Gene Symbol: Tff3
Description: trefoil factor 3
Alias: ITF, trefoil factor 3, intestinal trefoil factor, polypeptide P1.B, trefoil factor 3, intestinal
Species: rat
Products:     Tff3

Top Publications

  1. Suemori S, Lynch Devaney K, Podolsky D. Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family. Proc Natl Acad Sci U S A. 1991;88:11017-21 pubmed
    ..raised using a synthetic peptide based on the predicted C-terminal sequence of this protein, designated intestinal trefoil factor, demonstrated that it is primarily expressed and secreted onto the intestinal surface by goblet cells, ..
  2. Fernandez Estivariz C, Gu L, Gu L, Jonas C, Wallace T, Pascal R, et al. Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Am J Physiol Regul Integr Comp Physiol. 2003;284:R564-73 pubmed
    The trefoil factor family peptides TFF1, TFF2, and TFF3 are important for gut mucosal protection and restitution...
  3. Fueger P, Schisler J, Lu D, Babu D, Mirmira R, Newgard C, et al. Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function. Mol Endocrinol. 2008;22:1251-9 pubmed publisher
    ..In the current study, we demonstrate that overexpression of trefoil factor 3 (TFF3) in rat pancreatic islets results in a 4- to 5-fold increase in [(3)H]thymidine incorporation, with ..
  4. Feng Z, Fang D, Chen W, Wang R. Rodent IRR-219 (IgGFcgammaBP) and rTFF3, expressed mainly in the intestinal mucosa, depleted during dextran sulfate sodium-induced colitis. Dig Dis Sci. 2007;52:2104-12 pubmed
    IgGFcgammaBP and TFF3 are related with adaptation during injury, mucosal defense, and epithelial healing...
  5. Chinery R, Poulsom R, Rogers L, Jeffery R, Longcroft J, Hanby A, et al. Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ. Biochem J. 1992;285 ( Pt 1):5-8 pubmed
    A cDNA encoding rat intestinal trefoil factor (rITF) was prepared by reverse transcription and PCR amplification. The sequence obtained was well conserved with that of other trefoil peptides...
  6. Fu T, Stellmacher A, Znalesniak E, Dieterich D, Kalbacher H, Hoffmann W. Tff3 is expressed in neurons and microglial cells. Cell Physiol Biochem. 2014;34:1912-9 pubmed publisher
    The trefoil factor family (TFF) peptide TFF3 is typically secreted by mucous epithelia, but is also expressed in the immune system and the brain. It was the aim of this study to determine the cerebral cell types which express Tff3...
  7. Wu J, Zhang J, Xue G, Zhang H. Expression and localization of trefoil factor family genes in rat submandibular glands. Biotech Histochem. 2014;89:424-32 pubmed publisher
    The trefoil factor (TFF) family, which comprises TFF1, TFF2 and TFF3, plays an essential role in epithelial regeneration within the gastrointestinal tract...
  8. Yu H, He Y, Zhang X, Peng Z, Yang Y, Zhu R, et al. The rat IgGFc?BP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction. PLoS ONE. 2011;6:e20334 pubmed publisher
    ..Rat goblet cell-secreted TFF3, IgGFc?BP and Muc2, existing in the two intestinal mucus layers, are bound together by covalent interactions in the ..
  9. Fança Berthon P, Michel C, Pagniez A, Rival M, Van Seuningen I, Darmaun D, et al. Intrauterine growth restriction alters postnatal colonic barrier maturation in rats. Pediatr Res. 2009;66:47-52 pubmed publisher
    ..Mucins and trefoil factor family 3 (TFF3) actively contribute to epithelium protection and healing...

Scientific Experts

More Information


  1. Femia A, Tarquini E, Salvadori M, Ferri S, Giannini A, Dolara P, et al. K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine. Int J Cancer. 2008;122:117-23 pubmed
    ..The expression of the intestinal trefoil factor (ITF), a marker of goblet cell lineage, was reduced in MDF and tumors compared to normal mucosa but not ..
  2. Vestergaard E, Borre M, Poulsen S, Nexø E, Tørring N. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clin Cancer Res. 2006;12:807-12 pubmed
    Through cDNA array analyses and immunohistochemistry on tissue microarrays, trefoil factor 3 (TFF3) was recently shown to be overexpressed in prostate cancer...
  3. Van De Bovenkamp J, Korteland Van Male A, Büller H, Einerhand A, Dekker J. Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression. Hum Pathol. 2003;34:156-65 pubmed
    ..immunohistochemically of secretory mucins (MUC2, MUC5AC, MUC5B, and MUC6), trefoil peptides (TFF1, TFF2, and TFF3), and sucrase-isomaltase (SI). GMD, found in 37 patients, correlated positively to gastric H...
  4. Probst J, Skutella T, Müller Schmid A, Jirikowski G, Hoffmann W. Molecular and cellular analysis of rP1.B in the rat hypothalamus: in situ hybridization and immunohistochemistry of a new P-domain neuropeptide. Brain Res Mol Brain Res. 1995;33:269-76 pubmed
    ..B. The deduced polypeptide consists of a single P-domain and its amino acid sequence matches that of rat intestinal trefoil factor (rITF). Thus far, rP1.B is the only P-domain peptide expressed in neuronal cells of the CNS...
  5. Sands B, Ogata H, Lynch Devaney K, deBeaumont M, Ezzell R, Podolsky D. Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter. J Biol Chem. 1995;270:9353-61 pubmed
    b>Intestinal trefoil factor (ITF) is a small peptide bearing the unique motif of intrachain disulfide bonds characteristic of the trefoil family...
  6. Xu L, Li J, Sun M, Sun H. Expression of intestinal trefoil factor, proliferating cell nuclear antigen and histological changes in intestine of rats after intrauterine asphyxia. World J Gastroenterol. 2005;11:2291-5 pubmed
    To study the expressions of intestinal trefoil factor (ITF) and proliferating cell nuclear antigen (PCNA) and histologic changes in intestine, to investigate the relationship between ITF and intestinal damage and repair after ..
  7. Debata P, Panda H, Supakar P. Altered expression of trefoil factor 3 and cathepsin L gene in rat kidney during aging. Biogerontology. 2007;8:25-30 pubmed
    ..In this report we demonstrate that in aged kidney there is a decrease in the expression of trefoil factor 3 gene and an age-related increase in the expression of cathepsin L gene as revealed by differential display ..
  8. Jackerott M, Lee Y, Møllgård K, Kofod H, Jensen J, Rohleder S, et al. Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Endocrinology. 2006;147:5752-9 pubmed
    ..Immunocytochemical staining of adult human pancreas showed abundant TFF3 immunoreactivity in pancreatic islets and some duct cells, whereas weak TFF1 and no TFF2 staining were detected...
  9. Chan V, Chan M, Leung W, Leung P, Sung J, Chan F. Intestinal trefoil factor promotes invasion in non-tumorigenic Rat-2 fibroblast cell. Regul Pept. 2005;127:87-94 pubmed
    b>Intestinal trefoil factor (TFF3) is essential in regulating cell migration and maintaining mucosal integrity in gastrointestinal tract. We previously showed that TFF3 was overexpressed in gastric carcinoma...
  10. Shi L, Zhang B, Yu H, Yu J, Xi J. Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model. J Perinat Med. 2007;35:443-6 pubmed
    ..Among these factors, the intestinal trefoil factor (ITF) is known as cytoprotective to the gut...
  11. Park Y, Franklin J, Settle S, Levy S, Chung E, Jeyakumar L, et al. Gene expression profile analysis of mouse colon embryonic development. Genesis. 2005;41:1-12 pubmed
  12. Oh D, Demeester S, Dunst C, Mori R, Lehman B, Kuramochi H, et al. Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling. Surg Endosc. 2009;23:1346-52 pubmed publisher
    ..This validates this model for studying the pathogenesis of Barrett's esophagus. Use of this model has potential for assessment of the impact of various therapies on the natural history of reflux disease. ..
  13. Babyatsky M, Lin J, Yio X, Chen A, Zhang J, Zheng Y, et al. Trefoil factor-3 expression in human colon cancer liver metastasis. Clin Exp Metastasis. 2009;26:143-51 pubmed publisher
    Deaths from colorectal cancer are often due to liver metastasis. Trefoil factor-3 (TFF3) is expressed by normal intestinal epithelial cells and its expression is maintained throughout the colon adenoma-carcinoma sequence...
  14. Tan X, Hsueh W, Chang H, Wei K, Gonzalez Crussi F. Characterization of a putative receptor for intestinal trefoil factor in rat small intestine: identification by in situ binding and ligand blotting. Biochem Biophys Res Commun. 1997;237:673-7 pubmed
    b>Intestinal trefoil factor (ITF), a small peptide secreted by intestinal goblet cells, maintains mucosal integrity and promotes epithelial wound healing...
  15. Xue Y, Shen L, Cui Y, Zhang H, Chen Q, Cui A, et al. Tff3, as a novel peptide, regulates hepatic glucose metabolism. PLoS ONE. 2013;8:e75240 pubmed publisher
    ..The trefoil peptides are a family of small regulatory proteins and Tff3 is widely expressed in multiple tissues including liver...
  16. Poulsom R, Chinery R, Sarraf C, Lalani E, Stamp G, Elia G, et al. Trefoil peptide expression in intestinal adaptation and renewal. Scand J Gastroenterol Suppl. 1992;192:17-28 pubmed
    ..We have also cloned the newest trefoil peptide intestinal trefoil factor from human and rat intestinal mucosa and shown its co-expression with mucus by normal intestinal goblet ..
  17. Yio X, Zhang J, Babyatsky M, Chen A, Lin J, Fan Q, et al. Trefoil factor family-3 is associated with aggressive behavior of colon cancer cells. Clin Exp Metastasis. 2005;22:157-65 pubmed
    Trefoil factor family 3 (TFF3) is expressed by intestinal epithelial cells and it mainly functions to protect the mucosa from injury...