Gene Symbol: Thoc2
Description: THO complex 2
Alias: RGD1561623, THO complex subunit 2
Cheng H, Dufu K, Lee C, Hsu J, Dias A, Reed R. Human mRNA export machinery recruited to the 5' end of mRNA. Cell. 2006;127:1389-400 pubmed
..As a consequence, the mRNA would be exported in a 5' to 3' direction through the nuclear pore, as observed in early electron micrographs of giant Balbiani ring mRNPs. ..
Katahira J. mRNA export and the TREX complex. Biochim Biophys Acta. 2012;1819:507-13 pubmed publisher
..This review describes the functional roles of the TREX complex in gene expression and the nuclear export of mRNAs. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing. ..
Guo S, Hakimi M, Baillat D, Chen X, Farber M, Klein Szanto A, et al
. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res. 2005;65:3011-6 pubmed
..These results not only identify hTREX84 as a prognosticator of breast cancer but also delineate human TREX complex as a target for therapeutic drugs against breast cancer. ..
Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
..Together, these data provide the first direct evidence that the complete hTREX complex is essential for the export of KSHV intronless mRNAs and infectious virus production. ..
Folco E, Lee C, Dufu K, Yamazaki T, Reed R. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PLoS ONE. 2012;7:e43804 pubmed publisher
..We now show that this is also the case for PDIP3 and ZC11A. Thus, together with previous work, our data indicate that the TREX complex participates in multiple ATP-dependent interactions. ..
Di Gregorio E, Bianchi F, Schiavi A, Chiotto A, Rolando M, Verdun di Cantogno L, et al
. A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. J Med Genet. 2013;50:543-51 pubmed publisher
..3 is translocated 2 kb upstream of the THO complex subunit 2 (THOC2) gene on chromosome Xq25...
Wang L, Miao Y, Zheng X, Lackford B, Zhou B, Han L, et al
. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell. 2013;13:676-90 pubmed publisher
Kumar R, Corbett M, van Bon B, Woenig J, Weir L, Douglas E, et al
. THOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual Disability. Am J Hum Genet. 2015;97:302-10 pubmed publisher
..Here, we report that variants in THOC2, which encodes a subunit of the highly conserved TREX mRNA-export complex, cause syndromic intellectual disability ..