Timm23

Summary

Gene Symbol: Timm23
Description: translocase of inner mitochondrial membrane 23
Alias: mitochondrial import inner membrane translocase subunit Tim23, translocase of inner mitochondrial membrane 23 homolog
Species: rat

Top Publications

  1. Bauer M, Gempel K, Reichert A, Rappold G, Lichtner P, Gerbitz K, et al. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol. 1999;289:69-82 pubmed
    ..Both TIM complexes display a native molecular mass of 110 kDa. We suggest that the structural organization of TIM23.17 preprotein translocases is conserved from low to high eukaryotes. ..
  2. Guo Y, Cheong N, Zhang Z, De Rose R, Deng Y, Farber S, et al. Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. J Biol Chem. 2004;279:24813-25 pubmed
    ..Thus Tim50 is important for both mitochondrial function and early neuronal development. ..
  3. Karbowski M, Norris K, Cleland M, Jeong S, Youle R. Role of Bax and Bak in mitochondrial morphogenesis. Nature. 2006;443:658-62 pubmed
    ..Our results show that Bax and Bak regulate mitochondrial dynamics in healthy cells and indicate that Bcl-2 family members may also regulate apoptosis through organelle morphogenesis machineries. ..
  4. Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
    ..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..
  5. Wenz L, OpaliÅ„ski Å, Wiedemann N, Becker T. Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 2015;1853:1119-29 pubmed publisher
    ..Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis. ..
  6. Guarani V, McNeill E, Paulo J, Huttlin E, Fröhlich F, Gygi S, et al. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. elife. 2015;4: pubmed publisher
    ..Collectively, our work uncovers a previously unrecognized subunit of the MICOS complex, necessary for CJ integrity, cristae morphology, and mitochondrial function and provides a resource for further analysis of MICOS architecture. ..
  7. Ishihara N, Mihara K. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. J Biochem. 1998;123:722-32 pubmed
    ..These assays thus demonstrated the 18.1, 21.9, and 45 kDa proteins to be the translocator components of the rat mitochondrial inner membrane and, therefore, the functional homologues of Tim17, Tim23, and Tim44, respectively. ..
  8. Ishihara N, Komiya T, Sakaguchi M, Ito A, Mihara K. Characterization of the initial steps of precursor import into rat liver mitoplasts. J Biochem. 1998;124:824-34 pubmed
    ..These results suggest that the precursor is first targeted to the inner membrane component DeltaPsi-dependently, then transferred to the Tim system consisting of Tim23-Tim17, and finally imported into the matrix. ..
  9. Colavecchia M, Christie L, Kanwar Y, Hood D. Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway. Am J Physiol Endocrinol Metab. 2003;284:E29-35 pubmed
    ..Finally, mtHsp70 may play a regulatory role in the import process that is independent of its interaction with Tim44. ..

More Information

Publications11

  1. Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
    ..Together, we propose a model showing how Magmas:DnaJC19 subcomplex is associated with TIM23 complex and thus regulates mitochondrial import process. ..
  2. Singh K, Hood D. Effect of denervation-induced muscle disuse on mitochondrial protein import. Am J Physiol Cell Physiol. 2011;300:C138-45 pubmed publisher
    ..e., increased ROS production and decreased respiration) during chronic disuse, which likely contribute to the activation of degradative pathways leading to muscle atrophy. ..