Gene Symbol: Tfdp2
Description: transcription factor Dp-2
Alias: Tcfdp2, transcription factor Dp-2, transcription factor Dp-2 (E2F dimerization partner 2)
Trimarchi J, Fairchild B, Verona R, Moberg K, Andon N, Lees J. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc Natl Acad Sci U S A. 1998;95:2850-5 pubmed
..Instead, it can act to repress the transcription of E2F responsive genes by countering the activity of the other E2F complexes via a pRB-, p107-, or p130-independent mechanism. ..
Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al
. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein. ..
Vara D, Bicknell K, Coxon C, Brooks G. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. J Biol Chem. 2003;278:21388-94 pubmed
..Thus, we have shown that the inhibition of E2F function prevents the development of hypertrophy. Targeting E2F function might be a useful approach for treating diseases that cause pathophysiological hypertrophic growth. ..
Rubin S, Gall A, Zheng N, Pavletich N. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell. 2005;123:1093-106 pubmed
..Our findings explain the requirement of RbC for high-affinity E2F binding and growth suppression and establish a mechanism for the regulation of Rb-E2F association by phosphorylation. ..
Zaragoza K, Begay V, Schuetz A, Heinemann U, Leutz A. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol. 2010;30:2293-304 pubmed publisher
..Our data suggest a tripartite balance between C/EBPalpha, E2F/DP, and pocket proteins in the control of proliferation, differentiation, and tumorigenesis. ..
Wu C, Zukerberg L, Ngwu C, Harlow E, Lees J. In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995;15:2536-46 pubmed
..However, the various E2F/DP complexes display strong differences in the ability to bind to either pRB or p107 in vivo, and the specificity of pRB or p107 binding is mediated by the E2F subunit. ..