Timp1

Summary

Gene Symbol: Timp1
Description: TIMP metallopeptidase inhibitor 1
Alias: TIMP-1, Timp, metalloproteinase inhibitor 1, tissue inhibitor of metallopeptidase 1, tissue inhibitor of metalloproteinase 1, tissue inhibitor of metalloproteinases 1
Species: rat
Products:     Timp1

Top Publications

  1. Ye H, Azar D. Expression of gelatinases A and B, and TIMPs 1 and 2 during corneal wound healing. Invest Ophthalmol Vis Sci. 1998;39:913-21 pubmed
    To determine the expression of gelatinases A and B and the localization of tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 during the early stages of corneal wound healing in rats. METHODS...
  2. Tayebjee M, Nadar S, MacFadyen R, Lip G. Tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9 levels in patients with hypertension Relationship to tissue Doppler indices of diastolic relaxation. Am J Hypertens. 2004;17:770-4 pubmed
    ..Tissue inhibitor of metalloproteinase-1 (TIMP-1) is linked to extracellular matrix fibrosis and is elevated in hypertension...
  3. Roderfeld M, Geier A, Dietrich C, Siewert E, Jansen B, Gartung C, et al. Cytokine blockade inhibits hepatic tissue inhibitor of metalloproteinase-1 expression and up-regulates matrix metalloproteinase-9 in toxic liver injury. Liver Int. 2006;26:579-86 pubmed
    Tissue inhibitor of metalloproteinases (TIMP)-1, the most important endogenous inhibitor of matrix metalloproteinases, plays a pivotal role in the pathogenesis of liver fibrosis and may represent an effective therapeutic target in the ..
  4. Hultström M, Leh S, Skogstrand T, Iversen B. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Nephrol Dial Transplant. 2008;23:896-903 pubmed
    ..procollagen-n- and -c-proteinase, matrix metalloproteases, MMP-2 and MMP-9, tissue inhibitor of metalloproteases, TIMP-1 and TIMP-2. Western blot was used to quantify the proteins of MMP-2, MMP-9, TIMP-1 and TIMP-2...
  5. Zhang N, LI J, Wang J, Zhang H. [The effect of bone marrow mesenchymal stem cell transplantation on diabetic cardiomyopathy]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008;36:1115-9 pubmed
    ..reaction analysis for matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1, zymography analysis for activities of MMP-2 and Western blot analysis for troponin T...
  6. Kallakury B, Karikehalli S, Haholu A, Sheehan C, Azumi N, Ross J. Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res. 2001;7:3113-9 pubmed
    ..from 153 RCCs were immunostained using specific antibodies against MMP2, MMP9, (Novocastra, Burlingame, CA) TIMP1, and TIMP2 (NeoMarkers, Fremont, CA) proteins...
  7. Li H, Simon H, Bocan T, Peterson J. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Cardiovasc Res. 2000;46:298-306 pubmed
    ..Left ventricular (LV) mRNA [MMP-1,-2,-3,-7,-9,-11,-13,-14; TIMP-1,-2,-3,-4; and collagen alpha1(I) and alpha1(III)] and protein (MMP-2 and MMP-9 zymographic activity; Western blot ..
  8. Li Y, McTiernan C, Feldman A. Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells. Cardiovasc Res. 1999;42:162-72 pubmed
    ..The TIMP-1 mRNA was upregulated in cardiac cells, while TIMP-1 protein levels were unchanged in myocytes but downregulated ..
  9. Wang X, Shi K, Li J, Chen T, Guo Y, Liu Y, et al. Effects of angiotensin II intervention on MMP-2, MMP-9, TIMP-1, and collagen expression in rats with pulmonary hypertension. Genet Mol Res. 2015;14:1707-17 pubmed publisher
    ..Real-time fluorescent quantitative PCR was used to detect MMP2, MMP9, TIMP1, COL1A1, and COL4A1 mRNA expression. Picro-sirius red staining was performed to detect collagen protein expression...

More Information

Publications97

  1. Boujrad N, Ogwuegbu S, Garnier M, Lee C, Martin B, Papadopoulos V. Identification of a stimulator of steroid hormone synthesis isolated from testis. Science. 1995;268:1609-12 pubmed
    ..The 28- and 38-kD proteins were shown to be identical to the tissue inhibitor of metalloproteinase-1 (TIMP-1) and the proenzyme form of cathepsin L, respectively...
  2. Okada A, Garnier J, Vicaire S, Basset P. Cloning of the cDNA encoding rat tissue inhibitor of metalloproteinase 1 (TIMP-1), amino acid comparison with other TIMPs, and gene expression in rat tissues. Gene. 1994;147:301-2 pubmed
    We have cloned the cDNA encoding the rat tissue inhibitor of metalloproteinase 1 (TIMP-1) from a cDNA library derived from healing skin wounds...
  3. Abdel Aziz M, Badary D, Hussein M. Renal damage following Alloxan-induced diabetes is associated with generation of reactive oxygen species, alterations of p53, TGF-?1, and extracellular matrix metalloproteinases in rats. Cell Biol Int. 2017;41:525-533 pubmed publisher
    ..The expression patterns of p53, TGF-?1were evaluated using Western blot and immunohistochemical methods. TIMP-1 expression pattern was determined using RT-PCR and immunohistochemical methods...
  4. Zhou Y, Tan X, Kuang W, Liu L, Wan L. Erythromycin ameliorates cigarette-smoke-induced emphysema and inflammation in rats. Transl Res. 2012;159:464-72 pubmed publisher
    ..0002) and Bax (P = 0.0002), and inhibited the expressions of matrix metalloproteinase (MMP)-9 (P = 0.0019) and TIMP-1 protein (P = 0.04) and the MMP-9/TIMP-1 ratio (P = 0.0002) in the lungs of CS-induced emphysema in rats...
  5. Siu M, Lee W, Cheng C. The interplay of collagen IV, tumor necrosis factor-alpha, gelatinase B (matrix metalloprotease-9), and tissue inhibitor of metalloproteases-1 in the basal lamina regulates Sertoli cell-tight junction dynamics in the rat testis. Endocrinology. 2003;144:371-87 pubmed
    ..Taken collectively, these observations strengthen the notion that ECM is involved in the regulation of junction dynamics in addition to its structural role in the testis. ..
  6. Wang X, Zhou T, Liu B, Wei L, Shi K, Zhao S, et al. [Changes of MMP-2,9 and TIMP-1 expressions in rats with pulmonary arterial hypertension after captopril and losartan interventions]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009;40:255-9 pubmed
    ..of captopril and losartan on the expressions of matrix metalloproteinase-2,9 (MMP-2,9) and metalloproteinase-1 (TIMP-1) in rats with pulmonary arterial hypertension, and the mechanisms of captopril and losartan in intervening the ..
  7. Qiao H, Lu J, Cheng H, Liu L, Ma Q, Fu W, et al. [Regulatory effects of inhaled steroids on expression of matrix metalloproteinase-9 and its inhibitor in asthmatic rats]. Zhonghua Er Ke Za Zhi. 2005;43:591-4 pubmed
    To investigate the role of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor (TIMP-1) in the pathogenesis of bronchial asthma and assess the effect of steroid treatment on MMP-9 and TIMP-1 levels...
  8. Louboutin J, Reyes B, Agrawal L, Van Bockstaele E, Strayer D. HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy. Eur J Neurosci. 2011;34:2015-23 pubmed publisher
    ..Antioxidant gene delivery blunted gp120-induced MMP production. We also studied the effect of gp120 on TIMP-1 and TIMP-2 production. TIMP-1 and TIMP-2 levels increased 6 h after gp120 injection into rat caudate-putamen (CP)...
  9. Wang X, Barone F, White R, Feuerstein G. Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression following focal stroke. Stroke. 1998;29:516-20 pubmed
    ..A cDNA that encodes for tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) was identified in the subtractive cDNA library...
  10. Wang K, Lin B, Brems J, Gamelli R. Hepatic apoptosis can modulate liver fibrosis through TIMP1 pathway. Apoptosis. 2013;18:566-77 pubmed publisher
    ..The present study aimed to investigate the role of inducible TIMP1 in the pathogenesis of hepatic apoptosis-fibrosis...
  11. Wang C, Li D, Qian Y, Wang J, Jing H. Increased matrix metalloproteinase-9 activity and mRNA expression in lung injury following cardiopulmonary bypass. Lab Invest. 2012;92:910-6 pubmed publisher
    ..activity and gene expression of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) of lungs using rat model of CPB...
  12. Reis S, Leite K, Viana N, Lopes R, Moura C, Ivanovic R, et al. MMP9 overexpression is associated with good surgical outcome in children with UPJO: Preliminary results. BMC Urol. 2016;16:44 pubmed publisher
    ..present study was to investigate for the first time in the literature whether MMP9 and its specific inhibitors, TIMP1 and RECK, are expressed in a reproducible, specific pattern in UPJ...
  13. Hasegawa Baba Y, Doi K. Changes in TIMP-1 and -2 expression in the early stage of porcine serum-induced liver fibrosis in rats. Exp Toxicol Pathol. 2011;63:357-61 pubmed publisher
    It is widely recognized that tissue inhibitors of metalloproteinases (TIMPs), especially TIMP-1 and -2, play a key role in the progression of hepatic fibrosis...
  14. Iulita M, Do Carmo S, Ower A, Fortress A, Flores Aguilar L, Hanna M, et al. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Brain. 2014;137:860-72 pubmed publisher
    ..Our study thus provides a novel paradigm for cholinergic neuroprotection in Alzheimer's disease and Down's syndrome. ..
  15. Katoh N, Hirano S, Suehiro M, Ikenaga K, Yasuno H. Increased levels of serum tissue inhibitor of metalloproteinase-1 but not metalloproteinase-3 in atopic dermatitis. Clin Exp Immunol. 2002;127:283-8 pubmed
    ..examined the role of TIMPs and MMPs in the pathogenesis of atopic dermatitis (AD) by evaluating the serum levels of TIMP-1 and MMP-3 in 40 patients with AD and 20 control subjects by ELISA...
  16. Chua P, Melish M, Yu Q, Yanagihara R, Yamamoto K, Nerurkar V. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clin Diagn Lab Immunol. 2003;10:308-14 pubmed
    ..Previously, matrix metalloproteinase 9 (MMP-9), which is secreted complexed to tissue inhibitor of metalloproteinase 1 (TIMP-1), has been implicated in abdominal aortic aneurysm formation...
  17. Krex D, Röhl H, Konig I, Ziegler A, Schackert H, Schackert G. Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms. Stroke. 2003;34:2817-21 pubmed
    ..To investigate the possible impact of genetic variants within the genes encoding TIMP-1, -2, and -3, we conducted this case-control study...
  18. Lee T, Lee K, Baik H. Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading. Angle Orthod. 2009;79:733-9 pubmed publisher
    To test the hypothesis that orthodontic pressure does not induce gene transcription of IL-1beta, MMP-9, and TIMP-1 in pressure gingival soft tissue...
  19. Koyama Y, Baba A, Matsuda T. Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain. Neuroscience. 2007;147:620-30 pubmed
    ..To clarify the extracellular signals involved in TIMP production in the brain, the effects of endothelins (ETs), a family of vasoconstricting peptides, were examined. I...
  20. Tayebjee M, Karalis I, Nadar S, Beevers D, MacFadyen R, Lip G. Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension. Am J Hypertens. 2005;18:325-9 pubmed
    ..in circulating matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases-1 and -2 (TIMP-1 and TIMP-2, respectively) in patients with GH, when compared with normotensive women with normal pregnancies and ..
  21. Wei Wei Y, Qin X. Contrary regulation of TIMP-1 and MMP-9 by hepatocyte growth factor antibody after lung injury. Chin Med Sci J. 2011;26:216-20 pubmed
    ..on the lung expression level of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Thirty male Wistar rats were randomly divided into 3 groups: control group, model group, and intervention group...
  22. Narayanan N, Pushpakumar S, Givvimani S, Kundu S, Metreveli N, James D, et al. Epigenetic regulation of aortic remodeling in hyperhomocysteinemia. FASEB J. 2014;28:3411-22 pubmed publisher
    ..Aza treatment decreased the expression of DNMT1, MMP9, TIMP1, and S-adenosyl homocysteine hydrolase (SAHH) and upregulated methylene tetrahydrofolate reductase (MTHFR)...
  23. Takahashi I, Onodera K, Bae J, Mitani H, Sasano Y, Mitani H. Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats. J Mol Histol. 2005;36:355-66 pubmed
    ..This study attempted to clarify the age-related changes in the mRNA expression patterns of MMP-2, MMP-9, TIMP-1, TIMP-2, and TIMP-3 in mandibular condylar cartilage in comparison to tibial growth plate and articular cartilage ..
  24. Li J, Liao E, Dai R, Wei Q, Luo X. Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells. J Mol Histol. 2004;35:723-31 pubmed
    ..and in situ hybridization to observe changes in the expression of mRNA and the proteins MMP-8, MMP-13 and TIMP-1 in osteoblastic cells in rat proximal tibia...
  25. Taghavi S, Krenn K, Jaksch P, Klepetko W, Aharinejad S. Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. Am J Transplant. 2005;5:1548-52 pubmed
    ..patients (34 BO syndrome (BOS) 0, 15 BOS 0-p, and 23 BOS 1) serum and broncho-alveolar lavage (BAL) MMP and TIMP levels were examined by ELISA. The BAL cell counts were additionally analyzed...
  26. Rivera S, Ogier C, Jourquin J, Timsit S, Szklarczyk A, Miller K, et al. Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia. Eur J Neurosci. 2002;15:19-32 pubmed
    ..of the ischemic rat hippocampus, the kinetics and cellular distribution of gelatinase B and its principal inhibitor TIMP-1 and we assessed by in situ zymography, the net gelatinolytic activity at the cellular level...
  27. Schrohl A, Meijer van Gelder M, Holten Andersen M, Christensen I, Look M, Mouridsen H, et al. Primary tumor levels of tissue inhibitor of metalloproteinases-1 are predictive of resistance to chemotherapy in patients with metastatic breast cancer. Clin Cancer Res. 2006;12:7054-8 pubmed
    ..Tissue inhibitor of metalloproteinases-1 (TIMP-1) has been shown to protect against apoptosis, and the purpose of the present study was to test the hypothesis ..
  28. Liu L, Jiang H, Zhang X, Zhao D. [Effect of Salvia miltiorrhiza monomer IH764-3 on MMP-13 and TIMP-1 by downregulating the expression of focal adhesion kinase in hepatic stellate cell stimulated by H2O2]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007;23:482-6 pubmed
    To investigate the effect of IH764-3 on the expression of MMP-13 and TIMP-1 by H2O2-stimulated hepatic stellate cell and the alteration of FAK during this process. The expression of MMP-13 and FAK mRNA was examined by RT-PCR...
  29. Guo W, Chen G, Zhu C, Wang H. [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma]. Zhonghua Fu Chan Ke Za Zhi. 2002;37:604-7 pubmed
    To study the expression of matrix metalloproteinase (MMP)-2, 9 and tissue inhibitor of metalloproteinase (TIMP)-1, 2 protein in human endometrial carcinoma tissue and its relation to the invasion and metastasis of endometrial carcinoma...
  30. Zhao Y, Xiao A, Cao X, Zhu C. Expression of matrix metalloproteinase -2, -9 and tissue inhibitors of metalloproteinase -1, -2, -3 mRNAs in rat uterus during early pregnancy. Mol Reprod Dev. 2002;62:149-58 pubmed
    ..MMP-2, -9) activities, and expression of mRNAs for MMP-2, -9 and tissue inhibitors of matrix metalloproteinases (TIMP-1, -2, -3) in the rat uterus during early pregnancy (day 1-7)...
  31. Määttä M, Talvensaari Mattila A, Turpeenniemi Hujanen T, Santala M. Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in differential diagnosis between low malignant potential (LMP) and malignant ovarian tumours. Anticancer Res. 2007;27:2753-8 pubmed
    ..This study aimed to evaluate whether matrix metalloproteinases (MMP-2, MMP-9, MMP-2-TIMP-2 complex) or their tissue inhibitors (TIMP-1, TIMP-2) could be used as preoperative serum markers in ..
  32. Guo C, Xu L, He Q, Liang T, Duan X, Li R. Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-? expression and inhibition of PI3K/Akt pathway. Food Chem Toxicol. 2013;56:436-42 pubmed publisher
    ..Moreover, the expression of tissue inhibitor of metal protease-1 (TIMP-1) was decreased, while the expression of matrix metalloproteinase-2 (MMP-2) was increased...
  33. Docherty A, Lyons A, Smith B, Wright E, Stephens P, Harris T, et al. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature. 1985;318:66-9 pubmed
    ..and cytokines, and also at the level of their extracellular activity through the action of a specific inhibitor, TIMP (tissue inhibitor of metalloproteinases), which irreversibly forms inactive complexes with metalloproteinases...
  34. Lee S, Song K, Shin D, Ahn S, Ha E, Kim D, et al. Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes. Diabetes Res Clin Pract. 2005;69:175-9 pubmed
    ..We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age-matched controls...
  35. HANDY J, Fu P, Kumar P, Mells J, Sharma S, Saxena N, et al. Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Biochem J. 2011;440:385-95 pubmed publisher
    ..Adiponectin also promotes SOCS-3-Ob-R association and blocks leptin-stimulated formation of extracellular TIMP-1 (tissue inhibitor of metalloproteinases-1)-MMP-1 (matrix metalloproteinase-1) complexes in vitro...
  36. Kwon J, Kim Y, Cho A, Cho H, Kim J, Hong M, et al. Regulation of MMP/TIMP by HUVEC transplantation attenuates ventricular remodeling in response to myocardial infarction. Life Sci. 2014;101:15-26 pubmed publisher
    ..The ratios of matrix metalloproteinase (MMP)-2 or MMP-9 to tissue inhibitor of metalloproteinase (TIMP)-1 or TIMP-3 were decreased in the MI-HV group compared with the MI-V group...
  37. Benekareddy M, Mehrotra P, Kulkarni V, Ramakrishnan P, Dias B, Vaidya V. Antidepressant treatments regulate matrix metalloproteinases-2 and -9 (MMP-2/MMP-9) and tissue inhibitors of the metalloproteinases (TIMPS 1-4) in the adult rat hippocampus. Synapse. 2008;62:590-600 pubmed publisher
  38. Okulski P, Jay T, Jaworski J, Duniec K, Dzwonek J, Konopacki F, et al. TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex. Biol Psychiatry. 2007;62:359-62 pubmed
    ..We tested whether induction of hippocampal-prefrontal LTP results in accumulation of tissue inhibitor of MMP-1, TIMP-1 mRNA, in the PFC of rats and whether adenovirally driven overexpression of TIMP-1 affects LTP...
  39. Thibert K, Raymond G, Nascene D, Miller W, Tolar J, Orchard P, et al. Cerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction. PLoS ONE. 2012;7:e50430 pubmed publisher
    ..We hypothesize that disruption may occur through the degradation of the extracellular matrix defining the BBB by matrix metalloproteinases (MMPs). MMPs have not been evaluated in the setting of cALD...
  40. Zhang C, Li X, Zhang T, Fu J, Cui X. Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload. Acta Pharmacol Sin. 2013;34:1301-9 pubmed publisher
    To study the effects of hydrogen sulfide (H2S) on the left ventricular expression of MMP-8, MMP-13, and TIMP-1 in a rat model of congenital heart disease. Male SD rats underwent abdominal aorta-inferior vena cava shunt operation...
  41. Parsons C, Bradford B, Pan C, Cheung E, Schauer M, Knorr A, et al. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. 2004;40:1106-15 pubmed
    ..Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase (MMP) activity...
  42. Lo Y, Tsai Y, Wu S, Chen J, Chao J. Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells. J Med Food. 2011;14:1135-43 pubmed publisher
    ..growth factor-?1 (TGF-?1), matrix metalloproteinase (MMP)-2, and tissue inhibitor of metalloproteinase (TIMP)-1 was suppressed by ginsenoside Rb1 at 10-80 ?g/mL (P<.05)...
  43. Sa Y, Hao J, Samineni D, Clark J, Pyne Geithman G, Broderick J, et al. Brain distribution and elimination of recombinant human TIMP-1 after cerebral ischemia and reperfusion in rats. Neurol Res. 2011;33:433-8 pubmed publisher
    To investigate recombinant human TIMP-1 ((125)I-rhTIMP-1) half-life in blood and its distribution in rat brain tissue after cerebral ischemia/reperfusion as part of a therapeutic development paradigm...
  44. Shi W, Ju J, Xiao H, Xue F, Wu J, Pan M, et al. Dynamics of MMP?9, MMP?2 and TIMP?1 in a rat model of brain injury combined with traumatic heterotopic ossification. Mol Med Rep. 2017;15:2129-2135 pubmed publisher
    ..matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase?2 (MMP?2) and tissue inhibitor of metalloproteinase?1 (TIMP?1) in a rat model of brain injury combined with traumatic heterotopic ossification (HO)...
  45. Jiang Y, Sun H, Zhang J, Huang F, Liu J. [Effect of shRNA-mediated silencing of CTGF and TIMP-1 on mRNA expression of CTGF, TIMP-1, and PC I and secretion of extracellular matrix in rat hepatic stellate cells]. Zhonghua Gan Zang Bing Za Zhi. 2012;20:576-80 pubmed publisher
    To investigate the effect of short hairpin RNA (shRNA)-mediated silencing of CTGF and TIMP-1 in hepatic stellate cells (HSCs) on mRNA expression of TIMP-1, CTGF, and procollagen type-I (PC I), as well as secretion of extracellular matrix (..
  46. Wollmer M, Papassotiropoulos A, Streffer J, Grimaldi L, Kapaki E, Salani G, et al. Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease. Psychiatr Genet. 2002;12:155-60 pubmed
    b>Tissue inhibitor of metalloproteinases 1 (TIMP-1) inhibits several proteinases including a disintegrin and metalloproteinase 10 (ADAM10), a major alpha-secretase that cleaves the beta-amyloid precursor protein within its amyloidogenic ..
  47. Li H, Cui D, Tong X, Ma N, Gao Y, Cui X, et al. [The role of matrix metalloproteinases in extracellular matrix remodelling in chronic obstructive pulmonary disease rat models]. Zhonghua Nei Ke Za Zhi. 2002;41:393-8 pubmed
    ..The expression of MMP-9,MMP-2 and tissue inhibitor of metalloproteinase-1(TIMP-1) in bronchi and lung tissue was verfied by immunohistochemical analysis and by reverse transcription-polymerase ..
  48. Zhang Y, Chen X, Wu D, Shi S, Yin Z, Ding R, et al. Expression of tissue inhibitor of matrix metalloproteinases-1 during aging in rat liver. World J Gastroenterol. 2005;11:3696-700 pubmed
    To investigate the expression and role of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) during natural aging in rat liver and to detect the expression of matrix metalloproteinase-2 (MMP-2) and MMP-9...
  49. Bugno M, Graeve L, Gatsios P, Koj A, Heinrich P, Travis J, et al. Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter. Nucleic Acids Res. 1995;23:5041-7 pubmed
    The rat tissue inhibitor of metalloproteinase 1 (TIMP-1) gene is expressed in rat hepatocytes, and this expression is up-regulated by interleukin 6 (IL-6)...
  50. Maddahi A, Chen Q, Edvinsson L. Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. BMC Neurosci. 2009;10:56 pubmed publisher
    ..is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Here, we found an infarct volume of 24...
  51. Chen J, Ren Z, Zhu M, Khalil R. Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy. Biochem Pharmacol. 2017;138:81-95 pubmed publisher
    ..MMPs) plays a role in HTN-Preg and IUGR, the levels/activity of MMP-9, tissue inhibitor of metalloproteinase (TIMP-1), and their dimerization forms were measured in the placenta, uterus, and uterine artery of normal pregnant (Preg)..
  52. Lin S, Saxena N, Ding X, Stein L, Anania F. Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism. Mol Endocrinol. 2006;20:3376-88 pubmed
    ..A key molecule synthesized is the tissue inhibitor of metalloproteinase I (TIMP-1), which acts to inhibit the activity of matrix metalloproteinases...
  53. Wada K, Sato H, Kinoh H, Kajita M, Yamamoto H, Seiki M. Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases. Gene. 1998;211:57-62 pubmed
    ..Enzyme activity of MMP-C31 and -H19 was inhibited by human tissue inhibitor of MMPs (TIMP)-1, TIMP-2 and synthetic MMP inhibitors, BB94 and CT543, indicating that the catalytic sites of these C...
  54. Hernandez Guillamon M, Delgado P, Ortega L, Pares M, Rosell A, Garcia Bonilla L, et al. Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. J Neurosci Res. 2009;87:2115-25 pubmed publisher
    ..We aimed to investigate the effects of beta-amyloid (Abeta) on the MMP-9/TIMP-1 balance and its involvement in Abeta toxicity in neurons and glial cells...
  55. Espey L, Ujioka T, Okamura H, Richards J. Metallothionein-1 messenger RNA transcription in steroid-secreting cells of the rat ovary during the periovulatory period. Biol Reprod. 2003;68:1895-902 pubmed
    ..In contrast, a disintegrin and metalloproteinase with thrombospondin motifs and a tissue inhibitor of metalloproteinase 1, which were also detected by the RT-PCR differential display procedure, reached a peak at 12 h ..
  56. Calabrò A, Grappone C, Pellegrini G, Evangelista S, Tramontana M, Schuppan D, et al. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Digestion. 2004;70:127-38 pubmed
    ..collagenase (MMP-13), stromelysin (MMP-3), and their major inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1) during experimental gastric ulcer healing induced in rats by acetic acid injection...
  57. Jiang X, Gao G. [The influence of angiotensin II receptor blockade on the expressions of Col I and TIMP-1 mRNA in cardiac fibroblast of adult rat]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007;38:954-7 pubmed
    ..reverse transcription PCR was used to determine the mRNA levels of collagen I (Col I ) and tissue inhibitor of metalloproteinase 1 (TIMP-1). Losartan-treatment making AT1 blockade decreased Col I mRNA to 71...
  58. Tinnes S, Ringwald J, Haas C. TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy. FASEB J. 2013;27:2542-52 pubmed publisher
    ..slice cultures as an epilepsy model and found a significant increase of tissue inhibitor of metalloproteases 1 (TIMP-1) levels and strongly enhanced TIMP-1 immunolabeling in hippocampal neurons...
  59. Florys B, Głowińska B, Urban M, Peczynska J. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes]. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12:184-9 pubmed
    ..evaluation of MMP-2, MMP-9 and TIMP-1, TIMP-2 levels in children and adolescents with type 1 diabetes. 74 patients in the mean age 15 years (+/-3...
  60. He C, Huang J, Wang W, Jin M, Ye F, Wu H, et al. [Effects of Liangxue Tongyu Formula on brain edema and expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with intracerebral hemorrhage]. Zhong Xi Yi Jie He Xue Bao. 2010;8:347-51 pubmed publisher
    ..Matrix metalloproteinase-9 (MMP-9) level, and MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA expressions in perihematoma area were detected by gelatin zymography and fluorescence quantitative real-..
  61. Osman B, Akool E, Doller A, Müller R, Pfeilschifter J, Eberhardt W. Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin. Biochem Pharmacol. 2011;81:134-43 pubmed publisher
    ..of rapamycin on the cytokine-triggered matrix metalloproteinase 9 (MMP-9)/tissue inhibitor of metalloproteinase (TIMP)-1 protease-antiprotease system which is critically involved in renal inflammation and fibrosis...
  62. Huang B, Zhao X, Zheng L, Zhang L, Ni B, Wang Y. Different expression of tissue inhibitor of metalloproteinase family members in rat dorsal root ganglia and their changes after peripheral nerve injury. Neuroscience. 2011;193:421-8 pubmed publisher
    ..The enzymatic activity of MMP9 and MMP2 is balanced specifically by tissue inhibitor of metalloproteinase 1 (TIMP1) and TIMP2, respectively...
  63. Heymans S, Schroen B, Vermeersch P, Milting H, Gao F, Kassner A, et al. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Circulation. 2005;112:1136-44 pubmed
    ..Cardiac mRNA expression of TIMP-1 and TIMP-2 was significantly increased in AS compared with control patients (mRNA transcript levels normalized to ..
  64. Johanns M, Lemoine P, Janssens V, Grieco G, Moestrup S, Nielsen R, et al. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Sci Rep. 2017;7:4328 pubmed publisher
    ..the clearance of a complex between the zymogen form of MMP-2 (proMMP-2) and tissue inhibitor of metalloproteinases, TIMP-2, in HT1080 human fibrosarcoma cells...
  65. Fioruci Fontanelli B, Chuffa L, Mendes L, Pinheiro P, Delella F, Kurokawa C, et al. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression in the prostatic tissue of two ethanol-preferring rat models. Anal Cell Pathol (Amst). 2015;2015:954548 pubmed publisher
    We investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats...
  66. Wang Y, Huang G, Mo B, Wang C. Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats. Genet Mol Res. 2016;15: pubmed publisher
    ..the expression of collagen-IV, matrix metalloproteinase (MMP), and tissue inhibitor of matrix metalloproteinase (TIMP) to understand the pharmacological role of artesunate in pulmonary fibrosis...
  67. Lu J, Hao J, Du H, Xiao B, Li Y, Yang X, et al. Amlodipine and Atorvastatin Improved Hypertensive Cardiac Remodeling through Regulation of MMPs/TIMPs in SHR Rats. Cell Physiol Biochem. 2016;39:47-60 pubmed publisher
    ..Enzyme activity of MMP-2 and MMP-9 was assessed with Gelatin zymography. MMP-2, MMP-9, TIMP-1 and TIMP-2 mRNA and protein expression was studied by RT-PCR and Western blot...
  68. Salzmann J, Limb G, Khaw P, Gregor Z, Webster L, Chignell A, et al. Matrix metalloproteinases and their natural inhibitors in fibrovascular membranes of proliferative diabetic retinopathy. Br J Ophthalmol. 2000;84:1091-6 pubmed
    ..characteristic of this complication of diabetes mellitus, are associated with specific anomalies of MMP or TIMP expression...
  69. Aoki T, Kataoka H, Moriwaki T, Nozaki K, Hashimoto N. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Stroke. 2007;38:2337-45 pubmed
    ..Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by inhibiting the activity of matrix metalloproteinases (MMPs)...
  70. Suryadevara R, Holter S, Borgmann K, Persidsky R, Labenz Zink C, Persidsky Y, et al. Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia. Glia. 2003;44:47-56 pubmed
    ..We hypothesized that in response to injury and inflammation in HAD, astrocytes regulate the production of TIMP-1, the inducible type of TIMP that is important in inflammation...
  71. Kinoshita T, Ishikawa Y, Arita M, Akishima Fukasawa Y, Fujita K, Inomata N, et al. Antifibrotic response of cardiac fibroblasts in hypertensive hearts through enhanced TIMP-1 expression by basic fibroblast growth factor. Cardiovasc Pathol. 2014;23:92-100 pubmed publisher
    ..In contrast, bFGF treatment in the CFs induced a marked increase in tissue inhibitor of MMP (TIMP)-1 expression and a marked decline in MMP-9 activation...
  72. Rodriguez Parkitna J, Korostynski M, Kaminska Chowaniec D, Obara I, Mika J, Przewlocka B, et al. Comparison of gene expression profiles in neuropathic and inflammatory pain. J Physiol Pharmacol. 2006;57:401-14 pubmed
    ..four genes, intercellular adhesion molecule 1 (ICAM-1), calcitonin gene related peptide (CGRP), tissue inhibitor of metalloproteinase 1 (TIMP-1), chemokine-like receptor 1 was confirmed by reverse transcription Real-Time PCR (qPCR) ..
  73. Babaei S, Bayat M. Pentoxifylline Accelerates Wound Healing Process by Modulating Gene Expression of MMP-1, MMP-3, and TIMP-1 in Normoglycemic Rats. J Invest Surg. 2015;28:196-201 pubmed publisher
    ..parameters and modulate matrix metalloproteinaseses-1 (MMP-1) and MMP-3, and matrix metalloproteinase inhibitor-1 (TIMP-1) in normoglycemic (NG) rat model of wound healing...
  74. Wang C, Li Z, Liu X, Peng Q, Li F, Li D, et al. Effect of Liuweibuqi capsule, a Chinese patent medicine, on the JAK1/STAT3 pathway and MMP9/TIMP1 in a chronic obstructive pulmonary disease rat model. J Tradit Chin Med. 2015;35:54-62 pubmed
    ..using enzyme-linked immunosorbent assay, and changes in the JAK/STAT pathway, MMP-9, and MMPs inhibitor 1 (TIMP1) were detected by immunohistochemistry, RT-PCR, and western blotting, respectively...
  75. Zhu P, Yu H, Huang S, Xiang H, Li F, Zheng W. Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 co‑expression vector on the proliferation of rat vascular smooth muscle cells. Mol Med Rep. 2015;12:5671-8 pubmed publisher
    Tissue kallikrein 1 (TK1) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1) are important in inhibiting vascular smooth muscle cell (VSMC) proliferation and improving vascular remodeling, respectively...
  76. Gouyer V, Conti M, Devos P, Zerimech F, Copin M, Créme E, et al. Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent. Cancer. 2005;103:1676-84 pubmed
    ..In this study, mRNA expression levels of MMP-1, MMP-9, TIMP-1, and TIMP-2 were evaluated in patients with resected NSCLC, and their associations with disease progression and ..
  77. Matsumoto E, Nakatsukasa H, Nouso K, Kobayashi Y, Nakamura S, Suzuki M, et al. Increased levels of tissue inhibitor of metalloproteinase-1 in human hepatocellular carcinoma. Liver Int. 2004;24:379-83 pubmed
    ..However, the role of TIMPs in these processes is not clear. To examine the potential involvement of TIMP-1 in HCC and the association between TIMP-1 and clinical outcome of patients with HCC...
  78. Hundhausen C, Misztela D, Berkhout T, Broadway N, Saftig P, Reiss K, et al. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood. 2003;102:1186-95 pubmed
    ..Our data demonstrate that ADAM10 is involved in the constitutive cleavage of CX3CL1 and thereby may regulate the recruitment of monocytic cells to CX3CL1-expressing cell layers. ..
  79. Chun S, Popliker M, Reich R, Tsafriri A. Localization of preovulatory expression of plasminogen activator inhibitor type-1 and tissue inhibitor of metalloproteinase type-1 mRNAs in the rat ovary. Biol Reprod. 1992;47:245-53 pubmed
    ..localization of plasminogen activator inhibitor type-1 (PAI-1) and tissue inhibitor of metalloproteinase type-1 (TIMP-1) mRNAs by in situ hybridization...
  80. Nie Q, Duan G, Luo X, Xie Y, Luo H, Zhou Y, et al. Expression of TIMP-1 and TIMP-2 in rats with hepatic fibrosis. World J Gastroenterol. 2004;10:86-90 pubmed
    To investigate the location and expression of TIMP-1 and TIMP-2 in the liver of normal and experimental hepatic fibrosis in rats...
  81. Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, et al. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol. 2011;178:1177-89 pubmed publisher
    ..These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. ..
  82. Dagues N, Pawlowski V, Sobry C, Hanton G, Borde F, Soler S, et al. Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. Toxicol Sci. 2007;100:238-47 pubmed
    ..Activation of genes coding for pro- and antioxidant enzymes, cytokines, adhesion molecules, and tissue inhibitor of metalloproteinase 1 (TIMP-1) indicates that biomechanical stimuli may contribute to vascular oxidant stress, ..
  83. Sieuwerts A, Usher P, Meijer van Gelder M, Timmermans M, Martens J, Brunner N, et al. Concentrations of TIMP1 mRNA splice variants and TIMP-1 protein are differentially associated with prognosis in primary breast cancer. Clin Chem. 2007;53:1280-8 pubmed
    ..We evaluated the prognostic value of TIMP1 mRNA and a novel TIMP1 mRNA splice variant in 1301 primary breast cancer patients...
  84. Głowińska Olszewska B, Urban M. Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents. Metabolism. 2007;56:799-805 pubmed
    ..Plasma levels of MMP-9 and TIMP-1 were measured immunoenzymatically in 45 obese children and adolescents, aged 15 +/- 1.8 years...
  85. Almarza A, Augustine S, Woo S. Changes in gene expression of matrix constituents with respect to passage of ligament and tendon fibroblasts. Ann Biomed Eng. 2008;36:1927-33 pubmed publisher
    ..Collagen Type III, Fibronectin, Metalloprotease-13 [MMP-13], and Tissue Inhibitor of Metallopreotease-1 [TIMP-1]) were quantitatively assessed...
  86. Bertrand Philippe M, Ruddell R, Arthur M, Thomas J, Mungalsingh N, Mann D. Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2. J Biol Chem. 2004;279:24530-9 pubmed
    b>Tissue inhibitor of metalloproteinase 1 (TIMP1) is a contributory factor to fibrosis of a variety of organs including the liver...
  87. Zhou X, Wen G, Zhao Y, Liu Y, Li J. Inhibitory effects of alkaline extract of Citrus reticulata on pulmonary fibrosis. J Ethnopharmacol. 2013;146:372-8 pubmed publisher
    ..as mRNA and protein expressions of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and tumor necrosis factor-? (TNF-?) in rat lung tissues were analyzed...
  88. Cheng Y, Kuo W, Wu H, Lai T, Wu C, Hwang J, et al. ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells. Mol Cell Biochem. 2009;325:69-77 pubmed publisher
    ..ZAK over-expression in H9c2 cardiomyoblast cells increases the metalloproteinase tissue inhibitor 1/2 (TIMP-1/2) protein level, which reduces matria metalloproteinase-9 (MMP-9) activity and also activates c-JNK N-terminal ..