Gene Symbol: Tfap2c
Description: transcription factor AP-2 gamma
Alias: AP2-gamma, Tcfap2c, transcription factor AP-2 gamma, activating enhancer binding protein 2 gamma, activator protein 2 gamma
Species: rat
Products:     Tfap2c

Top Publications

  1. Lim L, Fang L, Swendeman S, Sheffery M. Characterization of the molecularly cloned murine alpha-globin transcription factor CP2. J Biol Chem. 1993;268:18008-17 pubmed
    ..These results define the CP2 factor binding site in more detail and help characterize the activities of the factor in vivo. ..
  2. Li Q, Pan H, Guan L, Su D, Ma X. CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression. Biochem Biophys Res Commun. 2012;423:895-9 pubmed publisher
    ..we found that the G184S and S192G mutant decreased cooperation between CITED2 and transcription factor AP2-gamma (TFAP2C) in the transactivation of the PITX2C gene...
  3. Jäger R, Schäfer S, Hau Liersch M, Schorle H. Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Dev Dyn. 2010;239:1027-33 pubmed publisher
    ..Therefore, AP-2gamma is functionally involved in branching morphogenesis of the mammary epithelium, possibly by controlling genetic processes downstream of ovarian hormones. ..
  4. Weber S, Eckert D, Nettersheim D, Gillis A, Schäfer S, Kuckenberg P, et al. Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance. Biol Reprod. 2010;82:214-23 pubmed publisher
    ..Here we report on the expression pattern of the transcription factor Tcfap2c, a putative downstream target of Prdm1, during normal mouse embryogenesis and the consequences of its specific ..
  5. Bamforth S, Braganca J, Farthing C, Schneider J, Broadbent C, Michell A, et al. Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet. 2004;36:1189-96 pubmed
    ..We propose that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2(-/-) mice, and that such malformations may be the sole manifestation of a laterality defect. ..
  6. Eloranta J, Hurst H. Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J Biol Chem. 2002;277:30798-804 pubmed
    ..Transient transfection studies indicate that sumolation of AP-2 decreases its transcription activation potential, and we discuss the possible mechanisms for the observed suppression of AP-2 transactivation. ..
  7. Zhu C, Huang Y, Oberley L, Domann F. A family of AP-2 proteins down-regulate manganese superoxide dismutase expression. J Biol Chem. 2001;276:14407-13 pubmed
    ..These results indicate that AP-2-mediated transcriptional repression contributes to the constitutively low expression of Mn-SOD in SV40-transformed fibroblasts and suggest a mechanism for Mn-SOD down-regulation in cancer. ..
  8. Bamforth S, Braganca J, Eloranta J, Murdoch J, Marques F, Kranc K, et al. Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet. 2001;29:469-74 pubmed
    ..As certain Tfap2 isoforms are essential in neural crest, neural tube and cardiac development, we propose that abnormal embryogenesis in mice lacking Cited2 results, at least in part, from its role as a Tfap2 co-activator. ..
  9. Werling U, Schorle H. Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol. 2002;22:3149-56 pubmed
    ..Therefore, AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells. ..

More Information


  1. Maconochie M, Krishnamurthy R, Nonchev S, Meier P, Manzanares M, Mitchell P, et al. Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family. Development. 1999;126:1483-94 pubmed
    ..Our findings have identified the cis-components that allow Hoxa2 to be regulated independently in rhombomeres and cranial neural crest cells. ..
  2. Shi D, Kellems R. Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development. J Biol Chem. 1998;273:27331-8 pubmed
    ..In situ hybridization analysis revealed that AP-2gamma expression was enriched in the trophoblast lineage throughout development, suggesting that AP-2gamma may be critical for trophoblast development and differentiation. ..
  3. Williamson J, Bosher J, Skinner A, Sheer D, Williams T, Hurst H. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors. Genomics. 1996;35:262-4 pubmed
    ..Tcfap2b and Tcfap2c map to mouse chromosomes 1A2-4 and 2H3-4, respectively, while TFAP2B and TFAP2C map to human chromosomes 6p12 and ..
  4. Ozturk A, Donald L, Li L, Duckworth H, Duckworth M. Proteomic identification of AP2 gamma as a rat placental lactogen II trophoblast cell-specific enhancer binding protein. Endocrinology. 2006;147:4319-29 pubmed
    ..Several peptides of AP2 gamma, a key trophoblast cell-specific transcription factor, were identified...
  5. Guttormsen J, Koster M, Stevens J, Roop D, Williams T, Winger Q. Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol. 2008;317:187-95 pubmed publisher
    ..These results document an important role for AP-2 gamma in skin development, and reveal the existence of regulatory factors that can compensate for AP-2 gamma in its absence. ..
  6. Kidder B, Palmer S. Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 2010;20:458-72 pubmed publisher
    ..immunoprecipitation with DNA microarray hybridization (ChIP-chip) analysis to investigate targets of the TFs-TCFAP2C, EOMES, ETS2, and GATA3-and a chromatin remodeling factor, SMARCA4...
  7. Kuckenberg P, Buhl S, Woynecki T, van Fürden B, Tolkunova E, Seiffe F, et al. The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Mol Cell Biol. 2010;30:3310-20 pubmed publisher
    ..Here, we report that the transcription factor Tcfap2c is expressed at a high level in the trophectoderm and is able to induce trophoblast fate in embryonic stem cells...
  8. Trishkina A, Konopliannikov A. [The methods of irradiation dose fractionation and rate change used in studying the capacity for the postradiation repair of CFU-s forming splenic colonies after 8 and 12 days following bone marrow cell transplantation]. Radiobiologiia. 1992;32:312-6 pubmed
    ..A more committed CFU-S-8 population was found to surpass a younger and less committed CFU-S-12 population with respect to their repairability. ..
  9. Kang H, Lee M, Kang H, Kim S, Ahn J, Na H, et al. Differential regulation of estrogen receptor ? expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 2014;74:1484-94 pubmed publisher
    ..complex that was pulled down by an oligonucleotide encoding ERpro315 revealed that the transcription factor AP-2? (TFAP2C) and the IFN-?-inducible protein 16 (IFI16) were components of the complex...