Gene Symbol: Timm50
Description: translocase of inner mitochondrial membrane 50
Alias: mitochondrial import inner membrane translocase subunit TIM50, translocase of inner mitochondrial membrane 50 homolog
Species: rat
Products:     Timm50

Top Publications

  1. Guo Y, Cheong N, Zhang Z, De Rose R, Deng Y, Farber S, et al. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. J Biol Chem. 2004;279:24813-25 pubmed
    ..Thus Tim50 is important for both mitochondrial function and early neuronal development. ..
  2. Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
    ..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..
  3. Xu H, Somers Z, Robinson M, Hebert M. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. BMC Cell Biol. 2005;6:29 pubmed
    ..Tim50a may play a role in snRNP biogenesis given its cellular localization and protein interaction characteristics. We hypothesize that Tim50a takes part in the release of snRNPs and SMN from the CB. ..
  4. Wenz L, OpaliÅ„ski Å, Wiedemann N, Becker T. Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 2015;1853:1119-29 pubmed publisher
    ..Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis. ..