Gene Symbol: Tgfbi
Description: transforming growth factor, beta induced
Alias: BIGH3, Big-h3, transforming growth factor-beta-induced protein ig-h3, transforming growth factor, beta induced, 68 kDa
Species: rat
Products:     Tgfbi

Top Publications

  1. Munier F, Korvatska E, Djemai A, Le Paslier D, Zografos L, Pescia G, et al. Kerato-epithelin mutations in four 5q31-linked corneal dystrophies. Nat Genet. 1997;15:247-51 pubmed
    ..Our data establish a common molecular origin for the 5q31-linked corneal dystrophies. ..
  2. Lee S, Bae J, Park S, Lee B, Park R, Choi J, et al. Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose. Kidney Int. 2003;64:1012-21 pubmed
    ..betaig-h3 may be important in the development of diabetic nephropathy. Furthermore, the level of urinary betaig-h3 may be useful as an early marker reflecting disease onset and progression. ..
  3. Sun B, Li C, Lim S, Jung J, Lee S, Kim I, et al. Expression of transforming growth factor-beta-inducible gene-h3 in normal and cyclosporine-treated rat kidney. J Lab Clin Med. 2004;143:175-83 pubmed
    ..746, P =.05). Our observations indicate that an increase in betaig-h3 expression, along with TGF-beta1 up-regulation, is closely associated with tubulointerstitial fibrosis in a rat model of chronic CsA nephropathy. ..
  4. Li C, Lim S, Choi B, Lee S, Cha J, Kim I, et al. Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy. Am J Nephrol. 2005;25:611-20 pubmed
    ..Pravastatin thus effectively abrogated the upregulation of betaig-h3 gene expression and associated TGF-beta1 production, and this was associated with attenuated TIF in this model of chronic CsA-induced nephropathy. ..
  5. Ohno S, Tanaka N, Ueki M, Honda K, Tanimoto K, Yoneno K, et al. Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-beta. Connect Tissue Res. 2005;46:227-34 pubmed
    ..These results suggest that mechanical strain negatively regulates the terminal differentiation of chondrocytes through the signal pathway of TGF-ss with the induction of RGD-CAP. ..
  6. Ferguson J, Thoma B, Mikesh M, Kramer R, Bennett K, Purchio A, et al. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003;313:93-105 pubmed
  7. Chitra P, Swathi T, Sahay R, Reddy G, Menon R, Kumar P. Growth Hormone Induces Transforming Growth Factor-Beta-Induced Protein in Podocytes: Implications for Podocyte Depletion and Proteinuria. J Cell Biochem. 2015;116:1947-56 pubmed publisher
    ..Therefore, we conclude that the GH-dependent increase in TGFBIp in the podocyte is one of the mechanisms responsible for podocyte depletion in DN. ..
  8. Aitkenhead M, Wang S, Nakatsu M, Mestas J, Heard C, Hughes C. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res. 2002;63:159-71 pubmed
    ..These data expand the suite of genes implicated in vascular remodeling and angiogenesis. ..
  9. Hilliard L, Russo L, Comper W. Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart. Am J Nephrol. 2009;29:454-64 pubmed publisher
    ..These findings implicate for the first time betaig-h3 expression and lysosomal activity as a key factor in the induction of albuminuria and cardiovascular disease associated with hypertension. ..

More Information


  1. Ferguson J, Mikesh M, Wheeler E, LeBaron R. Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein. Mech Dev. 2003;120:851-64 pubmed
    ..Taken together, the results indicate that Beta-ig is expressed principally in collagen-rich tissues where it may interact with cells and ECM molecules, perhaps playing a role in tissue morphogenesis. ..
  2. Sciandra F, Morlacchi S, Allamand V, De Benedetti G, Macchia G, Petrucci T, et al. First molecular characterization and immunolocalization of keratoepithelin in adult human skeletal muscle. Matrix Biol. 2008;27:360-70 pubmed publisher
  3. Kim B, Olzmann J, Choi S, Ahn S, Kim T, Cho H, et al. Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome. J Biol Chem. 2009;284:19580-91 pubmed publisher
    ..The 5q31-linked corneal dystrophies are commonly caused by mutations in the TGFBI (transforming growth factor-beta-induced) gene...