Gene Symbol: Timm17a
Description: translocase of inner mitochondrial membrane 17A
Alias: Tim17, Timm17, mitochondrial import inner membrane translocase subunit Tim17-A, inner membrane preprotein translocase Tim17a, translocase of inner mitochondrial membrane 17 homolog A, translocator of inner mitochondrial membrane 17 kDa, a, translocator of inner mitochondrial membrane 17a
Bauer M, Gempel K, Reichert A, Rappold G, Lichtner P, Gerbitz K, et al
. Genetic and structural characterization of the human mitochondrial inner membrane translocase. J Mol Biol. 1999;289:69-82 pubmed
..yeast Saccharomyces cerevisiae, translocation of preproteins into the matrix requires the membrane proteins Tim23, Tim17 and Tim44, which drive translocation in cooperation with mtHsp70 and its co-chaperone Mge1p...
Ishihara N, Komiya T, Sakaguchi M, Ito A, Mihara K. Characterization of the initial steps of precursor import into rat liver mitoplasts. J Biochem. 1998;124:824-34 pubmed
..precursor-import steps: DeltaPsi-dependent initial binding of the precursor, precursor transfer to the Tim23-Tim17 stage, DeltaPsi-dependent translocation of the presequence across the inner membrane, and the complete ..
Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..
Ishihara N, Mihara K. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. J Biochem. 1998;123:722-32 pubmed
..a significant structural homology to the components of the translocase of the yeast mitochondrial inner membrane, Tim17, Tim23, and Tim44. The 18.1 and 21...
Hinojos C, Boerwinkle E, Fornage M, Doris P. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hypertension. 2005;45:698-704 pubmed
..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression. ..
Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
..Together, we propose a model showing how Magmas:DnaJC19 subcomplex is associated with TIM23 complex and thus regulates mitochondrial import process. ..
Wenz L, OpaliÅ„ski Å, Wiedemann N, Becker T. Cooperation of protein machineries in mitochondrial protein sorting. Biochim Biophys Acta. 2015;1853:1119-29 pubmed publisher
..Therefore, we propose that the protein transport systems are part of a complicated protein network for mitochondrial biogenesis. ..