyd D, Bhanji N, et al
. Phosphatidylinositol phosphate kinase type 1gamma and beta1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem. 2003;278:31202-9 pubmed
..The results suggest that ternary complex formation with a single talin FERM domain is unlikely, although both integrins and PIP kinase may bind simultaneously to the talin anti-parallel dimer. ..
Luo G, Herrera A, Horowits R. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. Biochemistry. 1999;38:6135-43 pubmed
Bouvard D, Vignoud L, Dupe Manet S, Abed N, Fournier H, Vincent Monegat C, et al
. Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. J Biol Chem. 2003;278:6567-74 pubmed
..Altogether, these results suggest that ICAP-1 alpha plays a key role in cell adhesion by acting as a negative regulator of beta(1) integrin avidity. ..
Brzoska E, Wrobel E, Grabowska I, Moraczewski J. Talin distribution during the differentiation of satellite cells isolated from rat skeletal muscle. Cell Mol Biol Lett. 2004;9:723-37 pubmed
..We also demonstrated that the expression of talin during satellite cell differentiation was constant in both the control and TPA-treated cells. ..
Kaneko Y, Lecce L, Murphy C. Ovarian hormones regulate expression of the focal adhesion proteins, talin and paxillin, in rat uterine luminal but not glandular epithelial cells. Histochem Cell Biol. 2009;132:613-22 pubmed publisher
..In particular, focal adhesion disassembly in uterine luminal epithelial cells, a key component to establish successful implantation, is predominantly under the influence of progesterone. ..
Tan C, Kwok J, Heller J, Zhao R, Eva R, Fawcett J. Full length talin stimulates integrin activation and axon regeneration. Mol Cell Neurosci. 2015;68:1-8 pubmed publisher
..In vivo, we find that talin is present in PNS axons (sciatic nerve), and also in CNS axons of the corticospinal tract. ..
van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, et al
. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002;156:361-76 pubmed
..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins. ..
Jiang G, Giannone G, Critchley D, Fukumoto E, Sheetz M. Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature. 2003;424:334-7 pubmed
Izard T, Vonrhein C. Structural basis for amplifying vinculin activation by talin. J Biol Chem. 2004;279:27667-78 pubmed
..These findings support a model in which talin binds to and activates multiple vinculin molecules to provoke rapid reorganization of the actin cytoskeleton. ..