Gene Symbol: Tfrc
Description: transferrin receptor
Alias: Trfr, transferrin receptor protein 1, tfR, tfR1
Species: rat
Products:     Tfrc

Top Publications

  1. Roberts K, Griswold M. Characterization of rat transferrin receptor cDNA: the regulation of transferrin receptor mRNA in testes and in Sertoli cells in culture. Mol Endocrinol. 1990;4:531-42 pubmed
  2. Sheikh N, Dudas J, Ramadori G. Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat. Lab Invest. 2007;87:713-25 pubmed
    ..An upregulation of transferrin, transferrin receptor 1 (TfR1), TfR2, ferritin-H, iron responsive element binding protein-1 (IRP1), IRP2 and divalent metal transporter gene ..
  3. Levy J, Jin O, Fujiwara Y, Kuo F, Andrews N. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999;21:396-9 pubmed
    ..Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo receptor-mediated endocytosis into specialized endosomes...
  4. Geminard C, de Gassart A, Blanc L, Vidal M. Degradation of AP2 during reticulocyte maturation enhances binding of hsc70 and Alix to a common site on TFR for sorting into exosomes. Traffic. 2004;5:181-93 pubmed
    ..The transferrin receptor (TfR) is completely lost from the red cell surface by its segregation in the secreted vesicles where it interacts with ..
  5. Aleo Luján E, Gil López C, González Fernández F, Villegas Martínez A, Valverde Moreno F. [Serum transferrin receptor in healthy children. Diagnostic yield in ferropenic and infectious anemia]. An Pediatr (Barc). 2004;60:428-35 pubmed
    The serum transferrin receptor (TfR) presents certain advantages over other parameters of cellular iron status because it does not vary in acute or chronic diseases...
  6. Schalinske K, Blemings K, Steffen D, Chen O, Eisenstein R. Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line. Proc Natl Acad Sci U S A. 1997;94:10681-6 pubmed iron responsive element(s) (IREs) in the 5' or 3' untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Two IRPs, IRP1 and IRP2, have been identified previously...
  7. Cornock R, Gambling L, Langley Evans S, McArdle H, McMullen S. The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat. Reprod Biol Endocrinol. 2013;11:32 pubmed publisher
  8. Garcia S, Gellein K, Syversen T, Aschner M. Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol Sci. 2007;95:205-14 pubmed
    ..The results of this study confirm that there is homeostatic relationship among several essential metals in the brain and not simply between Fe and Mn. ..
  9. Hofer T, Marzetti E, Xu J, Seo A, Gulec S, Knutson M, et al. Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Exp Gerontol. 2008;43:563-70 pubmed publisher
    ..These results suggest that RNA oxidation, possibly mediated by increased non-heme iron, might contribute to muscle atrophy due to disuse particularly in aged muscle...

More Information


  1. Daniels Wells T, Widney D, Leoh L, Martínez Maza O, Penichet M. Efficacy of an Anti-transferrin Receptor 1 Antibody Against AIDS-related Non-Hodgkin Lymphoma: A Brief Communication. J Immunother. 2015;38:307-10 pubmed publisher
    The transferrin receptor 1 (TfR1), also known as CD71, is a target for antibody-based cancer immunotherapy due to its high expression on the surface of cancer cells and its ability to internalize...
  2. Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
  3. Weizer Stern O, Adamsky K, Amariglio N, Rachmilewitz E, Breda L, Rivella S, et al. mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. Am J Hematol. 2006;81:479-83 pubmed
    ..We found decreased expression of hepcidin and TfR2 and increased expression of TfR1 and NGAL in the beta-thalassemia mouse models, compared with the control mice...
  4. Ishii K, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, et al. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med. 2009;15:259-66 pubmed publisher
    ..Owing to the heightened iron demand in osteoclast development, transferrin receptor 1 (TfR1) expression was induced post-transcriptionally via iron regulatory protein 2...
  5. Geminard C, Nault F, Johnstone R, Vidal M. Characteristics of the interaction between Hsc70 and the transferrin receptor in exosomes released during reticulocyte maturation. J Biol Chem. 2001;276:9910-6 pubmed
    The transferrin receptor (TfR) of reticulocytes is released in vesicular form (exosomes) during their maturation to erythrocytes...
  6. Kolachala V, Sesikeran B, Nair K. Evidence for a sequential transfer of iron amongst ferritin, transferrin and transferrin receptor during duodenal absorption of iron in rat and human. World J Gastroenterol. 2007;13:1042-52 pubmed
    ..It is concluded that the intestine takes up iron through a sequential transfer involving interaction of luminal transferrin, transferrin-transferrin receptor and ferritin. ..
  7. Bridle K, Crawford D, Ramm G. Identification and characterization of the hepatic stellate cell transferrin receptor. Am J Pathol. 2003;162:1661-7 pubmed
    ..This suggests that transferrin may be an important factor in the activation of hepatic stellate cells in conditions of iron overload. ..
  8. Mortensen M, Ferguson D, Edelmann M, Kessler B, Morten K, Komatsu M, et al. Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A. 2010;107:832-7 pubmed publisher
    ..In summary, we show that the selective removal of mitochondria by autophagy, but not other organelles, during erythropoeisis is essential and that this is a necessary developmental step in erythroid cells...
  9. Zhang D, Senecal T, Ghosh M, Ollivierre Wilson H, Tu T, Rouault T. Hepcidin regulates ferroportin expression and intracellular iron homeostasis of erythroblasts. Blood. 2011;118:2868-77 pubmed publisher
    ..Our results may explain why iron deficiency anemia is the most pronounced early manifestation of mammalian iron deficiency...
  10. Högemann Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, et al. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003;5:495-506 pubmed
    ..Because overexpression of endogenous transferrin receptor (TfR) has been qualitatively described for various cancers and is presumably due to malignant transformation of cells, ..
  11. Wang K, Wang C, Liu B, Jiang S. [Effect of copper deficiency on iron metabolism in rats]. Wei Sheng Yan Jiu. 2010;39:426-9 pubmed
  12. Tacchini L, Fusar Poli D, Bernelli Zazzera A, Cairo G. Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion. Hepatology. 2002;36:103-11 pubmed
    ..The aim of the present study was to address the regulation of transferrin receptor (TfR), which mediates cellular iron uptake, during I/R...
  13. Sergent Tanguy S, Veziers J, Bonnamain V, Boudin H, Neveu I, Naveilhan P. Cell surface antigens on rat neural progenitors and characterization of the CD3 (+)/CD3 (-) cell populations. Differentiation. 2006;74:530-41 pubmed
    ..The results reveal particular surface antigen profiles, giving new perspectives on the properties of rat brain-derived cells. ..
  14. Widera A, Beloussow K, Kim K, Crandall E, Shen W. Phenotype-dependent synthesis of transferrin receptor in rat alveolar epithelial cell monolayers. Cell Tissue Res. 2003;312:313-8 pubmed
    ..These data suggest that alveolar type II (but not type I) cells express functional transferrin receptor in adult rat alveolar epithelium. ..
  15. Du F, Qian Z, Luo Q, Yung W, Ke Y. Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats. Mol Neurobiol. 2015;52:101-14 pubmed publisher
    ..across the brain-blood barrier, iron uptake and release, and also the expression of transferrin receptor-1 (TfR1), divalent metal transporter 1 (DMT1), and ferroportin 1 (Fpn1) in cultured microvascular endothelial cells and ..
  16. Zhao Y, Feresin R, Falcon Perez J, Salazar G. Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity. Traffic. 2016;17:267-88 pubmed publisher
    ..We propose that ZnT10 plays a role in signal transduction, which is mediated by homo and heterodimerization with other ZnTs. ..
  17. Liu C, Liu Y, Zeng L, Zhang S, Xu H. [The expression of TfR1 mRNA and IRP1 mRNA in the placenta from different maternal iron status]. Zhonghua Xue Ye Xue Za Zhi. 2007;28:255-8 pubmed
    To investigate the mRNA expression of transferrin receptor 1 (TfR1) and iron regulatory protein 1 (IRP1) in the full-term placenta from different maternal iron status, and explore the mechanism of placental iron transport and regulation...
  18. Baynes R, Shih Y, Hudson B, Cook J. Characterization of transferrin receptor released by K562 erythroleukemia cells. Proc Soc Exp Biol Med. 1991;197:416-23 pubmed
    ..The remaining three were not identifiable. K562 cells provide a useful in vitro model for studying the production of membrane-bound and soluble forms of released transferrin receptor. ..
  19. Du G, Huang P, Liang B, Frohman M. Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell. 2004;15:1024-30 pubmed
  20. Orsi A, Razi M, Dooley H, Robinson D, Weston A, Collinson L, et al. Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy. Mol Biol Cell. 2012;23:1860-73 pubmed publisher
  21. Ma L, Wang W, Zhao M, Li M. Foot-shock stress-induced regional iron accumulation and altered iron homeostatic mechanisms in rat brain. Biol Trace Elem Res. 2008;126:204-13 pubmed publisher
    ..Expression of ferritin, Transferrin receptor (TfR), divalent metal transporter 1 (DMT1, with or without iron-responsive element), lactoferrin (Lf), and iron ..
  22. Chirasani S, Markovic D, Synowitz M, Eichler S, Wisniewski P, Kaminska B, et al. Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells. J Mol Med (Berl). 2009;87:153-67 pubmed publisher
    Transferrin receptors (TfR) are overexpressed in brain tumors, but the pathological relevance has not been fully explored...
  23. Shabtai M, Ye H, Frischer Z, Martin J, Waltzer W, Malinowski K. Increased expression of activation markers in renal cell carcinoma infiltrating lymphocytes. J Urol. 2002;168:2216-9 pubmed
    ..These factors may be particularly valuable for the further study of renal cell carcinoma-host interactivity. ..
  24. Bhattacharyya S, Warfield K, Ruthel G, Bavari S, Aman M, Hope T. Ebola virus uses clathrin-mediated endocytosis as an entry pathway. Virology. 2010;401:18-28 pubmed publisher
    ..Furthermore, since chlorpromazine inhibits EBOV infection, novel therapeutic modalities could be designed based on this lead compound. ..
  25. Sirokmány G, Szidonya L, Káldi K, Gaborik Z, Ligeti E, Geiszt M. Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPases. J Biol Chem. 2006;281:6096-105 pubmed
    ..We suggest that p50RhoGAP provides a link between Rab and Rho GTPases in the regulation of receptor-mediated endocytosis. ..
  26. Verges M, Havel R, Mostov K. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Proc Natl Acad Sci U S A. 1999;96:10146-51 pubmed
  27. Abu Rizq H, Mansour M, Safer A, Afzal M. Cyto-protective and immunomodulating effect of Curcuma longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Inflammopharmacology. 2008;16:87-95 pubmed publisher
    ..Turmeric crude extract, at both low and high dose, was found to be more efficient as compared to purified curcumin. ..
  28. Khomenko T, Szabo S, Deng X, Ishikawa H, Anderson G, McLaren G. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1277-86 pubmed publisher
  29. Cao H, Schroeder B, Chen J, Schott M, McNiven M. The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase. J Biol Chem. 2016;291:16424-37 pubmed publisher
    Clathrin-mediated endocytosis of transferrin (Tf) and its cognate receptor (TfR1) is a central pathway supporting the uptake of trophic iron. It has generally been assumed that this is a constitutive process...
  30. Tian Y, Zhao J, Zhao B, Gao Q, Xu J, Liu D. The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise. Biol Trace Elem Res. 2012;147:261-6 pubmed publisher
    ..01 or P < 0.05). The training regime significantly increased TfR mRNA levels in the bone marrow cells of the exercised rats compared with the sedentary group (1.8 ± 0.5 vs. 1...
  31. Schonfeld E, Yasharel I, Yavin E, Brand A. Docosahexaenoic acid enhances iron uptake by modulating iron transporters and accelerates apoptotic death in PC12 cells. Neurochem Res. 2007;32:1673-84 pubmed
  32. Cheloufi S, Dos Santos C, Chong M, Hannon G. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010;465:584-9 pubmed publisher
    ..Our findings link the conservation of Argonaute catalysis to a conserved mechanism of microRNA biogenesis that is important for vertebrate development. ..
  33. Feder J, Penny D, Irrinki A, Lee V, Lebron J, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A. 1998;95:1472-7 pubmed
    ..HFE proteins that both the wild-type and H63D HFE proteins form stable complexes with the transferrin receptor (TfR). The C282Y mutation nearly completely prevents the association of the mutant HFE protein with the TfR...
  34. Mechtersheimer G, Kruger K, Born I, Moller P. Antigenic profile of mammary fibroadenoma and cystosarcoma phyllodes. A study using antibodies to estrogen- and progesterone receptors and to a panel of cell surface molecules. Pathol Res Pract. 1990;186:427-38 pubmed
  35. Zahn C, Kaup M, Fluhrer R, Fuchs H. The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b. FEBS J. 2013;280:1653-63 pubmed publisher
    ..Although shedding of the human transferrin receptor-1 (TfR1) has been known for > 30 years and soluble TfR1 is an accepted diagnostic marker, the fate of the remaining N-..
  36. Kennard M, Richardson D, Gabathuler R, Ponka P, Jefferies W. A novel iron uptake mechanism mediated by GPI-anchored human p97. EMBO J. 1995;14:4178-86 pubmed
    ..These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals. ..
  37. Kaur C, Sivakumar V, Ling E. Expression of tranferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment. Glia. 2007;55:263-73 pubmed
    Transferrin receptors (Tfrc) are membrane bound glycoproteins which function to mediate cellular uptake of iron from transferrin. We examined expression of Tfrc in the pineal gland of rats of different ages from 1 day to 12 weeks...
  38. Martin F, Xu X, von Löhneysen K, Gilmartin T, Friedman J. SOD2 deficient erythroid cells up-regulate transferrin receptor and down-regulate mitochondrial biogenesis and metabolism. PLoS ONE. 2011;6:e16894 pubmed publisher
    ..SA is primarily an acquired, clonal marrow disorder occurring in individuals over 60 years of age with uncertain etiology...
  39. Sun L, Hua Y, Vergarajauregui S, Diab H, Puertollano R. Novel Role of TRPML2 in the Regulation of the Innate Immune Response. J Immunol. 2015;195:4922-32 pubmed publisher
    ..Overall, our study reveals interesting differences in the regulation and distribution of the members of the TRPML family and identifies a novel role for TRPML2 in the innate immune response. ..
  40. Schroeder S, Reddy M, Schalinske K. Retinoic acid modulates hepatic iron homeostasis in rats by attenuating the RNA-binding activity of iron regulatory proteins. J Nutr. 2007;137:2686-90 pubmed
    ..Taken together, these results indicate that IRP represent a mechanistic link between vitamin A and the regulation of iron homeostasis, a key finding toward further understanding this important nutrient-nutrient interaction. ..
  41. Yang D, Wang F, Elliott R, Head J. Expression of transferrin receptor and ferritin H-chain mRNA are associated with clinical and histopathological prognostic indicators in breast cancer. Anticancer Res. 2001;21:541-9 pubmed
    ..Additionally, the quantitation of expression of transferrin receptor and ferritin heavy chain mRNA may be useful for assessing prognosis and guiding therapeutic decisions in breast cancer patients. ..
  42. Bai M, Gad H, Turacchio G, Cocucci E, Yang J, Li J, et al. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011;13:559-67 pubmed publisher
    ..The role of ARFGAP1 in AP-2-regulated endocytosis has mechanistic parallels with its roles in COPI transport, as both its GAP activity and coat function contribute to promoting AP-2 transport. ..
  43. Thomas C, Gaffney Stomberg E, Sun B, O Brien K, Kerstetter J, Insogna K. Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats. FASEB J. 2013;27:2476-83 pubmed publisher
    ..2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold...
  44. Yang D, Jiang X, Elliott R, Head J. Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene. Anticancer Res. 2001;21:1777-87 pubmed
    ..In this study, phosphorothioated antisense TfR oligonucleotides (TfR-ODna) targeted to the sequences of TfR mRNA including the AUG initiation codon and the ..
  45. Abraham J, Corbett K, Farzan M, Choe H, Harrison S. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010;17:438-44 pubmed publisher
    ..The GP1 subunit of the surface glycoprotein mediates cell attachment through transferrin receptor 1 (TfR1). We report the structure of Machupo virus (MACV) GP1 bound with human TfR1...
  46. Deane E, Ilie A, Sizdahkhani S, Das Gupta M, Orlowski J, McKinney R. Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation. J Neurosci. 2013;33:595-610 pubmed publisher
    ..These data suggest that NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory...
  47. Maas T, Eidenmüller J, Brandt R. Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem. 2000;275:15733-40 pubmed
  48. Hoepken H, Korten T, Robinson S, Dringen R. Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate. J Neurochem. 2004;88:1194-202 pubmed the cellular content of the iron storage protein ferritin and a decrease in the amount of transferrin receptor (TfR), which is involved in the transferrin-mediated uptake of iron into cells...
  49. Van Kanegan M, Strack S. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Mol Cell Biol. 2009;29:662-74 pubmed publisher
  50. Hehnly H, Doxsey S. Rab11 endosomes contribute to mitotic spindle organization and orientation. Dev Cell. 2014;28:497-507 pubmed publisher
    ..We propose that Rab11 and its associated endosomes cocontribute to these processes through retrograde transport to poles by dynein...
  51. Simovich M, Conrad M, Umbreit J, Moore E, Hainsworth L, Smith H. Cellular location of proteins related to iron absorption and transport. Am J Hematol. 2002;69:164-70 pubmed
    ..This suggests that there may be intracellular roles for these proteins in addition to their serving to transit iron across the cell surface membrane. ..
  52. Zhu B, McLaughlin S, Na R, Liu J, Cui Y, Martin C, et al. Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. Blood. 2008;112:2071-80 pubmed publisher transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocytes and reduced Tfr1 expression is associated with anemia...
  53. Fitzgerald D, Bjorn M, Ferris R, Winkelhake J, Frankel A, Hamilton T, et al. Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer. Cancer Res. 1987;47:1407-10 pubmed
    ..The injection of 30 micrograms of an irrelevant immunotoxin, MOPC21-RTA, or 30 to 500 micrograms of the 454A12 antibody had no antitumor activity. ..
  54. Waheed A, Britton R, Grubb J, Sly W, Fleming R. HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron. Arch Biochem Biophys. 2008;474:193-7 pubmed publisher
    ..These observations indicate that HFE influences the functional properties of TfR2, and suggests a model in which the interaction of these proteins might influence signal transduction to hepcidin. ..
  55. Andersen H, Gambling L, Holtrop G, McArdle H. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Br J Nutr. 2007;97:239-46 pubmed
    ..The pattern closely mirrors that seen in Fe deficiency, suggesting that the changes are a consequence of the decrease in serum Fe, implying that the developing fetus not only suffers from Cu, but also from Fe deficiency. ..
  56. Kim B, Wang F, Dufner Beattie J, Andrews G, Eide D, Petris M. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem. 2004;279:4523-30 pubmed
    ..These findings suggest that zinc-regulated trafficking of human and mouse ZIP4 is a key mechanism controlling dietary zinc absorption and cellular zinc homeostasis. ..
  57. Ohgami R, Campagna D, Greer E, Antiochos B, McDonald A, Chen J, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet. 2005;37:1264-9 pubmed
    ..Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells. ..
  58. Bogan J, Lodish H. Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4. J Cell Biol. 1999;146:609-20 pubmed
  59. Dumitriu B, Bhattaram P, Dy P, Huang Y, Quayum N, Jensen J, et al. Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions. PLoS ONE. 2010;5:e12088 pubmed publisher
    ..It is primarily involved in enhancing the survival rate and maturation process of erythroid cells and acts at least in part by upregulating Bcl2l1. ..
  60. Blanc L, Liu J, Vidal M, Chasis J, An X, Mohandas N. The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. Blood. 2009;114:3928-34 pubmed publisher
    ..These results lead us to suggest that AQP-1 sorting into exosomes may be the mechanism by which the reticulocyte adapts to environmental changes during its maturation...
  61. Kudoh S, Stanley J, Edinger M, Tubbs R, Klein E, Bukowski R, et al. T lymphocytes infiltrating renal cell carcinoma have a reduced expression of transferrin receptor. Int J Cancer. 1994;58:369-75 pubmed
    ..Here we report that T-TIL from patients with renal cell carcinoma (RCC) also have a defect in transferrin receptor (TfR) expression that is not present in T-PBL cells...
  62. Kuvibidila S, Gauthier T, Warrier R, Rayford W. Increased levels of serum transferrin receptor and serum transferrin receptor/log ferritin ratios in men with prostate cancer and the implications for body-iron stores. J Lab Clin Med. 2004;144:176-82 pubmed
    ..422, P < .05) but did not correlate with tissue inflammation, tumor stage, or acute-phase proteins. It appears that prostate cancer is not associated with increased body-iron stores. ..
  63. Turturro S, Shen X, Shyam R, YUE B, Ying H. Effects of mutations and deletions in the human optineurin gene. Springerplus. 2014;3:99 pubmed publisher
    ..Examination of mutants and deletion fragments located at various sites of optineurin gene provide clues as to what regions of the gene may play a critical role in the development of pathologic consequences. ..
  64. Taylor D, Watt N, Perera W, Hooper N. Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J Cell Sci. 2005;118:5141-53 pubmed
    ..In addition, we have been able to assign distinct functions in the endocytic process to separate regions of the protein. ..
  65. Chen C, Garcia Santos D, Ishikawa Y, Seguin A, Li L, Fegan K, et al. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013;17:343-52 pubmed publisher
    ..Here we report that sorting nexin 3 (Snx3) facilitates the recycling of transferrin receptor (Tfrc) and thus is required for the proper delivery of iron to erythroid progenitors...
  66. Bogan J, Hendon N, McKee A, Tsao T, Lodish H. Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature. 2003;425:727-33 pubmed
    ..Our data suggest that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether. ..
  67. Meli R, Mattace Raso G, Irace C, Simeoli R, Di Pascale A, Paciello O, et al. High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats. PLoS ONE. 2013;8:e66570 pubmed publisher
    ..activity of iron regulatory protein 1 (IRP1) was evidenced, associated with the increase in transferrin receptor-1 (TfR1) expression and ferritin down-regulation...
  68. Shang T, Kotamraju S, Kalivendi S, Hillard C, Kalyanaraman B. 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. J Biol Chem. 2004;279:19099-112 pubmed
    ..This, in turn, stimulated transferrin receptor (TfR)-dependent iron signaling via activation of the iron-regulatory protein/iron-responsive element interaction...
  69. Barisani D, Parafioriti A, Bardella M, Zoller H, Conte D, Armiraglio E, et al. Adaptive changes of duodenal iron transport proteins in celiac disease. Physiol Genomics. 2004;17:316-25 pubmed
    ..transporter 1 (DMT1), duodenal cytochrome b (Dcytb), ferroportin 1 (FP1), hephaestin, and transferrin receptor 1 (TfR1) expression, as well as iron regulatory protein (IRP) activity in duodenal biopsies from control, anemic, and CD ..
  70. Han J, Day J, Connor J, Beard J. Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr Neurosci. 2003;6:1-10 pubmed
    The mechanism of the regulation of transferrin (Tf) and transferrin receptor (TfR) levels in rat brain by dietary iron status is not fully elucidated...
  71. Lelliott P, McMorran B, Foote S, Burgio G. Erythrocytic Iron Deficiency Enhances Susceptibility to Plasmodium chabaudi Infection in Mice Carrying a Missense Mutation in Transferrin Receptor 1. Infect Immun. 2015;83:4322-34 pubmed publisher
    ..This line carries a missense mutation in the gene for transferrin receptor 1 (TFR1)...