Gene Symbol: Timm44
Description: translocase of inner mitochondrial membrane 44
Alias: mitochondrial import inner membrane translocase subunit TIM44, translocator of inner mitochondrial membrane 44
Bauer M, Gempel K, Reichert A, Rappold G, Lichtner P, Gerbitz K, et al
. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol. 1999;289:69-82 pubmed
..Both TIM complexes display a native molecular mass of 110 kDa. We suggest that the structural organization of TIM23.17 preprotein translocases is conserved from low to high eukaryotes. ..
Ishihara N, Mihara K. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. J Biochem. 1998;123:722-32 pubmed
..These assays thus demonstrated the 18.1, 21.9, and 45 kDa proteins to be the translocator components of the rat mitochondrial inner membrane and, therefore, the functional homologues of Tim17, Tim23, and Tim44, respectively. ..
Matsuoka T, Wada J, Hashimoto I, Zhang Y, Eguchi J, Ogawa N, et al
. Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats. Diabetes. 2005;54:2882-90 pubmed
..Tim44 and its related molecules in mitochondrial import machinery complex are novel targets in the therapeutic interventions for diabetes and its vascular complications. ..
Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
..Together, we propose a model showing how Magmas:DnaJC19 subcomplex is associated with TIM23 complex and thus regulates mitochondrial import process. ..
Colavecchia M, Christie L, Kanwar Y, Hood D. Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway. Am J Physiol Endocrinol Metab. 2003;284:E29-35 pubmed
..Finally, mtHsp70 may play a regulatory role in the import process that is independent of its interaction with Tim44. ..
Zhong Q, Kowluru R. Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Invest Ophthalmol Vis Sci. 2011;52:8739-46 pubmed publisher
..PCR confirmed alternations in the gene expressions of fusion (Mfn2), carrier (Timm44 and Slc25a21), Akt1, and fission proteins (Dnm1l)...
Santos J, Kowluru R. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes Metab Res Rev. 2013;29:204-13 pubmed publisher
..Strategies targeting mitochondrial membrane transport proteins could have the potential of improving mitochondrial biogenesis and slowing or halting the progression of diabetic retinopathy. ..
Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..