Timm22

Summary

Gene Symbol: Timm22
Description: translocase of inner mitochondrial membrane 22
Alias: mitochondrial import inner membrane translocase subunit Tim22, translocase of inner mitochondrial membrane 22 homolog
Species: rat
Products:     Timm22

Top Publications

  1. Bauer M, Rothbauer U, Mühlenbein N, Smith R, Gerbitz K, Neupert W, et al. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett. 1999;464:41-7 pubmed
    ..We report the identification, chromosomal localization and expressional analysis of six human family members which represent further candidate genes for neurodegenerative diseases. ..
  2. Mühlenbein N, Hofmann S, Rothbauer U, Bauer M. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. J Biol Chem. 2004;279:13540-6 pubmed
    ..We conclude that different mechanisms and specific requirements for import and insertion of mammalian carrier preproteins have evolved in higher eukaryotes. ..
  3. Neupert W, Herrmann J. Translocation of proteins into mitochondria. Annu Rev Biochem. 2007;76:723-49 pubmed
    ..This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research. ..
  4. Callegari S, Richter F, Chojnacka K, Jans D, Lorenzi I, Pacheu Grau D, et al. TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett. 2016;590:4147-4158 pubmed publisher
    ..Our analyses demonstrate that TIM29 is required for the structural integrity of the TIM22 complex and for import of substrate proteins by the carrier translocase. ..
  5. Vukotic M, Nolte H, König T, Saita S, Ananjew M, Kruger M, et al. Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria. Mol Cell. 2017;67:471-483.e7 pubmed publisher
    ..AGK assembles with TIMM22 and TIMM29 and supports the import of a subset of multi-spanning membrane proteins...
  6. Kang Y, Stroud D, Baker M, De Souza D, Frazier A, Liem M, et al. Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex. Mol Cell. 2017;67:457-470.e5 pubmed publisher
    ..Our identification of AGK as a bona fide subunit of TIM22 provides an exciting and unexpected link between mitochondrial protein import and Sengers syndrome. ..